| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Boxer Capital Management, LLC | 1,796,341 | 2,211,341 | +415,000 | 5.27 | 10.34 | +5.07 | buy |
| TANG CAPITAL MANAGEMENT LLC | 2,900,000 | 3,200,000 | +300,000 | 1.56 | 1.50 | -0.06 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 250,420 | 114,082 | +136,338 | 0.20 | 0.05 | 0.00 | sell |
| Exome Asset Management LLC | 294,846 | 397,846 | +103,000 | 2.57 | 3.05 | +0.47 | buy |
| CANTOR FITZGERALD, L. P. | 40,000 | 125,667 | +85,667 | 0.01 | 0.02 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 275,852 | 327,452 | +51,600 | 0.00 | 0.00 | +0.00 | buy |
| Rosalind Advisors, Inc. | 850,000 | 900,000 | +50,000 | 4.03 | 3.96 | -0.07 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 82,562 | 123,780 | +41,218 | 0.06 | 0.11 | +0.05 | buy |
| ALGERT GLOBAL LLC | 45,820 | 79,370 | +33,550 | 0.01 | 0.02 | 0.00 | buy |
| ALPS ADVISORS INC | 56,328 | 41,602 | +14,726 | 0.00 | 0.00 | 0.00 | sell |
| NEOS Investment Management LLC | 37,522 | 40,906 | +3,384 | 0.01 | 0.00 | -0.00 | buy |
| TEMA ETFS LLC | 37,522 | 40,906 | +3,384 | 0.11 | 0.10 | -0.01 | buy |
| Velan Capital Investment Management LP | 182,083 | 183,083 | +1,000 | 1.83 | 1.70 | -0.12 | buy |
| Rafferty Asset Management, LLC | 78,608 | 79,531 | +923 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 855,238 | 855,988 | +750 | 0.05 | 0.04 | -0.01 | buy |
| PROFUND ADVISORS LLC | 16,834 | 17,022 | +188 | 0.01 | 0.01 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 15,448 | 15,483 | +35 | 0.01 | 0.01 | -0.00 | buy |
| Optimize Financial Inc | 14,379 | 14,277 | -102 | 0.10 | 0.08 | -0.02 | sell |
| HORIZON KINETICS ASSET MANAGEMENT LLC | 14,396 | 13,792 | -604 | 0.00 | 0.00 | -0.00 | sell |
| MOODY ALDRICH PARTNERS LLC | 197,385 | 194,451 | -2,934 | 0.40 | 0.35 | -0.05 | sell |
| MPM BioImpact LLC | 987,036 | 983,780 | -3,256 | 1.65 | 1.58 | -0.07 | sell |
| Virtus Investment Advisers, LLC | 13,434 | 9,513 | -3,921 | 0.04 | 0.03 | -0.01 | sell |
| Persistent Asset Partners Ltd | 17,143 | 7,492 | -9,651 | 0.15 | 0.06 | -0.09 | sell |
| Catalio Capital Management, LP | 355,640 | 330,337 | -25,303 | 0.86 | 0.64 | -0.22 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 10,853,832 | 10,819,209 | -34,623 | 0.01 | 0.01 | -0.00 | sell |
| SummitTX Capital, L.P. | 109,071 | 69,202 | -39,869 | 0.05 | 0.03 | -0.02 | sell |
| DIADEMA PARTNERS LP | 74,530 | 32,483 | -42,047 | 0.58 | 0.19 | -0.39 | sell |
| Parkman Healthcare Partners LLC | 950,399 | 896,710 | -53,689 | 1.10 | 0.96 | -0.14 | sell |
| Artisan Partners Limited Partnership | 565,075 | 511,371 | -53,704 | 0.01 | 0.01 | -0.00 | sell |
| Redmile Group, LLC | 4,898,527 | 4,664,791 | -233,736 | 4.51 | 4.61 | +0.10 | sell |
| Nan Fung Group Holdings Ltd | 414,246 | 63,719 | -350,527 | 3.29 | 0.93 | -2.36 | sell |
| Sofinnova Investments, Inc. | 2,479,939 | 1,806,529 | -673,410 | 1.58 | 1.03 | -0.55 | sell |
| BRAIDWELL LP | 1,461,826 | 422,887 | -1,038,939 | 0.50 | 0.13 | -0.37 | sell |