| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Octagon Capital Advisors LP | 9,187,883 | 18,350,000 | +9,162,117 | 1.45 | 2.82 | +1.37 | buy |
| NEA Management Company, LLC | 18,093,034 | 18,093,034 | 0 | 0.98 | 0.92 | -0.05 | hold |
| VANGUARD GROUP INC | 11,754,397 | 10,034,149 | -1,720,248 | 0.00 | 0.00 | -0.00 | sell |
| Alyeska Investment Group, L.P. | 5,767,456 | 8,808,514 | +3,041,058 | 0.03 | 0.03 | +0.00 | buy |
| ARCH Venture Management, LLC | 8,055,916 | 8,055,916 | 0 | 3.05 | 3.17 | +0.12 | hold |
| FMR LLC | 7,935,735 | 7,933,000 | -2,735 | 0.00 | 0.00 | -0.00 | sell |
| 683 Capital Management, LLC | 5,800,000 | 6,975,000 | +1,175,000 | 0.58 | 0.62 | +0.04 | buy |
| Palo Alto Investors LP | 6,277,093 | 6,277,093 | 0 | 0.80 | 0.88 | +0.08 | hold |
| SILVERARC CAPITAL MANAGEMENT, LLC | 5,645,352 | 6,171,847 | +526,495 | 1.25 | 1.25 | -0.01 | buy |
| Samsara BioCapital, LLC | 6,130,268 | 6,130,268 | 0 | 1.16 | 0.76 | -0.40 | hold |
| Monaco Asset Management SAM | 3,850,920 | 5,371,641 | +1,520,721 | 1.59 | 2.16 | +0.57 | buy |
| Siren, L.L.C. | 13,281,610 | 5,208,968 | -8,072,642 | 0.66 | 0.21 | -0.45 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 3,948,249 | 5,104,760 | +1,156,511 | 0.01 | 0.01 | +0.00 | buy |
| Eversept Partners, LP | 4,978,458 | 4,978,458 | 0 | 0.38 | 0.46 | +0.09 | hold |
| HHLR ADVISORS, LTD. | 4,974,041 | 4,974,041 | 0 | 0.11 | 0.16 | +0.05 | hold |
| Opaleye Management Inc. | 3,665,010 | 4,490,000 | +824,990 | 0.62 | 0.71 | +0.09 | buy |
| MILLENNIUM MANAGEMENT LLC | 3,128,888 | 3,586,067 | +457,179 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 3,391,483 | 3,391,483 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Rock Springs Capital Management LP | 3,266,960 | 3,266,960 | 0 | 0.10 | 0.11 | +0.01 | hold |
| PLATINUM INVESTMENT MANAGEMENT LTD | 3,524,908 | 3,180,295 | -344,613 | 0.16 | 0.17 | +0.01 | sell |
| BlackRock, Inc. | 2,805,642 | 3,029,209 | +223,567 | 0.00 | 0.00 | -0.00 | buy |
| ABSOLUTE INVESTMENT ADVISERS, LLC | 2,750,000 | 2,750,000 | 0 | 0.20 | 0.19 | -0.01 | hold |
| MARSHALL WACE, LLP | 3,484,932 | 2,534,378 | -950,554 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,212,377 | 2,250,461 | +38,084 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 2,112,745 | 2,112,745 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 1,744,805 | 1,712,503 | -32,302 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,887,512 | 1,534,668 | -352,844 | 0.01 | 0.00 | -0.00 | sell |
| Laurion Capital Management LP | 1,487,982 | 1,487,982 | 0 | 0.09 | 0.08 | -0.01 | hold |
| DAFNA Capital Management LLC | 1,419,262 | 1,409,262 | -10,000 | 0.33 | 0.32 | -0.01 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,228,077 | 1,241,979 | +13,902 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 800,000 | 1,157,500 | +357,500 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 468,499 | 1,097,999 | +629,500 | 0.31 | 0.75 | +0.43 | buy |
| TWO SIGMA INVESTMENTS, LP | 630,961 | 891,279 | +260,318 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 67,546 | 862,413 | +794,867 | 0.01 | 0.06 | +0.05 | buy |
| STATE STREET CORP | 712,776 | 768,476 | +55,700 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 787,288 | 728,459 | -58,829 | 0.01 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 228,455 | 695,915 | +467,460 | 0.00 | 0.00 | +0.00 | buy |
| HIGHBRIDGE CAPITAL MANAGEMENT LLC | 597,694 | 597,694 | 0 | 0.02 | 0.02 | -0.00 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 350,961 | 577,874 | +226,913 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 552,000 | 541,000 | -11,000 | 0.01 | 0.01 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 104,612 | 414,847 | +310,235 | 0.01 | 0.03 | +0.02 | buy |
| NORTHERN TRUST CORP | 410,700 | 411,326 | +626 | 0.00 | 0.00 | -0.00 | buy |
| SMITH, MOORE & CO. | 226,000 | 300,000 | +74,000 | 0.02 | 0.02 | +0.00 | buy |
| MACKENZIE FINANCIAL CORP | 50,050 | 299,815 | +249,765 | 0.00 | 0.00 | +0.00 | buy |
| MACKENZIE FINANCIAL CORP | 50,050 | 299,815 | +249,765 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 416,958 | 295,613 | -121,345 | 0.07 | 0.06 | -0.01 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 274,529 | 265,407 | -9,122 | 0.00 | 0.00 | -0.00 | sell |
| Diametric Capital, LP | 287,259 | 223,770 | -63,489 | 0.14 | 0.14 | -0.00 | sell |
| Opti Capital Management, LP | 0 | 182,319 | +182,319 | 0.00 | 0.01 | +0.01 | buy |
| Schonfeld Strategic Advisors LLC | 236,600 | 154,700 | -81,900 | 0.00 | 0.00 | -0.00 | sell |
| Birchview Capital, LP | 138,176 | 138,176 | 0 | 0.12 | 0.10 | -0.02 | hold |
| Aster Capital Management (DIFC) Ltd | 134,563 | 134,563 | 0 | 0.03 | 0.05 | +0.02 | hold |
| Sequoia Financial Advisors, LLC | 118,500 | 118,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GOLDMAN SACHS GROUP INC | 730,754 | 114,556 | -616,198 | 0.00 | 0.00 | -0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 1,328 | 107,470 | +106,142 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 100,000 | +100,000 | 0.00 | 0.00 | +0.00 | buy |
| Financial Advocates Investment Management | 93,550 | 78,616 | -14,934 | 0.01 | 0.00 | -0.00 | sell |
| Velan Capital Investment Management LP | 0 | 75,000 | +75,000 | 0.00 | 0.06 | +0.06 | buy |
| GROUP ONE TRADING LLC | 11,064 | 74,644 | +63,580 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 146,957 | 71,944 | -75,013 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 6,434,046 | 64,777 | -6,369,269 | 0.00 | 0.00 | -0.00 | sell |
| CHOREO, LLC | 48,111 | 48,111 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FULLCIRCLE WEALTH LLC | 0 | 47,954 | +47,954 | 0.00 | 0.03 | +0.03 | buy |
| PRUDENTIAL FINANCIAL INC | 47,050 | 47,050 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TUDOR INVESTMENT CORP ET AL | 46,464 | 46,464 | 0 | 0.00 | 0.00 | -0.00 | hold |
| US BANCORP \DE\ | 39,655 | 39,655 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HB Wealth Management, LLC | 27,500 | 37,700 | +10,200 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 34,947 | +34,947 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 34,471 | 34,471 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sivia Capital Partners, LLC | 39,018 | 28,018 | -11,000 | 0.02 | 0.01 | -0.01 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 26,158 | 26,158 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Cetera Investment Advisers | 12,536 | 25,036 | +12,500 | 0.00 | 0.00 | +0.00 | buy |
| STEPH & CO | 20,000 | 25,000 | +5,000 | 0.01 | 0.01 | +0.00 | buy |
| Clearstead Advisors, LLC | 22,000 | 22,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| XTX Topco Ltd | 0 | 21,339 | +21,339 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 20,220 | 20,220 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WOLVERINE TRADING, LLC | 10,876 | 18,912 | +8,036 | 0.00 | 0.00 | +0.00 | buy |
| Cambridge Investment Research Advisors, Inc. | 16,000 | 16,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Vanguard Personalized Indexing Management, LLC | 12,054 | 14,564 | +2,510 | 0.00 | 0.00 | +0.00 | buy |
| Traynor Capital Management, Inc. | 14,000 | 14,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Texas Yale Capital Corp. | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Moors & Cabot, Inc. | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Steward Partners Investment Advisory, LLC | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 954 | 954 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Federation des caisses Desjardins du Quebec | 750 | 750 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Farther Finance Advisors, LLC | 0 | 400 | +400 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 21,064 | 100 | -20,964 | 0.00 | 0.00 | -0.00 | sell |
| PFS Partners, LLC | 128 | 63 | -65 | 0.00 | 0.00 | -0.00 | sell |
| Morton Brown Family Wealth, LLC | 25 | 25 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Capital Advisors, Ltd. LLC | 141 | 17 | -124 | 0.00 | 0.00 | 0.00 | sell |
| CITIGROUP INC | 657,838 | 3 | -657,835 | 0.00 | 0.00 | -0.00 | sell |
| AGF MANAGEMENT LTD | 0 | 0 | 0 | 0.01 | 0.01 | +0.00 | hold |
| TD ASSET MANAGEMENT INC | 916,250 | 0 | -916,250 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 3,065,136 | 0 | -3,065,136 | 0.01 | 0.00 | -0.01 | sell |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 261 | 0 | -261 | 0.00 | 0.00 | -0.00 | sell |
| WHITEBOX ADVISORS LLC | 0 | 0 | 0 | 0.23 | 0.20 | -0.03 | hold |
| ALGERT GLOBAL LLC | 119,062 | 0 | -119,062 | 0.00 | 0.00 | -0.00 | sell |
| WOLVERINE ASSET MANAGEMENT LLC | 0 | 0 | 0 | 0.21 | 0.22 | +0.01 | hold |
| CIBC Private Wealth Group LLC | 1,000 | 0 | -1,000 | 0.00 | 0.00 | -0.00 | sell |
| Context Capital Management, LLC | 0 | 0 | 0 | 0.31 | 0.46 | +0.15 | hold |