| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 0 | 3,298,256 | +3,298,256 | 0.00 | 0.00 | +0.00 | buy |
| Fairmount Funds Management LLC | 3,204,841 | 3,204,841 | 0 | 6.76 | 6.49 | -0.27 | hold |
| BRAIDWELL LP | 2,058,303 | 2,894,513 | +836,210 | 1.21 | 2.05 | +0.84 | buy |
| BAKER BROS. ADVISORS LP | 2,818,323 | 2,818,323 | 0 | 0.67 | 0.73 | +0.06 | hold |
| Rubric Capital Management LP | 2,419,103 | 2,419,103 | 0 | 1.19 | 0.99 | -0.20 | hold |
| HHLR ADVISORS, LTD. | 3,144,556 | 1,582,635 | -1,561,921 | 1.45 | 0.87 | -0.58 | sell |
| Pictet Asset Management Holding SA | 1,303,716 | 1,207,749 | -95,967 | 0.03 | 0.03 | +0.01 | sell |
| MORGAN STANLEY | 1,985,486 | 1,025,471 | -960,015 | 0.00 | 0.00 | -0.00 | sell |
| Parkman Healthcare Partners LLC | 647,142 | 755,244 | +108,102 | 1.65 | 2.41 | +0.76 | buy |
| DIMENSIONAL FUND ADVISORS LP | 664,040 | 742,307 | +78,267 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 615,836 | 730,943 | +115,107 | 0.11 | 0.16 | +0.05 | buy |
| STATE STREET CORP | 1,417,947 | 704,712 | -713,235 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 1,882 | 696,810 | +694,928 | 0.00 | 0.00 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 600,630 | 649,630 | +49,000 | 0.67 | 0.88 | +0.21 | buy |
| TANG CAPITAL MANAGEMENT LLC | 625,309 | 628,609 | +3,300 | 1.19 | 1.12 | -0.07 | buy |
| ArrowMark Colorado Holdings LLC | 608,868 | 531,286 | -77,582 | 0.14 | 0.17 | +0.03 | sell |
| MILLENNIUM MANAGEMENT LLC | 621,948 | 516,526 | -105,422 | 0.01 | 0.01 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 0 | 508,373 | +508,373 | 0.00 | 0.00 | +0.00 | buy |
| Granahan Investment Management, LLC | 568,735 | 507,369 | -61,366 | 0.42 | 0.50 | +0.07 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 848,894 | 482,976 | -365,918 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 114,309 | 436,668 | +322,359 | 0.43 | 1.83 | +1.40 | buy |
| Qube Research & Technologies Ltd | 0 | 388,356 | +388,356 | 0.00 | 0.02 | +0.02 | buy |
| JANE STREET GROUP, LLC | 29,636 | 345,092 | +315,456 | 0.00 | 0.01 | +0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 231,079 | 324,064 | +92,985 | 0.02 | 0.04 | +0.02 | buy |
| D. E. Shaw & Co., Inc. | 169,648 | 320,997 | +151,349 | 0.00 | 0.01 | +0.01 | buy |
| Soleus Capital Management, L.P. | 200,000 | 302,500 | +102,500 | 0.33 | 0.63 | +0.30 | buy |
| NORTHERN TRUST CORP | 292,933 | 255,206 | -37,727 | 0.00 | 0.00 | +0.00 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 239,156 | 239,682 | +526 | 0.13 | 0.18 | +0.05 | buy |
| BANK OF AMERICA CORP /DE/ | 214,847 | 211,118 | -3,729 | 0.00 | 0.00 | +0.00 | sell |
| OBERWEIS ASSET MANAGEMENT INC/ | 0 | 201,000 | +201,000 | 0.00 | 0.26 | +0.26 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 199,799 | 200,516 | +717 | 0.70 | 0.87 | +0.18 | buy |
| JPMORGAN CHASE & CO | 0 | 199,973 | +199,973 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 54,820 | 198,413 | +143,593 | 0.00 | 0.01 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 181,966 | 195,852 | +13,886 | 0.17 | 0.23 | +0.05 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 87,002 | 192,926 | +105,924 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 25,786 | 189,986 | +164,200 | 0.00 | 0.02 | +0.02 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 0 | 186,626 | +186,626 | 0.00 | 0.01 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 125,995 | 184,169 | +58,174 | 0.00 | 0.01 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 175,321 | +175,321 | 0.00 | 0.00 | +0.00 | buy |
| CASTLEARK MANAGEMENT LLC | 0 | 167,200 | +167,200 | 0.00 | 0.17 | +0.17 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 140,061 | 161,643 | +21,582 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 201,715 | 155,192 | -46,523 | 0.06 | 0.05 | -0.01 | sell |
| PRUDENTIAL FINANCIAL INC | 141,500 | 118,720 | -22,780 | 0.00 | 0.00 | +0.00 | sell |
| Linden Thomas Advisory Services, LLC | 118,302 | 117,710 | -592 | 0.34 | 0.40 | +0.06 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 147,865 | 114,756 | -33,109 | 0.01 | 0.01 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 57,230 | 106,219 | +48,989 | 0.00 | 0.01 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 79,200 | 100,001 | +20,801 | 0.01 | 0.01 | +0.00 | buy |
| Bank of New York Mellon Corp | 115,143 | 91,669 | -23,474 | 0.00 | 0.00 | +0.00 | sell |
| ALGERT GLOBAL LLC | 18,603 | 91,159 | +72,556 | 0.01 | 0.06 | +0.05 | buy |
| MARSHALL WACE, LLP | 0 | 90,571 | +90,571 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 255,000 | 90,000 | -165,000 | 0.04 | 0.02 | -0.02 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 92,408 | 89,626 | -2,782 | 0.00 | 0.00 | +0.00 | sell |
| Schonfeld Strategic Advisors LLC | 88,391 | 89,300 | +909 | 0.01 | 0.02 | +0.01 | buy |
| HUSSMAN STRATEGIC ADVISORS, INC. | 147,000 | 84,000 | -63,000 | 0.76 | 0.52 | -0.24 | sell |
| Jefferies Financial Group Inc. | 0 | 80,600 | +80,600 | 0.00 | 0.03 | +0.03 | buy |
| DEUTSCHE BANK AG\ | 0 | 80,314 | +80,314 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 78,600 | 78,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 113,995 | 75,169 | -38,826 | 0.06 | 0.05 | -0.01 | sell |
| HighVista Strategies LLC | 88,688 | 74,639 | -14,049 | 0.60 | 0.64 | +0.04 | sell |
| Knights of Columbus Asset Advisors LLC | 166,272 | 72,756 | -93,516 | 0.20 | 0.12 | -0.08 | sell |
| Jackson Creek Investment Advisors LLC | 54,296 | 70,296 | +16,000 | 0.37 | 0.52 | +0.15 | buy |
| FRANKLIN RESOURCES INC | 66,433 | 67,533 | +1,100 | 0.00 | 0.00 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 68,434 | 66,816 | -1,618 | 0.00 | 0.00 | +0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 10,610 | 66,567 | +55,957 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 64,629 | +64,629 | 0.00 | 0.00 | +0.00 | buy |
| Lion Point Capital, LP | 104,691 | 61,400 | -43,291 | 6.12 | 6.16 | +0.04 | sell |
| RHUMBLINE ADVISERS | 56,066 | 59,864 | +3,798 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 64,943 | 57,627 | -7,316 | 0.00 | 0.00 | +0.00 | sell |
| Invesco Ltd. | 0 | 55,488 | +55,488 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 66,951 | 52,851 | -14,100 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 0 | 49,507 | +49,507 | 0.00 | 0.00 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 45,377 | 48,460 | +3,083 | 0.02 | 0.03 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 47,717 | +47,717 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 11,163 | 45,607 | +34,444 | 0.00 | 0.02 | +0.02 | buy |
| Legal & General Group Plc | 43,902 | 45,404 | +1,502 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 38,976 | 44,538 | +5,562 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 44,229 | +44,229 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 29,226 | 41,870 | +12,644 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 39,560 | +39,560 | 0.00 | 0.00 | +0.00 | buy |
| Nebula Research & Development LLC | 15,070 | 39,004 | +23,934 | 0.05 | 0.12 | +0.07 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 38,389 | 38,034 | -355 | 0.00 | 0.00 | +0.00 | sell |
| PDT Partners, LLC | 0 | 37,242 | +37,242 | 0.00 | 0.08 | +0.08 | buy |
| Woodline Partners LP | 0 | 34,029 | +34,029 | 0.00 | 0.01 | +0.01 | buy |
| BOSUN ASSET MANAGEMENT, LLC | 21,875 | 33,824 | +11,949 | 0.24 | 0.41 | +0.16 | buy |
| Cerity Partners LLC | 0 | 33,384 | +33,384 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 7,894 | 31,696 | +23,802 | 0.00 | 0.00 | +0.00 | buy |
| M&T BANK CORP | 36,389 | 30,735 | -5,654 | 0.00 | 0.00 | +0.00 | sell |
| GLOBEFLEX CAPITAL L P | 6,790 | 27,940 | +21,150 | 0.01 | 0.07 | +0.05 | buy |
| XTX Topco Ltd | 16,828 | 27,302 | +10,474 | 0.03 | 0.05 | +0.02 | buy |
| SEGALL BRYANT & HAMILL, LLC | 0 | 27,026 | +27,026 | 0.00 | 0.01 | +0.01 | buy |
| STRS OHIO | 30,600 | 26,900 | -3,700 | 0.00 | 0.00 | +0.00 | sell |
| Verition Fund Management LLC | 0 | 26,784 | +26,784 | 0.00 | 0.00 | +0.00 | buy |
| Fisher Asset Management, LLC | 30,225 | 26,124 | -4,101 | 0.00 | 0.00 | +0.00 | sell |
| Semanteon Capital Management, LP | 0 | 22,057 | +22,057 | 0.00 | 0.38 | +0.38 | buy |
| MetLife Investment Management, LLC | 9,482 | 21,721 | +12,239 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 11,075 | 20,691 | +9,616 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 16,270 | 20,461 | +4,191 | 0.00 | 0.00 | +0.00 | buy |
| Advantage Alpha Capital Partners LP | 31,258 | 20,367 | -10,891 | 0.13 | 0.12 | -0.01 | sell |
| TUDOR INVESTMENT CORP ET AL | 0 | 20,235 | +20,235 | 0.00 | 0.01 | +0.01 | buy |
| Paloma Partners Management Co | 0 | 19,300 | +19,300 | 0.00 | 0.03 | +0.03 | buy |