| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 9,545,336 | 10,045,336 | +500,000 | 0.98 | 1.16 | +0.18 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 6,548,930 | 9,236,057 | +2,687,127 | 0.01 | 0.01 | +0.00 | buy |
| Redmile Group, LLC | 3,729,983 | 5,562,096 | +1,832,113 | 1.12 | 3.03 | +1.91 | buy |
| FCPM III SERVICES B.V. | 4,866,449 | 4,866,449 | 0 | 5.62 | 6.46 | +0.84 | hold |
| MILLENNIUM MANAGEMENT LLC | 461,862 | 3,118,035 | +2,656,173 | 0.00 | 0.02 | +0.02 | buy |
| VANGUARD GROUP INC | 2,770,328 | 2,895,114 | +124,786 | 0.00 | 0.00 | +0.00 | buy |
| Omega Fund Management, LLC | 3,001,319 | 2,461,319 | -540,000 | 15.82 | 16.41 | +0.59 | sell |
| Atlas Venture Life Science Advisors, LLC | 2,098,300 | 2,098,300 | 0 | 1.58 | 1.99 | +0.41 | hold |
| MORGAN STANLEY | 2,654,034 | 1,735,654 | -918,380 | 0.00 | 0.00 | -0.00 | sell |
| Camber Capital Management LP | 2,750,000 | 1,350,000 | -1,400,000 | 0.79 | 0.47 | -0.32 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,191,793 | 1,210,993 | +19,200 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 6,486,696 | 1,157,861 | -5,328,835 | 0.00 | 0.00 | -0.00 | sell |
| RTW INVESTMENTS, LP | 0 | 1,133,787 | +1,133,787 | 0.00 | 0.16 | +0.16 | buy |
| BRAIDWELL LP | 0 | 1,013,377 | +1,013,377 | 0.00 | 0.29 | +0.29 | buy |
| Jefferies Financial Group Inc. | 1,000,000 | 1,000,000 | 0 | 0.17 | 0.18 | +0.01 | hold |
| Schonfeld Strategic Advisors LLC | 158,291 | 981,235 | +822,944 | 0.01 | 0.07 | +0.06 | buy |
| D. E. Shaw & Co., Inc. | 997,786 | 931,780 | -66,006 | 0.01 | 0.01 | +0.00 | sell |
| EcoR1 Capital, LLC | 0 | 850,341 | +850,341 | 0.00 | 0.23 | +0.23 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 805,440 | +805,440 | 0.00 | 0.74 | +0.74 | buy |
| FMR LLC | 286,479 | 747,188 | +460,709 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 513,340 | 666,077 | +152,737 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 977,852 | 610,681 | -367,171 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 157,818 | 536,326 | +378,508 | 0.00 | 0.01 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 522,046 | 528,136 | +6,090 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 0 | 525,000 | +525,000 | 0.00 | 0.64 | +0.64 | buy |
| NORTHERN TRUST CORP | 483,644 | 463,259 | -20,385 | 0.00 | 0.00 | +0.00 | sell |
| NORGES BANK | 459,900 | 459,900 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 418,664 | 432,299 | +13,635 | 0.00 | 0.00 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 309,779 | 405,516 | +95,737 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 293,622 | 293,622 | 0 | 0.02 | 0.03 | +0.00 | hold |
| TD ASSET MANAGEMENT INC | 238,846 | 249,940 | +11,094 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 272,133 | 241,275 | -30,858 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 67,440 | 214,886 | +147,446 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 222,600 | 209,700 | -12,900 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 308,841 | 207,020 | -101,821 | 0.01 | 0.00 | -0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 92,991 | 206,436 | +113,445 | 0.02 | 0.05 | +0.03 | buy |
| Nan Fung Group Holdings Ltd | 204,939 | 204,939 | 0 | 1.55 | 1.97 | +0.42 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 113,649 | 185,516 | +71,867 | 0.00 | 0.01 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 184,761 | +184,761 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 96,514 | 184,023 | +87,509 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 162,755 | 180,226 | +17,471 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 0 | 158,770 | +158,770 | 0.00 | 0.14 | +0.14 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 148,172 | 147,519 | -653 | 0.00 | 0.00 | +0.00 | sell |
| CANTOR FITZGERALD, L. P. | 0 | 145,919 | +145,919 | 0.00 | 0.26 | +0.26 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 161,053 | 145,153 | -15,900 | 0.00 | 0.00 | +0.00 | sell |
| J. Goldman & Co LP | 0 | 136,050 | +136,050 | 0.00 | 0.05 | +0.05 | buy |
| Jump Financial, LLC | 20,941 | 125,450 | +104,509 | 0.00 | 0.02 | +0.02 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 212,653 | 102,269 | -110,384 | 0.01 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 14,380 | 87,923 | +73,543 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 86,657 | 85,598 | -1,059 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 79,191 | 84,923 | +5,732 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 390,031 | 84,674 | -305,357 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 69,800 | 84,500 | +14,700 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 79,693 | 84,033 | +4,340 | 0.03 | 0.03 | -0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 133,195 | 83,674 | -49,521 | 0.00 | 0.00 | -0.00 | sell |
| Fisher Asset Management, LLC | 77,663 | 77,663 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 16,721 | 76,098 | +59,377 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 18,894 | 72,207 | +53,313 | 0.00 | 0.01 | +0.01 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 66,405 | 71,815 | +5,410 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 70,113 | +70,113 | 0.00 | 0.05 | +0.05 | buy |
| Verition Fund Management LLC | 16,338 | 68,325 | +51,987 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 46,730 | 67,980 | +21,250 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 0 | 66,071 | +66,071 | 0.00 | 0.06 | +0.06 | buy |
| Trexquant Investment LP | 100,434 | 61,198 | -39,236 | 0.02 | 0.01 | -0.01 | sell |
| BARCLAYS PLC | 108,530 | 59,700 | -48,830 | 0.00 | 0.00 | -0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 56,609 | 57,043 | +434 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 52,112 | +52,112 | 0.00 | 0.03 | +0.03 | buy |
| AMERICAN CENTURY COMPANIES INC | 43,198 | 50,785 | +7,587 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 30,251 | 49,754 | +19,503 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 49,261 | +49,261 | 0.00 | 0.09 | +0.09 | buy |
| ALPS ADVISORS INC | 43,294 | 47,891 | +4,597 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 44,520 | 42,820 | -1,700 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 36,820 | 42,565 | +5,745 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 18,171 | 39,170 | +20,999 | 0.01 | 0.02 | +0.01 | buy |
| Legal & General Group Plc | 34,742 | 38,439 | +3,697 | 0.00 | 0.00 | +0.00 | buy |
| LMR Partners LLP | 0 | 33,559 | +33,559 | 0.00 | 0.01 | +0.01 | buy |
| Pennant Investors, LP | 30,500 | 30,500 | 0 | 0.07 | 0.07 | +0.01 | hold |
| WELLS FARGO & COMPANY/MN | 26,398 | 29,801 | +3,403 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 0 | 29,460 | +29,460 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 12,221 | 29,373 | +17,152 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 12,272 | 29,344 | +17,072 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 802,984 | 29,300 | -773,684 | 0.11 | 0.00 | -0.11 | sell |
| MetLife Investment Management, LLC | 26,645 | 28,918 | +2,273 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,962 | 27,383 | +24,421 | 0.00 | 0.00 | +0.00 | buy |
| CORNERCAP INVESTMENT COUNSEL INC | 26,493 | 26,167 | -326 | 0.03 | 0.04 | +0.01 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 26,459 | 25,811 | -648 | 0.00 | 0.00 | +0.00 | sell |
| Entropy Technologies, LP | 59,326 | 25,689 | -33,637 | 0.05 | 0.02 | -0.03 | sell |
| EXCHANGE TRADED CONCEPTS, LLC | 32,232 | 24,584 | -7,648 | 0.01 | 0.01 | -0.00 | sell |
| UBS Group AG | 367,986 | 23,227 | -344,759 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 0 | 22,680 | +22,680 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 91,137 | 22,625 | -68,512 | 0.02 | 0.01 | -0.01 | sell |
| CITIGROUP INC | 542,489 | 19,863 | -522,626 | 0.00 | 0.00 | -0.00 | sell |
| Laurion Capital Management LP | 0 | 19,707 | +19,707 | 0.00 | 0.01 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 18,555 | +18,555 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 17,965 | 17,741 | -224 | 0.00 | 0.00 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 10,572 | 17,547 | +6,975 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 15,771 | 16,943 | +1,172 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 14,710 | 16,348 | +1,638 | 0.00 | 0.00 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 15,626 | 15,626 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Russell Investments Group, Ltd. | 17,111 | 14,832 | -2,279 | 0.00 | 0.00 | -0.00 | sell |