| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Rosalind Advisors, Inc. | 260,000 | 850,000 | +590,000 | 1.61 | 4.03 | +2.42 | buy |
| Exome Asset Management LLC | 54,738 | 294,846 | +240,108 | 0.50 | 2.57 | +2.08 | buy |
| TANG CAPITAL MANAGEMENT LLC | 2,700,000 | 2,900,000 | +200,000 | 2.16 | 1.56 | -0.60 | buy |
| Nan Fung Group Holdings Ltd | 321,746 | 414,246 | +92,500 | 3.33 | 3.29 | -0.04 | buy |
| Parkman Healthcare Partners LLC | 869,759 | 950,399 | +80,640 | 1.40 | 1.10 | -0.30 | buy |
| MPM BioImpact LLC | 950,000 | 987,036 | +37,036 | 1.63 | 1.65 | +0.02 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 241,570 | 250,420 | +8,850 | 0.24 | 0.20 | 0.00 | buy |
| Fisher Asset Management, LLC | 77,663 | 81,949 | +4,286 | 0.00 | 0.00 | -0.00 | buy |
| J. Goldman & Co LP | 112,683 | 115,861 | +3,178 | 0.04 | 0.03 | -0.01 | buy |
| Rafferty Asset Management, LLC | 77,308 | 78,608 | +1,300 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 15,559 | 16,834 | +1,275 | 0.01 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 854,309 | 855,238 | +929 | 0.07 | 0.05 | -0.02 | buy |
| Velan Capital Investment Management LP | 181,367 | 182,083 | +716 | 1.90 | 1.83 | -0.07 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,616 | 1,970 | +354 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 158,794 | 158,760 | -34 | 0.17 | 0.11 | -0.06 | sell |
| China Universal Asset Management Co., Ltd. | 16,317 | 15,448 | -869 | 0.02 | 0.01 | -0.00 | sell |
| ALPS ADVISORS INC | 60,917 | 56,328 | -4,589 | 0.00 | 0.00 | -0.00 | sell |
| Redmile Group, LLC | 4,905,527 | 4,898,527 | -7,000 | 4.14 | 4.51 | +0.37 | sell |
| Persistent Asset Partners Ltd | 29,103 | 17,143 | -11,960 | 0.35 | 0.15 | -0.20 | sell |
| BRAIDWELL LP | 1,477,102 | 1,461,826 | -15,276 | 0.53 | 0.50 | -0.03 | sell |
| TD ASSET MANAGEMENT INC | 294,298 | 275,852 | -18,446 | 0.00 | 0.00 | -0.00 | sell |
| DIADEMA PARTNERS LP | 114,000 | 74,530 | -39,470 | 1.56 | 0.58 | -0.98 | sell |
| Artisan Partners Limited Partnership | 611,013 | 565,075 | -45,938 | 0.01 | 0.01 | -0.00 | sell |
| FCPM III SERVICES B.V. | 3,970,668 | 3,909,696 | -60,972 | 8.12 | 9.21 | +1.10 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 10,962,883 | 10,853,832 | -109,051 | 0.02 | 0.01 | -0.00 | sell |
| Sofinnova Investments, Inc. | 3,149,522 | 2,479,939 | -669,583 | 2.78 | 1.58 | -1.20 | sell |