| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Sanofi | 12,197,737 | 12,197,737 | 0 | 31.44 | 30.86 | -0.58 | hold |
| PERCEPTIVE ADVISORS LLC | 10,326,103 | 10,786,658 | +460,555 | 1.76 | 2.26 | +0.50 | buy |
| Rubric Capital Management LP | 7,000,000 | 9,100,000 | +2,100,000 | 0.74 | 1.13 | +0.39 | buy |
| JOHNSON & JOHNSON | 6,641,064 | 6,641,064 | 0 | 8.82 | 11.23 | +2.42 | hold |
| BlackRock, Inc. | 3,168,148 | 4,757,178 | +1,589,030 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,000,000 | 4,400,000 | +400,000 | 0.05 | 0.08 | +0.03 | buy |
| Opaleye Management Inc. | 2,123,259 | 3,550,000 | +1,426,741 | 2.42 | 4.34 | +1.92 | buy |
| MILLENNIUM MANAGEMENT LLC | 3,465,699 | 2,971,752 | -493,947 | 0.02 | 0.03 | +0.00 | sell |
| 683 Capital Management, LLC | 2,450,000 | 2,300,000 | -150,000 | 1.97 | 2.86 | +0.89 | sell |
| Woodline Partners LP | 300,323 | 1,500,135 | +1,199,812 | 0.01 | 0.06 | +0.05 | buy |
| STATE STREET CORP | 753,378 | 1,393,222 | +639,844 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,589,940 | 1,312,703 | -277,237 | 0.00 | 0.00 | +0.00 | sell |
| Knoll Capital Management, LLC | 1,250,000 | 1,250,000 | 0 | 6.01 | 9.42 | +3.41 | hold |
| KENNEDY CAPITAL MANAGEMENT LLC | 858,379 | 1,105,421 | +247,042 | 0.16 | 0.26 | +0.11 | buy |
| Long Focus Capital Management, LLC | 524,745 | 1,080,300 | +555,555 | 0.20 | 0.60 | +0.40 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 13,673 | 1,015,106 | +1,001,433 | 0.00 | 0.05 | +0.05 | buy |
| D. E. Shaw & Co., Inc. | 425,281 | 852,902 | +427,621 | 0.00 | 0.01 | +0.00 | buy |
| HEIGHTS CAPITAL MANAGEMENT, INC | 0 | 850,000 | +850,000 | 0.00 | 2.65 | +2.65 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 584,899 | 849,082 | +264,183 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 719,702 | 691,200 | -28,502 | 0.05 | 0.07 | +0.01 | sell |
| CITADEL ADVISORS LLC | 115,995 | 650,489 | +534,494 | 0.00 | 0.01 | +0.00 | buy |
| Nuveen, LLC | 132,454 | 639,459 | +507,005 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 206,210 | 601,972 | +395,762 | 0.08 | 0.29 | +0.20 | buy |
| PFM Health Sciences, LP | 0 | 455,286 | +455,286 | 0.00 | 0.53 | +0.53 | buy |
| Hennion & Walsh Asset Management, Inc. | 354,755 | 421,979 | +67,224 | 0.10 | 0.16 | +0.06 | buy |
| NORTHERN TRUST CORP | 271,879 | 409,855 | +137,976 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 350,174 | +350,174 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 441,414 | 327,416 | -113,998 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 244,944 | 289,720 | +44,776 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 24,338 | 205,212 | +180,874 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 70,953 | 202,393 | +131,440 | 0.00 | 0.00 | +0.00 | buy |
| Ghisallo Capital Management LLC | 0 | 200,000 | +200,000 | 0.00 | 0.05 | +0.05 | buy |
| AQR CAPITAL MANAGEMENT LLC | 110,993 | 196,583 | +85,590 | 0.00 | 0.00 | +0.00 | buy |
| Privium Fund Management B.V. | 212,112 | 196,112 | -16,000 | 0.38 | 0.49 | +0.10 | sell |
| UBS Group AG | 303,198 | 184,574 | -118,624 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 18,584 | 162,412 | +143,828 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 148,065 | +148,065 | 0.00 | 0.04 | +0.04 | buy |
| Russell Investments Group, Ltd. | 97,168 | 147,199 | +50,031 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 126,331 | 142,923 | +16,592 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 142,434 | +142,434 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 100,194 | 142,434 | +42,240 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 100,097 | 138,352 | +38,255 | 0.00 | 0.00 | +0.00 | buy |
| BLAIR WILLIAM & CO/IL | 125,422 | 125,478 | +56 | 0.00 | 0.00 | +0.00 | buy |
| Voleon Capital Management LP | 22,359 | 117,790 | +95,431 | 0.00 | 0.03 | +0.02 | buy |
| Swiss National Bank | 0 | 111,400 | +111,400 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 38,138 | 98,955 | +60,817 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 94,435 | 94,540 | +105 | 0.00 | 0.00 | -0.00 | buy |
| ALPS ADVISORS INC | 0 | 93,186 | +93,186 | 0.00 | 0.01 | +0.01 | buy |
| Prosight Management, LP | 2,629,971 | 90,000 | -2,539,971 | 3.73 | 0.21 | -3.53 | sell |
| Aquatic Capital Management LLC | 946 | 87,064 | +86,118 | 0.00 | 0.04 | +0.04 | buy |
| RHUMBLINE ADVISERS | 55,761 | 86,848 | +31,087 | 0.00 | 0.00 | +0.00 | buy |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 68,200 | 77,700 | +9,500 | 0.01 | 0.01 | +0.01 | buy |
| DAVENPORT & Co LLC | 69,200 | 72,370 | +3,170 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 26,800 | 69,092 | +42,292 | 0.00 | 0.01 | +0.01 | buy |
| Fort Sheridan Advisors LLC | 66,860 | 66,441 | -419 | 0.07 | 0.10 | +0.03 | sell |
| Quantinno Capital Management LP | 56,402 | 66,134 | +9,732 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 97,620 | 65,393 | -32,227 | 0.01 | 0.01 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 0 | 64,368 | +64,368 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 61,071 | +61,071 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,447 | 60,550 | +58,103 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 53,856 | 60,490 | +6,634 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 30,216 | 59,573 | +29,357 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 54,590 | 54,690 | +100 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 16,594 | 53,909 | +37,315 | 0.00 | 0.00 | +0.00 | buy |
| BROWN ADVISORY INC | 50,000 | 50,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 31,430 | 49,380 | +17,950 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 10,345 | 49,200 | +38,855 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 48,474 | +48,474 | 0.00 | 0.00 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 0 | 47,854 | +47,854 | 0.00 | 0.02 | +0.02 | buy |
| SEI INVESTMENTS CO | 99,627 | 47,600 | -52,027 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 40,193 | +40,193 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 22,701 | 35,278 | +12,577 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 31,932 | 34,510 | +2,578 | 0.08 | 0.11 | +0.03 | buy |
| Virtus Investment Advisers, LLC | 30,570 | 34,119 | +3,549 | 0.07 | 0.11 | +0.03 | buy |
| Legal & General Group Plc | 3,811 | 32,780 | +28,969 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 5,372 | 32,733 | +27,361 | 0.00 | 0.00 | +0.00 | buy |
| LETKO, BROSSEAU & ASSOCIATES INC | 32,000 | 32,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| AXQ CAPITAL, LP | 0 | 31,189 | +31,189 | 0.00 | 0.05 | +0.05 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 0 | 30,700 | +30,700 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 39,787 | 28,898 | -10,889 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 0 | 28,769 | +28,769 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 43,356 | 28,007 | -15,349 | 0.01 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 0 | 27,995 | +27,995 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 21,516 | 27,684 | +6,168 | 0.00 | 0.00 | +0.00 | buy |
| Beacon Pointe Advisors, LLC | 26,763 | 26,763 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CreativeOne Wealth, LLC | 26,424 | 26,424 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Mitsubishi UFJ Asset Management Co., Ltd. | 22,033 | 24,528 | +2,495 | 0.00 | 0.00 | +0.00 | buy |
| Diversified Trust Co | 0 | 23,922 | +23,922 | 0.00 | 0.01 | +0.01 | buy |
| IEQ CAPITAL, LLC | 0 | 22,330 | +22,330 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 2,800 | 22,200 | +19,400 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 7,263 | 21,063 | +13,800 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 15,459 | 20,459 | +5,000 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 0 | 17,957 | +17,957 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 11,661 | 17,732 | +6,071 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 13,190 | 17,030 | +3,840 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 0 | 15,324 | +15,324 | 0.00 | 0.00 | +0.00 | buy |
| Entropy Technologies, LP | 0 | 15,136 | +15,136 | 0.00 | 0.01 | +0.01 | buy |
| Perigon Wealth Management, LLC | 15,140 | 15,029 | -111 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 14,284 | 14,739 | +455 | 0.01 | 0.01 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 14,501 | +14,501 | 0.00 | 0.00 | +0.00 | buy |