| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| NEA Management Company, LLC | 18,093,034 | 18,093,034 | 0 | 1.68 | 2.61 | +0.94 | hold |
| Octagon Capital Advisors LP | 18,350,000 | 17,050,000 | -1,300,000 | 4.95 | 7.00 | +2.05 | sell |
| BlackRock, Inc. | 12,142,596 | 13,846,054 | +1,703,458 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 11,410,792 | 12,009,773 | +598,981 | 0.00 | 0.00 | +0.00 | buy |
| ARCH Venture Management, LLC | 8,055,916 | 8,055,916 | 0 | 3.31 | 4.30 | +0.99 | hold |
| Samsara BioCapital, LLC | 6,130,268 | 6,130,268 | 0 | 1.54 | 2.10 | +0.56 | hold |
| Palo Alto Investors LP | 5,739,013 | 5,464,349 | -274,664 | 1.50 | 2.66 | +1.16 | sell |
| Siren, L.L.C. | 5,208,968 | 5,208,968 | 0 | 0.33 | 0.54 | +0.20 | hold |
| 683 Capital Management, LLC | 6,340,000 | 5,059,200 | -1,280,800 | 0.79 | 1.21 | +0.42 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 7,146,022 | 5,012,969 | -2,133,053 | 0.02 | 0.02 | +0.00 | sell |
| HHLR ADVISORS, LTD. | 4,974,041 | 4,974,041 | 0 | 0.20 | 0.32 | +0.12 | hold |
| SILVERARC CAPITAL MANAGEMENT, LLC | 5,146,782 | 4,779,082 | -367,700 | 1.30 | 1.82 | +0.52 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 4,555,080 | 4,689,531 | +134,451 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 7,315,325 | 4,085,346 | -3,229,979 | 0.00 | 0.00 | +0.00 | sell |
| STATE STREET CORP | 2,481,406 | 3,883,667 | +1,402,261 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 3,812,797 | +3,812,797 | 0.00 | 0.29 | +0.29 | buy |
| MILLENNIUM MANAGEMENT LLC | 496,248 | 3,619,329 | +3,123,081 | 0.00 | 0.01 | +0.01 | buy |
| Rock Springs Capital Management LP | 3,266,960 | 3,266,960 | 0 | 0.25 | 0.50 | +0.25 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 2,732,294 | 2,980,188 | +247,894 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 2,881,904 | +2,881,904 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 2,770,046 | +2,770,046 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 3,545,000 | 2,725,000 | -820,000 | 0.88 | 1.01 | +0.13 | sell |
| TWO SIGMA INVESTMENTS, LP | 1,745,127 | 2,287,251 | +542,124 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 767,561 | 2,284,216 | +1,516,655 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 4,459,087 | 1,909,087 | -2,550,000 | 0.02 | 0.02 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 1,672,200 | 1,870,100 | +197,900 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,621,419 | 1,729,634 | +108,215 | 0.00 | 0.00 | +0.00 | buy |
| ABSOLUTE INVESTMENT ADVISERS, LLC | 1,500,000 | 1,500,000 | 0 | 0.10 | 0.13 | +0.03 | hold |
| NORTHERN TRUST CORP | 1,520,126 | 1,495,403 | -24,723 | 0.00 | 0.00 | +0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,091,564 | 1,408,118 | +316,554 | 0.01 | 0.01 | +0.01 | buy |
| Monaco Asset Management SAM | 3,550,000 | 1,379,416 | -2,170,584 | 1.65 | 1.35 | -0.30 | sell |
| Focus Partners Wealth | 1,150,000 | 1,325,198 | +175,198 | 0.00 | 0.01 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 2,261,455 | 1,278,921 | -982,534 | 0.00 | 0.00 | +0.00 | sell |
| Nuveen, LLC | 246,864 | 1,077,135 | +830,271 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 1,054,356 | +1,054,356 | 0.00 | 0.04 | +0.04 | buy |
| ROYAL BANK OF CANADA | 0 | 1,001,606 | +1,001,606 | 0.00 | 0.00 | +0.00 | buy |
| Eversept Partners, LP | 1,695,762 | 925,233 | -770,529 | 0.21 | 0.19 | -0.02 | sell |
| TANG CAPITAL MANAGEMENT LLC | 0 | 800,000 | +800,000 | 0.00 | 0.08 | +0.08 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 770,574 | +770,574 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 1,383,863 | 764,165 | -619,698 | 0.11 | 0.13 | +0.02 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 726,800 | +726,800 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 702,065 | +702,065 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 685,049 | +685,049 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 646,615 | +646,615 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 641,715 | +641,715 | 0.00 | 0.00 | +0.00 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 1,117,972 | 635,397 | -482,575 | 0.00 | 0.00 | +0.00 | sell |
| MORGAN STANLEY | 0 | 566,419 | +566,419 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 545,679 | +545,679 | 0.00 | 0.01 | +0.01 | buy |
| SILVERBACK ASSET MANAGEMENT LLC | 350,000 | 500,000 | +150,000 | 0.07 | 0.17 | +0.10 | buy |
| Woodline Partners LP | 495,153 | 495,153 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Exome Asset Management LLC | 1,097,999 | 451,699 | -646,300 | 1.11 | 0.78 | -0.33 | sell |
| Bank of New York Mellon Corp | 386,708 | 448,211 | +61,503 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 239,245 | 352,086 | +112,841 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 485,900 | 335,900 | -150,000 | 0.01 | 0.02 | +0.00 | sell |
| MACKENZIE FINANCIAL CORP | 553,064 | 309,050 | -244,014 | 0.00 | 0.00 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 160,695 | 299,582 | +138,887 | 0.00 | 0.00 | +0.00 | buy |
| SMITH, MOORE & CO. | 300,000 | 280,000 | -20,000 | 0.03 | 0.06 | +0.03 | sell |
| Informed Momentum Co LLC | 0 | 278,422 | +278,422 | 0.00 | 0.08 | +0.08 | buy |
| XTX Topco Ltd | 98,976 | 274,782 | +175,806 | 0.01 | 0.04 | +0.03 | buy |
| BARCLAYS PLC | 338,792 | 271,706 | -67,086 | 0.00 | 0.00 | +0.00 | sell |
| D. E. Shaw & Co., Inc. | 56,808 | 248,818 | +192,010 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 231,049 | 225,060 | -5,989 | 0.00 | 0.00 | +0.00 | sell |
| ADAR1 Capital Management, LLC | 227,228 | 212,531 | -14,697 | 0.05 | 0.06 | +0.01 | sell |
| Qube Research & Technologies Ltd | 249,784 | 208,789 | -40,995 | 0.00 | 0.00 | +0.00 | sell |
| Stonepine Capital Management, LLC | 0 | 204,770 | +204,770 | 0.00 | 0.44 | +0.44 | buy |
| JPMORGAN CHASE & CO | 90,447 | 194,369 | +103,922 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 760,448 | 190,815 | -569,633 | 0.07 | 0.04 | -0.02 | sell |
| Cubist Systematic Strategies, LLC | 0 | 162,785 | +162,785 | 0.00 | 0.01 | +0.01 | buy |
| LPL Financial LLC | 0 | 138,326 | +138,326 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 138,176 | 138,176 | 0 | 0.17 | 0.27 | +0.11 | hold |
| PRELUDE CAPITAL MANAGEMENT, LLC | 374,169 | 136,200 | -237,969 | 0.04 | 0.03 | -0.02 | sell |
| Merit Financial Group, LLC | 0 | 134,688 | +134,688 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 730,357 | 132,552 | -597,805 | 0.08 | 0.03 | -0.05 | sell |
| Sequoia Financial Advisors, LLC | 118,500 | 117,500 | -1,000 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 98,157 | 116,667 | +18,510 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 105,961 | 105,226 | -735 | 0.00 | 0.00 | +0.00 | sell |
| MetLife Investment Management, LLC | 115,813 | 101,513 | -14,300 | 0.00 | 0.00 | +0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 98,303 | 100,847 | +2,544 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 95,291 | 100,658 | +5,367 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 122,644 | 99,155 | -23,489 | 0.00 | 0.00 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 26,420 | 98,680 | +72,260 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 17,117 | 96,403 | +79,286 | 0.00 | 0.00 | +0.00 | buy |
| HB Wealth Management, LLC | 0 | 94,748 | +94,748 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 103,947 | 87,274 | -16,673 | 0.00 | 0.00 | +0.00 | sell |
| CHOREO, LLC | 76,111 | 85,111 | +9,000 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 95,796 | 79,709 | -16,087 | 0.00 | 0.00 | +0.00 | sell |
| Cambridge Investment Research Advisors, Inc. | 19,300 | 77,440 | +58,140 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 233,170 | 74,531 | -158,639 | 0.01 | 0.01 | -0.00 | sell |
| Velan Capital Investment Management LP | 75,000 | 70,000 | -5,000 | 0.09 | 0.17 | +0.08 | sell |
| Graham Capital Management, L.P. | 46,894 | 67,367 | +20,473 | 0.00 | 0.01 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 72,061 | 65,379 | -6,682 | 0.00 | 0.00 | +0.00 | sell |
| SEI INVESTMENTS CO | 0 | 61,186 | +61,186 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 59,100 | +59,100 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 42,915 | 51,314 | +8,399 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 51,264 | +51,264 | 0.00 | 0.05 | +0.05 | buy |
| PRUDENTIAL FINANCIAL INC | 50,415 | 50,715 | +300 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 46,464 | 50,103 | +3,639 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 46,367 | +46,367 | 0.00 | 0.05 | +0.05 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 77,000 | 43,600 | -33,400 | 0.00 | 0.00 | +0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 35,271 | 42,671 | +7,400 | 0.00 | 0.00 | +0.00 | buy |