| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 12,626,103 | 12,626,103 | 0 | 3.09 | 3.00 | -0.09 | hold |
| Sanofi | 12,197,737 | 12,197,737 | 0 | 45.25 | 38.56 | -6.70 | hold |
| JOHNSON & JOHNSON | 6,641,064 | 6,641,064 | 0 | 13.14 | 10.85 | -2.29 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 6,034,578 | 4,184,578 | -1,850,000 | 0.07 | 0.05 | -0.01 | sell |
| Prosight Management, LP | 4,587,423 | 4,089,509 | -497,914 | 7.29 | 8.08 | +0.79 | sell |
| Rubric Capital Management LP | 3,726,451 | 3,726,451 | 0 | 0.39 | 0.41 | +0.02 | hold |
| BlackRock, Inc. | 2,862,408 | 2,774,272 | -88,136 | 0.00 | 0.00 | +0.00 | sell |
| 683 Capital Management, LLC | 2,690,000 | 2,625,000 | -65,000 | 1.78 | 1.96 | +0.18 | sell |
| MILLENNIUM MANAGEMENT LLC | 785,181 | 2,560,969 | +1,775,788 | 0.00 | 0.02 | +0.01 | buy |
| J. Goldman & Co LP | 2,044,574 | 1,800,931 | -243,643 | 0.42 | 0.56 | +0.14 | sell |
| Knoll Capital Management, LLC | 1,250,000 | 1,250,000 | 0 | 5.79 | 5.51 | -0.28 | hold |
| MORGAN STANLEY | 454,354 | 1,241,994 | +787,640 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 789,702 | 709,702 | -80,000 | 0.04 | 0.06 | +0.01 | sell |
| STATE STREET CORP | 682,202 | 681,031 | -1,171 | 0.00 | 0.00 | +0.00 | sell |
| 22NW, LP | 586,519 | 586,519 | 0 | 2.41 | 2.27 | -0.13 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 557,569 | 555,313 | -2,256 | 0.00 | 0.00 | +0.00 | sell |
| Long Focus Capital Management, LLC | 524,745 | 524,745 | 0 | 0.22 | 0.25 | +0.03 | hold |
| VANGUARD GROUP INC | 420,674 | 463,935 | +43,261 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 303,875 | 300,343 | -3,532 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 273,935 | 270,893 | -3,042 | 0.00 | 0.00 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 146,513 | 260,219 | +113,706 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 201,610 | 204,865 | +3,255 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 200,323 | +200,323 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 266,666 | 198,206 | -68,460 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 0 | 173,202 | +173,202 | 0.00 | 0.00 | +0.00 | buy |
| Privium Fund Management B.V. | 163,000 | 163,000 | 0 | 0.23 | 0.24 | +0.01 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 222,421 | 141,736 | -80,685 | 0.00 | 0.00 | -0.00 | sell |
| BLAIR WILLIAM & CO/IL | 132,533 | 132,533 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Nuveen, LLC | 139,145 | 131,142 | -8,003 | 0.00 | 0.00 | +0.00 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 208,308 | 127,534 | -80,774 | 0.09 | 0.07 | -0.02 | sell |
| Qube Research & Technologies Ltd | 81,231 | 115,051 | +33,820 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 64,127 | 108,981 | +44,854 | 0.02 | 0.03 | +0.02 | buy |
| AQR CAPITAL MANAGEMENT LLC | 106,626 | 107,784 | +1,158 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 108,202 | 105,799 | -2,403 | 0.00 | 0.00 | +0.00 | sell |
| JANE STREET GROUP, LLC | 0 | 104,493 | +104,493 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 104,742 | 104,059 | -683 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 108,110 | 84,001 | -24,109 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 79,392 | 82,844 | +3,452 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 81,858 | +81,858 | 0.00 | 0.14 | +0.14 | buy |
| UBS Group AG | 72,899 | 81,593 | +8,694 | 0.00 | 0.00 | +0.00 | buy |
| AMH Equity Ltd | 0 | 80,000 | +80,000 | 0.00 | 0.83 | +0.83 | buy |
| Jump Financial, LLC | 0 | 70,600 | +70,600 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 44,153 | 69,500 | +25,347 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 35,189 | 69,243 | +34,054 | 0.01 | 0.01 | +0.01 | buy |
| Fort Sheridan Advisors LLC | 68,423 | 65,633 | -2,790 | 0.06 | 0.07 | +0.01 | sell |
| RHUMBLINE ADVISERS | 63,715 | 60,679 | -3,036 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 24,867 | 60,394 | +35,527 | 0.00 | 0.00 | +0.00 | buy |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 44,500 | 59,200 | +14,700 | 0.00 | 0.01 | +0.00 | buy |
| Quantinno Capital Management LP | 48,893 | 57,233 | +8,340 | 0.00 | 0.00 | -0.00 | buy |
| DAVENPORT & Co LLC | 55,200 | 55,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 54,590 | 54,590 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BROWN ADVISORY INC | 50,000 | 50,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Dynamic Technology Lab Private Ltd | 0 | 45,417 | +45,417 | 0.00 | 0.06 | +0.06 | buy |
| ExodusPoint Capital Management, LP | 0 | 42,973 | +42,973 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 26,845 | 42,645 | +15,800 | 0.00 | 0.00 | +0.00 | buy |
| Sender Co & Partners, Inc. | 60,640 | 40,668 | -19,972 | 0.11 | 0.13 | +0.02 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 88,575 | 38,628 | -49,947 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 0 | 34,264 | +34,264 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 29,124 | 33,321 | +4,197 | 0.00 | 0.00 | +0.00 | buy |
| LETKO, BROSSEAU & ASSOCIATES INC | 45,300 | 32,000 | -13,300 | 0.01 | 0.00 | -0.00 | sell |
| CreativeOne Wealth, LLC | 36,583 | 31,574 | -5,009 | 0.01 | 0.01 | +0.00 | sell |
| SG Americas Securities, LLC | 0 | 29,992 | +29,992 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 22,951 | 27,307 | +4,356 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 32,514 | 26,406 | -6,108 | 0.00 | 0.00 | -0.00 | sell |
| LEVIN CAPITAL STRATEGIES, L.P. | 25,000 | 25,000 | 0 | 0.02 | 0.02 | +0.00 | hold |
| GSA CAPITAL PARTNERS LLP | 0 | 24,660 | +24,660 | 0.00 | 0.02 | +0.02 | buy |
| MetLife Investment Management, LLC | 30,837 | 24,196 | -6,641 | 0.00 | 0.00 | -0.00 | sell |
| SkyView Investment Advisors, LLC | 24,000 | 24,000 | 0 | 0.02 | 0.03 | +0.00 | hold |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 22,972 | +22,972 | 0.00 | 0.03 | +0.03 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 22,776 | 22,776 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Beacon Pointe Advisors, LLC | 0 | 20,763 | +20,763 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 11,904 | 19,143 | +7,239 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 22,811 | 19,038 | -3,773 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 12,771 | 16,586 | +3,815 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 16,574 | 16,016 | -558 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 16,824 | 15,475 | -1,349 | 0.00 | 0.00 | +0.00 | sell |
| CIBC Private Wealth Group LLC | 15,000 | 15,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Hobbs Group Advisors, LLC | 14,213 | 14,213 | 0 | 0.03 | 0.04 | +0.00 | hold |
| China Universal Asset Management Co., Ltd. | 16,141 | 14,101 | -2,040 | 0.01 | 0.01 | -0.00 | sell |
| CITIGROUP INC | 18,283 | 13,414 | -4,869 | 0.00 | 0.00 | -0.00 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 12,237 | 12,237 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 11,661 | 11,661 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Family Management Corp | 10,000 | 10,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 4,810 | 8,937 | +4,127 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 8,434 | 7,850 | -584 | 0.00 | 0.00 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 7,263 | 7,263 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FNY Investment Advisers, LLC | 9,360 | 6,429 | -2,931 | 0.03 | 0.02 | -0.01 | sell |
| FMR LLC | 5,463 | 5,524 | +61 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 0 | 5,500 | +5,500 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 4,415 | 4,415 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Arax Advisory Partners | 0 | 4,283 | +4,283 | 0.00 | 0.00 | +0.00 | buy |
| State of Alaska, Department of Revenue | 0 | 4,030 | +4,030 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 4,871 | 3,481 | -1,390 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 3,104 | 3,110 | +6 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 2,595 | +2,595 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 2,254 | 2,272 | +18 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 2,001 | 1,731 | -270 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 1,607 | 1,607 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Tower Research Capital LLC (TRC) | 8,797 | 1,502 | -7,295 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1,841 | 1,269 | -572 | 0.00 | 0.00 | -0.00 | sell |