| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Artal Group S.A. | 6,399,819 | 12,058,968 | +5,659,149 | 0.23 | 0.37 | +0.14 | buy |
| Eversept Partners, LP | 4,427,857 | 6,432,715 | +2,004,858 | 0.31 | 0.52 | +0.20 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 5,357,778 | 6,954,110 | +1,596,332 | 0.17 | 0.26 | +0.08 | buy |
| 683 Capital Management, LLC | 1,726,139 | 3,314,700 | +1,588,561 | 0.11 | 0.25 | +0.14 | buy |
| Octagon Capital Advisors LP | 8,187,883 | 9,187,883 | +1,000,000 | 1.20 | 1.34 | +0.14 | buy |
| NEA Management Company, LLC | 15,727,942 | 15,838,009 | +110,067 | 1.01 | 0.96 | -0.05 | buy |
| SMITH, MOORE & CO. | 66,000 | 126,000 | +60,000 | 0.01 | 0.01 | +0.01 | buy |
| Financial Advocates Investment Management | 72,850 | 98,350 | +25,500 | 0.00 | 0.01 | +0.00 | buy |
| waypoint wealth counsel | 11,458 | 11,758 | +300 | 0.01 | 0.01 | +0.00 | buy |
| PFS Partners, LLC | 140 | 130 | -10 | 0.00 | 0.00 | -0.00 | sell |
| Birchview Capital, LP | 209,088 | 138,176 | -70,912 | 0.15 | 0.10 | -0.05 | sell |
| Palo Alto Investors LP | 6,530,288 | 5,958,888 | -571,400 | 0.51 | 0.59 | +0.07 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 1,932,568 | 1,338,090 | -594,478 | 0.29 | 0.20 | -0.10 | sell |
| ARMISTICE CAPITAL, LLC | 4,956,000 | 4,156,000 | -800,000 | 0.06 | 0.05 | -0.01 | sell |
| Madison Avenue Partners, LP | 6,130,268 | 5,054,472 | -1,075,796 | 0.72 | 0.65 | -0.07 | sell |
| HIGHBRIDGE CAPITAL MANAGEMENT LLC | 3,031,306 | 1,310,477 | -1,720,829 | 0.14 | 0.06 | -0.08 | sell |
| Monashee Investment Management LLC | 5,304,212 | 3,459,854 | -1,844,358 | 1.85 | 0.56 | -1.29 | sell |
| Alyeska Investment Group, L.P. | 6,803,500 | 2,913,216 | -3,890,284 | 0.04 | 0.02 | -0.02 | sell |
| Nantahala Capital Management, LLC | 6,089,471 | 672,856 | -5,416,615 | 0.43 | 0.04 | -0.40 | sell |
| Opaleye Management Inc. | 8,000,000 | 0 | -8,000,000 | 1.01 | 0.78 | -0.23 | sell |