| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Rubric Capital Management LP | 3,383,239 | 3,909,806 | +526,567 | 1.35 | 1.74 | +0.39 | buy |
| VANGUARD GROUP INC | 3,359,101 | 3,131,602 | -227,499 | 0.00 | 0.00 | +0.00 | sell |
| BAKER BROS. ADVISORS LP | 2,818,323 | 2,824,669 | +6,346 | 0.69 | 0.76 | +0.07 | buy |
| TANG CAPITAL MANAGEMENT LLC | 2,118,579 | 2,328,609 | +210,030 | 2.60 | 3.26 | +0.65 | buy |
| Fairmount Funds Management LLC | 1,102,248 | 1,772,839 | +670,591 | 3.80 | 6.36 | +2.56 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 1,034,321 | 1,267,989 | +233,668 | 0.06 | 0.07 | +0.01 | buy |
| BRAIDWELL LP | 1,962,909 | 1,102,580 | -860,329 | 1.53 | 1.04 | -0.49 | sell |
| MORGAN STANLEY | 1,076,399 | 1,066,279 | -10,120 | 0.00 | 0.00 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 847,124 | 1,019,968 | +172,844 | 0.02 | 0.03 | +0.01 | buy |
| Pictet Asset Management Holding SA | 1,133,931 | 984,597 | -149,334 | 0.03 | 0.03 | -0.00 | sell |
| Qube Research & Technologies Ltd | 235,128 | 888,364 | +653,236 | 0.01 | 0.03 | +0.03 | buy |
| Point72 Asset Management, L.P. | 1,149,411 | 848,549 | -300,862 | 0.07 | 0.06 | -0.02 | sell |
| FMR LLC | 804,143 | 806,898 | +2,755 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 397,745 | 791,305 | +393,560 | 0.01 | 0.02 | +0.01 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 735,417 | +735,417 | 0.00 | 0.01 | +0.01 | buy |
| BlackRock, Inc. | 3,432,699 | 702,880 | -2,729,819 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 209,939 | 657,475 | +447,536 | 0.06 | 0.20 | +0.14 | buy |
| DIMENSIONAL FUND ADVISORS LP | 772,303 | 648,336 | -123,967 | 0.00 | 0.00 | -0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 611,278 | 647,980 | +36,702 | 0.13 | 0.14 | +0.01 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 624,545 | 638,233 | +13,688 | 0.82 | 0.95 | +0.14 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 399,743 | 623,689 | +223,946 | 0.04 | 0.06 | +0.02 | buy |
| JANE STREET GROUP, LLC | 129,291 | 558,392 | +429,101 | 0.01 | 0.02 | +0.02 | buy |
| Parkman Healthcare Partners LLC | 762,621 | 488,796 | -273,825 | 2.01 | 1.56 | -0.44 | sell |
| ArrowMark Colorado Holdings LLC | 535,707 | 465,899 | -69,808 | 0.19 | 0.23 | +0.04 | sell |
| Trexquant Investment LP | 236,483 | 456,987 | +220,504 | 0.06 | 0.14 | +0.08 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 225,430 | 425,947 | +200,517 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 145,567 | 416,572 | +271,005 | 0.01 | 0.03 | +0.02 | buy |
| AQR CAPITAL MANAGEMENT LLC | 491,761 | 398,232 | -93,529 | 0.01 | 0.01 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 156,328 | 383,668 | +227,340 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 394,522 | 369,502 | -25,020 | 0.00 | 0.00 | +0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 65,110 | 333,923 | +268,813 | 0.01 | 0.03 | +0.03 | buy |
| Granahan Investment Management, LLC | 361,894 | 310,992 | -50,902 | 0.40 | 0.35 | -0.05 | sell |
| OBERWEIS ASSET MANAGEMENT INC/ | 237,200 | 305,200 | +68,000 | 0.26 | 0.37 | +0.10 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 309,190 | 288,636 | -20,554 | 0.23 | 0.24 | +0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 239,647 | 272,629 | +32,982 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 60,647 | 267,393 | +206,746 | 0.00 | 0.01 | +0.01 | buy |
| Soleus Capital Management, L.P. | 469,500 | 254,689 | -214,811 | 0.82 | 0.49 | -0.33 | sell |
| ALGERT GLOBAL LLC | 230,467 | 232,187 | +1,720 | 0.13 | 0.13 | +0.01 | buy |
| Jump Financial, LLC | 0 | 226,038 | +226,038 | 0.00 | 0.08 | +0.08 | buy |
| ROYAL BANK OF CANADA | 0 | 223,208 | +223,208 | 0.00 | 0.00 | +0.00 | buy |
| Hillsdale Investment Management Inc. | 0 | 200,574 | +200,574 | 0.00 | 0.20 | +0.20 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 172,666 | 171,437 | -1,229 | 0.80 | 0.86 | +0.06 | sell |
| TWO SIGMA INVESTMENTS, LP | 0 | 163,740 | +163,740 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 54,279 | 139,782 | +85,503 | 0.00 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 116,412 | 135,282 | +18,870 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 7,278 | 134,404 | +127,126 | 0.00 | 0.02 | +0.02 | buy |
| ExodusPoint Capital Management, LP | 32,382 | 133,276 | +100,894 | 0.01 | 0.04 | +0.04 | buy |
| Hennion & Walsh Asset Management, Inc. | 184,126 | 133,014 | -51,112 | 0.18 | 0.15 | -0.03 | sell |
| NORDEA INVESTMENT MANAGEMENT AB | 128,050 | 130,160 | +2,110 | 0.00 | 0.00 | +0.00 | buy |
| GREAT LAKES ADVISORS, LLC | 0 | 126,789 | +126,789 | 0.00 | 0.03 | +0.03 | buy |
| Walleye Capital LLC | 86,203 | 119,885 | +33,682 | 0.02 | 0.03 | +0.01 | buy |
| Linden Thomas Advisory Services, LLC | 117,281 | 116,115 | -1,166 | 0.34 | 0.35 | +0.02 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 91,032 | 113,990 | +22,958 | 0.00 | 0.00 | +0.00 | buy |
| Weiss Asset Management LP | 0 | 111,710 | +111,710 | 0.00 | 0.05 | +0.05 | buy |
| FRANKLIN RESOURCES INC | 66,942 | 108,574 | +41,632 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 105,747 | +105,747 | 0.00 | 0.44 | +0.44 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 55,976 | 104,705 | +48,729 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 46,407 | 102,886 | +56,479 | 0.07 | 0.16 | +0.09 | buy |
| Fisher Asset Management, LLC | 144,251 | 102,259 | -41,992 | 0.00 | 0.00 | -0.00 | sell |
| SEI INVESTMENTS CO | 75,636 | 101,496 | +25,860 | 0.00 | 0.00 | +0.00 | buy |
| GLOBEFLEX CAPITAL L P | 88,596 | 88,596 | 0 | 0.18 | 0.20 | +0.02 | hold |
| TWO SIGMA ADVISERS, LP | 0 | 85,400 | +85,400 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 103,673 | 84,915 | -18,758 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 101,042 | 84,067 | -16,975 | 0.01 | 0.01 | -0.00 | sell |
| MARSHALL WACE, LLP | 0 | 76,347 | +76,347 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 88,215 | 75,959 | -12,256 | 0.41 | 0.43 | +0.02 | sell |
| STATE STREET CORP | 708,809 | 72,904 | -635,905 | 0.00 | 0.00 | -0.00 | sell |
| Hudson Bay Capital Management LP | 200,000 | 70,780 | -129,220 | 0.03 | 0.01 | -0.02 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 164,372 | 70,315 | -94,057 | 0.00 | 0.00 | -0.00 | sell |
| Nebula Research & Development LLC | 38,314 | 69,884 | +31,570 | 0.08 | 0.16 | +0.09 | buy |
| Schonfeld Strategic Advisors LLC | 49,847 | 68,751 | +18,904 | 0.01 | 0.01 | +0.01 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 67,500 | +67,500 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 71,900 | 64,600 | -7,300 | 0.00 | 0.00 | -0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 63,439 | 64,232 | +793 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 83,151 | 61,095 | -22,056 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 97,992 | 60,125 | -37,867 | 0.04 | 0.04 | +0.01 | sell |
| Y-Intercept (Hong Kong) Ltd | 0 | 59,564 | +59,564 | 0.00 | 0.04 | +0.04 | buy |
| Engineers Gate Manager LP | 0 | 59,275 | +59,275 | 0.00 | 0.02 | +0.02 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 53,317 | 58,964 | +5,647 | 0.00 | 0.00 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 41,412 | 56,540 | +15,128 | 0.18 | 0.25 | +0.08 | buy |
| Jain Global LLC | 0 | 55,554 | +55,554 | 0.00 | 0.02 | +0.02 | buy |
| Baird Financial Group, Inc. | 0 | 55,312 | +55,312 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 291,196 | 54,587 | -236,609 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 33,107 | 53,202 | +20,095 | 0.00 | 0.00 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 50,000 | 52,434 | +2,434 | 0.03 | 0.04 | +0.01 | buy |
| HRT FINANCIAL LP | 0 | 51,964 | +51,964 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 505,451 | 50,942 | -454,509 | 0.00 | 0.00 | -0.00 | sell |
| DARK FOREST CAPITAL MANAGEMENT LP | 14,108 | 48,207 | +34,099 | 0.01 | 0.05 | +0.04 | buy |
| IEQ CAPITAL, LLC | 43,625 | 46,916 | +3,291 | 0.01 | 0.01 | +0.00 | buy |
| Lion Point Capital, LP | 45,900 | 45,900 | 0 | 6.50 | 8.62 | +2.12 | hold |
| Cerity Partners LLC | 40,708 | 41,904 | +1,196 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 139,275 | 37,602 | -101,673 | 0.07 | 0.03 | -0.05 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 11,352 | 35,743 | +24,391 | 0.04 | 0.16 | +0.13 | buy |
| Knights of Columbus Asset Advisors LLC | 62,624 | 32,622 | -30,002 | 0.10 | 0.05 | -0.04 | sell |
| AMERIPRISE FINANCIAL INC | 37,271 | 32,257 | -5,014 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 121,859 | 31,739 | -90,120 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 34,322 | 31,498 | -2,824 | 0.00 | 0.00 | +0.00 | sell |
| Legal & General Group Plc | 39,929 | 30,858 | -9,071 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 49,989 | 30,616 | -19,373 | 0.00 | 0.00 | -0.00 | sell |
| SummitTX Capital, L.P. | 0 | 30,200 | +30,200 | 0.00 | 0.04 | +0.04 | buy |