| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Camber Capital Management LP | 1,550,000 | 2,000,000 | +450,000 | 1.17 | 1.23 | +0.06 | buy |
| Sofinnova Investments, Inc. | 348,889 | 503,844 | +154,955 | 0.53 | 0.60 | +0.06 | buy |
| TD ASSET MANAGEMENT INC | 133,823 | 267,646 | +133,823 | 0.00 | 0.01 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 337,662 | 221,062 | +116,600 | 0.01 | 0.01 | -0.01 | sell |
| LOOMIS SAYLES & CO L P | 1,187,227 | 1,290,450 | +103,223 | 0.04 | 0.04 | -0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,733,012 | 5,793,199 | +60,187 | 0.02 | 0.01 | -0.00 | buy |
| ALGERT GLOBAL LLC | 130,804 | 84,682 | +46,122 | 0.13 | 0.07 | 0.00 | sell |
| Rafferty Asset Management, LLC | 144,692 | 186,801 | +42,109 | 0.02 | 0.02 | -0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 238,541 | 271,056 | +32,515 | 0.92 | 0.90 | -0.02 | buy |
| ExodusPoint Capital Management, LP | 152,138 | 124,972 | +27,166 | 0.04 | 0.03 | 0.00 | sell |
| Altium Capital Management LLC | 130,000 | 155,000 | +25,000 | 2.36 | 1.53 | -0.83 | buy |
| Woodline Partners LP | 275,001 | 293,622 | +18,621 | 0.08 | 0.06 | -0.02 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 89,762 | 82,476 | +7,286 | 0.01 | 0.01 | -0.00 | sell |
| PROFUND ADVISORS LLC | 26,512 | 31,557 | +5,045 | 0.03 | 0.03 | -0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 25,768 | 30,467 | +4,699 | 0.12 | 0.11 | -0.01 | buy |
| ALPS ADVISORS INC | 42,467 | 43,550 | +1,083 | 0.01 | 0.01 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 757 | 1,509 | +752 | 0.01 | 0.01 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 4,631 | 4,216 | -415 | 0.06 | 0.04 | -0.02 | sell |
| BIT Capital GmbH | 7,173 | 5,912 | -1,261 | 0.02 | 0.01 | -0.01 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 31,800 | 9,900 | -21,900 | 0.00 | 0.00 | -0.00 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 900,952 | 874,210 | -26,742 | 1.13 | 0.90 | -0.23 | sell |
| EMERALD ADVISERS, LLC | 1,086,287 | 1,052,524 | -33,763 | 1.10 | 0.87 | -0.23 | sell |
| OSTERWEIS CAPITAL MANAGEMENT INC | 117,855 | 51,250 | -66,605 | 0.18 | 0.06 | -0.12 | sell |
| Integral Health Asset Management, LLC | 445,000 | 250,000 | -195,000 | 1.36 | 0.61 | -0.75 | sell |
| Redmile Group, LLC | 4,420,533 | 4,163,922 | -256,611 | 3.94 | 3.39 | -0.55 | sell |
| LORD, ABBETT & CO. LLC | 1,038,506 | 184,419 | -854,087 | 0.08 | 0.01 | -0.07 | sell |