| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Rubric Capital Management LP | 3,909,806 | 4,000,000 | +90,194 | 1.74 | 2.09 | +0.35 | buy |
| VANGUARD GROUP INC | 3,131,602 | 3,063,135 | -68,467 | 0.00 | 0.00 | +0.00 | sell |
| BAKER BROS. ADVISORS LP | 2,824,669 | 2,824,669 | 0 | 0.76 | 0.79 | +0.03 | hold |
| TANG CAPITAL MANAGEMENT LLC | 2,328,609 | 2,328,609 | 0 | 3.26 | 3.48 | +0.22 | hold |
| Fairmount Funds Management LLC | 1,772,839 | 1,772,839 | 0 | 6.36 | 6.19 | -0.16 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 1,267,989 | 1,618,521 | +350,532 | 0.07 | 0.11 | +0.04 | buy |
| MORGAN STANLEY | 1,066,279 | 1,362,923 | +296,644 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 791,305 | 1,134,186 | +342,881 | 0.02 | 0.04 | +0.01 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 735,417 | 1,068,263 | +332,846 | 0.01 | 0.03 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,019,968 | 1,014,125 | -5,843 | 0.03 | 0.03 | +0.01 | sell |
| Pictet Asset Management Holding SA | 984,597 | 932,096 | -52,501 | 0.03 | 0.03 | +0.01 | sell |
| FMR LLC | 806,898 | 799,755 | -7,143 | 0.00 | 0.00 | +0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 623,689 | 725,355 | +101,666 | 0.06 | 0.09 | +0.03 | buy |
| Qube Research & Technologies Ltd | 888,364 | 689,888 | -198,476 | 0.03 | 0.04 | +0.00 | sell |
| Parkman Healthcare Partners LLC | 488,796 | 671,592 | +182,796 | 1.56 | 2.86 | +1.30 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 647,980 | 654,585 | +6,605 | 0.14 | 0.18 | +0.04 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 425,947 | 653,411 | +227,464 | 0.01 | 0.02 | +0.01 | buy |
| BRAIDWELL LP | 1,102,580 | 643,180 | -459,400 | 1.04 | 0.74 | -0.30 | sell |
| DIMENSIONAL FUND ADVISORS LP | 648,336 | 632,123 | -16,213 | 0.00 | 0.01 | +0.00 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 638,233 | 577,822 | -60,411 | 0.95 | 1.22 | +0.27 | sell |
| Point72 Asset Management, L.P. | 848,549 | 566,927 | -281,622 | 0.06 | 0.05 | -0.01 | sell |
| GOLDMAN SACHS GROUP INC | 383,668 | 546,510 | +162,842 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 369,502 | 533,375 | +163,873 | 0.00 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 272,629 | 495,483 | +222,854 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 163,740 | 461,770 | +298,030 | 0.01 | 0.03 | +0.02 | buy |
| JANE STREET GROUP, LLC | 558,392 | 461,388 | -97,004 | 0.02 | 0.02 | -0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 64,232 | 458,304 | +394,072 | 0.00 | 0.01 | +0.00 | buy |
| BlackRock, Inc. | 702,880 | 457,647 | -245,233 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 119,885 | 413,086 | +293,201 | 0.03 | 0.13 | +0.10 | buy |
| NOMURA HOLDINGS INC | 0 | 397,139 | +397,139 | 0.00 | 0.07 | +0.07 | buy |
| Cubist Systematic Strategies, LLC | 657,475 | 381,319 | -276,156 | 0.20 | 0.21 | +0.01 | sell |
| Trexquant Investment LP | 456,987 | 359,838 | -97,149 | 0.14 | 0.14 | +0.00 | sell |
| ArrowMark Colorado Holdings LLC | 465,899 | 340,627 | -125,272 | 0.23 | 0.25 | +0.01 | sell |
| AQR CAPITAL MANAGEMENT LLC | 398,232 | 332,417 | -65,815 | 0.01 | 0.01 | -0.00 | sell |
| CITADEL ADVISORS LLC | 267,393 | 314,556 | +47,163 | 0.01 | 0.01 | +0.00 | buy |
| OBERWEIS ASSET MANAGEMENT INC/ | 305,200 | 305,200 | 0 | 0.37 | 0.45 | +0.09 | hold |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 333,923 | 298,347 | -35,576 | 0.03 | 0.04 | +0.00 | sell |
| Granahan Investment Management, LLC | 310,992 | 283,571 | -27,421 | 0.35 | 0.45 | +0.10 | sell |
| Fisher Asset Management, LLC | 102,259 | 282,288 | +180,029 | 0.00 | 0.00 | +0.00 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 171,437 | 247,301 | +75,864 | 0.86 | 1.47 | +0.61 | buy |
| Hillsdale Investment Management Inc. | 200,574 | 225,374 | +24,800 | 0.20 | 0.26 | +0.06 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 288,636 | 214,364 | -74,272 | 0.24 | 0.25 | +0.01 | sell |
| JPMORGAN CHASE & CO | 135,282 | 192,456 | +57,174 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 85,400 | 177,100 | +91,700 | 0.00 | 0.01 | +0.01 | buy |
| Rockefeller Capital Management L.P. | 0 | 173,438 | +173,438 | 0.00 | 0.01 | +0.01 | buy |
| SEI INVESTMENTS CO | 101,496 | 171,169 | +69,673 | 0.00 | 0.01 | +0.00 | buy |
| Aberdeen Group plc | 0 | 158,722 | +158,722 | 0.00 | 0.01 | +0.01 | buy |
| CASTLEARK MANAGEMENT LLC | 0 | 158,632 | +158,632 | 0.00 | 0.17 | +0.17 | buy |
| Soleus Capital Management, L.P. | 254,689 | 150,000 | -104,689 | 0.49 | 0.31 | -0.18 | sell |
| SG Americas Securities, LLC | 134,404 | 139,318 | +4,914 | 0.02 | 0.02 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 15,181 | 138,312 | +123,131 | 0.00 | 0.01 | +0.01 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 130,160 | 131,074 | +914 | 0.00 | 0.00 | +0.00 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 0 | 126,260 | +126,260 | 0.00 | 0.03 | +0.03 | buy |
| Hennion & Walsh Asset Management, Inc. | 133,014 | 121,819 | -11,195 | 0.15 | 0.17 | +0.02 | sell |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 67,500 | 121,400 | +53,900 | 0.00 | 0.01 | +0.00 | buy |
| Linden Thomas Advisory Services, LLC | 116,115 | 116,040 | -75 | 0.35 | 0.46 | +0.10 | sell |
| Jump Financial, LLC | 226,038 | 112,935 | -113,103 | 0.08 | 0.07 | -0.01 | sell |
| PDT Partners, LLC | 102,886 | 101,622 | -1,264 | 0.16 | 0.25 | +0.09 | sell |
| Informed Momentum Co LLC | 105,747 | 97,939 | -7,808 | 0.44 | 0.43 | -0.01 | sell |
| GLOBEFLEX CAPITAL L P | 88,596 | 93,396 | +4,800 | 0.20 | 0.56 | +0.36 | buy |
| Voleon Capital Management LP | 0 | 89,166 | +89,166 | 0.00 | 0.08 | +0.08 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 75,959 | 88,910 | +12,951 | 0.43 | 0.50 | +0.07 | buy |
| Engineers Gate Manager LP | 59,275 | 87,464 | +28,189 | 0.02 | 0.04 | +0.02 | buy |
| Squarepoint Ops LLC | 416,572 | 85,198 | -331,374 | 0.03 | 0.01 | -0.02 | sell |
| Schonfeld Strategic Advisors LLC | 68,751 | 83,881 | +15,130 | 0.01 | 0.02 | +0.01 | buy |
| RAYMOND JAMES FINANCIAL INC | 84,915 | 79,079 | -5,836 | 0.00 | 0.00 | +0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 20,418 | 77,984 | +57,566 | 0.04 | 0.25 | +0.21 | buy |
| ADAR1 Capital Management, LLC | 56,540 | 75,187 | +18,647 | 0.25 | 0.29 | +0.04 | buy |
| STATE STREET CORP | 72,904 | 75,050 | +2,146 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 67,905 | +67,905 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 64,600 | 65,700 | +1,100 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 70,315 | 65,112 | -5,203 | 0.00 | 0.00 | +0.00 | sell |
| MARSHALL WACE, LLP | 76,347 | 61,316 | -15,031 | 0.00 | 0.00 | +0.00 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 9,140 | 60,344 | +51,204 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 60,125 | 60,125 | 0 | 0.04 | 0.09 | +0.05 | hold |
| ExodusPoint Capital Management, LP | 133,276 | 59,876 | -73,400 | 0.04 | 0.03 | -0.01 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 59,000 | +59,000 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 104,705 | 55,519 | -49,186 | 0.00 | 0.00 | -0.00 | sell |
| Baird Financial Group, Inc. | 55,312 | 55,312 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NORTHERN TRUST CORP | 54,587 | 52,407 | -2,180 | 0.00 | 0.00 | +0.00 | sell |
| UBS Group AG | 30,616 | 49,817 | +19,201 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 61,095 | 49,182 | -11,913 | 0.00 | 0.00 | -0.00 | sell |
| IEQ CAPITAL, LLC | 46,916 | 45,987 | -929 | 0.01 | 0.01 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 50,942 | 45,562 | -5,380 | 0.00 | 0.00 | +0.00 | sell |
| DARK FOREST CAPITAL MANAGEMENT LP | 48,207 | 43,346 | -4,861 | 0.05 | 0.05 | -0.01 | sell |
| Cerity Partners LLC | 41,904 | 43,036 | +1,132 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 38,117 | +38,117 | 0.00 | 0.11 | +0.11 | buy |
| ALGERT GLOBAL LLC | 232,187 | 35,847 | -196,340 | 0.13 | 0.02 | -0.11 | sell |
| AMERIPRISE FINANCIAL INC | 32,257 | 33,546 | +1,289 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 31,739 | 32,529 | +790 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 31,498 | 31,498 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 30,858 | 30,858 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Artia Global Partners LP | 29,200 | 29,200 | 0 | 0.21 | 0.20 | -0.01 | hold |
| Invesco Ltd. | 20,289 | 25,678 | +5,389 | 0.00 | 0.00 | +0.00 | buy |
| Lion Point Capital, LP | 45,900 | 23,400 | -22,500 | 8.62 | 5.16 | -3.46 | sell |
| TOTH FINANCIAL ADVISORY CORP | 10,700 | 21,565 | +10,865 | 0.03 | 0.09 | +0.06 | buy |
| Jain Global LLC | 55,554 | 20,927 | -34,627 | 0.02 | 0.01 | -0.01 | sell |
| Nuveen, LLC | 0 | 20,233 | +20,233 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 20,715 | 19,841 | -874 | 0.00 | 0.00 | +0.00 | sell |
| AIGEN INVESTMENT MANAGEMENT, LP | 9,410 | 19,777 | +10,367 | 0.04 | 0.12 | +0.08 | buy |