| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| WELLINGTON MANAGEMENT GROUP LLP | 17,889,834 | 24,220,226 | +6,330,392 | 0.01 | 0.02 | +0.00 | buy |
| Blackstone Inc. | 20,485,611 | 20,485,611 | 0 | 0.32 | 0.34 | +0.02 | hold |
| Syncona Portfolio Ltd | 21,346,829 | 18,554,624 | -2,792,205 | 86.51 | 83.42 | -3.08 | sell |
| FMR LLC | 12,295,167 | 17,773,873 | +5,478,706 | 0.00 | 0.00 | +0.00 | buy |
| Deep Track Capital, LP | 15,272,172 | 15,272,172 | 0 | 1.59 | 1.77 | +0.18 | hold |
| Avoro Capital Advisors LLC | 12,345,678 | 12,345,678 | 0 | 0.57 | 0.65 | +0.08 | hold |
| TFG Asset Management GP Ltd | 8,000,000 | 8,000,000 | 0 | 8.63 | 9.25 | +0.62 | hold |
| ARMISTICE CAPITAL, LLC | 6,250,000 | 6,872,000 | +622,000 | 0.57 | 0.65 | +0.08 | buy |
| Frazier Life Sciences Management, L.P. | 4,623,324 | 4,623,324 | 0 | 0.75 | 0.67 | -0.08 | hold |
| Affinity Asset Advisors, LLC | 4,300,000 | 4,500,000 | +200,000 | 2.36 | 2.53 | +0.18 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,414,087 | 3,841,502 | -572,585 | 0.00 | 0.00 | -0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,639,000 | 3,639,000 | 0 | 0.21 | 0.20 | -0.01 | hold |
| Laurion Capital Management LP | 3,646,230 | 3,189,547 | -456,683 | 0.41 | 0.74 | +0.33 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,200,000 | 2,950,000 | -250,000 | 0.02 | 0.02 | -0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 2,452,040 | 2,864,632 | +412,592 | 0.01 | 0.01 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 3,441,667 | 2,811,955 | -629,712 | 2.29 | 3.08 | +0.79 | sell |
| STEMPOINT CAPITAL LP | 2,662,732 | 2,616,602 | -46,130 | 2.73 | 2.85 | +0.12 | sell |
| Bank of New York Mellon Corp | 2,531,688 | 1,830,521 | -701,167 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 2,904,843 | 1,817,955 | -1,086,888 | 0.00 | 0.00 | -0.00 | sell |
| Perpetual Ltd | 2,400,412 | 1,599,252 | -801,160 | 0.09 | 0.06 | -0.03 | sell |
| JPMORGAN CHASE & CO | 523,700 | 1,284,708 | +761,008 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 1,188,493 | 1,062,393 | -126,100 | 0.04 | 0.04 | -0.00 | sell |
| Rock Springs Capital Management LP | 1,032,988 | 1,032,988 | 0 | 0.11 | 0.12 | +0.01 | hold |
| MILLENNIUM MANAGEMENT LLC | 813,031 | 862,804 | +49,773 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 757,535 | 757,535 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TWO SIGMA INVESTMENTS, LP | 1,005,916 | 732,282 | -273,634 | 0.01 | 0.01 | -0.00 | sell |
| Alphabet Inc. | 698,262 | 698,262 | 0 | 0.12 | 0.14 | +0.01 | hold |
| STATE STREET CORP | 596,143 | 606,544 | +10,401 | 0.00 | 0.00 | -0.00 | buy |
| HighVista Strategies LLC | 518,820 | 533,024 | +14,204 | 0.66 | 0.67 | +0.01 | buy |
| DAFNA Capital Management LLC | 346,667 | 486,667 | +140,000 | 0.29 | 0.42 | +0.13 | buy |
| Atle Fund Management AB | 226,145 | 442,423 | +216,278 | 0.48 | 0.75 | +0.28 | buy |
| Eversept Partners, LP | 610,902 | 406,558 | -204,344 | 0.16 | 0.11 | -0.05 | sell |
| WELLS FARGO & COMPANY/MN | 380,306 | 385,873 | +5,567 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 802,081 | 364,995 | -437,086 | 0.01 | 0.00 | -0.00 | sell |
| MAI Capital Management | 334,000 | 329,239 | -4,761 | 0.01 | 0.01 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 256,700 | 318,000 | +61,300 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 525,788 | 303,008 | -222,780 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 0 | 298,086 | +298,086 | 0.00 | 0.08 | +0.08 | buy |
| BANK OF AMERICA CORP /DE/ | 253,493 | 267,040 | +13,547 | 0.00 | 0.00 | +0.00 | buy |
| BIT Capital GmbH | 174,987 | 257,929 | +82,942 | 0.06 | 0.09 | +0.03 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,145,056 | 250,871 | -894,185 | 0.01 | 0.00 | -0.01 | sell |
| Vontobel Holding Ltd. | 207,097 | 200,941 | -6,156 | 0.00 | 0.00 | +0.00 | sell |
| Erste Asset Management GmbH | 195,000 | 195,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Privium Fund Management B.V. | 160,639 | 185,639 | +25,000 | 0.14 | 0.17 | +0.03 | buy |
| Octagon Capital Advisors LP | 176,000 | 176,000 | 0 | 0.10 | 0.10 | +0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 164,686 | 164,921 | +235 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 135,791 | 156,978 | +21,187 | 0.00 | 0.00 | +0.00 | buy |
| Cetera Investment Advisers | 134,500 | 132,000 | -2,500 | 0.00 | 0.00 | -0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 148,577 | 121,035 | -27,542 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 207,048 | 98,406 | -108,642 | 0.00 | 0.00 | -0.00 | sell |
| Clearstead Advisors, LLC | 96,107 | 96,107 | 0 | 0.01 | 0.01 | -0.00 | hold |
| D. E. Shaw & Co., Inc. | 582,865 | 91,687 | -491,178 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 86,256 | 86,256 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Mitsubishi UFJ Asset Management Co., Ltd. | 74,398 | 67,979 | -6,419 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 189,240 | 67,329 | -121,911 | 0.00 | 0.00 | -0.00 | sell |
| Rathbones Group PLC | 67,300 | 67,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 110,377 | 67,123 | -43,254 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 60,512 | 60,512 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GOLDMAN SACHS GROUP INC | 78,364 | 60,012 | -18,352 | 0.00 | 0.00 | -0.00 | sell |
| Handelsbanken Fonder AB | 56,000 | 56,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WEALTH EFFECTS LLC | 49,000 | 51,000 | +2,000 | 0.06 | 0.06 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 38,126 | 41,866 | +3,740 | 0.00 | 0.00 | +0.00 | buy |
| Bellevue Group AG | 32,500 | 41,500 | +9,000 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 23,434 | 38,393 | +14,959 | 0.01 | 0.02 | +0.00 | buy |
| TRUST CO OF TOLEDO NA /OH/ | 36,265 | 36,265 | 0 | 0.02 | 0.02 | -0.00 | hold |
| LPL Financial LLC | 33,585 | 35,875 | +2,290 | 0.00 | 0.00 | -0.00 | buy |
| HERBST GROUP, LLC | 0 | 25,000 | +25,000 | 0.00 | 0.06 | +0.06 | buy |
| Bayesian Capital Management, LP | 39,400 | 23,400 | -16,000 | 0.02 | 0.01 | -0.01 | sell |
| ALTFEST L J & CO INC | 0 | 21,820 | +21,820 | 0.00 | 0.01 | +0.01 | buy |
| OSAIC HOLDINGS, INC. | 20,575 | 20,575 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VIRTUS ADVISERS, LLC | 19,984 | 20,348 | +364 | 0.03 | 0.03 | +0.00 | buy |
| Invesco Ltd. | 16,324 | 18,748 | +2,424 | 0.00 | 0.00 | +0.00 | buy |
| EWA, LLC | 17,738 | 16,707 | -1,031 | 0.03 | 0.02 | -0.01 | sell |
| Marex Group plc | 12,500 | 15,500 | +3,000 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 15,868 | 15,264 | -604 | 0.00 | 0.00 | -0.00 | sell |
| BLAIR WILLIAM & CO/IL | 18,794 | 14,932 | -3,862 | 0.00 | 0.00 | -0.00 | sell |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 13,951 | +13,951 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 12,313 | 11,796 | -517 | 0.00 | 0.00 | -0.00 | sell |
| UNITED BANK | 11,500 | 10,850 | -650 | 0.00 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SIMPLEX TRADING, LLC | 16 | 8,816 | +8,800 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 5,955 | 7,220 | +1,265 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 5,802 | 6,107 | +305 | 0.00 | 0.00 | +0.00 | buy |
| Golden State Equity Partners | 0 | 3,900 | +3,900 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 16,952 | 3,544 | -13,408 | 0.00 | 0.00 | -0.00 | sell |
| QUADRANT CAPITAL GROUP LLC | 3,024 | 3,024 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Tower Research Capital LLC (TRC) | 13,337 | 2,940 | -10,397 | 0.00 | 0.00 | -0.00 | sell |
| GAMMA Investing LLC | 1,469 | 2,860 | +1,391 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 2,564 | 2,564 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Byrne Asset Management LLC | 1,500 | 1,400 | -100 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 0 | 993 | +993 | 0.00 | 0.00 | +0.00 | buy |
| NBC SECURITIES, INC. | 800 | 800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| US BANCORP \DE\ | 1,382 | 664 | -718 | 0.00 | 0.00 | -0.00 | sell |
| Close Asset Management Ltd | 500 | 500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LAZARD ASSET MANAGEMENT LLC | 483 | 178 | -305 | 0.00 | 0.00 | -0.00 | sell |
| Cornerstone Planning Group LLC | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HUNTINGTON NATIONAL BANK | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VICTORY CAPITAL MANAGEMENT INC | 132,580 | 0 | -132,580 | 0.00 | 0.00 | -0.00 | sell |
| Itau Unibanco Holding S.A. | 3,763 | 0 | -3,763 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 22,242 | 0 | -22,242 | 0.00 | 0.00 | -0.00 | sell |