| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| WELLINGTON MANAGEMENT GROUP LLP | 10,763,001 | 17,889,834 | +7,126,833 | 0.01 | 0.01 | -0.00 | buy |
| FMR LLC | 9,016,390 | 12,295,167 | +3,278,777 | 0.00 | 0.00 | -0.00 | buy |
| GREAT POINT PARTNERS LLC | 1,166,667 | 3,441,667 | +2,275,000 | 1.16 | 2.29 | +1.13 | buy |
| MORGAN STANLEY | 690,473 | 2,904,843 | +2,214,370 | 0.00 | 0.00 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 4,672,000 | 6,250,000 | +1,578,000 | 0.79 | 0.57 | -0.22 | buy |
| Laurion Capital Management LP | 2,090,471 | 3,646,230 | +1,555,759 | 0.37 | 0.41 | +0.04 | buy |
| Bank of New York Mellon Corp | 1,450,791 | 2,531,688 | +1,080,897 | 0.00 | 0.00 | -0.00 | buy |
| Affinity Asset Advisors, LLC | 3,375,000 | 4,300,000 | +925,000 | 3.50 | 2.36 | -1.14 | buy |
| Exome Asset Management LLC | 0 | 839,472 | +839,472 | 0.00 | 2.60 | +2.60 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 323,900 | 1,145,056 | +821,156 | 0.00 | 0.01 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 1,672,732 | 2,452,040 | +779,308 | 0.01 | 0.01 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 228,842 | 1,005,916 | +777,074 | 0.00 | 0.01 | +0.00 | buy |
| Qube Research & Technologies Ltd | 48,575 | 802,081 | +753,506 | 0.00 | 0.01 | +0.00 | buy |
| Eversept Partners, LP | 0 | 610,902 | +610,902 | 0.00 | 0.16 | +0.16 | buy |
| STATE STREET CORP | 45,856 | 596,143 | +550,287 | 0.00 | 0.00 | +0.00 | buy |
| TFG Asset Management GP Ltd | 7,525,682 | 8,000,000 | +474,318 | 13.20 | 8.63 | -4.57 | buy |
| MILLENNIUM MANAGEMENT LLC | 380,528 | 813,031 | +432,503 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 128,909 | 523,700 | +394,791 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 828,761 | 1,188,493 | +359,732 | 0.06 | 0.04 | -0.01 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 266,692 | +266,692 | 0.00 | 0.08 | +0.08 | buy |
| HighVista Strategies LLC | 261,324 | 518,820 | +257,496 | 0.59 | 0.66 | +0.06 | buy |
| TWO SIGMA ADVISERS, LP | 31,100 | 256,700 | +225,600 | 0.00 | 0.00 | +0.00 | buy |
| Vontobel Holding Ltd. | 0 | 207,097 | +207,097 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 25,500 | 212,294 | +186,794 | 0.00 | 0.01 | +0.01 | buy |
| SG Americas Securities, LLC | 19,853 | 189,240 | +169,387 | 0.00 | 0.00 | +0.00 | buy |
| Perpetual Ltd | 2,234,515 | 2,400,412 | +165,897 | 0.14 | 0.09 | -0.05 | buy |
| DAFNA Capital Management LLC | 216,667 | 346,667 | +130,000 | 0.31 | 0.29 | -0.03 | buy |
| Atle Fund Management AB | 96,345 | 226,145 | +129,800 | 0.37 | 0.48 | +0.11 | buy |
| Privium Fund Management B.V. | 50,058 | 160,639 | +110,581 | 0.09 | 0.14 | +0.05 | buy |
| Rafferty Asset Management, LLC | 0 | 99,319 | +99,319 | 0.00 | 0.00 | +0.00 | buy |
| Clearstead Advisors, LLC | 0 | 96,107 | +96,107 | 0.00 | 0.01 | +0.01 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 0 | 74,398 | +74,398 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 60,512 | +60,512 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 0 | 56,000 | +56,000 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 92,848 | 135,791 | +42,943 | 0.00 | 0.00 | -0.00 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 27,395 | +27,395 | 0.00 | 0.01 | +0.01 | buy |
| Bayesian Capital Management, LP | 15,600 | 39,400 | +23,800 | 0.01 | 0.02 | +0.01 | buy |
| Squarepoint Ops LLC | 0 | 20,589 | +20,589 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 0 | 19,984 | +19,984 | 0.00 | 0.03 | +0.03 | buy |
| JANE STREET GROUP, LLC | 75,644 | 93,275 | +17,631 | 0.00 | 0.00 | -0.00 | buy |
| Daiwa Securities Group Inc. | 575 | 15,868 | +15,293 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 12,313 | +12,313 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,616 | 13,337 | +11,721 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH EFFECTS LLC | 41,000 | 49,000 | +8,000 | 0.10 | 0.06 | -0.03 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 5,955 | +5,955 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 11,071 | 16,324 | +5,253 | 0.00 | 0.00 | -0.00 | buy |
| Itau Unibanco Holding S.A. | 0 | 3,763 | +3,763 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 376,772 | 380,306 | +3,534 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 2,314 | 5,802 | +3,488 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 7,370 | 10,111 | +2,741 | 0.00 | 0.00 | -0.00 | buy |
| Cetera Investment Advisers | 131,781 | 134,500 | +2,719 | 0.00 | 0.00 | -0.00 | buy |
| GAMMA Investing LLC | 1,058 | 1,469 | +411 | 0.00 | 0.00 | -0.00 | buy |
| OSAIC HOLDINGS, INC. | 20,475 | 20,575 | +100 | 0.00 | 0.00 | -0.00 | buy |
| TRUST CO OF TOLEDO NA /OH/ | 36,265 | 36,265 | 0 | 0.04 | 0.02 | -0.02 | hold |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,639,000 | 3,639,000 | 0 | 0.40 | 0.21 | -0.19 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,200,000 | 3,200,000 | 0 | 0.04 | 0.02 | -0.02 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 86,256 | 86,256 | 0 | 0.00 | 0.00 | -0.00 | hold |
| UNITED BANK | 11,500 | 11,500 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Rathbones Group PLC | 67,300 | 67,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Blackstone Inc. | 20,485,611 | 20,485,611 | 0 | 0.56 | 0.32 | -0.25 | hold |
| Allianz Asset Management GmbH | 38,700 | 38,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rock Springs Capital Management LP | 1,032,988 | 1,032,988 | 0 | 0.17 | 0.11 | -0.06 | hold |
| Avoro Capital Advisors LLC | 12,345,678 | 12,345,678 | 0 | 0.92 | 0.57 | -0.35 | hold |
| QUADRANT CAPITAL GROUP LLC | 3,024 | 3,024 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Alphabet Inc. | 698,262 | 698,262 | 0 | 0.18 | 0.12 | -0.05 | hold |
| Bellevue Group AG | 32,500 | 32,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Close Asset Management Ltd | 500 | 500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Syncona Portfolio Ltd | 21,346,829 | 21,346,829 | 0 | 90.76 | 86.51 | -4.26 | hold |
| Cornerstone Planning Group LLC | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Octagon Capital Advisors LP | 176,000 | 176,000 | 0 | 0.14 | 0.10 | -0.04 | hold |
| Deep Track Capital, LP | 15,272,172 | 15,272,172 | 0 | 2.80 | 1.59 | -1.21 | hold |
| Frazier Life Sciences Management, L.P. | 4,623,324 | 4,623,324 | 0 | 1.24 | 0.75 | -0.49 | hold |
| Marex Group plc | 12,500 | 12,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Erste Asset Management GmbH | 195,000 | 195,000 | 0 | 0.02 | 0.01 | -0.01 | hold |
| FRANKLIN RESOURCES INC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HUNTINGTON NATIONAL BANK | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| NBC SECURITIES, INC. | 800 | 800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| US BANCORP \DE\ | 1,384 | 1,382 | -2 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 2,633 | 2,564 | -69 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 160 | 0 | -160 | 0.00 | 0.00 | -0.00 | sell |
| Byrne Asset Management LLC | 1,800 | 1,500 | -300 | 0.01 | 0.00 | -0.00 | sell |
| BLAIR WILLIAM & CO/IL | 19,107 | 18,794 | -313 | 0.00 | 0.00 | -0.00 | sell |
| LPL Financial LLC | 34,569 | 33,585 | -984 | 0.00 | 0.00 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 135,160 | 132,580 | -2,580 | 0.00 | 0.00 | -0.00 | sell |
| Aquatic Capital Management LLC | 3,100 | 0 | -3,100 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 27,034 | 23,434 | -3,600 | 0.02 | 0.01 | -0.01 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 115,399 | 110,377 | -5,022 | 0.00 | 0.00 | -0.00 | sell |
| EWA, LLC | 24,300 | 17,738 | -6,562 | 0.04 | 0.03 | -0.01 | sell |
| LAZARD ASSET MANAGEMENT LLC | 7,372 | 483 | -6,889 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 7,417 | 16 | -7,401 | 0.00 | 0.00 | -0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 676,025 | 668,349 | -7,676 | 0.04 | 0.02 | -0.02 | sell |
| BANK OF AMERICA CORP /DE/ | 261,526 | 253,493 | -8,033 | 0.00 | 0.00 | -0.00 | sell |
| EXCHANGE TRADED CONCEPTS, LLC | 49,989 | 38,126 | -11,863 | 0.01 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 16,692 | 0 | -16,692 | 0.00 | 0.00 | -0.00 | sell |
| B. Riley Wealth Advisors, Inc. | 17,000 | 0 | -17,000 | 0.00 | 0.00 | -0.00 | sell |
| Caption Management, LLC | 20,100 | 0 | -20,100 | 0.01 | 0.00 | -0.01 | sell |
| MAI Capital Management | 354,306 | 334,000 | -20,306 | 0.02 | 0.01 | -0.01 | sell |
| EntryPoint Capital, LLC | 21,540 | 0 | -21,540 | 0.12 | 0.00 | -0.12 | sell |
| BIT Capital GmbH | 209,478 | 174,987 | -34,491 | 0.12 | 0.06 | -0.06 | sell |