| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 36,038 | 4,221,836 | +4,185,798 | 0.01 | 0.88 | +0.87 | buy |
| GOLDMAN SACHS GROUP INC | 658,096 | 2,277,276 | +1,619,180 | 0.00 | 0.00 | +0.00 | buy |
| EcoR1 Capital, LLC | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.33 | +0.33 | buy |
| Sio Capital Management, LLC | 0 | 720,036 | +720,036 | 0.00 | 0.79 | +0.79 | buy |
| Boxer Capital Management, LLC | 750,000 | 1,175,000 | +425,000 | 1.60 | 1.18 | -0.42 | buy |
| Candriam S.C.A. | 0 | 394,027 | +394,027 | 0.00 | 0.02 | +0.02 | buy |
| ADAR1 Capital Management, LLC | 1,241,322 | 1,582,987 | +341,665 | 0.90 | 0.73 | -0.17 | buy |
| Eversept Partners, LP | 0 | 334,861 | +334,861 | 0.00 | 0.17 | +0.17 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 0 | 311,124 | +311,124 | 0.00 | 0.09 | +0.09 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 255,495 | +255,495 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 249,740 | +249,740 | 0.00 | 0.03 | +0.03 | buy |
| CITADEL ADVISORS LLC | 158,359 | 398,729 | +240,370 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 228,570 | 451,822 | +223,252 | 0.10 | 0.16 | +0.07 | buy |
| RTW INVESTMENTS, LP | 7,140,352 | 7,356,916 | +216,564 | 0.70 | 0.56 | -0.14 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 181,281 | +181,281 | 0.00 | 0.01 | +0.01 | buy |
| SummitTX Capital, L.P. | 108,803 | 288,889 | +180,086 | 0.03 | 0.07 | +0.04 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 171,936 | +171,936 | 0.00 | 0.15 | +0.15 | buy |
| BlackRock, Inc. | 6,069,633 | 6,239,239 | +169,606 | 0.00 | 0.00 | -0.00 | buy |
| Engineers Gate Manager LP | 0 | 150,494 | +150,494 | 0.00 | 0.01 | +0.01 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 138,488 | +138,488 | 0.00 | 0.06 | +0.06 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 56,723 | 170,040 | +113,317 | 0.00 | 0.00 | +0.00 | buy |
| Tidal Investments LLC | 0 | 106,885 | +106,885 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 33,163 | 131,425 | +98,262 | 0.01 | 0.02 | +0.01 | buy |
| Quantinno Capital Management LP | 12,289 | 108,477 | +96,188 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 12,357 | 104,875 | +92,518 | 0.00 | 0.02 | +0.02 | buy |
| STATE STREET CORP | 3,693,107 | 3,782,237 | +89,130 | 0.00 | 0.00 | -0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 86,910 | +86,910 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 66,875 | 152,828 | +85,953 | 0.01 | 0.02 | +0.01 | buy |
| SG Americas Securities, LLC | 71,955 | 151,674 | +79,719 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 71,592 | +71,592 | 0.00 | 0.00 | +0.00 | buy |
| ZACKS INVESTMENT MANAGEMENT | 0 | 70,360 | +70,360 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 68,978 | +68,978 | 0.00 | 0.01 | +0.01 | buy |
| Corient Private Wealth LLC | 0 | 58,527 | +58,527 | 0.00 | 0.00 | +0.00 | buy |
| TEMA ETFS LLC | 51,282 | 106,885 | +55,603 | 0.04 | 0.05 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,750,194 | 1,801,525 | +51,331 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 539,600 | 589,120 | +49,520 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 215,330 | 253,449 | +38,119 | 0.00 | 0.00 | -0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 37,274 | +37,274 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 30,714 | +30,714 | 0.00 | 0.01 | +0.01 | buy |
| DRW Securities, LLC | 0 | 26,467 | +26,467 | 0.00 | 0.01 | +0.01 | buy |
| B Group, Inc. | 0 | 26,000 | +26,000 | 0.00 | 0.15 | +0.15 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 25,324 | +25,324 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 47,364 | 72,145 | +24,781 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 587,890 | 611,759 | +23,869 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 8,121 | 31,492 | +23,371 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 23,199 | +23,199 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,119,357 | 1,140,099 | +20,742 | 0.00 | 0.00 | -0.00 | buy |
| Virtu Financial LLC | 0 | 18,851 | +18,851 | 0.00 | 0.01 | +0.01 | buy |
| Cerity Partners LLC | 0 | 18,422 | +18,422 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 606,844 | 623,979 | +17,135 | 0.01 | 0.01 | -0.00 | buy |
| Blueshift Asset Management, LLC | 0 | 15,566 | +15,566 | 0.00 | 0.04 | +0.04 | buy |
| E Fund Management Co., Ltd. | 0 | 14,893 | +14,893 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 14,695 | 28,615 | +13,920 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 178,911 | 192,350 | +13,439 | 0.00 | 0.00 | -0.00 | buy |
| Magnetar Financial LLC | 0 | 13,402 | +13,402 | 0.00 | 0.00 | +0.00 | buy |
| Polymer Capital Management (US) LLC | 0 | 11,764 | +11,764 | 0.00 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 41,181 | 52,407 | +11,226 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 14,357 | 25,444 | +11,087 | 0.00 | 0.01 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 11,030 | +11,030 | 0.00 | 0.00 | +0.00 | buy |
| Scientech Research LLC | 0 | 10,720 | +10,720 | 0.00 | 0.07 | +0.07 | buy |
| CWM, LLC | 4,047 | 12,409 | +8,362 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 3,841 | 10,968 | +7,127 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 19,862 | 26,065 | +6,203 | 0.04 | 0.03 | -0.02 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 25,319 | 30,818 | +5,499 | 0.00 | 0.00 | +0.00 | buy |
| Velan Capital Investment Management LP | 15,000 | 20,000 | +5,000 | 0.08 | 0.10 | +0.01 | buy |
| MetLife Investment Management, LLC | 34,328 | 38,355 | +4,027 | 0.00 | 0.00 | -0.00 | buy |
| Creative Planning | 45,161 | 49,081 | +3,920 | 0.00 | 0.00 | -0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 15,414 | 17,786 | +2,372 | 0.00 | 0.00 | -0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 0 | 2,141 | +2,141 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 494 | 2,432 | +1,938 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 12,782 | 14,653 | +1,871 | 0.01 | 0.01 | -0.00 | buy |
| Steward Partners Investment Advisory, LLC | 2,063 | 3,750 | +1,687 | 0.00 | 0.00 | +0.00 | buy |
| CULLEN/FROST BANKERS, INC. | 0 | 1,422 | +1,422 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 3,899 | 5,257 | +1,358 | 0.00 | 0.00 | +0.00 | buy |
| Advisory Services Network, LLC | 0 | 1,228 | +1,228 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 53,944 | 54,944 | +1,000 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 632 | 1,586 | +954 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 40,352 | 41,223 | +871 | 0.00 | 0.00 | -0.00 | buy |
| FIFTH THIRD BANCORP | 0 | 787 | +787 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 52,145 | 52,922 | +777 | 0.02 | 0.01 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 26,133 | 26,786 | +653 | 0.07 | 0.06 | -0.01 | buy |
| Hurley Capital, LLC | 0 | 645 | +645 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 100 | 639 | +539 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 3,812 | 4,307 | +495 | 0.00 | 0.00 | -0.00 | buy |
| MAI Capital Management | 19 | 476 | +457 | 0.00 | 0.00 | +0.00 | buy |
| Summit Financial, LLC | 11,041 | 11,386 | +345 | 0.00 | 0.00 | -0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 0 | 255 | +255 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 313 | 553 | +240 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,540 | 1,752 | +212 | 0.00 | 0.00 | -0.00 | buy |
| US BANCORP \DE\ | 3,139 | 3,339 | +200 | 0.00 | 0.00 | -0.00 | buy |
| SIGNATUREFD, LLC | 2,186 | 2,361 | +175 | 0.00 | 0.00 | -0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 9 | 179 | +170 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 100 | 248 | +148 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 0 | 117 | +117 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 1,013 | 1,112 | +99 | 0.00 | 0.00 | -0.00 | buy |
| Root Financial Partners, LLC | 0 | 32 | +32 | 0.00 | 0.00 | +0.00 | buy |
| Parkside Financial Bank & Trust | 60 | 79 | +19 | 0.00 | 0.00 | +0.00 | buy |
| SJS Investment Consulting Inc. | 0 | 17 | +17 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 12,585 | 12,595 | +10 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Advisory Services, LLC | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |