| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Deep Track Capital, LP | 11,869,297 | 15,272,172 | +3,402,875 | 2.68 | 2.80 | +0.12 | buy |
| STEMPOINT CAPITAL LP | 451,375 | 2,965,721 | +2,514,346 | 0.78 | 5.06 | +4.27 | buy |
| PERCEPTIVE ADVISORS LLC | 1,831,167 | 4,330,745 | +2,499,578 | 0.26 | 0.48 | +0.22 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,001,208 | 5,488,986 | +2,487,778 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 1,550,408 | 3,375,000 | +1,824,592 | 1.99 | 3.50 | +1.51 | buy |
| Laurion Capital Management LP | 885,471 | 2,090,471 | +1,205,000 | 0.05 | 0.11 | +0.06 | buy |
| Cormorant Asset Management, LP | 5,450,000 | 6,616,667 | +1,166,667 | 1.68 | 1.85 | +0.18 | buy |
| Frazier Life Sciences Management, L.P. | 3,746,857 | 4,623,324 | +876,467 | 1.29 | 1.24 | -0.05 | buy |
| ARMISTICE CAPITAL, LLC | 3,850,000 | 4,672,000 | +822,000 | 0.34 | 0.40 | +0.06 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 538,766 | 155,857 | +382,909 | 0.25 | 0.07 | 0.00 | sell |
| BIT Capital GmbH | 30,063 | 209,478 | +179,415 | 0.02 | 0.10 | +0.08 | buy |
| Perpetual Ltd | 2,064,731 | 2,234,515 | +169,784 | 0.14 | 0.14 | +0.00 | buy |
| DAFNA Capital Management LLC | 191,070 | 216,667 | +25,597 | 0.29 | 0.31 | +0.02 | buy |
| Privium Fund Management B.V. | 34,967 | 50,058 | +15,091 | 0.07 | 0.09 | +0.02 | buy |
| China Universal Asset Management Co., Ltd. | 16,263 | 27,034 | +10,771 | 0.02 | 0.02 | +0.00 | buy |
| MAI Capital Management | 351,906 | 354,306 | +2,400 | 0.03 | 0.02 | -0.01 | buy |
| Byrne Asset Management LLC | 2,700 | 1,800 | -900 | 0.01 | 0.01 | -0.01 | sell |
| EWA, LLC | 25,678 | 24,300 | -1,378 | 0.08 | 0.04 | -0.03 | sell |
| WEALTH EFFECTS LLC | 43,000 | 41,000 | -2,000 | 0.10 | 0.10 | -0.01 | sell |
| Rathbones Group PLC | 69,300 | 67,300 | -2,000 | 0.00 | 0.00 | -0.00 | sell |
| Bellevue Group AG | 50,000 | 32,500 | -17,500 | 0.00 | 0.00 | -0.00 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 308,502 | 279,820 | -28,682 | 0.38 | 0.23 | -0.15 | sell |
| FRED ALGER MANAGEMENT, LLC | 1,354,331 | 1,196,876 | -157,455 | 0.05 | 0.04 | -0.01 | sell |
| TFG Asset Management GP Ltd | 8,000,000 | 7,525,682 | -474,318 | 12.41 | 10.88 | -1.53 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,825,532 | 3,200,000 | -625,532 | 0.05 | 0.04 | -0.01 | sell |
| Paradigm Biocapital Advisors LP | 12,611,335 | 6,425,803 | -6,185,532 | 3.81 | 1.44 | -2.36 | sell |