| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BRAIDWELL LP | 1,013,377 | 3,070,837 | +2,057,460 | 0.29 | 0.95 | +0.67 | buy |
| STATE STREET CORP | 1,157,861 | 2,340,042 | +1,182,181 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 10,045,336 | 11,045,336 | +1,000,000 | 1.16 | 1.25 | +0.10 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 9,236,057 | 9,879,250 | +643,193 | 0.01 | 0.01 | +0.00 | buy |
| VANGUARD GROUP INC | 2,895,114 | 3,466,247 | +571,133 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 422,914 | +422,914 | 0.00 | 0.05 | +0.05 | buy |
| ALLIANCEBERNSTEIN L.P. | 67,980 | 489,009 | +421,029 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 805,440 | 1,200,000 | +394,560 | 0.74 | 0.94 | +0.20 | buy |
| Parkman Healthcare Partners LLC | 525,000 | 763,747 | +238,747 | 0.64 | 1.07 | +0.42 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,210,993 | 1,428,301 | +217,308 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 61,198 | 266,471 | +205,273 | 0.01 | 0.04 | +0.03 | buy |
| Rafferty Asset Management, LLC | 0 | 101,214 | +101,214 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 59,700 | 158,491 | +98,791 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 85,598 | 180,958 | +95,360 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 463,259 | 549,501 | +86,242 | 0.00 | 0.00 | +0.00 | buy |
| Nan Fung Group Holdings Ltd | 204,939 | 287,846 | +82,907 | 1.97 | 2.72 | +0.75 | buy |
| Arizona PSPRS Trust | 0 | 76,100 | +76,100 | 0.00 | 0.03 | +0.03 | buy |
| UBS Group AG | 23,227 | 91,017 | +67,790 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 432,299 | 484,797 | +52,498 | 0.00 | 0.00 | +0.00 | buy |
| LMR Partners LLP | 33,559 | 82,479 | +48,920 | 0.01 | 0.02 | +0.01 | buy |
| Sofinnova Investments, Inc. | 0 | 48,138 | +48,138 | 0.00 | 0.04 | +0.04 | buy |
| Woodline Partners LP | 293,622 | 332,943 | +39,321 | 0.03 | 0.03 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 147,519 | 184,208 | +36,689 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 76,098 | 111,957 | +35,859 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 50,785 | 84,591 | +33,806 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 27,786 | +27,786 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 102,269 | 128,208 | +25,939 | 0.00 | 0.01 | +0.00 | buy |
| CITIGROUP INC | 19,863 | 45,722 | +25,859 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 84,674 | 108,908 | +24,234 | 0.00 | 0.00 | +0.00 | buy |
| Bayesian Capital Management, LP | 0 | 23,975 | +23,975 | 0.00 | 0.03 | +0.03 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 23,003 | +23,003 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 22,917 | +22,917 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 20,416 | +20,416 | 0.00 | 0.01 | +0.01 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 20,254 | +20,254 | 0.00 | 0.02 | +0.02 | buy |
| Squarepoint Ops LLC | 0 | 19,564 | +19,564 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 14,832 | 29,521 | +14,689 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 13,889 | +13,889 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 24,405 | 37,287 | +12,882 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 8,540 | +8,540 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 29,801 | 38,250 | +8,449 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 241,275 | 249,349 | +8,074 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 249,940 | 257,622 | +7,682 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 528,136 | 535,640 | +7,504 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 22,680 | 29,669 | +6,989 | 0.00 | 0.01 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 8,263 | 15,011 | +6,748 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 28,918 | 35,134 | +6,216 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 7,214 | 13,140 | +5,926 | 0.01 | 0.02 | +0.01 | buy |
| Graham Capital Management, L.P. | 22,625 | 28,449 | +5,824 | 0.01 | 0.01 | +0.00 | buy |
| Corebridge Financial, Inc. | 27,061 | 32,551 | +5,490 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 5,136 | +5,136 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 10,414 | 15,541 | +5,127 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 16,348 | 21,047 | +4,699 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 47,891 | 52,301 | +4,410 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 4,339 | +4,339 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 84,923 | 88,148 | +3,225 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 16,943 | 19,849 | +2,906 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 0 | 2,712 | +2,712 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 4,017 | 6,167 | +2,150 | 0.00 | 0.00 | +0.00 | buy |
| nVerses Capital, LLC | 0 | 1,300 | +1,300 | 0.00 | 0.01 | +0.01 | buy |
| Legal & General Group Plc | 38,439 | 39,631 | +1,192 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 3,687 | 4,437 | +750 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,834 | 2,471 | +637 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 464 | 862 | +398 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 1,317 | 1,545 | +228 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 9,569 | 9,739 | +170 | 0.04 | 0.05 | +0.01 | buy |
| Parallel Advisors, LLC | 344 | 494 | +150 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 0 | 123 | +123 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 0 | 120 | +120 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 15 | 115 | +100 | 0.00 | 0.00 | +0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 76 | +76 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 1,890 | 1,956 | +66 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 0 | 59 | +59 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 382 | 409 | +27 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 4,393 | 4,393 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MassMutual Private Wealth & Trust, FSB | 295 | 295 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JANUS HENDERSON GROUP PLC | 17,741 | 17,741 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Amundi | 2,513 | 2,513 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 5,534 | 5,534 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 200 | 200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RTW INVESTMENTS, LP | 1,133,787 | 1,133,787 | 0 | 0.16 | 0.18 | +0.02 | hold |
| PDT Partners, LLC | 158,770 | 158,770 | 0 | 0.14 | 0.15 | +0.02 | hold |
| EcoR1 Capital, LLC | 850,341 | 850,341 | 0 | 0.23 | 0.32 | +0.09 | hold |
| Omega Fund Management, LLC | 2,461,319 | 2,461,319 | 0 | 16.41 | 16.86 | +0.45 | hold |
| EverSource Wealth Advisors, LLC | 157 | 157 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WOLFF WIESE MAGANA LLC | 100 | 100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Covestor Ltd | 11 | 11 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Farther Finance Advisors, LLC | 45 | 45 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FCPM III SERVICES B.V. | 4,866,449 | 4,866,449 | 0 | 6.46 | 9.16 | +2.70 | hold |
| Erste Asset Management GmbH | 11,900 | 11,900 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Fisher Asset Management, LLC | 77,663 | 77,663 | 0 | 0.00 | 0.00 | +0.00 | hold |
| COMERICA BANK | 1,052 | 1,052 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 1,736 | 1,736 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MARTINGALE ASSET MANAGEMENT L P | 15,626 | 15,626 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 4,994 | 4,994 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 12,844 | 12,844 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AlphaQuest LLC | 13,510 | 13,496 | -14 | 0.02 | 0.01 | -0.00 | sell |
| Smartleaf Asset Management LLC | 367 | 342 | -25 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 781 | 652 | -129 | 0.00 | 0.00 | -0.00 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 13,219 | 12,903 | -316 | 0.02 | 0.03 | +0.01 | sell |
| HORIZON KINETICS ASSET MANAGEMENT LLC | 14,396 | 13,792 | -604 | 0.00 | 0.00 | -0.00 | sell |