| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Syncona Portfolio Ltd | 21,346,829 | 21,346,829 | 0 | 87.15 | 90.76 | +3.62 | hold |
| Blackstone Inc. | 20,485,611 | 20,485,611 | 0 | 0.61 | 0.56 | -0.05 | hold |
| Deep Track Capital, LP | 11,869,297 | 15,272,172 | +3,402,875 | 2.68 | 2.80 | +0.12 | buy |
| Avoro Capital Advisors LLC | 0 | 12,345,678 | +12,345,678 | 0.00 | 0.92 | +0.92 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 10,763,001 | +10,763,001 | 0.00 | 0.01 | +0.01 | buy |
| FMR LLC | 2,225 | 9,016,390 | +9,014,165 | 0.00 | 0.00 | +0.00 | buy |
| TFG Asset Management GP Ltd | 8,000,000 | 7,525,682 | -474,318 | 13.08 | 13.20 | +0.12 | sell |
| Cormorant Asset Management, LP | 5,450,000 | 6,616,667 | +1,166,667 | 1.68 | 1.86 | +0.18 | buy |
| Paradigm Biocapital Advisors LP | 12,611,335 | 6,425,803 | -6,185,532 | 3.81 | 1.44 | -2.36 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,001,208 | 5,488,986 | +2,487,778 | 0.00 | 0.00 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 3,850,000 | 4,672,000 | +822,000 | 0.66 | 0.79 | +0.14 | buy |
| Frazier Life Sciences Management, L.P. | 3,746,857 | 4,623,324 | +876,467 | 1.29 | 1.24 | -0.05 | buy |
| PERCEPTIVE ADVISORS LLC | 1,831,167 | 4,330,745 | +2,499,578 | 0.26 | 0.49 | +0.22 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 3,639,000 | +3,639,000 | 0.00 | 0.40 | +0.40 | buy |
| Affinity Asset Advisors, LLC | 1,550,408 | 3,375,000 | +1,824,592 | 1.99 | 3.50 | +1.51 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,825,532 | 3,200,000 | -625,532 | 0.05 | 0.04 | -0.01 | sell |
| STEMPOINT CAPITAL LP | 451,375 | 2,965,721 | +2,514,346 | 0.78 | 5.06 | +4.27 | buy |
| Commodore Capital LP | 0 | 2,300,000 | +2,300,000 | 0.00 | 0.98 | +0.98 | buy |
| Perpetual Ltd | 2,064,731 | 2,234,515 | +169,784 | 0.14 | 0.14 | +0.00 | buy |
| Laurion Capital Management LP | 885,471 | 2,090,471 | +1,205,000 | 0.20 | 0.37 | +0.17 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 1,672,732 | 1,672,732 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Bank of New York Mellon Corp | 0 | 1,450,791 | +1,450,791 | 0.00 | 0.00 | +0.00 | buy |
| Lynx1 Capital Management LP | 1,858,409 | 1,390,160 | -468,249 | 4.71 | 2.28 | -2.42 | sell |
| FRED ALGER MANAGEMENT, LLC | 1,354,331 | 1,196,876 | -157,455 | 0.05 | 0.04 | -0.01 | sell |
| GREAT POINT PARTNERS LLC | 0 | 1,166,667 | +1,166,667 | 0.00 | 1.16 | +1.16 | buy |
| MARSHALL WACE, LLP | 496,953 | 1,039,677 | +542,724 | 0.01 | 0.01 | +0.00 | buy |
| Rock Springs Capital Management LP | 0 | 1,032,988 | +1,032,988 | 0.00 | 0.17 | +0.17 | buy |
| Walleye Capital LLC | 850,151 | 828,761 | -21,390 | 0.08 | 0.06 | -0.02 | sell |
| Alphabet Inc. | 698,262 | 698,262 | 0 | 0.21 | 0.18 | -0.03 | hold |
| MORGAN STANLEY | 0 | 690,473 | +690,473 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 39,765 | 686,480 | +646,715 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 676,025 | +676,025 | 0.00 | 0.04 | +0.04 | buy |
| D. E. Shaw & Co., Inc. | 221,489 | 646,959 | +425,470 | 0.00 | 0.01 | +0.00 | buy |
| LGT CAPITAL PARTNERS LTD. | 550,000 | 550,000 | 0 | 0.11 | 0.11 | +0.00 | hold |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 512,847 | +512,847 | 0.00 | 0.01 | +0.01 | buy |
| Integral Health Asset Management, LLC | 0 | 500,000 | +500,000 | 0.00 | 0.31 | +0.31 | buy |
| Monashee Investment Management LLC | 0 | 492,000 | +492,000 | 0.00 | 0.37 | +0.37 | buy |
| Schonfeld Strategic Advisors LLC | 560,252 | 429,152 | -131,100 | 0.03 | 0.02 | -0.01 | sell |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 384,796 | +384,796 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 60,730 | 380,528 | +319,798 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 407,450 | 376,772 | -30,678 | 0.00 | 0.00 | -0.00 | sell |
| MAI Capital Management | 351,906 | 354,306 | +2,400 | 0.03 | 0.02 | -0.01 | buy |
| TD ASSET MANAGEMENT INC | 135,300 | 342,406 | +207,106 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 159,600 | 323,900 | +164,300 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 308,502 | 279,820 | -28,682 | 0.38 | 0.23 | -0.15 | sell |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 21,328 | 273,929 | +252,601 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 261,526 | +261,526 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 0 | 261,324 | +261,324 | 0.00 | 0.59 | +0.59 | buy |
| TWO SIGMA INVESTMENTS, LP | 257,256 | 228,842 | -28,414 | 0.00 | 0.00 | -0.00 | sell |
| DAFNA Capital Management LLC | 191,070 | 216,667 | +25,597 | 0.29 | 0.31 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 131,731 | 216,341 | +84,610 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 65,527 | 211,647 | +146,120 | 0.00 | 0.00 | +0.00 | buy |
| BIT Capital GmbH | 30,063 | 209,478 | +179,415 | 0.02 | 0.12 | +0.10 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 205,225 | +205,225 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 195,000 | 195,000 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Octagon Capital Advisors LP | 0 | 176,000 | +176,000 | 0.00 | 0.14 | +0.14 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 538,766 | 155,857 | -382,909 | 0.11 | 0.03 | -0.08 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 119,230 | 135,160 | +15,930 | 0.00 | 0.00 | +0.00 | buy |
| Cetera Investment Advisers | 131,500 | 131,781 | +281 | 0.01 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 27,433 | 128,909 | +101,476 | 0.00 | 0.00 | +0.00 | buy |
| Global IMC LLC | 118,721 | 118,721 | 0 | 0.18 | 0.17 | -0.01 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 4,268 | 115,399 | +111,131 | 0.00 | 0.00 | +0.00 | buy |
| Atle Fund Management AB | 96,345 | 96,345 | 0 | 0.49 | 0.37 | -0.11 | hold |
| UBS Group AG | 84,655 | 92,848 | +8,193 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 86,256 | 86,256 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CITIGROUP INC | 2,545 | 82,585 | +80,040 | 0.00 | 0.00 | +0.00 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 50,000 | 79,374 | +29,374 | 0.01 | 0.01 | +0.00 | buy |
| JANE STREET GROUP, LLC | 67,495 | 75,644 | +8,149 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 53,004 | 71,219 | +18,215 | 0.00 | 0.00 | +0.00 | buy |
| Rathbones Group PLC | 69,300 | 67,300 | -2,000 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 60,928 | +60,928 | 0.00 | 0.00 | +0.00 | buy |
| Privium Fund Management B.V. | 34,967 | 50,058 | +15,091 | 0.07 | 0.09 | +0.02 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 48,849 | 49,989 | +1,140 | 0.01 | 0.01 | -0.00 | buy |
| Qube Research & Technologies Ltd | 1,953 | 48,575 | +46,622 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 52,387 | 45,856 | -6,531 | 0.00 | 0.00 | -0.00 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 21,171 | 41,812 | +20,641 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH EFFECTS LLC | 43,000 | 41,000 | -2,000 | 0.10 | 0.10 | -0.01 | sell |
| Allianz Asset Management GmbH | 0 | 38,700 | +38,700 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 37,300 | +37,300 | 0.00 | 0.00 | +0.00 | buy |
| TRUST CO OF TOLEDO NA /OH/ | 36,265 | 36,265 | 0 | 0.04 | 0.04 | -0.00 | hold |
| LPL Financial LLC | 40,544 | 34,569 | -5,975 | 0.00 | 0.00 | -0.00 | sell |
| Bellevue Group AG | 50,000 | 32,500 | -17,500 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 29,600 | 31,100 | +1,500 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 16,263 | 27,034 | +10,771 | 0.02 | 0.02 | +0.00 | buy |
| Jump Financial, LLC | 154,164 | 25,500 | -128,664 | 0.03 | 0.00 | -0.03 | sell |
| EWA, LLC | 25,678 | 24,300 | -1,378 | 0.08 | 0.04 | -0.03 | sell |
| EntryPoint Capital, LLC | 10,084 | 21,540 | +11,456 | 0.06 | 0.12 | +0.06 | buy |
| OSAIC HOLDINGS, INC. | 21,838 | 20,475 | -1,363 | 0.00 | 0.00 | +0.00 | sell |
| Caption Management, LLC | 3,759 | 20,100 | +16,341 | 0.00 | 0.01 | +0.01 | buy |
| SG Americas Securities, LLC | 0 | 19,853 | +19,853 | 0.00 | 0.00 | +0.00 | buy |
| BLAIR WILLIAM & CO/IL | 27,107 | 19,107 | -8,000 | 0.00 | 0.00 | -0.00 | sell |
| B. Riley Wealth Advisors, Inc. | 0 | 17,000 | +17,000 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 16,692 | +16,692 | 0.00 | 0.00 | +0.00 | buy |
| Bayesian Capital Management, LP | 0 | 15,600 | +15,600 | 0.00 | 0.01 | +0.01 | buy |
| Marex Group plc | 0 | 12,500 | +12,500 | 0.00 | 0.00 | +0.00 | buy |
| UNITED BANK | 11,500 | 11,500 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Invesco Ltd. | 10,078 | 11,071 | +993 | 0.00 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 13,691 | 7,417 | -6,274 | 0.00 | 0.00 | -0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 11,551 | 7,372 | -4,179 | 0.00 | 0.00 | -0.00 | sell |