| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Redmile Group, LLC | 3,811,988 | 4,420,533 | +608,545 | 2.92 | 3.94 | +1.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,495,616 | 5,733,012 | +237,396 | 0.01 | 0.02 | +0.00 | buy |
| EMERALD ADVISERS, LLC | 963,041 | 1,086,287 | +123,246 | 0.82 | 1.10 | 0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 424,855 | 337,662 | +87,193 | 0.01 | 0.01 | +0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 21,800 | 89,762 | +67,962 | 0.00 | 0.01 | +0.01 | buy |
| Integral Health Asset Management, LLC | 395,000 | 445,000 | +50,000 | 1.45 | 1.36 | 0.00 | buy |
| OSTERWEIS CAPITAL MANAGEMENT INC | 150,865 | 117,855 | +33,010 | 0.18 | 0.18 | 0.00 | sell |
| ExodusPoint Capital Management, LP | 124,225 | 152,138 | +27,913 | 0.03 | 0.04 | 0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 262,200 | 238,541 | +23,659 | 0.89 | 0.92 | 0.00 | sell |
| Altium Capital Management LLC | 148,000 | 130,000 | +18,000 | 1.56 | 2.36 | 0.00 | sell |
| PROFUND ADVISORS LLC | 40,303 | 26,512 | +13,791 | 0.04 | 0.03 | 0.00 | sell |
| ALGERT GLOBAL LLC | 141,014 | 130,804 | +10,210 | 0.12 | 0.13 | 0.00 | sell |
| ALPS ADVISORS INC | 37,327 | 42,467 | +5,140 | 0.01 | 0.01 | 0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 23,432 | 25,768 | +2,336 | 0.12 | 0.12 | 0.00 | buy |
| TD ASSET MANAGEMENT INC | 144,563 | 133,823 | -10,740 | 0.00 | 0.00 | +0.00 | sell |
| BIT Capital GmbH | 24,828 | 7,173 | -17,655 | 0.07 | 0.02 | -0.05 | sell |