| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Rubric Capital Management LP | 4,000,000 | 3,328,653 | -671,347 | 2.09 | 1.64 | -0.44 | sell |
| VANGUARD GROUP INC | 3,063,135 | 3,112,937 | +49,802 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 2,824,669 | 2,826,246 | +1,577 | 0.79 | 0.68 | -0.11 | buy |
| TANG CAPITAL MANAGEMENT LLC | 2,328,609 | 2,259,889 | -68,720 | 3.48 | 4.60 | +1.12 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 1,618,521 | 1,713,043 | +94,522 | 0.11 | 0.12 | +0.01 | buy |
| FMR LLC | 799,755 | 1,642,863 | +843,108 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,362,923 | 1,360,044 | -2,879 | 0.00 | 0.00 | +0.00 | sell |
| Fairmount Funds Management LLC | 1,772,839 | 1,319,688 | -453,151 | 6.19 | 4.14 | -2.05 | sell |
| D. E. Shaw & Co., Inc. | 1,134,186 | 1,241,621 | +107,435 | 0.04 | 0.04 | +0.00 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 1,068,263 | 1,068,216 | -47 | 0.03 | 0.03 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 653,411 | 831,777 | +178,366 | 0.02 | 0.02 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 546,510 | 829,417 | +282,907 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,014,125 | 825,285 | -188,840 | 0.03 | 0.02 | -0.01 | sell |
| Point72 Asset Management, L.P. | 566,927 | 797,137 | +230,210 | 0.05 | 0.05 | +0.00 | buy |
| Pictet Asset Management Holding SA | 932,096 | 787,520 | -144,576 | 0.03 | 0.03 | -0.00 | sell |
| Qube Research & Technologies Ltd | 689,888 | 766,291 | +76,403 | 0.04 | 0.05 | +0.01 | buy |
| CITADEL ADVISORS LLC | 314,556 | 742,118 | +427,562 | 0.01 | 0.02 | +0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 725,355 | 739,326 | +13,971 | 0.09 | 0.08 | -0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 632,123 | 683,505 | +51,382 | 0.01 | 0.01 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 671,592 | 665,208 | -6,384 | 2.86 | 2.61 | -0.25 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 654,585 | 632,827 | -21,758 | 0.18 | 0.18 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 533,375 | 630,291 | +96,916 | 0.01 | 0.01 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 577,822 | 596,431 | +18,609 | 1.22 | 1.35 | +0.13 | buy |
| Soleus Capital Management, L.P. | 150,000 | 587,000 | +437,000 | 0.31 | 1.03 | +0.72 | buy |
| SG Americas Securities, LLC | 139,318 | 541,396 | +402,078 | 0.02 | 0.03 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 461,770 | 530,496 | +68,726 | 0.03 | 0.03 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 512,163 | +512,163 | 0.00 | 0.01 | +0.01 | buy |
| BlackRock, Inc. | 457,647 | 446,603 | -11,044 | 0.00 | 0.00 | -0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 458,304 | 425,232 | -33,072 | 0.01 | 0.01 | +0.00 | sell |
| NOMURA HOLDINGS INC | 397,139 | 412,639 | +15,500 | 0.07 | 0.05 | -0.02 | buy |
| Aberdeen Group plc | 158,722 | 400,598 | +241,876 | 0.01 | 0.03 | +0.02 | buy |
| AQR CAPITAL MANAGEMENT LLC | 332,417 | 353,062 | +20,645 | 0.01 | 0.01 | -0.00 | buy |
| Logos Global Management LP | 0 | 350,000 | +350,000 | 0.00 | 0.96 | +0.96 | buy |
| ArrowMark Colorado Holdings LLC | 340,627 | 333,702 | -6,925 | 0.25 | 0.30 | +0.06 | sell |
| ALLIANCEBERNSTEIN L.P. | 0 | 328,274 | +328,274 | 0.00 | 0.00 | +0.00 | buy |
| Granahan Investment Management, LLC | 283,571 | 316,213 | +32,642 | 0.45 | 0.56 | +0.11 | buy |
| BRAIDWELL LP | 643,180 | 313,823 | -329,357 | 0.74 | 0.41 | -0.33 | sell |
| OBERWEIS ASSET MANAGEMENT INC/ | 305,200 | 312,800 | +7,600 | 0.45 | 0.47 | +0.02 | buy |
| Fisher Asset Management, LLC | 282,288 | 267,274 | -15,014 | 0.00 | 0.00 | -0.00 | sell |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 247,301 | 250,975 | +3,674 | 1.47 | 1.58 | +0.11 | buy |
| JANE STREET GROUP, LLC | 461,388 | 242,430 | -218,958 | 0.02 | 0.01 | -0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 495,483 | 229,364 | -266,119 | 0.00 | 0.00 | -0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 298,347 | 228,933 | -69,414 | 0.04 | 0.03 | -0.01 | sell |
| Trexquant Investment LP | 359,838 | 225,128 | -134,710 | 0.14 | 0.08 | -0.06 | sell |
| Hillsdale Investment Management Inc. | 225,374 | 224,074 | -1,300 | 0.26 | 0.26 | -0.01 | sell |
| SEI INVESTMENTS CO | 171,169 | 217,496 | +46,327 | 0.01 | 0.01 | +0.00 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 214,364 | 210,910 | -3,454 | 0.25 | 0.27 | +0.02 | sell |
| TWO SIGMA ADVISERS, LP | 177,100 | 208,300 | +31,200 | 0.01 | 0.02 | +0.00 | buy |
| CASTLEARK MANAGEMENT LLC | 158,632 | 192,192 | +33,560 | 0.17 | 0.23 | +0.06 | buy |
| ORBIMED ADVISORS LLC | 0 | 187,199 | +187,199 | 0.00 | 0.16 | +0.16 | buy |
| Rockefeller Capital Management L.P. | 173,438 | 173,438 | 0 | 0.01 | 0.01 | -0.00 | hold |
| JANUS HENDERSON GROUP PLC | 12,179 | 153,428 | +141,249 | 0.00 | 0.00 | +0.00 | buy |
| Voleon Capital Management LP | 89,166 | 151,283 | +62,117 | 0.08 | 0.13 | +0.05 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 121,400 | 148,774 | +27,374 | 0.01 | 0.01 | +0.00 | buy |
| Walleye Capital LLC | 413,086 | 143,293 | -269,793 | 0.13 | 0.03 | -0.10 | sell |
| LAZARD ASSET MANAGEMENT LLC | 138,312 | 140,301 | +1,989 | 0.01 | 0.01 | +0.00 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 126,260 | 126,409 | +149 | 0.03 | 0.04 | +0.00 | buy |
| Linden Thomas Advisory Services, LLC | 116,040 | 114,462 | -1,578 | 0.46 | 0.48 | +0.02 | sell |
| NORDEA INVESTMENT MANAGEMENT AB | 131,074 | 110,682 | -20,392 | 0.00 | 0.00 | -0.00 | sell |
| PDT Partners, LLC | 101,622 | 101,622 | 0 | 0.25 | 0.27 | +0.02 | hold |
| Informed Momentum Co LLC | 97,939 | 96,018 | -1,921 | 0.43 | 0.44 | +0.01 | sell |
| Atika Capital Management LLC | 0 | 93,970 | +93,970 | 0.00 | 0.54 | +0.54 | buy |
| GLOBEFLEX CAPITAL L P | 93,396 | 93,396 | 0 | 0.56 | 0.59 | +0.03 | hold |
| Jump Financial, LLC | 112,935 | 91,429 | -21,506 | 0.07 | 0.05 | -0.02 | sell |
| Squarepoint Ops LLC | 85,198 | 85,182 | -16 | 0.01 | 0.01 | +0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 121,819 | 79,200 | -42,619 | 0.17 | 0.11 | -0.06 | sell |
| UBS Group AG | 49,817 | 77,916 | +28,099 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 75,050 | 73,002 | -2,048 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 77,984 | 68,994 | -8,990 | 0.25 | 0.25 | -0.01 | sell |
| Swiss National Bank | 65,700 | 68,600 | +2,900 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 83,881 | 63,995 | -19,886 | 0.02 | 0.01 | -0.01 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 65,112 | 63,530 | -1,582 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 52,407 | 60,297 | +7,890 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 60,125 | 60,125 | 0 | 0.09 | 0.08 | -0.01 | hold |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 60,344 | 58,692 | -1,652 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 7,668 | 54,393 | +46,725 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 79,079 | 49,192 | -29,887 | 0.00 | 0.00 | -0.00 | sell |
| SummitTX Capital, L.P. | 0 | 48,808 | +48,808 | 0.00 | 0.06 | +0.06 | buy |
| JPMORGAN CHASE & CO | 192,456 | 48,397 | -144,059 | 0.00 | 0.00 | -0.00 | sell |
| IEQ CAPITAL, LLC | 45,987 | 47,841 | +1,854 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 45,562 | 45,783 | +221 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 43,036 | 43,219 | +183 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 6,939 | 42,897 | +35,958 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 55,519 | 42,402 | -13,117 | 0.00 | 0.00 | -0.00 | sell |
| Baird Financial Group, Inc. | 55,312 | 42,237 | -13,075 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 40,429 | +40,429 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 87,464 | 39,873 | -47,591 | 0.04 | 0.02 | -0.02 | sell |
| Man Group plc | 67,905 | 39,447 | -28,458 | 0.01 | 0.00 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 6,395 | 35,889 | +29,494 | 0.01 | 0.03 | +0.03 | buy |
| Invesco Ltd. | 25,678 | 32,334 | +6,656 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 33,546 | 32,116 | -1,430 | 0.00 | 0.00 | +0.00 | sell |
| Jain Global LLC | 20,927 | 31,806 | +10,879 | 0.01 | 0.01 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 31,498 | 31,498 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Artia Global Partners LP | 29,200 | 29,200 | 0 | 0.20 | 0.19 | -0.01 | hold |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 0 | 28,955 | +28,955 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 75,187 | 28,728 | -46,459 | 0.29 | 0.09 | -0.20 | sell |
| Legal & General Group Plc | 30,858 | 28,566 | -2,292 | 0.00 | 0.00 | -0.00 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 13,563 | 27,804 | +14,241 | 0.08 | 0.18 | +0.09 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 18,283 | 23,659 | +5,376 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 0 | 23,496 | +23,496 | 0.00 | 0.00 | +0.00 | buy |