| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Fairmount Funds Management LLC | 1,102,248 | 1,772,839 | +670,591 | 3.80 | 6.36 | +2.56 | buy |
| Rubric Capital Management LP | 3,383,239 | 3,909,806 | +526,567 | 1.35 | 1.63 | +0.29 | buy |
| TANG CAPITAL MANAGEMENT LLC | 2,118,579 | 2,328,609 | +210,030 | 2.60 | 3.26 | +0.65 | buy |
| OBERWEIS ASSET MANAGEMENT INC/ | 237,200 | 305,200 | +68,000 | 0.26 | 0.37 | +0.10 | buy |
| PDT Partners, LLC | 46,407 | 102,886 | +56,479 | 0.07 | 0.16 | +0.09 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 611,278 | 647,980 | +36,702 | 0.13 | 0.14 | +0.01 | buy |
| Nebula Research & Development LLC | 38,314 | 69,884 | +31,570 | 0.08 | 0.16 | +0.09 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 11,352 | 35,743 | +24,391 | 0.04 | 0.16 | +0.13 | buy |
| Aster Capital Management (DIFC) Ltd | 1,456 | 21,398 | +19,942 | 0.01 | 0.13 | +0.13 | buy |
| ADAR1 Capital Management, LLC | 41,412 | 56,540 | +15,128 | 0.18 | 0.25 | +0.08 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 624,545 | 638,233 | +13,688 | 0.82 | 0.95 | +0.14 | buy |
| Asset Management One Co., Ltd. | 1,860 | 13,470 | +11,610 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 2,818,323 | 2,824,669 | +6,346 | 0.69 | 0.76 | +0.07 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 50,000 | 52,434 | +2,434 | 0.03 | 0.04 | +0.01 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 128,050 | 130,160 | +2,110 | 0.00 | 0.00 | +0.00 | buy |
| Polymer Capital Management (US) LLC | 9,142 | 10,486 | +1,344 | 0.06 | 0.05 | -0.01 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 63,439 | 64,232 | +793 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 8,426 | 8,503 | +77 | 0.02 | 0.02 | +0.00 | buy |
| Linden Thomas Advisory Services, LLC | 117,281 | 116,115 | -1,166 | 0.34 | 0.35 | +0.02 | sell |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 172,666 | 171,437 | -1,229 | 0.80 | 0.86 | +0.06 | sell |
| Virtus Investment Advisers, LLC | 17,828 | 16,026 | -1,802 | 0.11 | 0.15 | +0.04 | sell |
| Sound View Wealth Advisors Group, LLC | 14,657 | 12,505 | -2,152 | 0.03 | 0.03 | -0.00 | sell |
| Advantage Alpha Capital Partners LP | 13,597 | 11,020 | -2,577 | 0.07 | 0.08 | +0.01 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 88,215 | 75,959 | -12,256 | 0.41 | 0.43 | +0.02 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 309,190 | 288,636 | -20,554 | 0.23 | 0.24 | +0.01 | sell |
| Knights of Columbus Asset Advisors LLC | 62,624 | 32,622 | -30,002 | 0.10 | 0.05 | -0.04 | sell |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 97,992 | 60,125 | -37,867 | 0.03 | 0.04 | +0.01 | sell |
| Fisher Asset Management, LLC | 144,251 | 102,259 | -41,992 | 0.00 | 0.00 | -0.00 | sell |
| Granahan Investment Management, LLC | 361,894 | 310,992 | -50,902 | 0.40 | 0.35 | -0.05 | sell |
| Hennion & Walsh Asset Management, Inc. | 184,126 | 133,014 | -51,112 | 0.18 | 0.15 | -0.03 | sell |
| ArrowMark Colorado Holdings LLC | 535,707 | 465,899 | -69,808 | 0.19 | 0.23 | +0.04 | sell |
| Soleus Capital Management, L.P. | 469,500 | 254,689 | -214,811 | 0.82 | 0.49 | -0.33 | sell |
| Parkman Healthcare Partners LLC | 762,621 | 488,796 | -273,825 | 2.01 | 1.56 | -0.44 | sell |
| BRAIDWELL LP | 1,962,909 | 1,102,580 | -860,329 | 1.53 | 1.04 | -0.49 | sell |