| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Octagon Capital Advisors LP | 9,187,883 | 18,350,000 | +9,162,117 | 1.45 | 2.82 | +1.37 | buy |
| Alyeska Investment Group, L.P. | 5,767,456 | 8,808,514 | +3,041,058 | 0.03 | 0.03 | +0.00 | buy |
| Monaco Asset Management SAM | 3,850,920 | 5,371,641 | +1,520,721 | 1.59 | 2.16 | +0.57 | buy |
| 683 Capital Management, LLC | 5,800,000 | 6,975,000 | +1,175,000 | 0.44 | 0.39 | -0.04 | buy |
| Opaleye Management Inc. | 3,665,010 | 4,490,000 | +824,990 | 0.62 | 0.71 | +0.09 | buy |
| Exome Asset Management LLC | 468,499 | 1,097,999 | +629,500 | 0.31 | 0.75 | +0.43 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 5,645,352 | 6,171,847 | +526,495 | 1.25 | 1.25 | -0.01 | buy |
| SMITH, MOORE & CO. | 226,000 | 300,000 | +74,000 | 0.02 | 0.02 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 552,000 | 541,000 | +11,000 | 0.01 | 0.01 | 0.00 | sell |
| STEPH & CO | 20,000 | 25,000 | +5,000 | 0.01 | 0.01 | +0.00 | buy |
| PFS Partners, LLC | 128 | 63 | -65 | 0.00 | 0.00 | -0.00 | sell |
| DAFNA Capital Management LLC | 1,419,262 | 1,409,262 | -10,000 | 0.33 | 0.32 | -0.01 | sell |
| Sivia Capital Partners, LLC | 39,018 | 28,018 | -11,000 | 0.02 | 0.01 | -0.01 | sell |
| Financial Advocates Investment Management | 93,550 | 78,616 | -14,934 | 0.01 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 787,288 | 728,459 | -58,829 | 0.01 | 0.00 | -0.00 | sell |
| Diametric Capital, LP | 287,259 | 223,770 | -63,489 | 0.14 | 0.14 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 416,958 | 295,613 | -121,345 | 0.07 | 0.06 | -0.01 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 3,524,908 | 3,180,295 | -344,613 | 0.16 | 0.17 | +0.01 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,887,512 | 1,534,668 | -352,844 | 0.01 | 0.00 | -0.00 | sell |
| Siren, L.L.C. | 13,281,610 | 5,208,968 | -8,072,642 | 0.66 | 0.21 | -0.45 | sell |