| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 638,421 | 12,263,918 | +11,625,497 | 0.00 | 0.00 | +0.00 | buy |
| Artal Group S.A. | 6,399,819 | 12,058,968 | +5,659,149 | 0.23 | 0.38 | +0.14 | buy |
| MORGAN STANLEY | 0 | 5,568,872 | +5,568,872 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 3,807,661 | +3,807,661 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 3,695,227 | +3,695,227 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 2,103,048 | +2,103,048 | 0.00 | 0.01 | +0.01 | buy |
| Eversept Partners, LP | 4,427,857 | 6,432,715 | +2,004,858 | 0.41 | 0.58 | +0.17 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 5,357,778 | 6,954,110 | +1,596,332 | 0.17 | 0.26 | +0.08 | buy |
| 683 Capital Management, LLC | 1,726,139 | 3,314,700 | +1,588,561 | 0.15 | 0.30 | +0.16 | buy |
| CITIGROUP INC | 196,732 | 1,705,436 | +1,508,704 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,664,502 | 2,726,251 | +1,061,749 | 0.00 | 0.00 | +0.00 | buy |
| Octagon Capital Advisors LP | 8,187,883 | 9,187,883 | +1,000,000 | 1.20 | 1.34 | +0.14 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 997,001 | +997,001 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 1,972,839 | 2,937,931 | +965,092 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 0 | 504,800 | +504,800 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 536,095 | 1,022,261 | +486,166 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 330,151 | 713,551 | +383,400 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 379,882 | +379,882 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 11,268,328 | 11,635,634 | +367,306 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 20,791 | 312,357 | +291,566 | 0.00 | 0.00 | +0.00 | buy |
| Monaco Asset Management SAM | 0 | 280,000 | +280,000 | 0.00 | 0.10 | +0.10 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 1,534,662 | 1,805,137 | +270,475 | 0.01 | 0.01 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 271,310 | 506,888 | +235,578 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 228,592 | +228,592 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 13,891 | 221,803 | +207,912 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 185,300 | +185,300 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,080,642 | 1,219,829 | +139,187 | 0.00 | 0.00 | +0.00 | buy |
| NEA Management Company, LLC | 15,727,942 | 15,838,009 | +110,067 | 1.01 | 0.96 | -0.05 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,165,579 | 2,272,925 | +107,346 | 0.00 | 0.00 | +0.00 | buy |
| SMITH, MOORE & CO. | 66,000 | 126,000 | +60,000 | 0.01 | 0.01 | +0.01 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 58,335 | +58,335 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 53,458 | +53,458 | 0.00 | 0.01 | +0.01 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 0 | 47,908 | +47,908 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 1,053,400 | 1,100,800 | +47,400 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 46,441 | +46,441 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 39,161 | +39,161 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 32,897 | +32,897 | 0.00 | 0.00 | +0.00 | buy |
| Financial Advocates Investment Management | 72,850 | 98,350 | +25,500 | 0.00 | 0.01 | +0.00 | buy |
| HCR Wealth Advisors | 0 | 22,000 | +22,000 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 10,324 | 31,683 | +21,359 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 0 | 20,700 | +20,700 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 12,318 | +12,318 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 10,505 | +10,505 | 0.00 | 0.00 | +0.00 | buy |
| Sequoia Financial Advisors, LLC | 58,500 | 68,500 | +10,000 | 0.00 | 0.00 | -0.00 | buy |
| Schonfeld Strategic Advisors LLC | 359,900 | 369,660 | +9,760 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 436,760 | 442,786 | +6,026 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 6,801 | 12,200 | +5,399 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 33,504 | 34,543 | +1,039 | 0.00 | 0.00 | +0.00 | buy |
| waypoint wealth counsel | 11,458 | 11,758 | +300 | 0.01 | 0.01 | +0.00 | buy |
| Advisory Services Network, LLC | 0 | 40 | +40 | 0.00 | 0.00 | +0.00 | buy |
| Morton Brown Family Wealth, LLC | 0 | 25 | +25 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 17,000 | 17,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RHUMBLINE ADVISERS | 3,404 | 3,404 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 19,908 | 19,908 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 838,600 | 838,600 | 0 | 0.10 | 0.07 | -0.03 | hold |
| WHITEBOX ADVISORS LLC | 0 | 0 | 0 | 0.19 | 0.16 | -0.03 | hold |
| ARCH Venture Management, LLC | 8,055,916 | 8,055,916 | 0 | 4.36 | 4.50 | +0.14 | hold |
| WOLVERINE ASSET MANAGEMENT LLC | 0 | 0 | 0 | 0.17 | 0.13 | -0.03 | hold |
| Context Capital Management, LLC | 0 | 0 | 0 | 0.70 | 0.55 | -0.15 | hold |
| ABSOLUTE INVESTMENT ADVISERS, LLC | 5,000,000 | 5,000,000 | 0 | 0.28 | 0.27 | -0.01 | hold |
| Texas Yale Capital Corp. | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Weiss Asset Management LP | 2,000,000 | 2,000,000 | 0 | 0.13 | 0.13 | -0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 4 | 4 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DAFNA Capital Management LLC | 1,476,052 | 1,476,052 | 0 | 0.38 | 0.32 | -0.06 | hold |
| Bank of New York Mellon Corp | 91,246 | 91,246 | 0 | 0.00 | 0.00 | +0.00 | hold |
| 683 Capital Management, LLC | 0 | 0 | 0 | 0.61 | 0.56 | -0.05 | hold |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 0 | 0 | 0.11 | 0.06 | -0.04 | hold |
| Verition Fund Management LLC | 0 | 0 | 0 | 0.05 | 0.03 | -0.01 | hold |
| EcoR1 Capital, LLC | 9,195,404 | 9,195,404 | 0 | 0.26 | 0.22 | -0.04 | hold |
| Rock Springs Capital Management LP | 0 | 0 | 0 | 0.10 | 0.09 | -0.01 | hold |
| Rock Springs Capital Management LP | 3,266,960 | 3,266,960 | 0 | 0.07 | 0.07 | +0.00 | hold |
| Arcus Capital Partners, LLC | 10,042 | 10,042 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Cetera Investment Advisers | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Samsara BioCapital, LLC | 6,130,268 | 6,130,268 | 0 | 1.56 | 0.87 | -0.69 | hold |
| DeepCurrents Investment Group LLC | 0 | 0 | 0 | 0.55 | 0.45 | -0.10 | hold |
| HHLR ADVISORS, LTD. | 4,974,041 | 4,974,041 | 0 | 0.09 | 0.09 | -0.00 | hold |
| Shaolin Capital Management LLC | 0 | 0 | 0 | 0.46 | 0.41 | -0.05 | hold |
| SILVERARC CAPITAL MANAGEMENT, LLC | 6,130,268 | 6,130,268 | 0 | 1.90 | 1.73 | -0.18 | hold |
| Federation des caisses Desjardins du Quebec | 790 | 790 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Clearstead Advisors, LLC | 22,000 | 22,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FARALLON CAPITAL MANAGEMENT LLC | 6,130,272 | 6,130,272 | 0 | 0.03 | 0.03 | +0.01 | hold |
| HIGHBRIDGE CAPITAL MANAGEMENT LLC | 0 | 0 | 0 | 0.55 | 0.50 | -0.06 | hold |
| TUDOR INVESTMENT CORP ET AL | 46,464 | 46,464 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 0 | 0 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PFS Partners, LLC | 140 | 130 | -10 | 0.00 | 0.00 | -0.00 | sell |
| Beaird Harris Wealth Management, LLC | 74 | 0 | -74 | 0.00 | 0.00 | -0.00 | sell |
| CARY STREET PARTNERS INVESTMENT ADVISORY LLC | 100 | 0 | -100 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 200 | 100 | -100 | 0.00 | 0.00 | -0.00 | sell |
| TORONTO DOMINION BANK | 112 | 0 | -112 | 0.00 | 0.00 | -0.00 | sell |
| Authentikos Wealth Advisory, LLC | 150 | 0 | -150 | 0.00 | 0.00 | -0.00 | sell |
| Capital Advisors, Ltd. LLC | 208 | 0 | -208 | 0.00 | 0.00 | 0.00 | sell |
| Daiwa Securities Group Inc. | 260 | 0 | -260 | 0.00 | 0.00 | 0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 4,591 | 1,035 | -3,556 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 5,774 | 0 | -5,774 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 14,730 | 0 | -14,730 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 30,156 | 4,802 | -25,354 | 0.00 | 0.00 | -0.00 | sell |
| CreativeOne Wealth, LLC | 27,750 | 0 | -27,750 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 6,168,143 | 6,140,232 | -27,911 | 0.01 | 0.01 | +0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 564,303 | 499,822 | -64,481 | 0.00 | 0.00 | +0.00 | sell |
| Birchview Capital, LP | 209,088 | 138,176 | -70,912 | 0.15 | 0.10 | -0.05 | sell |