| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Point72 Asset Management, L.P. | 95,977 | 712,543 | +616,566 | 0.00 | 0.02 | +0.01 | buy |
| Ally Bridge Group (NY) LLC | 0 | 528,491 | +528,491 | 0.00 | 4.09 | +4.09 | buy |
| NAN FUNG TRINITY (HK) Ltd | 0 | 465,527 | +465,527 | 0.00 | 0.52 | +0.52 | buy |
| GOLDMAN SACHS GROUP INC | 690,167 | 1,117,331 | +427,164 | 0.00 | 0.00 | +0.00 | buy |
| Boxer Capital Management, LLC | 1,796,341 | 2,211,341 | +415,000 | 5.27 | 10.34 | +5.07 | buy |
| TANG CAPITAL MANAGEMENT LLC | 2,900,000 | 3,200,000 | +300,000 | 1.56 | 1.50 | -0.06 | buy |
| CITADEL ADVISORS LLC | 22,755 | 277,474 | +254,719 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 0 | 231,650 | +231,650 | 0.00 | 1.42 | +1.42 | buy |
| BARCLAYS PLC | 154,796 | 372,110 | +217,314 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 949,872 | 1,165,455 | +215,583 | 0.00 | 0.00 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 187,720 | +187,720 | 0.00 | 0.07 | +0.07 | buy |
| Candriam S.C.A. | 0 | 171,527 | +171,527 | 0.00 | 0.01 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 0 | 157,550 | +157,550 | 0.00 | 0.02 | +0.02 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 154,212 | +154,212 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 361,277 | 505,109 | +143,832 | 0.00 | 0.00 | +0.00 | buy |
| Saturn V Capital Management LP | 0 | 128,917 | +128,917 | 0.00 | 0.49 | +0.49 | buy |
| Exome Asset Management LLC | 294,846 | 397,846 | +103,000 | 2.57 | 3.05 | +0.47 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 333,237 | 432,652 | +99,415 | 0.01 | 0.01 | +0.00 | buy |
| UBS Group AG | 148,305 | 243,397 | +95,092 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 91,175 | +91,175 | 0.00 | 0.00 | +0.00 | buy |
| CANTOR FITZGERALD, L. P. | 40,000 | 125,667 | +85,667 | 0.01 | 0.03 | +0.01 | buy |
| Centiva Capital, LP | 0 | 74,253 | +74,253 | 0.00 | 0.05 | +0.05 | buy |
| ROYAL BANK OF CANADA | 0 | 67,979 | +67,979 | 0.00 | 0.00 | +0.00 | buy |
| Encompass More Asset Management | 0 | 66,730 | +66,730 | 0.00 | 0.15 | +0.15 | buy |
| XTX Topco Ltd | 0 | 62,794 | +62,794 | 0.00 | 0.02 | +0.02 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 208,078 | 269,118 | +61,040 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 58,242 | +58,242 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 2,398,047 | 2,452,688 | +54,641 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 13,751 | 67,929 | +54,178 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 275,852 | 327,452 | +51,600 | 0.00 | 0.00 | +0.00 | buy |
| LMR Partners LLP | 0 | 50,000 | +50,000 | 0.00 | 0.01 | +0.01 | buy |
| Rosalind Advisors, Inc. | 850,000 | 900,000 | +50,000 | 4.04 | 4.05 | +0.01 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 43,422 | +43,422 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 82,562 | 123,780 | +41,218 | 0.08 | 0.11 | +0.03 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 86,758 | 126,358 | +39,600 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 45,820 | 79,370 | +33,550 | 0.01 | 0.02 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 5,646 | 38,546 | +32,900 | 0.00 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 47,704 | 74,781 | +27,077 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 26,106 | +26,106 | 0.00 | 0.00 | +0.00 | buy |
| HUB Investment Partners, LLC | 0 | 25,367 | +25,367 | 0.00 | 0.01 | +0.01 | buy |
| GROUP ONE TRADING LLC | 0 | 19,723 | +19,723 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 189,177 | 206,562 | +17,385 | 0.00 | 0.00 | -0.00 | buy |
| Verition Fund Management LLC | 0 | 15,761 | +15,761 | 0.00 | 0.00 | +0.00 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 13,411 | +13,411 | 0.00 | 0.02 | +0.02 | buy |
| OXFORD ASSET MANAGEMENT LLP | 0 | 13,406 | +13,406 | 0.00 | 0.04 | +0.04 | buy |
| Quadrature Capital Ltd | 0 | 12,671 | +12,671 | 0.00 | 0.00 | +0.00 | buy |
| LETKO, BROSSEAU & ASSOCIATES INC | 0 | 10,800 | +10,800 | 0.00 | 0.00 | +0.00 | buy |
| SHERBROOKE PARK ADVISERS LLC | 0 | 10,735 | +10,735 | 0.00 | 0.04 | +0.04 | buy |
| ADAR1 Capital Management, LLC | 0 | 10,400 | +10,400 | 0.00 | 0.02 | +0.02 | buy |
| WELLS FARGO & COMPANY/MN | 158,276 | 168,005 | +9,729 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 457 | 9,692 | +9,235 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 936,360 | 944,506 | +8,146 | 0.00 | 0.00 | -0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 7,414 | +7,414 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 95,389 | 102,005 | +6,616 | 0.00 | 0.00 | -0.00 | buy |
| AlphaQuest LLC | 4,932 | 9,857 | +4,925 | 0.01 | 0.01 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 4,654 | +4,654 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 37,522 | 40,906 | +3,384 | 0.01 | 0.00 | -0.00 | buy |
| TEMA ETFS LLC | 37,522 | 40,906 | +3,384 | 0.11 | 0.10 | -0.01 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 3,185 | +3,185 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 5,010 | 6,889 | +1,879 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 4,594 | 5,972 | +1,378 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 75,140 | 76,340 | +1,200 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 552,046 | 553,163 | +1,117 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 52,780 | 53,805 | +1,025 | 0.00 | 0.00 | -0.00 | buy |
| Velan Capital Investment Management LP | 182,083 | 183,083 | +1,000 | 1.83 | 1.70 | -0.12 | buy |
| Rafferty Asset Management, LLC | 78,608 | 79,531 | +923 | 0.00 | 0.00 | -0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 15,405 | 16,178 | +773 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 5,026 | 5,781 | +755 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 855,238 | 855,988 | +750 | 0.05 | 0.04 | -0.01 | buy |
| Sterling Capital Management LLC | 1,293 | 1,947 | +654 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 0 | 537 | +537 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 4,429 | 4,822 | +393 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,599 | 2,978 | +379 | 0.00 | 0.00 | -0.00 | buy |
| BESSEMER GROUP INC | 33 | 398 | +365 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 503 | 712 | +209 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 16,834 | 17,022 | +188 | 0.01 | 0.01 | -0.00 | buy |
| Riggs Asset Managment Co. Inc. | 0 | 91 | +91 | 0.00 | 0.00 | +0.00 | buy |
| Hughes Financial Services, LLC | 0 | 62 | +62 | 0.00 | 0.00 | +0.00 | buy |
| Physician Wealth Advisors, Inc. | 73 | 111 | +38 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 15,448 | 15,483 | +35 | 0.01 | 0.01 | -0.00 | buy |
| PRINCIPAL SECURITIES, INC. | 0 | 26 | +26 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 1,531 | 1,556 | +25 | 0.00 | 0.00 | -0.00 | buy |
| CANADA LIFE ASSURANCE Co | 4,393 | 4,393 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 6,167 | 6,167 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MassMutual Private Wealth & Trust, FSB | 295 | 295 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 11,045,336 | 11,045,336 | 0 | 1.19 | 1.00 | -0.20 | hold |
| JANUS HENDERSON GROUP PLC | 17,741 | 17,741 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ensign Peak Advisors, Inc | 322,402 | 322,402 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Daiwa Securities Group Inc. | 200 | 200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RTW INVESTMENTS, LP | 2,065,010 | 2,065,010 | 0 | 0.31 | 0.27 | -0.03 | hold |
| MetLife Investment Management, LLC | 40,598 | 40,598 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EcoR1 Capital, LLC | 850,341 | 850,341 | 0 | 0.49 | 0.47 | -0.02 | hold |
| Omega Fund Management, LLC | 1,975,203 | 1,975,203 | 0 | 11.36 | 11.88 | +0.52 | hold |
| Versant Capital Management, Inc | 288 | 288 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SBI Securities Co., Ltd. | 11 | 11 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Covestor Ltd | 11 | 11 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Farther Finance Advisors, LLC | 45 | 45 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FCPM III SERVICES B.V. | 3,909,696 | 3,909,696 | 0 | 9.21 | 9.84 | +0.62 | hold |
| Erste Asset Management GmbH | 11,900 | 11,900 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 15,132 | 15,132 | 0 | 0.00 | 0.00 | -0.00 | hold |