| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Stonepine Capital Management, LLC | 228,894 | 1,389,622 | +1,160,728 | 1.11 | 5.39 | +4.28 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 653,594 | +653,594 | 0.00 | 0.34 | +0.34 | buy |
| SummitTX Capital, L.P. | 0 | 339,521 | +339,521 | 0.00 | 0.05 | +0.05 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 336,047 | +336,047 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 2,436,900 | 2,632,437 | +195,537 | 0.03 | 0.02 | -0.01 | buy |
| STATE STREET CORP | 39,700 | 146,900 | +107,200 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 78,345 | +78,345 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 10,102 | 85,918 | +75,816 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 390,160 | 456,371 | +66,211 | 0.00 | 0.00 | -0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 48,511 | +48,511 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 336,293 | 382,821 | +46,528 | 0.00 | 0.00 | -0.00 | buy |
| HRT FINANCIAL LP | 0 | 30,747 | +30,747 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 24,803 | +24,803 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 20,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 17,326 | +17,326 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 4,918,243 | 4,933,432 | +15,189 | 0.00 | 0.00 | -0.00 | buy |
| Diametric Capital, LP | 0 | 14,446 | +14,446 | 0.00 | 0.02 | +0.02 | buy |
| TWO SIGMA INVESTMENTS, LP | 94,531 | 108,875 | +14,344 | 0.00 | 0.00 | -0.00 | buy |
| Scientech Research LLC | 0 | 12,735 | +12,735 | 0.00 | 0.05 | +0.05 | buy |
| China Universal Asset Management Co., Ltd. | 10,000 | 16,000 | +6,000 | 0.00 | 0.01 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 406 | 1,405 | +999 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 74 | +74 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 33 | 36 | +3 | 0.00 | 0.00 | -0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 25,000 | 25,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HARBOURVEST PARTNERS LLC | 1,271,948 | 1,271,948 | 0 | 4.48 | 5.56 | +1.08 | hold |
| JANUS HENDERSON GROUP PLC | 6,307,636 | 6,307,636 | 0 | 0.02 | 0.01 | -0.00 | hold |
| Bank of New York Mellon Corp | 18,718 | 18,718 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AH Capital Management, L.L.C. | 2,125,339 | 2,125,339 | 0 | 0.82 | 0.73 | -0.10 | hold |
| Vivo Capital, LLC | 4,246,568 | 4,246,568 | 0 | 1.68 | 1.56 | -0.13 | hold |
| 5AM Venture Management, LLC | 5,869,091 | 5,869,091 | 0 | 11.31 | 7.19 | -4.12 | hold |
| SBI Securities Co., Ltd. | 10 | 10 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VICTORY CAPITAL MANAGEMENT INC | 82,790 | 82,450 | -340 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 74,509 | 70,666 | -3,843 | 0.00 | 0.00 | -0.00 | sell |
| Jefferies Financial Group Inc. | 11,361 | 0 | -11,361 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 21,403 | 9,887 | -11,516 | 0.00 | 0.00 | -0.00 | sell |
| Mariner, LLC | 15,371 | 0 | -15,371 | 0.00 | 0.00 | -0.00 | sell |
| 683 Capital Management, LLC | 126,363 | 108,000 | -18,363 | 0.06 | 0.04 | -0.02 | sell |
| OMERS ADMINISTRATION Corp | 18,800 | 0 | -18,800 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 34,720 | 0 | -34,720 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 73,601 | 34,693 | -38,908 | 0.00 | 0.00 | -0.00 | sell |
| Alyeska Investment Group, L.P. | 200,000 | 0 | -200,000 | 0.00 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,181,679 | 1,960,784 | -220,895 | 0.02 | 0.01 | -0.01 | sell |
| EcoR1 Capital, LLC | 325,000 | 0 | -325,000 | 0.09 | 0.00 | -0.09 | sell |
| Enavate Sciences GP, LLC | 3,035,825 | 2,190,920 | -844,905 | 3.67 | 2.75 | -0.92 | sell |