| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Cormorant Asset Management, LP | 392,167 | 5,450,000 | +5,057,833 | 0.05 | 1.68 | +1.63 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 3,825,532 | +3,825,532 | 0.00 | 0.05 | +0.05 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 3,001,208 | +3,001,208 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 1,831,167 | +1,831,167 | 0.00 | 0.26 | +0.26 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 1,354,331 | +1,354,331 | 0.00 | 0.05 | +0.05 | buy |
| Walleye Capital LLC | 0 | 850,151 | +850,151 | 0.00 | 0.08 | +0.08 | buy |
| MARSHALL WACE, LLP | 0 | 496,953 | +496,953 | 0.00 | 0.01 | +0.01 | buy |
| Lynx1 Capital Management LP | 1,363,025 | 1,858,409 | +495,384 | 2.10 | 4.71 | +2.61 | buy |
| Schonfeld Strategic Advisors LLC | 291,433 | 560,252 | +268,819 | 0.01 | 0.03 | +0.02 | buy |
| D. E. Shaw & Co., Inc. | 0 | 221,489 | +221,489 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 154,164 | +154,164 | 0.00 | 0.03 | +0.03 | buy |
| TD ASSET MANAGEMENT INC | 0 | 135,300 | +135,300 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 119,230 | +119,230 | 0.00 | 0.00 | +0.00 | buy |
| Global IMC LLC | 0 | 118,721 | +118,721 | 0.00 | 0.18 | +0.18 | buy |
| Perpetual Ltd | 1,973,048 | 2,064,731 | +91,683 | 0.05 | 0.14 | +0.09 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 65,527 | +65,527 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 66,821 | 131,731 | +64,910 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 60,730 | +60,730 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 13,992 | 67,495 | +53,503 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 53,004 | +53,004 | 0.00 | 0.00 | +0.00 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.01 | +0.01 | buy |
| Bellevue Group AG | 0 | 50,000 | +50,000 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Trading LLC | 0 | 44,633 | +44,633 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 215,695 | 257,256 | +41,561 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 39,765 | +39,765 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 31,969 | +31,969 | 0.00 | 0.00 | +0.00 | buy |
| BIT Capital GmbH | 0 | 30,063 | +30,063 | 0.00 | 0.02 | +0.02 | buy |
| JPMORGAN CHASE & CO | 0 | 27,433 | +27,433 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 286,065 | 308,502 | +22,437 | 0.14 | 0.38 | +0.24 | buy |
| OSAIC HOLDINGS, INC. | 0 | 21,838 | +21,838 | 0.00 | 0.00 | +0.00 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 21,328 | +21,328 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 21,171 | +21,171 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 16,263 | +16,263 | 0.00 | 0.02 | +0.02 | buy |
| BLAIR WILLIAM & CO/IL | 13,107 | 27,107 | +14,000 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 36,462 | 48,849 | +12,387 | 0.00 | 0.01 | +0.01 | buy |
| EWA, LLC | 18,317 | 25,678 | +7,361 | 0.04 | 0.08 | +0.03 | buy |
| TWO SIGMA ADVISERS, LP | 25,100 | 29,600 | +4,500 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 3,759 | +3,759 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 976 | 4,268 | +3,292 | 0.00 | 0.00 | +0.00 | buy |
| Byrne Asset Management LLC | 0 | 2,700 | +2,700 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 0 | 2,545 | +2,545 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 82,310 | 84,655 | +2,345 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 1,384 | +1,384 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 0 | 575 | +575 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 11,020 | 11,551 | +531 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 40,325 | 40,544 | +219 | 0.00 | 0.00 | +0.00 | buy |
| Parkside Financial Bank & Trust | 0 | 200 | +200 | 0.00 | 0.00 | +0.00 | buy |
| TRUST CO OF TOLEDO NA /OH/ | 36,265 | 36,265 | 0 | 0.02 | 0.04 | +0.02 | hold |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 1,672,732 | 1,672,732 | 0 | 0.01 | 0.01 | +0.01 | hold |
| RHUMBLINE ADVISERS | 1,148 | 1,148 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 86,256 | 86,256 | 0 | 0.00 | 0.00 | +0.00 | hold |
| UNITED BANK | 11,500 | 11,500 | 0 | 0.00 | 0.01 | +0.01 | hold |
| Blackstone Inc. | 20,485,611 | 20,485,611 | 0 | 0.20 | 0.61 | +0.41 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 29,822 | 29,822 | 0 | 0.00 | 0.01 | +0.00 | hold |
| LGT CAPITAL PARTNERS LTD. | 550,000 | 550,000 | 0 | 0.05 | 0.11 | +0.06 | hold |
| QUADRANT CAPITAL GROUP LLC | 3,024 | 3,024 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Alphabet Inc. | 698,262 | 698,262 | 0 | 0.10 | 0.21 | +0.10 | hold |
| Close Asset Management Ltd | 500 | 500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Syncona Portfolio Ltd | 21,346,829 | 21,346,829 | 0 | 74.11 | 87.15 | +13.04 | hold |
| Ikarian Capital, LLC | 262,694 | 262,694 | 0 | 0.23 | 0.46 | +0.24 | hold |
| Privium Fund Management B.V. | 34,967 | 34,967 | 0 | 0.02 | 0.07 | +0.04 | hold |
| Cornerstone Planning Group LLC | 100 | 100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Frazier Life Sciences Management, L.P. | 3,746,857 | 3,746,857 | 0 | 0.58 | 1.29 | +0.71 | hold |
| Erste Asset Management GmbH | 195,000 | 195,000 | 0 | 0.01 | 0.02 | +0.01 | hold |
| FMR LLC | 2,225 | 2,225 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HUNTINGTON NATIONAL BANK | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| NBC SECURITIES, INC. | 800 | 800 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE STREET CORP | 52,387 | 52,387 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Invesco Ltd. | 10,314 | 10,078 | -236 | 0.00 | 0.00 | +0.00 | sell |
| Ulland Investment Advisors, LLC | 1,000 | 0 | -1,000 | 0.00 | 0.00 | -0.00 | sell |
| Cetera Investment Advisers | 134,000 | 131,500 | -2,500 | 0.00 | 0.01 | +0.00 | sell |
| Rathbones Group PLC | 73,300 | 69,300 | -4,000 | 0.00 | 0.00 | +0.00 | sell |
| WEALTH EFFECTS LLC | 47,000 | 43,000 | -4,000 | 0.05 | 0.10 | +0.05 | sell |
| SIMPLEX TRADING, LLC | 18,027 | 13,691 | -4,336 | 0.00 | 0.00 | +0.00 | sell |
| Focused Wealth Management, Inc | 5,000 | 0 | -5,000 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 17,696 | 9,793 | -7,903 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 10,268 | 1,953 | -8,315 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 13,880 | 0 | -13,880 | 0.00 | 0.00 | -0.00 | sell |
| B. Riley Wealth Advisors, Inc. | 17,000 | 0 | -17,000 | 0.00 | 0.00 | -0.00 | sell |
| MAI Capital Management | 369,480 | 351,906 | -17,574 | 0.01 | 0.03 | +0.02 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 585,919 | 538,766 | -47,153 | 0.02 | 0.11 | +0.09 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 273,679 | 159,600 | -114,079 | 0.00 | 0.00 | +0.00 | sell |
| ALPS ADVISORS INC | 128,147 | 0 | -128,147 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 557,525 | 407,450 | -150,075 | 0.00 | 0.00 | +0.00 | sell |
| Affinity Asset Advisors, LLC | 1,992,466 | 1,550,408 | -442,058 | 1.52 | 1.99 | +0.47 | sell |
| ExodusPoint Capital Management, LP | 710,355 | 251,361 | -458,994 | 0.02 | 0.02 | -0.00 | sell |
| Laurion Capital Management LP | 1,476,106 | 885,471 | -590,635 | 0.09 | 0.20 | +0.11 | sell |
| DAFNA Capital Management LLC | 928,253 | 191,070 | -737,183 | 0.67 | 0.29 | -0.38 | sell |
| Paradigm Biocapital Advisors LP | 14,406,782 | 12,611,335 | -1,795,447 | 2.29 | 3.81 | +1.52 | sell |
| ARMISTICE CAPITAL, LLC | 6,900,000 | 3,850,000 | -3,050,000 | 0.48 | 0.66 | +0.18 | sell |
| Deep Track Capital, LP | 15,000,000 | 11,869,297 | -3,130,703 | 1.36 | 2.68 | +1.32 | sell |
| TFG Asset Management GP Ltd | 12,000,000 | 8,000,000 | -4,000,000 | 5.10 | 13.08 | +7.98 | sell |