| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 0 | 4,640,970 | +4,640,970 | 0.00 | 0.01 | +0.01 | buy |
| Vivo Capital, LLC | 0 | 3,921,568 | +3,921,568 | 0.00 | 0.95 | +0.95 | buy |
| 5AM Venture Management, LLC | 2,927,915 | 5,869,091 | +2,941,176 | 1.63 | 6.45 | +4.82 | buy |
| FMR LLC | 607,946 | 3,023,434 | +2,415,488 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 1,960,784 | +1,960,784 | 0.00 | 0.01 | +0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 653,594 | +653,594 | 0.00 | 0.28 | +0.28 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 97,371 | +97,371 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 0 | 26,000 | +26,000 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 0 | 17,298 | +17,298 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 3,830 | 5,649 | +1,819 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 70 | +70 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 25,000 | 25,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HARBOURVEST PARTNERS LLC | 1,271,948 | 1,271,948 | 0 | 2.02 | 1.86 | -0.16 | hold |
| Alyeska Investment Group, L.P. | 200,000 | 200,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AH Capital Management, L.L.C. | 2,125,339 | 2,125,339 | 0 | 0.98 | 0.46 | -0.53 | hold |
| Enavate Sciences GP, LLC | 3,785,802 | 3,785,802 | 0 | 3.11 | 3.47 | +0.36 | hold |
| NORTHERN TRUST CORP | 14,615 | 14,615 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EverSource Wealth Advisors, LLC | 3 | 0 | -3 | 0.00 | 0.00 | -0.00 | sell |
| SBI Securities Co., Ltd. | 20 | 15 | -5 | 0.00 | 0.00 | +0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 101 | 0 | -101 | 0.00 | 0.00 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 83,060 | 82,790 | -270 | 0.00 | 0.00 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 427 | 78 | -349 | 0.00 | 0.00 | -0.00 | sell |
| CANTOR FITZGERALD, L. P. | 12,320 | 0 | -12,320 | 0.00 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 14,760 | 0 | -14,760 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 75,199 | 60,371 | -14,828 | 0.00 | 0.00 | +0.00 | sell |
| Qube Research & Technologies Ltd | 14,871 | 0 | -14,871 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 328,891 | 313,506 | -15,385 | 0.00 | 0.00 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 26,511 | 0 | -26,511 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 133,036 | 95,071 | -37,965 | 0.00 | 0.00 | +0.00 | sell |
| BlackRock, Inc. | 84,221 | 11,437 | -72,784 | 0.00 | 0.00 | -0.00 | sell |