| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MARSHALL WACE, LLP | 896,184 | 2,487,685 | +1,591,501 | 0.01 | 0.03 | +0.02 | buy |
| Rosalind Advisors, Inc. | 260,000 | 850,000 | +590,000 | 1.70 | 4.04 | +2.34 | buy |
| BlackRock, Inc. | 5,566,397 | 6,061,895 | +495,498 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 361,277 | +361,277 | 0.00 | 0.00 | +0.00 | buy |
| Catalio Capital Management, LP | 0 | 355,640 | +355,640 | 0.00 | 0.86 | +0.86 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 333,237 | +333,237 | 0.00 | 0.01 | +0.01 | buy |
| Ensign Peak Advisors, Inc | 0 | 322,402 | +322,402 | 0.00 | 0.01 | +0.01 | buy |
| Schonfeld Strategic Advisors LLC | 163,300 | 458,672 | +295,372 | 0.01 | 0.03 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,429,666 | 1,672,770 | +243,104 | 0.00 | 0.00 | -0.00 | buy |
| Exome Asset Management LLC | 54,738 | 294,846 | +240,108 | 0.50 | 2.57 | +2.08 | buy |
| VANGUARD GROUP INC | 3,595,848 | 3,833,033 | +237,185 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 88,006 | 322,343 | +234,337 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 2,700,000 | 2,900,000 | +200,000 | 2.16 | 1.56 | -0.60 | buy |
| MOODY ALDRICH PARTNERS LLC | 0 | 197,385 | +197,385 | 0.00 | 0.40 | +0.40 | buy |
| STATE STREET CORP | 2,204,051 | 2,398,047 | +193,996 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 778,163 | 949,872 | +171,709 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 571,022 | 690,167 | +119,145 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 45,096 | 155,903 | +110,807 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 106,484 | +106,484 | 0.00 | 0.01 | +0.01 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 17,816 | 119,051 | +101,235 | 0.03 | 0.05 | +0.02 | buy |
| Nan Fung Group Holdings Ltd | 321,746 | 414,246 | +92,500 | 3.33 | 3.29 | -0.04 | buy |
| WELLS FARGO & COMPANY/MN | 77,371 | 158,276 | +80,905 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 869,759 | 950,399 | +80,640 | 1.40 | 1.10 | -0.30 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 16,318 | 82,562 | +66,244 | 0.02 | 0.08 | +0.06 | buy |
| FMR LLC | 347,282 | 403,371 | +56,089 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 95,447 | 148,305 | +52,858 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 52,780 | +52,780 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 508,398 | 552,046 | +43,648 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 589,635 | 632,996 | +43,361 | 0.00 | 0.00 | -0.00 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 40,000 | +40,000 | 0.00 | 0.01 | +0.01 | buy |
| NEOS Investment Management LLC | 0 | 37,522 | +37,522 | 0.00 | 0.01 | +0.01 | buy |
| TEMA ETFS LLC | 0 | 37,522 | +37,522 | 0.00 | 0.11 | +0.11 | buy |
| MPM BioImpact LLC | 950,000 | 987,036 | +37,036 | 1.63 | 1.65 | +0.02 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 35,139 | +35,139 | 0.00 | 0.05 | +0.05 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,189,662 | 1,223,236 | +33,574 | 0.01 | 0.01 | -0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 44,880 | 75,140 | +30,260 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 85,379 | 115,469 | +30,090 | 0.00 | 0.00 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 19,667 | 47,704 | +28,037 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 111,850 | 133,243 | +21,393 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 65,762 | 86,758 | +20,996 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 12,219 | 32,594 | +20,375 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 15,405 | +15,405 | 0.00 | 0.00 | +0.00 | buy |
| CIBC WORLD MARKETS CORP | 0 | 15,211 | +15,211 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 174,518 | 189,177 | +14,659 | 0.00 | 0.00 | -0.00 | buy |
| Optimize Financial Inc | 0 | 14,379 | +14,379 | 0.00 | 0.05 | +0.05 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 194,004 | 208,078 | +14,074 | 0.00 | 0.00 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 13,434 | +13,434 | 0.00 | 0.04 | +0.04 | buy |
| AXQ CAPITAL, LP | 0 | 12,191 | +12,191 | 0.00 | 0.05 | +0.05 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 241,570 | 250,420 | +8,850 | 0.07 | 0.06 | -0.01 | buy |
| Graham Capital Management, L.P. | 30,180 | 38,118 | +7,938 | 0.01 | 0.01 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 37,699 | 44,352 | +6,653 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 5,534 | 11,410 | +5,876 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 5,646 | +5,646 | 0.00 | 0.00 | +0.00 | buy |
| Fisher Asset Management, LLC | 77,663 | 81,949 | +4,286 | 0.00 | 0.00 | -0.00 | buy |
| US BANCORP \DE\ | 673 | 4,594 | +3,921 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 30,267 | 33,584 | +3,317 | 0.00 | 0.00 | -0.00 | buy |
| J. Goldman & Co LP | 112,683 | 115,861 | +3,178 | 0.05 | 0.04 | -0.01 | buy |
| MetLife Investment Management, LLC | 37,659 | 40,598 | +2,939 | 0.00 | 0.00 | -0.00 | buy |
| Arizona State Retirement System | 12,894 | 15,439 | +2,545 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 12,946 | 15,132 | +2,186 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 561,561 | 563,701 | +2,140 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 38,970 | 40,711 | +1,741 | 0.00 | 0.00 | -0.00 | buy |
| Rafferty Asset Management, LLC | 77,308 | 78,608 | +1,300 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 15,559 | 16,834 | +1,275 | 0.01 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 854,309 | 855,238 | +929 | 0.07 | 0.05 | -0.02 | buy |
| Velan Capital Investment Management LP | 181,367 | 182,083 | +716 | 1.90 | 1.83 | -0.07 | buy |
| Creative Planning | 23,041 | 23,715 | +674 | 0.00 | 0.00 | -0.00 | buy |
| AMALGAMATED BANK | 1,736 | 2,363 | +627 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 17 | 578 | +561 | 0.00 | 0.00 | +0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 397 | +397 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,616 | 1,970 | +354 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 559 | 745 | +186 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 4,265 | 4,429 | +164 | 0.00 | 0.00 | -0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 1,956 | 2,104 | +148 | 0.00 | 0.00 | -0.00 | buy |
| Physician Wealth Advisors, Inc. | 0 | 73 | +73 | 0.00 | 0.00 | +0.00 | buy |
| TD PRIVATE CLIENT WEALTH LLC | 0 | 48 | +48 | 0.00 | 0.00 | +0.00 | buy |
| Parkside Financial Bank & Trust | 0 | 45 | +45 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,564 | 2,599 | +35 | 0.00 | 0.00 | -0.00 | buy |
| Stephens Consulting, LLC | 0 | 35 | +35 | 0.00 | 0.00 | +0.00 | buy |
| CREATIVE FINANCIAL DESIGNS INC /ADV | 0 | 33 | +33 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 882 | 902 | +20 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 157 | 173 | +16 | 0.00 | 0.00 | -0.00 | buy |
| Parallel Advisors, LLC | 494 | 503 | +9 | 0.00 | 0.00 | -0.00 | buy |
| CANADA LIFE ASSURANCE Co | 4,393 | 4,393 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 6,167 | 6,167 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HORIZON KINETICS ASSET MANAGEMENT LLC | 14,396 | 14,396 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 42,725 | 42,725 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MassMutual Private Wealth & Trust, FSB | 295 | 295 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 11,045,336 | 11,045,336 | 0 | 1.43 | 1.19 | -0.24 | hold |
| JANUS HENDERSON GROUP PLC | 17,741 | 17,741 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALGERT GLOBAL LLC | 45,820 | 45,820 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Daiwa Securities Group Inc. | 200 | 200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RTW INVESTMENTS, LP | 2,065,010 | 2,065,010 | 0 | 0.38 | 0.31 | -0.07 | hold |
| Swiss National Bank | 103,700 | 103,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EcoR1 Capital, LLC | 850,341 | 850,341 | 0 | 0.41 | 0.49 | +0.08 | hold |
| Omega Fund Management, LLC | 1,975,203 | 1,975,203 | 0 | 15.51 | 11.36 | -4.15 | hold |
| IFP Advisors, Inc | 4 | 4 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Russell Investments Group, Ltd. | 241 | 241 | 0 | 0.00 | 0.00 | -0.00 | hold |
| KLP KAPITALFORVALTNING AS | 12,400 | 12,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Versant Capital Management, Inc | 288 | 288 | 0 | 0.00 | 0.00 | -0.00 | hold |