| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 2,436,900 | +2,436,900 | 0.00 | 0.03 | +0.03 | buy |
| FMR LLC | 3,023,434 | 4,918,243 | +1,894,809 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 4,640,970 | 6,307,636 | +1,666,666 | 0.01 | 0.02 | +0.01 | buy |
| VANGUARD GROUP INC | 313,506 | 1,672,960 | +1,359,454 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 11,437 | 390,160 | +378,723 | 0.00 | 0.00 | +0.00 | buy |
| EcoR1 Capital, LLC | 0 | 325,000 | +325,000 | 0.00 | 0.09 | +0.09 | buy |
| Vivo Capital, LLC | 3,921,568 | 4,246,568 | +325,000 | 0.95 | 1.68 | +0.74 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 60,371 | 336,293 | +275,922 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 0 | 228,894 | +228,894 | 0.00 | 1.11 | +1.11 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,960,784 | 2,181,679 | +220,895 | 0.01 | 0.02 | +0.01 | buy |
| 683 Capital Management, LLC | 0 | 126,363 | +126,363 | 0.00 | 0.06 | +0.06 | buy |
| BARCLAYS PLC | 70 | 73,601 | +73,531 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 14,615 | 74,509 | +59,894 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 34,720 | +34,720 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 21,403 | +21,403 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 18,800 | +18,800 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 18,718 | +18,718 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 26,000 | 39,700 | +13,700 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 11,361 | +11,361 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 82,790 | 82,790 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 25,000 | 25,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HARBOURVEST PARTNERS LLC | 1,271,948 | 1,271,948 | 0 | 1.86 | 4.48 | +2.62 | hold |
| Alyeska Investment Group, L.P. | 200,000 | 200,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AH Capital Management, L.L.C. | 2,125,339 | 2,125,339 | 0 | 0.46 | 0.82 | +0.37 | hold |
| 5AM Venture Management, LLC | 5,869,091 | 5,869,091 | 0 | 6.45 | 11.31 | +4.86 | hold |
| SBI Securities Co., Ltd. | 15 | 10 | -5 | 0.00 | 0.00 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 78 | 33 | -45 | 0.00 | 0.00 | -0.00 | sell |
| Mariner, LLC | 17,298 | 15,371 | -1,927 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 97,371 | 94,531 | -2,840 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 5,649 | 406 | -5,243 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 95,071 | 10,102 | -84,969 | 0.00 | 0.00 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 653,594 | 0 | -653,594 | 0.28 | 0.00 | -0.28 | sell |
| Enavate Sciences GP, LLC | 3,785,802 | 3,035,825 | -749,977 | 3.47 | 3.67 | +0.20 | sell |