| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BRAIDWELL LP | 1,013,377 | 3,070,837 | +2,057,460 | 0.29 | 0.95 | +0.67 | buy |
| BAKER BROS. ADVISORS LP | 10,045,336 | 11,045,336 | +1,000,000 | 1.16 | 1.25 | +0.10 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 9,236,057 | 9,879,250 | +643,193 | 0.01 | 0.01 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 805,440 | 1,200,000 | +394,560 | 0.74 | 0.94 | +0.20 | buy |
| Parkman Healthcare Partners LLC | 525,000 | 763,747 | +238,747 | 0.63 | 1.07 | +0.44 | buy |
| Nan Fung Group Holdings Ltd | 204,939 | 287,846 | +82,907 | 1.97 | 2.72 | +0.75 | buy |
| LMR Partners LLP | 33,559 | 82,479 | +48,920 | 0.01 | 0.02 | +0.01 | buy |
| ALGERT GLOBAL LLC | 84,033 | 42,763 | +41,270 | 0.03 | 0.01 | 0.00 | sell |
| Woodline Partners LP | 293,622 | 332,943 | +39,321 | 0.03 | 0.03 | +0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 102,269 | 128,208 | +25,939 | 0.00 | 0.01 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 206,436 | 193,122 | +13,314 | 0.12 | 0.17 | 0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 71,815 | 58,587 | +13,228 | 0.00 | 0.00 | 0.00 | sell |
| TD ASSET MANAGEMENT INC | 249,940 | 257,622 | +7,682 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 7,214 | 13,140 | +5,926 | 0.01 | 0.02 | +0.01 | buy |
| ALPS ADVISORS INC | 47,891 | 52,301 | +4,410 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 9,569 | 9,739 | +170 | 0.04 | 0.05 | +0.01 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 13,219 | 12,903 | -316 | 0.02 | 0.03 | +0.01 | sell |
| HORIZON KINETICS ASSET MANAGEMENT LLC | 14,396 | 13,792 | -604 | 0.00 | 0.00 | -0.00 | sell |
| CORNERCAP INVESTMENT COUNSEL INC | 26,167 | 12,167 | -14,000 | 0.04 | 0.04 | +0.00 | sell |
| Entropy Technologies, LP | 25,689 | 11,493 | -14,196 | 0.02 | 0.01 | -0.01 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 83,674 | 39,521 | -44,153 | 0.00 | 0.00 | -0.00 | sell |
| J. Goldman & Co LP | 136,050 | 70,637 | -65,413 | 0.03 | 0.02 | -0.01 | sell |
| Redmile Group, LLC | 5,562,096 | 4,781,183 | -780,913 | 3.03 | 3.09 | +0.06 | sell |