| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| NEA Management Company, LLC | 18,093,034 | 18,093,034 | 0 | 2.61 | 2.86 | +0.25 | hold |
| BlackRock, Inc. | 13,846,054 | 17,056,878 | +3,210,824 | 0.00 | 0.00 | +0.00 | buy |
| Octagon Capital Advisors LP | 17,050,000 | 13,915,371 | -3,134,629 | 7.00 | 5.40 | -1.60 | sell |
| VANGUARD GROUP INC | 12,009,773 | 12,873,209 | +863,436 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 3,883,667 | 9,310,969 | +5,427,302 | 0.00 | 0.00 | +0.00 | buy |
| ARCH Venture Management, LLC | 8,055,916 | 8,055,916 | 0 | 4.30 | 3.83 | -0.47 | hold |
| Samsara BioCapital, LLC | 6,130,268 | 7,222,559 | +1,092,291 | 2.10 | 2.31 | +0.21 | buy |
| Siren, L.L.C. | 5,208,968 | 5,208,968 | 0 | 0.54 | 0.48 | -0.05 | hold |
| 683 Capital Management, LLC | 5,059,200 | 5,190,800 | +131,600 | 1.21 | 1.34 | +0.13 | buy |
| HHLR ADVISORS, LTD. | 4,974,041 | 4,974,041 | 0 | 0.32 | 0.50 | +0.18 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 4,689,531 | 4,872,714 | +183,183 | 0.00 | 0.00 | +0.00 | buy |
| Palo Alto Investors LP | 5,464,349 | 4,471,592 | -992,757 | 2.66 | 1.93 | -0.73 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 5,012,969 | 4,416,903 | -596,066 | 0.02 | 0.02 | -0.00 | sell |
| FMR LLC | 4,085,346 | 4,237,590 | +152,244 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 20,006 | 3,845,885 | +3,825,879 | 0.00 | 0.02 | +0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 3,619,329 | 3,584,288 | -35,041 | 0.01 | 0.01 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 2,287,251 | 3,397,110 | +1,109,859 | 0.01 | 0.02 | +0.01 | buy |
| Rock Springs Capital Management LP | 3,266,960 | 3,266,960 | 0 | 0.50 | 0.52 | +0.02 | hold |
| PERCEPTIVE ADVISORS LLC | 3,812,797 | 3,139,669 | -673,128 | 0.29 | 0.18 | -0.11 | sell |
| Opaleye Management Inc. | 2,725,000 | 2,720,000 | -5,000 | 1.01 | 1.11 | +0.10 | sell |
| TWO SIGMA ADVISERS, LP | 1,870,100 | 2,596,900 | +726,800 | 0.01 | 0.02 | +0.01 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,408,118 | 2,178,033 | +769,915 | 0.01 | 0.03 | +0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 4,779,082 | 2,135,722 | -2,643,360 | 1.82 | 0.96 | -0.86 | sell |
| BANK OF AMERICA CORP /DE/ | 2,881,904 | 1,906,669 | -975,235 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 299,582 | 1,792,114 | +1,492,532 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 2,770,046 | 1,771,381 | -998,665 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,729,634 | 1,685,778 | -43,856 | 0.00 | 0.00 | +0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 770,574 | 1,516,691 | +746,117 | 0.00 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 1,495,403 | 1,416,540 | -78,863 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 1,278,921 | 1,284,335 | +5,414 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 646,615 | 1,119,240 | +472,625 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 545,679 | 1,077,032 | +531,353 | 0.01 | 0.02 | +0.01 | buy |
| Monashee Investment Management LLC | 0 | 1,000,000 | +1,000,000 | 0.00 | 1.75 | +1.75 | buy |
| Integral Health Asset Management, LLC | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.16 | +0.16 | buy |
| HRT FINANCIAL LP | 0 | 956,879 | +956,879 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 566,419 | 918,888 | +352,469 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 1,909,087 | 909,087 | -1,000,000 | 0.02 | 0.01 | -0.01 | sell |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 635,397 | 750,308 | +114,911 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 2,284,216 | 704,787 | -1,579,429 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 2,980,188 | 658,888 | -2,321,300 | 0.01 | 0.00 | -0.01 | sell |
| Hennion & Walsh Asset Management, Inc. | 0 | 652,977 | +652,977 | 0.00 | 0.07 | +0.07 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 641,715 | 601,323 | -40,392 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 271,706 | 576,533 | +304,827 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 764,165 | 561,951 | -202,214 | 0.13 | 0.40 | +0.27 | sell |
| Qube Research & Technologies Ltd | 208,789 | 540,567 | +331,778 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 25,449 | 528,053 | +502,604 | 0.00 | 0.00 | +0.00 | buy |
| SILVERBACK ASSET MANAGEMENT LLC | 500,000 | 500,000 | 0 | 0.17 | 0.23 | +0.06 | hold |
| Invesco Ltd. | 352,086 | 478,909 | +126,823 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 274,782 | 456,329 | +181,547 | 0.04 | 0.04 | -0.00 | buy |
| Exome Asset Management LLC | 451,699 | 451,699 | 0 | 0.78 | 0.69 | -0.09 | hold |
| Bank of New York Mellon Corp | 448,211 | 447,901 | -310 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 194,369 | 428,903 | +234,534 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 116,667 | 361,921 | +245,254 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 138,326 | 358,917 | +220,591 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 332,336 | +332,336 | 0.00 | 0.02 | +0.02 | buy |
| Rafferty Asset Management, LLC | 0 | 312,804 | +312,804 | 0.00 | 0.00 | +0.00 | buy |
| Monaco Asset Management SAM | 1,379,416 | 309,211 | -1,070,205 | 1.35 | 0.28 | -1.07 | sell |
| Nuveen, LLC | 1,077,135 | 308,522 | -768,613 | 0.00 | 0.00 | -0.00 | sell |
| MACKENZIE FINANCIAL CORP | 309,050 | 306,453 | -2,597 | 0.00 | 0.00 | +0.00 | sell |
| SMITH, MOORE & CO. | 280,000 | 280,000 | 0 | 0.06 | 0.07 | +0.01 | hold |
| Informed Momentum Co LLC | 278,422 | 278,422 | 0 | 0.08 | 0.10 | +0.01 | hold |
| Jain Global LLC | 1,054,356 | 278,189 | -776,167 | 0.04 | 0.01 | -0.03 | sell |
| SEI INVESTMENTS CO | 61,186 | 228,896 | +167,710 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 221,591 | +221,591 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 225,060 | 214,869 | -10,191 | 0.00 | 0.00 | +0.00 | sell |
| ADAR1 Capital Management, LLC | 212,531 | 212,531 | 0 | 0.06 | 0.05 | -0.01 | hold |
| Atom Investors LP | 132,552 | 205,639 | +73,087 | 0.03 | 0.05 | +0.02 | buy |
| Stonepine Capital Management, LLC | 204,770 | 204,770 | 0 | 0.44 | 0.50 | +0.06 | hold |
| D. E. Shaw & Co., Inc. | 248,818 | 198,709 | -50,109 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 98,680 | 190,220 | +91,540 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 335,900 | 176,000 | -159,900 | 0.02 | 0.01 | -0.01 | sell |
| Russell Investments Group, Ltd. | 685,049 | 171,071 | -513,978 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 702,065 | 155,591 | -546,474 | 0.00 | 0.00 | -0.00 | sell |
| Merit Financial Group, LLC | 134,688 | 155,178 | +20,490 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 29,899 | 147,296 | +117,397 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 138,176 | 138,176 | 0 | 0.27 | 0.25 | -0.02 | hold |
| PRELUDE CAPITAL MANAGEMENT, LLC | 136,200 | 136,200 | 0 | 0.03 | 0.03 | +0.00 | hold |
| Brevan Howard Capital Management LP | 14,093 | 127,299 | +113,206 | 0.00 | 0.01 | +0.01 | buy |
| PROFUND ADVISORS LLC | 0 | 116,503 | +116,503 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 100,658 | 113,138 | +12,480 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 18,900 | 111,350 | +92,450 | 0.00 | 0.01 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 87,274 | 107,467 | +20,193 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 105,226 | 105,554 | +328 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 51,264 | 105,085 | +53,821 | 0.05 | 0.13 | +0.07 | buy |
| HB Wealth Management, LLC | 94,748 | 95,924 | +1,176 | 0.00 | 0.00 | +0.00 | buy |
| Lighthouse Investment Partners, LLC | 0 | 92,500 | +92,500 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 96,403 | 89,489 | -6,914 | 0.00 | 0.00 | -0.00 | sell |
| Sequoia Financial Advisors, LLC | 117,500 | 88,467 | -29,033 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 88,455 | +88,455 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 101,513 | 85,645 | -15,868 | 0.00 | 0.00 | +0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 100,847 | 85,582 | -15,265 | 0.00 | 0.00 | +0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 42,671 | 78,756 | +36,085 | 0.00 | 0.00 | +0.00 | buy |
| Cambridge Investment Research Advisors, Inc. | 77,440 | 76,940 | -500 | 0.00 | 0.00 | +0.00 | sell |
| Caption Management, LLC | 0 | 75,375 | +75,375 | 0.00 | 0.01 | +0.01 | buy |
| CHOREO, LLC | 85,111 | 75,111 | -10,000 | 0.00 | 0.00 | +0.00 | sell |
| SG Americas Securities, LLC | 21,195 | 74,129 | +52,934 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 73,896 | +73,896 | 0.00 | 0.06 | +0.06 | buy |
| Velan Capital Investment Management LP | 70,000 | 70,000 | 0 | 0.17 | 0.13 | -0.05 | hold |
| HighTower Advisors, LLC | 19,501 | 66,494 | +46,993 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 22,469 | 64,450 | +41,981 | 0.00 | 0.00 | +0.00 | buy |