| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Soleus Capital Management, L.P. | 150,000 | 587,000 | +437,000 | 0.31 | 1.03 | +0.72 | buy |
| Aberdeen Group plc | 158,722 | 400,598 | +241,876 | 0.01 | 0.03 | +0.02 | buy |
| Voleon Capital Management LP | 89,166 | 151,283 | +62,117 | 0.08 | 0.13 | +0.05 | buy |
| CASTLEARK MANAGEMENT LLC | 158,632 | 192,192 | +33,560 | 0.17 | 0.23 | +0.06 | buy |
| Granahan Investment Management, LLC | 283,571 | 316,213 | +32,642 | 0.45 | 0.56 | +0.11 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 577,822 | 596,431 | +18,609 | 1.22 | 1.35 | +0.13 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 13,563 | 27,804 | +14,241 | 0.08 | 0.18 | +0.09 | buy |
| OBERWEIS ASSET MANAGEMENT INC/ | 305,200 | 312,800 | +7,600 | 0.45 | 0.47 | +0.02 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 247,301 | 250,975 | +3,674 | 1.47 | 1.58 | +0.11 | buy |
| Sound View Wealth Advisors Group, LLC | 12,729 | 14,792 | +2,063 | 0.03 | 0.04 | +0.01 | buy |
| Round Rock Advisors, LLC | 5,156 | 7,055 | +1,899 | 0.03 | 0.04 | +0.01 | buy |
| BAKER BROS. ADVISORS LP | 2,824,669 | 2,826,246 | +1,577 | 0.79 | 0.68 | -0.11 | buy |
| JUNCTURE WEALTH STRATEGIES, LLC | 6,864 | 8,146 | +1,282 | 0.09 | 0.11 | +0.02 | buy |
| ROMAN BUTLER FULLERTON & CO | 5,388 | 6,388 | +1,000 | 0.05 | 0.07 | +0.02 | buy |
| Virtus Investment Advisers, LLC | 16,026 | 16,432 | +406 | 0.18 | 0.18 | +0.01 | buy |
| MARK SHEPTOFF FINANCIAL PLANNING, LLC | 16,100 | 16,350 | +250 | 0.30 | 0.32 | +0.02 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 126,260 | 126,409 | +149 | 0.03 | 0.04 | +0.00 | buy |
| Pallas Capital Advisors LLC | 8,540 | 8,570 | +30 | 0.01 | 0.01 | -0.00 | buy |
| Stone House Investment Management, LLC | 22 | 41 | +19 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 935 | 887 | -48 | 0.00 | 0.00 | -0.00 | sell |
| USA FINANCIAL FORMULAS | 816 | 657 | -159 | 0.01 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 7,620 | 7,359 | -261 | 0.02 | 0.02 | -0.00 | sell |
| Hillsdale Investment Management Inc. | 225,374 | 224,074 | -1,300 | 0.26 | 0.26 | -0.01 | sell |
| Linden Thomas Advisory Services, LLC | 116,040 | 114,462 | -1,578 | 0.46 | 0.48 | +0.02 | sell |
| Informed Momentum Co LLC | 97,939 | 96,018 | -1,921 | 0.43 | 0.44 | +0.01 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 214,364 | 210,910 | -3,454 | 0.25 | 0.27 | +0.02 | sell |
| Asset Management One Co., Ltd. | 8,223 | 4,282 | -3,941 | 0.00 | 0.00 | -0.00 | sell |
| Parkman Healthcare Partners LLC | 671,592 | 665,208 | -6,384 | 2.86 | 2.61 | -0.25 | sell |
| ArrowMark Colorado Holdings LLC | 340,627 | 333,702 | -6,925 | 0.25 | 0.30 | +0.06 | sell |
| Quantedge Capital Pte Ltd | 15,045 | 6,545 | -8,500 | 0.32 | 0.13 | -0.19 | sell |
| NORDEA INVESTMENT MANAGEMENT AB | 131,074 | 110,682 | -20,392 | 0.00 | 0.00 | -0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 654,585 | 632,827 | -21,758 | 0.18 | 0.18 | -0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 458,304 | 425,232 | -33,072 | 0.01 | 0.01 | +0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 121,819 | 79,200 | -42,619 | 0.17 | 0.11 | -0.06 | sell |
| ADAR1 Capital Management, LLC | 75,187 | 28,728 | -46,459 | 0.29 | 0.09 | -0.20 | sell |
| TANG CAPITAL MANAGEMENT LLC | 2,328,609 | 2,259,889 | -68,720 | 3.48 | 4.60 | +1.12 | sell |
| BRAIDWELL LP | 643,180 | 313,823 | -329,357 | 0.74 | 0.41 | -0.33 | sell |
| Fairmount Funds Management LLC | 1,772,839 | 1,319,688 | -453,151 | 6.19 | 4.14 | -2.05 | sell |
| Rubric Capital Management LP | 4,000,000 | 3,328,653 | -671,347 | 1.75 | 1.64 | -0.11 | sell |