| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 11,045,336 | 11,045,336 | 0 | 0.49 | 0.61 | +0.13 | hold |
| BlackRock, Inc. | 6,239,239 | 8,958,535 | +2,719,296 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 7,356,916 | 7,411,581 | +54,665 | 0.56 | 0.70 | +0.14 | buy |
| Ridgeback Capital Investments L.P. | 0 | 7,310,656 | +7,310,656 | 0.00 | 100.00 | +100.00 | buy |
| GOLDMAN SACHS GROUP INC | 2,277,276 | 4,541,018 | +2,263,742 | 0.00 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 3,782,237 | 4,440,144 | +657,907 | 0.00 | 0.00 | +0.00 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 4,221,836 | 4,389,836 | +168,000 | 0.88 | 1.02 | +0.15 | buy |
| Boxer Capital Management, LLC | 1,175,000 | 3,983,000 | +2,808,000 | 1.18 | 3.32 | +2.14 | buy |
| FCPM III SERVICES B.V. | 2,808,368 | 2,808,368 | 0 | 2.97 | 4.14 | +1.17 | hold |
| AQR CAPITAL MANAGEMENT LLC | 255,495 | 2,566,241 | +2,310,746 | 0.00 | 0.01 | +0.01 | buy |
| Logos Global Management LP | 0 | 2,500,000 | +2,500,000 | 0.00 | 1.19 | +1.19 | buy |
| JANE STREET GROUP, LLC | 428,145 | 2,322,545 | +1,894,400 | 0.00 | 0.02 | +0.01 | buy |
| Erste Asset Management GmbH | 2,120,000 | 2,120,000 | 0 | 0.14 | 0.18 | +0.04 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 1,801,525 | 2,035,187 | +233,662 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 2,336,528 | 1,789,964 | -546,564 | 0.01 | 0.01 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 8,121,433 | 1,620,963 | -6,500,470 | 0.01 | 0.00 | -0.01 | sell |
| Opaleye Management Inc. | 0 | 1,384,993 | +1,384,993 | 0.00 | 1.39 | +1.39 | buy |
| TORONTO DOMINION BANK | 1,591,030 | 1,275,000 | -316,030 | 0.02 | 0.02 | +0.00 | sell |
| UBS Group AG | 581,210 | 1,128,276 | +547,066 | 0.00 | 0.00 | +0.00 | buy |
| Artisan Partners Limited Partnership | 0 | 973,496 | +973,496 | 0.00 | 0.02 | +0.02 | buy |
| FMR LLC | 2,045,490 | 929,375 | -1,116,115 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 300,833 | 821,958 | +521,125 | 0.00 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 398,729 | 784,233 | +385,504 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 451,822 | 783,873 | +332,051 | 0.16 | 0.31 | +0.14 | buy |
| Invesco Ltd. | 190,925 | 724,244 | +533,319 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 723,262 | +723,262 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 646,213 | 693,003 | +46,790 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 57,614 | 677,524 | +619,910 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 589,120 | 665,618 | +76,498 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 1,582,987 | 655,784 | -927,203 | 0.73 | 0.34 | -0.39 | sell |
| Sixth Street Partners Management Company, L.P. | 0 | 639,986 | +639,986 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 611,759 | 639,986 | +28,227 | 0.00 | 0.00 | +0.00 | buy |
| Eversept Partners, LP | 334,861 | 590,252 | +255,391 | 0.17 | 0.36 | +0.19 | buy |
| Susquehanna Portfolio Strategies, LLC | 152,828 | 545,109 | +392,281 | 0.02 | 0.10 | +0.08 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,140,099 | 502,130 | -637,969 | 0.00 | 0.00 | -0.00 | sell |
| Jefferies Financial Group Inc. | 714,225 | 495,465 | -218,760 | 0.07 | 0.05 | -0.02 | sell |
| BANK OF AMERICA CORP /DE/ | 253,449 | 329,385 | +75,936 | 0.00 | 0.00 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 138,488 | 299,958 | +161,470 | 0.06 | 0.14 | +0.07 | buy |
| ARMISTICE CAPITAL, LLC | 0 | 264,000 | +264,000 | 0.00 | 0.08 | +0.08 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 623,979 | 253,450 | -370,529 | 0.01 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 204,791 | 235,405 | +30,614 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 89,622 | 227,063 | +137,441 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 197,578 | 215,302 | +17,724 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 380,988 | 191,424 | -189,564 | 0.01 | 0.01 | -0.00 | sell |
| Creative Planning | 49,081 | 174,164 | +125,083 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 150,494 | 172,998 | +22,504 | 0.01 | 0.02 | +0.01 | buy |
| Cerity Partners LLC | 18,422 | 167,504 | +149,082 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 344,751 | 166,592 | -178,159 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 158,362 | 159,975 | +1,613 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 131,354 | +131,354 | 0.00 | 0.00 | +0.00 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 311,124 | 130,195 | -180,929 | 0.09 | 0.03 | -0.05 | sell |
| Trexquant Investment LP | 0 | 128,503 | +128,503 | 0.00 | 0.01 | +0.01 | buy |
| Resolute Capital Asset Partners LLC | 0 | 125,000 | +125,000 | 0.00 | 0.59 | +0.59 | buy |
| Mariner, LLC | 0 | 110,276 | +110,276 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 15,589 | 108,877 | +93,288 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 15,211 | 108,184 | +92,973 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 87,740 | 103,943 | +16,203 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 151,674 | 92,476 | -59,198 | 0.00 | 0.00 | -0.00 | sell |
| HSBC HOLDINGS PLC | 0 | 92,154 | +92,154 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 89,500 | +89,500 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 72,145 | 89,096 | +16,951 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 25,324 | 82,000 | +56,676 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 0 | 81,982 | +81,982 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 42,739 | 80,515 | +37,776 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 54,944 | 77,455 | +22,511 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 118,476 | 76,349 | -42,127 | 0.00 | 0.00 | -0.00 | sell |
| Tidal Investments LLC | 106,885 | 75,572 | -31,313 | 0.00 | 0.00 | -0.00 | sell |
| TEMA ETFS LLC | 106,885 | 75,572 | -31,313 | 0.05 | 0.03 | -0.03 | sell |
| ALLIANCEBERNSTEIN L.P. | 62,140 | 72,300 | +10,160 | 0.00 | 0.00 | -0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 65,961 | +65,961 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 0 | 65,410 | +65,410 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 789,951 | 61,023 | -728,928 | 0.00 | 0.00 | -0.00 | sell |
| LMR Partners LLP | 0 | 50,699 | +50,699 | 0.00 | 0.00 | +0.00 | buy |
| Diametric Capital, LP | 0 | 50,186 | +50,186 | 0.00 | 0.06 | +0.06 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 0 | 47,414 | +47,414 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 38,355 | 46,374 | +8,019 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 45,403 | +45,403 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 41,223 | 45,325 | +4,102 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 108,477 | 43,451 | -65,026 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 30,818 | 40,853 | +10,035 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 0 | 40,361 | +40,361 | 0.00 | 0.28 | +0.28 | buy |
| KLCM Advisors, Inc. | 0 | 40,000 | +40,000 | 0.00 | 0.04 | +0.04 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 381,453 | 39,800 | -341,653 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 31,492 | 39,134 | +7,642 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 52,922 | 38,776 | -14,146 | 0.01 | 0.01 | -0.00 | sell |
| Virtus Investment Advisers, LLC | 26,786 | 36,846 | +10,060 | 0.06 | 0.10 | +0.04 | buy |
| Simplicity Wealth,LLC | 0 | 31,101 | +31,101 | 0.00 | 0.01 | +0.01 | buy |
| Bleakley Financial Group, LLC | 0 | 30,131 | +30,131 | 0.00 | 0.00 | +0.00 | buy |
| VERUS CAPITAL PARTNERS, LLC | 0 | 27,550 | +27,550 | 0.00 | 0.02 | +0.02 | buy |
| AXQ CAPITAL, LP | 26,065 | 27,121 | +1,056 | 0.03 | 0.03 | +0.01 | buy |
| Private Capital Advisors, Inc. | 0 | 27,066 | +27,066 | 0.00 | 0.03 | +0.03 | buy |
| Manchester Capital Management LLC | 0 | 25,675 | +25,675 | 0.00 | 0.04 | +0.04 | buy |
| Focus Partners Wealth | 0 | 25,208 | +25,208 | 0.00 | 0.00 | +0.00 | buy |
| Blueshift Asset Management, LLC | 15,566 | 25,176 | +9,610 | 0.04 | 0.06 | +0.03 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 25,061 | +25,061 | 0.00 | 0.05 | +0.05 | buy |
| Police & Firemen's Retirement System of New Jersey | 18,445 | 23,361 | +4,916 | 0.00 | 0.00 | +0.00 | buy |
| Focus Partners Advisor Solutions, LLC | 0 | 23,168 | +23,168 | 0.00 | 0.00 | +0.00 | buy |
| SYON CAPITAL LLC | 0 | 22,342 | +22,342 | 0.00 | 0.01 | +0.01 | buy |
| Ballentine Partners, LLC | 21,646 | 22,046 | +400 | 0.00 | 0.00 | +0.00 | buy |
| IRONWOOD INVESTMENT MANAGEMENT LLC | 0 | 21,525 | +21,525 | 0.00 | 0.08 | +0.08 | buy |