| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 1,642,863 | 6,823,700 | +5,180,837 | 0.00 | 0.02 | +0.01 | buy |
| Rubric Capital Management LP | 3,328,653 | 3,750,000 | +421,347 | 1.64 | 2.21 | +0.57 | buy |
| BAKER BROS. ADVISORS LP | 2,826,246 | 2,826,246 | 0 | 0.68 | 0.78 | +0.10 | hold |
| TANG CAPITAL MANAGEMENT LLC | 2,259,889 | 2,259,889 | 0 | 4.60 | 5.53 | +0.92 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 1,713,043 | 1,336,313 | -376,730 | 0.12 | 0.09 | -0.02 | sell |
| MORGAN STANLEY | 1,360,044 | 997,786 | -362,258 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 1,241,621 | 959,257 | -282,364 | 0.04 | 0.04 | -0.00 | sell |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 1,068,216 | 892,666 | -175,550 | 0.03 | 0.02 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 683,505 | 811,922 | +128,417 | 0.01 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 229,364 | 735,940 | +506,576 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 766,291 | 686,853 | -79,438 | 0.05 | 0.05 | +0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 739,326 | 649,629 | -89,697 | 0.08 | 0.07 | -0.01 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 831,777 | 647,731 | -184,046 | 0.02 | 0.02 | -0.00 | sell |
| Point72 Asset Management, L.P. | 797,137 | 640,958 | -156,179 | 0.05 | 0.05 | +0.00 | sell |
| SG Americas Securities, LLC | 541,396 | 640,179 | +98,783 | 0.03 | 0.03 | +0.00 | buy |
| Pictet Asset Management Holding SA | 787,520 | 623,288 | -164,232 | 0.03 | 0.03 | +0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 632,827 | 611,398 | -21,429 | 0.18 | 0.22 | +0.04 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 596,431 | 608,416 | +11,985 | 1.35 | 1.63 | +0.28 | buy |
| ALLIANCEBERNSTEIN L.P. | 328,274 | 598,888 | +270,614 | 0.00 | 0.01 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 825,285 | 564,420 | -260,865 | 0.02 | 0.02 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 630,291 | 523,691 | -106,600 | 0.01 | 0.01 | -0.00 | sell |
| Soleus Capital Management, L.P. | 587,000 | 521,353 | -65,647 | 1.03 | 1.02 | -0.01 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 499,792 | +499,792 | 0.00 | 0.05 | +0.05 | buy |
| BlackRock, Inc. | 446,603 | 486,737 | +40,134 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 153,428 | 481,023 | +327,595 | 0.00 | 0.01 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 512,163 | 480,175 | -31,988 | 0.01 | 0.01 | +0.00 | sell |
| CITADEL ADVISORS LLC | 742,118 | 474,750 | -267,368 | 0.02 | 0.02 | -0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 425,232 | 438,002 | +12,770 | 0.01 | 0.01 | +0.00 | buy |
| Fisher Asset Management, LLC | 267,274 | 428,972 | +161,698 | 0.00 | 0.01 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 530,496 | 420,914 | -109,582 | 0.03 | 0.02 | -0.02 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 42,897 | 383,811 | +340,914 | 0.00 | 0.02 | +0.02 | buy |
| AQR CAPITAL MANAGEMENT LLC | 353,062 | 378,697 | +25,635 | 0.01 | 0.01 | +0.00 | buy |
| Aberdeen Group plc | 400,598 | 373,634 | -26,964 | 0.03 | 0.03 | +0.00 | sell |
| NOMURA HOLDINGS INC | 412,639 | 342,939 | -69,700 | 0.05 | 0.14 | +0.09 | sell |
| OBERWEIS ASSET MANAGEMENT INC/ | 312,800 | 318,634 | +5,834 | 0.47 | 0.45 | -0.02 | buy |
| ArrowMark Colorado Holdings LLC | 333,702 | 316,956 | -16,746 | 0.30 | 0.41 | +0.10 | sell |
| MARSHALL WACE, LLP | 5,800 | 305,371 | +299,571 | 0.00 | 0.02 | +0.02 | buy |
| Penn Capital Management Company, LLC | 0 | 301,993 | +301,993 | 0.00 | 1.13 | +1.13 | buy |
| SEI INVESTMENTS CO | 217,496 | 284,005 | +66,509 | 0.01 | 0.01 | +0.00 | buy |
| BRAIDWELL LP | 313,823 | 272,522 | -41,301 | 0.41 | 0.44 | +0.02 | sell |
| Parkman Healthcare Partners LLC | 665,208 | 259,184 | -406,024 | 2.61 | 1.29 | -1.32 | sell |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 250,975 | 249,278 | -1,697 | 1.58 | 1.90 | +0.32 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 209,617 | +209,617 | 0.00 | 0.01 | +0.01 | buy |
| Granahan Investment Management, LLC | 316,213 | 209,256 | -106,957 | 0.56 | 0.49 | -0.07 | sell |
| CASTLEARK MANAGEMENT LLC | 192,192 | 181,512 | -10,680 | 0.23 | 0.29 | +0.06 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 210,910 | 181,360 | -29,550 | 0.27 | 0.32 | +0.06 | sell |
| ORBIMED ADVISORS LLC | 187,199 | 180,599 | -6,600 | 0.16 | 0.19 | +0.03 | sell |
| GOLDMAN SACHS GROUP INC | 829,417 | 174,901 | -654,516 | 0.00 | 0.00 | -0.00 | sell |
| Rockefeller Capital Management L.P. | 173,438 | 173,438 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Squarepoint Ops LLC | 85,182 | 158,093 | +72,911 | 0.01 | 0.02 | +0.01 | buy |
| Trexquant Investment LP | 225,128 | 135,280 | -89,848 | 0.08 | 0.05 | -0.04 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 228,933 | 134,516 | -94,417 | 0.03 | 0.03 | -0.01 | sell |
| Man Group plc | 39,447 | 127,186 | +87,739 | 0.00 | 0.01 | +0.01 | buy |
| Linden Thomas Advisory Services, LLC | 114,462 | 121,777 | +7,315 | 0.48 | 0.56 | +0.09 | buy |
| Voleon Capital Management LP | 151,283 | 120,385 | -30,898 | 0.13 | 0.12 | -0.01 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 126,409 | 114,289 | -12,120 | 0.04 | 0.04 | +0.00 | sell |
| JPMORGAN CHASE & CO | 48,397 | 107,017 | +58,620 | 0.00 | 0.00 | +0.00 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 110,682 | 106,635 | -4,047 | 0.00 | 0.00 | +0.00 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 58,692 | 104,654 | +45,962 | 0.00 | 0.01 | +0.00 | buy |
| GLOBEFLEX CAPITAL L P | 93,396 | 93,396 | 0 | 0.59 | 0.68 | +0.09 | hold |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 148,774 | 88,600 | -60,174 | 0.01 | 0.01 | -0.00 | sell |
| PDT Partners, LLC | 101,622 | 80,263 | -21,359 | 0.27 | 0.23 | -0.04 | sell |
| STATE STREET CORP | 73,002 | 76,633 | +3,631 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 68,600 | 71,500 | +2,900 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 77,916 | 69,700 | -8,216 | 0.00 | 0.00 | -0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 79,200 | 67,341 | -11,859 | 0.11 | 0.11 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 40,429 | 63,346 | +22,917 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 96,018 | 56,494 | -39,524 | 0.44 | 0.31 | -0.13 | sell |
| Brevan Howard Capital Management LP | 0 | 53,882 | +53,882 | 0.00 | 0.03 | +0.03 | buy |
| Penserra Capital Management LLC | 0 | 53,102 | +53,102 | 0.00 | 0.03 | +0.03 | buy |
| ExodusPoint Capital Management, LP | 7,958 | 52,303 | +44,345 | 0.00 | 0.03 | +0.02 | buy |
| Fieldview Capital Management, LLC | 0 | 51,072 | +51,072 | 0.00 | 0.72 | +0.72 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 63,530 | 50,299 | -13,231 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 42,402 | 44,525 | +2,123 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 45,783 | 44,320 | -1,463 | 0.00 | 0.00 | +0.00 | sell |
| Cerity Partners LLC | 43,219 | 43,712 | +493 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 63,995 | 43,599 | -20,396 | 0.01 | 0.02 | +0.00 | sell |
| Jain Global LLC | 31,806 | 43,027 | +11,221 | 0.01 | 0.03 | +0.01 | buy |
| IEQ CAPITAL, LLC | 47,841 | 42,950 | -4,891 | 0.01 | 0.01 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 31,498 | 41,975 | +10,477 | 0.00 | 0.00 | +0.00 | buy |
| Baird Financial Group, Inc. | 42,237 | 40,249 | -1,988 | 0.00 | 0.00 | +0.00 | sell |
| Jump Financial, LLC | 91,429 | 39,735 | -51,694 | 0.05 | 0.03 | -0.02 | sell |
| NORTHERN TRUST CORP | 60,297 | 36,924 | -23,373 | 0.00 | 0.00 | -0.00 | sell |
| Inspire Investing, LLC | 0 | 35,271 | +35,271 | 0.00 | 0.16 | +0.16 | buy |
| BARCLAYS PLC | 4,577 | 34,152 | +29,575 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 1,693 | 33,714 | +32,021 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 0 | 31,951 | +31,951 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 32,116 | 31,755 | -361 | 0.00 | 0.00 | +0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 49,192 | 31,089 | -18,103 | 0.00 | 0.00 | -0.00 | sell |
| Lisanti Capital Growth, LLC | 0 | 31,065 | +31,065 | 0.00 | 0.38 | +0.38 | buy |
| Artia Global Partners LP | 29,200 | 29,200 | 0 | 0.19 | 0.32 | +0.12 | hold |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 28,955 | 28,955 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Hudson Bay Capital Management LP | 0 | 27,670 | +27,670 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 32,334 | 27,656 | -4,678 | 0.00 | 0.00 | +0.00 | sell |
| Nuveen, LLC | 20,233 | 26,948 | +6,715 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 28,728 | 26,913 | -1,815 | 0.09 | 0.08 | -0.01 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 512,163 | 26,346 | -485,817 | 0.01 | 0.00 | -0.01 | sell |
| Legal & General Group Plc | 28,566 | 24,602 | -3,964 | 0.00 | 0.00 | +0.00 | sell |
| CWM, LLC | 20,605 | 22,913 | +2,308 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 140,301 | 21,432 | -118,869 | 0.01 | 0.00 | -0.01 | sell |