| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PRICE T ROWE ASSOCIATES INC /MD/ | 6,548,930 | 9,236,057 | +2,687,127 | 0.01 | 0.01 | +0.00 | buy |
| Redmile Group, LLC | 3,729,983 | 5,562,096 | +1,832,113 | 1.12 | 3.03 | +1.91 | buy |
| BAKER BROS. ADVISORS LP | 9,545,336 | 10,045,336 | +500,000 | 0.98 | 1.16 | +0.18 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 92,991 | 206,436 | +113,445 | 0.06 | 0.12 | 0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 212,653 | 102,269 | +110,384 | 0.01 | 0.00 | -0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 66,405 | 71,815 | +5,410 | 0.00 | 0.00 | 0.00 | buy |
| ALPS ADVISORS INC | 43,294 | 47,891 | +4,597 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 79,693 | 84,033 | +4,340 | 0.03 | 0.03 | 0.00 | buy |
| AlphaQuest LLC | 10,360 | 13,510 | +3,150 | 0.01 | 0.02 | 0.00 | buy |
| Diversified Trust Co | 11,460 | 11,638 | +178 | 0.00 | 0.00 | +0.00 | buy |
| CORNERCAP INVESTMENT COUNSEL INC | 26,493 | 26,167 | -326 | 0.03 | 0.04 | +0.01 | sell |
| VIRTUS ADVISERS, LLC | 11,165 | 9,569 | -1,596 | 0.05 | 0.04 | -0.01 | sell |
| China Universal Asset Management Co., Ltd. | 11,808 | 7,214 | -4,594 | 0.01 | 0.01 | -0.00 | sell |
| EntryPoint Capital, LLC | 17,704 | 8,051 | -9,653 | 0.13 | 0.11 | -0.02 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 23,587 | 13,219 | -10,368 | 0.04 | 0.02 | -0.02 | sell |
| Entropy Technologies, LP | 59,326 | 25,689 | -33,637 | 0.05 | 0.02 | -0.03 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 133,195 | 83,674 | -49,521 | 0.00 | 0.00 | -0.00 | sell |
| Omega Fund Management, LLC | 3,001,319 | 2,461,319 | -540,000 | 15.82 | 16.41 | +0.59 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 802,984 | 29,300 | -773,684 | 0.11 | 0.00 | -0.11 | sell |
| Camber Capital Management LP | 2,750,000 | 1,350,000 | -1,400,000 | 0.55 | 0.34 | -0.21 | sell |