| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 11,045,336 | 11,045,336 | 0 | 1.19 | 1.00 | -0.20 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 10,853,832 | 10,819,209 | -34,623 | 0.01 | 0.01 | -0.00 | sell |
| BlackRock, Inc. | 6,061,895 | 5,730,382 | -331,513 | 0.00 | 0.00 | -0.00 | sell |
| Redmile Group, LLC | 4,898,527 | 4,664,791 | -233,736 | 4.51 | 4.61 | +0.10 | sell |
| FCPM III SERVICES B.V. | 3,909,696 | 3,909,696 | 0 | 9.21 | 9.84 | +0.62 | hold |
| VANGUARD GROUP INC | 3,833,033 | 3,469,688 | -363,345 | 0.00 | 0.00 | -0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 2,900,000 | 3,200,000 | +300,000 | 1.56 | 1.50 | -0.06 | buy |
| STATE STREET CORP | 2,398,047 | 2,452,688 | +54,641 | 0.00 | 0.00 | -0.00 | buy |
| Boxer Capital Management, LLC | 1,796,341 | 2,211,341 | +415,000 | 5.27 | 10.34 | +5.07 | buy |
| RTW INVESTMENTS, LP | 2,065,010 | 2,065,010 | 0 | 0.31 | 0.27 | -0.03 | hold |
| Omega Fund Management, LLC | 1,975,203 | 1,975,203 | 0 | 11.36 | 11.88 | +0.52 | hold |
| MARSHALL WACE, LLP | 2,487,685 | 1,866,524 | -621,161 | 0.03 | 0.02 | -0.01 | sell |
| Sofinnova Investments, Inc. | 2,479,939 | 1,806,529 | -673,410 | 1.82 | 1.14 | -0.68 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,672,770 | 1,624,048 | -48,722 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 949,872 | 1,165,455 | +215,583 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 690,167 | 1,117,331 | +427,164 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 987,036 | 983,780 | -3,256 | 1.65 | 1.58 | -0.07 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 936,360 | 944,506 | +8,146 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 928,262 | 921,658 | -6,604 | 0.00 | 0.00 | -0.00 | sell |
| Rosalind Advisors, Inc. | 850,000 | 900,000 | +50,000 | 4.04 | 4.05 | +0.01 | buy |
| Parkman Healthcare Partners LLC | 950,399 | 896,710 | -53,689 | 1.10 | 0.96 | -0.14 | sell |
| Woodline Partners LP | 855,238 | 855,988 | +750 | 0.05 | 0.04 | -0.01 | buy |
| EcoR1 Capital, LLC | 850,341 | 850,341 | 0 | 0.49 | 0.47 | -0.02 | hold |
| MILLENNIUM MANAGEMENT LLC | 1,223,236 | 794,054 | -429,182 | 0.01 | 0.01 | -0.00 | sell |
| Point72 Asset Management, L.P. | 95,977 | 712,543 | +616,566 | 0.00 | 0.02 | +0.01 | buy |
| NORTHERN TRUST CORP | 632,996 | 586,767 | -46,229 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 552,046 | 553,163 | +1,117 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 563,701 | 533,007 | -30,694 | 0.00 | 0.00 | -0.00 | sell |
| Ally Bridge Group (NY) LLC | 0 | 528,491 | +528,491 | 0.00 | 4.09 | +4.09 | buy |
| Artisan Partners Limited Partnership | 565,075 | 511,371 | -53,704 | 0.01 | 0.01 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 796,580 | 506,596 | -289,984 | 0.01 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 361,277 | 505,109 | +143,832 | 0.00 | 0.00 | +0.00 | buy |
| NAN FUNG TRINITY (HK) Ltd | 0 | 465,527 | +465,527 | 0.00 | 0.52 | +0.52 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 333,237 | 432,652 | +99,415 | 0.01 | 0.01 | +0.00 | buy |
| BRAIDWELL LP | 1,461,826 | 422,887 | -1,038,939 | 0.50 | 0.13 | -0.37 | sell |
| Exome Asset Management LLC | 294,846 | 397,846 | +103,000 | 2.57 | 3.05 | +0.47 | buy |
| FMR LLC | 403,371 | 391,660 | -11,711 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 154,796 | 372,110 | +217,314 | 0.00 | 0.00 | +0.00 | buy |
| Catalio Capital Management, LP | 355,640 | 330,337 | -25,303 | 0.86 | 0.64 | -0.22 | sell |
| TD ASSET MANAGEMENT INC | 275,852 | 327,452 | +51,600 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 322,402 | 322,402 | 0 | 0.01 | 0.01 | -0.00 | hold |
| CITADEL ADVISORS LLC | 22,755 | 277,474 | +254,719 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 208,078 | 269,118 | +61,040 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 148,305 | 243,397 | +95,092 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 458,672 | 234,806 | -223,866 | 0.03 | 0.02 | -0.01 | sell |
| SECTORAL ASSET MANAGEMENT INC | 0 | 231,650 | +231,650 | 0.00 | 1.42 | +1.42 | buy |
| Bank of New York Mellon Corp | 189,177 | 206,562 | +17,385 | 0.00 | 0.00 | -0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 197,385 | 194,451 | -2,934 | 0.40 | 0.35 | -0.05 | sell |
| READYSTATE ASSET MANAGEMENT LP | 0 | 187,720 | +187,720 | 0.00 | 0.07 | +0.07 | buy |
| Velan Capital Investment Management LP | 182,083 | 183,083 | +1,000 | 1.83 | 1.70 | -0.12 | buy |
| Candriam S.C.A. | 0 | 171,527 | +171,527 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 158,276 | 168,005 | +9,729 | 0.00 | 0.00 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 157,550 | +157,550 | 0.00 | 0.02 | +0.02 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 154,212 | +154,212 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 156,236 | 153,089 | -3,147 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 133,243 | 133,111 | -132 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 152,536 | 131,485 | -21,051 | 0.02 | 0.01 | -0.00 | sell |
| Saturn V Capital Management LP | 0 | 128,917 | +128,917 | 0.00 | 0.49 | +0.49 | buy |
| Nuveen, LLC | 671,411 | 127,327 | -544,084 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 86,758 | 126,358 | +39,600 | 0.00 | 0.00 | +0.00 | buy |
| CANTOR FITZGERALD, L. P. | 40,000 | 125,667 | +85,667 | 0.01 | 0.03 | +0.01 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 82,562 | 123,780 | +41,218 | 0.08 | 0.11 | +0.03 | buy |
| Invesco Ltd. | 322,343 | 119,329 | -203,014 | 0.00 | 0.00 | -0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 250,420 | 114,082 | -136,338 | 0.06 | 0.03 | -0.03 | sell |
| RHUMBLINE ADVISERS | 95,389 | 102,005 | +6,616 | 0.00 | 0.00 | -0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 106,484 | 100,719 | -5,765 | 0.01 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 0 | 91,175 | +91,175 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 155,903 | 87,781 | -68,122 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 264,895 | 87,145 | -177,750 | 0.00 | 0.00 | -0.00 | sell |
| Fisher Asset Management, LLC | 81,949 | 81,949 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rafferty Asset Management, LLC | 78,608 | 79,531 | +923 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 45,820 | 79,370 | +33,550 | 0.01 | 0.02 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 75,140 | 76,340 | +1,200 | 0.00 | 0.00 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 47,704 | 74,781 | +27,077 | 0.00 | 0.00 | +0.00 | buy |
| Centiva Capital, LP | 0 | 74,253 | +74,253 | 0.00 | 0.05 | +0.05 | buy |
| Swiss National Bank | 103,700 | 73,500 | -30,200 | 0.00 | 0.00 | -0.00 | sell |
| SummitTX Capital, L.P. | 109,071 | 69,202 | -39,869 | 0.05 | 0.03 | -0.02 | sell |
| ROYAL BANK OF CANADA | 0 | 67,979 | +67,979 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 13,751 | 67,929 | +54,178 | 0.00 | 0.00 | +0.00 | buy |
| Encompass More Asset Management | 0 | 66,730 | +66,730 | 0.00 | 0.15 | +0.15 | buy |
| Nan Fung Group Holdings Ltd | 414,246 | 63,719 | -350,527 | 3.29 | 0.93 | -2.36 | sell |
| XTX Topco Ltd | 0 | 62,794 | +62,794 | 0.00 | 0.02 | +0.02 | buy |
| Brevan Howard Capital Management LP | 0 | 58,242 | +58,242 | 0.00 | 0.01 | +0.01 | buy |
| Qube Research & Technologies Ltd | 52,780 | 53,805 | +1,025 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 57,383 | 53,193 | -4,190 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 142,001 | 51,490 | -90,511 | 0.00 | 0.00 | -0.00 | sell |
| LMR Partners LLP | 0 | 50,000 | +50,000 | 0.00 | 0.01 | +0.01 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 43,422 | +43,422 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 41,842 | 41,842 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALPS ADVISORS INC | 56,328 | 41,602 | -14,726 | 0.00 | 0.00 | -0.00 | sell |
| NEOS Investment Management LLC | 37,522 | 40,906 | +3,384 | 0.01 | 0.00 | -0.00 | buy |
| TEMA ETFS LLC | 37,522 | 40,906 | +3,384 | 0.11 | 0.10 | -0.01 | buy |
| MetLife Investment Management, LLC | 40,598 | 40,598 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 73,275 | 39,952 | -33,323 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 44,352 | 39,942 | -4,410 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 115,469 | 39,435 | -76,034 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 5,646 | 38,546 | +32,900 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 42,725 | 38,278 | -4,447 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 220,587 | 36,304 | -184,283 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 40,711 | 35,864 | -4,847 | 0.00 | 0.00 | -0.00 | sell |