| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 11,045,336 | 11,045,336 | 0 | 1.00 | 0.33 | -0.66 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 10,819,209 | 8,306,433 | -2,512,776 | 0.01 | 0.00 | -0.01 | sell |
| RTW INVESTMENTS, LP | 2,065,010 | 6,395,732 | +4,330,722 | 0.27 | 0.33 | +0.06 | buy |
| BlackRock, Inc. | 5,730,382 | 5,775,896 | +45,514 | 0.00 | 0.00 | -0.00 | buy |
| FCPM III SERVICES B.V. | 3,909,696 | 4,158,368 | +248,672 | 9.84 | 3.48 | -6.36 | buy |
| Point72 Asset Management, L.P. | 712,543 | 3,629,902 | +2,917,359 | 0.02 | 0.03 | +0.02 | buy |
| VANGUARD GROUP INC | 3,469,688 | 3,479,395 | +9,707 | 0.00 | 0.00 | -0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 3,200,000 | 3,400,000 | +200,000 | 1.50 | 0.55 | -0.95 | buy |
| STATE STREET CORP | 2,452,688 | 2,924,125 | +471,437 | 0.00 | 0.00 | -0.00 | buy |
| BRAIDWELL LP | 422,887 | 2,750,092 | +2,327,205 | 0.13 | 0.34 | +0.21 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 432,652 | 2,628,100 | +2,195,448 | 0.01 | 0.02 | +0.01 | buy |
| READYSTATE ASSET MANAGEMENT LP | 187,720 | 2,621,012 | +2,433,292 | 0.07 | 0.53 | +0.46 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,624,048 | 1,695,448 | +71,400 | 0.00 | 0.00 | -0.00 | buy |
| Erste Asset Management GmbH | 11,900 | 1,630,000 | +1,618,100 | 0.00 | 0.07 | +0.07 | buy |
| MILLENNIUM MANAGEMENT LLC | 794,054 | 1,589,745 | +795,691 | 0.01 | 0.01 | -0.00 | buy |
| MORGAN STANLEY | 921,658 | 1,375,519 | +453,861 | 0.00 | 0.00 | -0.00 | buy |
| TORONTO DOMINION BANK | 0 | 1,372,052 | +1,372,052 | 0.00 | 0.01 | +0.01 | buy |
| FMR LLC | 391,660 | 1,361,079 | +969,419 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,165,455 | 1,251,501 | +86,046 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,117,331 | 1,134,751 | +17,420 | 0.00 | 0.00 | -0.00 | buy |
| Boxer Capital Management, LLC | 2,211,341 | 1,050,000 | -1,161,341 | 10.34 | 1.40 | -8.94 | sell |
| ADAR1 Capital Management, LLC | 10,400 | 978,894 | +968,494 | 0.02 | 0.41 | +0.39 | buy |
| UBS Group AG | 243,397 | 901,630 | +658,233 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 855,988 | 855,988 | 0 | 0.04 | 0.02 | -0.03 | hold |
| Quinn Opportunity Partners LLC | 0 | 650,721 | +650,721 | 0.00 | 0.20 | +0.20 | buy |
| NORTHERN TRUST CORP | 586,767 | 614,193 | +27,426 | 0.00 | 0.00 | -0.00 | buy |
| JANE STREET GROUP, LLC | 87,145 | 584,275 | +497,130 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 533,007 | 539,567 | +6,560 | 0.00 | 0.00 | -0.00 | buy |
| Redmile Group, LLC | 4,664,791 | 535,818 | -4,128,973 | 4.61 | 0.22 | -4.39 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 553,163 | 515,400 | -37,763 | 0.00 | 0.00 | -0.00 | sell |
| NAN FUNG TRINITY (HK) Ltd | 465,527 | 465,527 | 0 | 0.52 | 0.19 | -0.32 | hold |
| BARCLAYS PLC | 372,110 | 455,862 | +83,752 | 0.00 | 0.00 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 506,596 | 403,495 | -103,101 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 327,452 | 284,052 | -43,400 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 74,781 | 258,960 | +184,179 | 0.00 | 0.00 | +0.00 | buy |
| Omega Fund Management, LLC | 1,975,203 | 248,672 | -1,726,531 | 11.88 | 0.47 | -11.41 | sell |
| Jump Financial, LLC | 0 | 243,767 | +243,767 | 0.00 | 0.02 | +0.02 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 944,506 | 227,016 | -717,490 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 269,118 | 217,586 | -51,532 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 206,562 | 201,307 | -5,255 | 0.00 | 0.00 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 7,414 | 186,994 | +179,580 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 91,175 | 174,051 | +82,876 | 0.00 | 0.00 | -0.00 | buy |
| Caption Management, LLC | 0 | 170,000 | +170,000 | 0.00 | 0.04 | +0.04 | buy |
| TWO SIGMA INVESTMENTS, LP | 22,421 | 157,499 | +135,078 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 168,005 | 155,380 | -12,625 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 119,329 | 154,301 | +34,972 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 38,546 | 150,446 | +111,900 | 0.01 | 0.01 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 133,111 | 139,736 | +6,625 | 0.00 | 0.00 | -0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 121,396 | +121,396 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 277,474 | 120,232 | -157,242 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 505,109 | 109,284 | -395,825 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 79,531 | 108,592 | +29,061 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 102,005 | 99,315 | -2,690 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 10,199 | 98,731 | +88,532 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 100,719 | 83,245 | -17,474 | 0.00 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 0 | 81,234 | +81,234 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 126,358 | 74,414 | -51,944 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 73,640 | +73,640 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 397,846 | 73,614 | -324,232 | 3.05 | 0.20 | -2.84 | sell |
| Swiss National Bank | 73,500 | 73,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Squarepoint Ops LLC | 67,929 | 71,807 | +3,878 | 0.00 | 0.00 | -0.00 | buy |
| Nan Fung Group Holdings Ltd | 63,719 | 63,719 | 0 | 0.93 | 0.45 | -0.49 | hold |
| ALLIANCEBERNSTEIN L.P. | 51,490 | 63,540 | +12,050 | 0.00 | 0.00 | -0.00 | buy |
| Eversept Partners, LP | 0 | 59,992 | +59,992 | 0.00 | 0.02 | +0.02 | buy |
| Virtu Financial LLC | 0 | 59,685 | +59,685 | 0.00 | 0.01 | +0.01 | buy |
| Nuveen, LLC | 127,327 | 57,614 | -69,713 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 67,979 | 56,620 | -11,359 | 0.00 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 58,242 | 52,961 | -5,281 | 0.01 | 0.00 | -0.00 | sell |
| Diametric Capital, LP | 0 | 50,000 | +50,000 | 0.00 | 0.08 | +0.08 | buy |
| Graham Capital Management, L.P. | 0 | 44,697 | +44,697 | 0.00 | 0.01 | +0.01 | buy |
| NEOS Investment Management LLC | 40,906 | 42,966 | +2,060 | 0.00 | 0.00 | -0.00 | buy |
| TEMA ETFS LLC | 40,906 | 42,966 | +2,060 | 0.10 | 0.01 | -0.09 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 43,422 | 42,774 | -648 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 38,278 | 42,377 | +4,099 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 40,598 | 40,538 | -60 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 36,304 | 38,016 | +1,712 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 39,942 | 37,732 | -2,210 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 41,602 | 37,287 | -4,315 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 19,723 | 28,860 | +9,137 | 0.01 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 53,193 | 26,765 | -26,428 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 123,780 | 26,763 | -97,017 | 0.11 | 0.01 | -0.10 | sell |
| OSAIC HOLDINGS, INC. | 26,106 | 26,073 | -33 | 0.00 | 0.00 | -0.00 | sell |
| HUB Investment Partners, LLC | 25,367 | 25,367 | 0 | 0.01 | 0.00 | -0.00 | hold |
| AlphaQuest LLC | 9,857 | 25,030 | +15,173 | 0.01 | 0.01 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 35,864 | 24,704 | -11,160 | 0.00 | 0.00 | -0.00 | sell |
| Scientech Research LLC | 0 | 24,434 | +24,434 | 0.00 | 0.04 | +0.04 | buy |
| ExodusPoint Capital Management, LP | 157,550 | 23,732 | -133,818 | 0.02 | 0.00 | -0.02 | sell |
| PROFUND ADVISORS LLC | 17,022 | 23,669 | +6,647 | 0.01 | 0.00 | -0.00 | buy |
| Ballentine Partners, LLC | 0 | 21,944 | +21,944 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 19,011 | 21,192 | +2,181 | 0.00 | 0.00 | -0.00 | buy |
| Walleye Capital LLC | 0 | 21,055 | +21,055 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 17,741 | 20,945 | +3,204 | 0.00 | 0.00 | -0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 20,765 | +20,765 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 20,124 | +20,124 | 0.00 | 0.01 | +0.01 | buy |
| Velan Capital Investment Management LP | 183,083 | 20,000 | -163,083 | 1.70 | 0.08 | -1.62 | sell |
| GRIFFIN ASSET MANAGEMENT, INC. | 0 | 19,559 | +19,559 | 0.00 | 0.01 | +0.01 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 19,286 | +19,286 | 0.00 | 0.01 | +0.01 | buy |
| Police & Firemen's Retirement System of New Jersey | 15,132 | 18,445 | +3,313 | 0.00 | 0.00 | -0.00 | buy |
| Quantinno Capital Management LP | 0 | 17,605 | +17,605 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Trading LLC | 0 | 16,528 | +16,528 | 0.00 | 0.00 | +0.00 | buy |