| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Fairmount Funds Management LLC | 0 | 3,204,841 | +3,204,841 | 0.00 | 6.76 | +6.76 | buy |
| HHLR ADVISORS, LTD. | 0 | 3,144,556 | +3,144,556 | 0.00 | 1.45 | +1.45 | buy |
| BAKER BROS. ADVISORS LP | 0 | 2,818,323 | +2,818,323 | 0.00 | 0.67 | +0.67 | buy |
| Rubric Capital Management LP | 0 | 2,419,103 | +2,419,103 | 0.00 | 1.19 | +1.19 | buy |
| BRAIDWELL LP | 0 | 2,058,303 | +2,058,303 | 0.00 | 1.21 | +1.21 | buy |
| MORGAN STANLEY | 0 | 1,985,486 | +1,985,486 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 0 | 1,417,947 | +1,417,947 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 0 | 1,303,716 | +1,303,716 | 0.00 | 0.03 | +0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 848,894 | +848,894 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 664,040 | +664,040 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 0 | 647,142 | +647,142 | 0.00 | 1.65 | +1.65 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 625,309 | +625,309 | 0.00 | 1.19 | +1.19 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 621,948 | +621,948 | 0.00 | 0.01 | +0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 615,836 | +615,836 | 0.00 | 0.11 | +0.11 | buy |
| ArrowMark Colorado Holdings LLC | 0 | 608,868 | +608,868 | 0.00 | 0.14 | +0.14 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 0 | 600,630 | +600,630 | 0.00 | 0.67 | +0.67 | buy |
| Granahan Investment Management, LLC | 0 | 568,735 | +568,735 | 0.00 | 0.42 | +0.42 | buy |
| NORTHERN TRUST CORP | 0 | 292,933 | +292,933 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 255,000 | +255,000 | 0.00 | 0.04 | +0.04 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 0 | 239,156 | +239,156 | 0.00 | 0.13 | +0.13 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 231,079 | +231,079 | 0.00 | 0.02 | +0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 214,847 | +214,847 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 201,715 | +201,715 | 0.00 | 0.06 | +0.06 | buy |
| Soleus Capital Management, L.P. | 0 | 200,000 | +200,000 | 0.00 | 0.33 | +0.33 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 0 | 199,799 | +199,799 | 0.00 | 0.70 | +0.70 | buy |
| Hennion & Walsh Asset Management, Inc. | 0 | 181,966 | +181,966 | 0.00 | 0.17 | +0.17 | buy |
| D. E. Shaw & Co., Inc. | 0 | 169,648 | +169,648 | 0.00 | 0.00 | +0.00 | buy |
| Knights of Columbus Asset Advisors LLC | 0 | 166,272 | +166,272 | 0.00 | 0.20 | +0.20 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 147,865 | +147,865 | 0.00 | 0.01 | +0.01 | buy |
| HUSSMAN STRATEGIC ADVISORS, INC. | 0 | 147,000 | +147,000 | 0.00 | 0.76 | +0.76 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 141,500 | +141,500 | 0.00 | 0.00 | +0.00 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 140,061 | +140,061 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 125,995 | +125,995 | 0.00 | 0.00 | +0.00 | buy |
| Linden Thomas Advisory Services, LLC | 0 | 118,302 | +118,302 | 0.00 | 0.34 | +0.34 | buy |
| Bank of New York Mellon Corp | 0 | 115,143 | +115,143 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 114,309 | +114,309 | 0.00 | 0.43 | +0.43 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0 | 113,995 | +113,995 | 0.00 | 0.06 | +0.06 | buy |
| Lion Point Capital, LP | 0 | 104,691 | +104,691 | 0.00 | 6.12 | +6.12 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 92,408 | +92,408 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 0 | 88,688 | +88,688 | 0.00 | 0.60 | +0.60 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 88,391 | +88,391 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 87,002 | +87,002 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 79,200 | +79,200 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 0 | 78,600 | +78,600 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 69,226 | +69,226 | 0.00 | 0.01 | +0.01 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 0 | 68,434 | +68,434 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 66,951 | +66,951 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 66,433 | +66,433 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 0 | 64,943 | +64,943 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 60,614 | +60,614 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 57,230 | +57,230 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 56,066 | +56,066 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 54,820 | +54,820 | 0.00 | 0.00 | +0.00 | buy |
| Jackson Creek Investment Advisors LLC | 0 | 54,296 | +54,296 | 0.00 | 0.37 | +0.37 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 0 | 45,377 | +45,377 | 0.00 | 0.02 | +0.02 | buy |
| Legal & General Group Plc | 0 | 43,902 | +43,902 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 38,976 | +38,976 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 38,389 | +38,389 | 0.00 | 0.00 | +0.00 | buy |
| M&T BANK CORP | 0 | 36,389 | +36,389 | 0.00 | 0.00 | +0.00 | buy |
| Advantage Alpha Capital Partners LP | 0 | 31,258 | +31,258 | 0.00 | 0.13 | +0.13 | buy |
| STRS OHIO | 0 | 30,600 | +30,600 | 0.00 | 0.00 | +0.00 | buy |
| Fisher Asset Management, LLC | 0 | 30,225 | +30,225 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 29,636 | +29,636 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 29,226 | +29,226 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 29,093 | +29,093 | 0.00 | 0.03 | +0.03 | buy |
| Janney Montgomery Scott LLC | 0 | 28,231 | +28,231 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 25,786 | +25,786 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 24,845 | +24,845 | 0.00 | 0.00 | +0.00 | buy |
| BOSUN ASSET MANAGEMENT, LLC | 0 | 21,875 | +21,875 | 0.00 | 0.24 | +0.24 | buy |
| ALGERT GLOBAL LLC | 0 | 18,603 | +18,603 | 0.00 | 0.01 | +0.01 | buy |
| VIRTUS ADVISERS, LLC | 0 | 17,556 | +17,556 | 0.00 | 0.16 | +0.16 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 17,343 | +17,343 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 16,828 | +16,828 | 0.00 | 0.03 | +0.03 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 16,590 | +16,590 | 0.00 | 0.00 | +0.00 | buy |
| Robeco Institutional Asset Management B.V. | 0 | 15,982 | +15,982 | 0.00 | 0.00 | +0.00 | buy |
| Nebula Research & Development LLC | 0 | 15,070 | +15,070 | 0.00 | 0.05 | +0.05 | buy |
| PERSONAL CFO SOLUTIONS, LLC | 0 | 14,238 | +14,238 | 0.00 | 0.04 | +0.04 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 14,133 | +14,133 | 0.00 | 0.00 | +0.00 | buy |
| QRG CAPITAL MANAGEMENT, INC. | 0 | 14,033 | +14,033 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 12,774 | +12,774 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 12,569 | +12,569 | 0.00 | 0.01 | +0.01 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 12,510 | +12,510 | 0.00 | 0.02 | +0.02 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 12,179 | +12,179 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 12,168 | +12,168 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 11,882 | +11,882 | 0.00 | 0.00 | +0.00 | buy |
| SHERBROOKE PARK ADVISERS LLC | 0 | 11,733 | +11,733 | 0.00 | 0.04 | +0.04 | buy |
| PROFUND ADVISORS LLC | 0 | 11,504 | +11,504 | 0.00 | 0.01 | +0.01 | buy |
| Arizona State Retirement System | 0 | 11,192 | +11,192 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 11,163 | +11,163 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 11,075 | +11,075 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 11,000 | +11,000 | 0.00 | 0.01 | +0.01 | buy |
| Sound View Wealth Advisors Group, LLC | 0 | 10,642 | +10,642 | 0.00 | 0.02 | +0.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 10,610 | +10,610 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 10,076 | +10,076 | 0.00 | 0.09 | +0.09 | buy |
| Lynx1 Capital Management LP | 0 | 9,500 | +9,500 | 0.00 | 0.06 | +0.06 | buy |
| MetLife Investment Management, LLC | 0 | 9,482 | +9,482 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 7,894 | +7,894 | 0.00 | 0.00 | +0.00 | buy |
| GLOBEFLEX CAPITAL L P | 0 | 6,790 | +6,790 | 0.00 | 0.01 | +0.01 | buy |
| Ashton Thomas Private Wealth, LLC | 0 | 5,361 | +5,361 | 0.00 | 0.01 | +0.01 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 0 | 5,131 | +5,131 | 0.00 | 0.00 | +0.00 | buy |