| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 4,578,280 | 9,545,336 | +4,967,056 | 0.45 | 0.92 | +0.46 | buy |
| MORGAN STANLEY | 469,359 | 4,447,228 | +3,977,869 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 2,370,645 | 5,111,521 | +2,740,876 | 0.00 | 0.00 | -0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 1,811,710 | +1,811,710 | 0.00 | 0.28 | +0.28 | buy |
| GOLDMAN SACHS GROUP INC | 559,330 | 2,238,883 | +1,679,553 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 394,716 | +394,716 | 0.00 | 0.01 | +0.01 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 319,000 | +319,000 | 0.00 | 0.00 | +0.00 | buy |
| Vontobel Holding Ltd. | 0 | 305,412 | +305,412 | 0.00 | 0.02 | +0.02 | buy |
| Rafferty Asset Management, LLC | 186,801 | 463,397 | +276,596 | 0.02 | 0.02 | -0.00 | buy |
| Clearbridge Investments, LLC | 0 | 270,695 | +270,695 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 243,512 | +243,512 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 118,412 | 290,504 | +172,092 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 31,761 | 196,251 | +164,490 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 80,703 | 243,006 | +162,303 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 59,943 | 220,427 | +160,484 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 2,596,119 | 2,737,773 | +141,654 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,008,343 | 1,145,112 | +136,769 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 18,708 | 137,779 | +119,071 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 114,182 | +114,182 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 79,527 | 183,261 | +103,734 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0 | 100,000 | +100,000 | 0.00 | 0.03 | +0.03 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 82,476 | 180,442 | +97,966 | 0.01 | 0.01 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 125,671 | 220,647 | +94,976 | 0.00 | 0.00 | -0.00 | buy |
| GROUP ONE TRADING LLC | 45,840 | 135,243 | +89,403 | 0.03 | 0.04 | +0.00 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 76,869 | +76,869 | 0.00 | 0.06 | +0.06 | buy |
| Anson Funds Management LP | 0 | 73,228 | +73,228 | 0.00 | 0.12 | +0.12 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,793,199 | 5,849,251 | +56,052 | 0.01 | 0.01 | -0.01 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 54,650 | +54,650 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 31,557 | 74,233 | +42,676 | 0.03 | 0.03 | -0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 42,394 | +42,394 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 124,972 | 164,222 | +39,250 | 0.03 | 0.02 | -0.01 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 36,202 | +36,202 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 271,056 | 305,412 | +34,356 | 0.90 | 1.11 | +0.21 | buy |
| Pennant Investors, LP | 0 | 30,500 | +30,500 | 0.00 | 0.08 | +0.08 | buy |
| Graham Capital Management, L.P. | 19,867 | 50,175 | +30,308 | 0.01 | 0.01 | +0.00 | buy |
| Walleye Capital LLC | 0 | 30,058 | +30,058 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 452,743 | 481,834 | +29,091 | 0.00 | 0.00 | -0.00 | buy |
| CORNERCAP INVESTMENT COUNSEL INC | 0 | 26,493 | +26,493 | 0.00 | 0.04 | +0.04 | buy |
| E Fund Management Co., Ltd. | 0 | 24,739 | +24,739 | 0.00 | 0.01 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 130,662 | 154,748 | +24,086 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 378,310 | 401,942 | +23,632 | 0.00 | 0.00 | -0.00 | buy |
| Fisher Asset Management, LLC | 56,396 | 77,663 | +21,267 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 17,825 | +17,825 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 17,716 | +17,716 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 14,380 | +14,380 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 0 | 12,000 | +12,000 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 11,959 | +11,959 | 0.00 | 0.00 | +0.00 | buy |
| 683 Capital Management, LLC | 0 | 11,027 | +11,027 | 0.00 | 0.01 | +0.01 | buy |
| ROYAL BANK OF CANADA | 9,288 | 19,315 | +10,027 | 0.00 | 0.00 | -0.00 | buy |
| Bridgefront Capital, LLC | 0 | 10,023 | +10,023 | 0.00 | 0.06 | +0.06 | buy |
| Mirae Asset Global Investments Co., Ltd. | 30,364 | 40,223 | +9,859 | 0.00 | 0.00 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 4,216 | 11,931 | +7,715 | 0.04 | 0.06 | +0.02 | buy |
| Lion Point Capital, LP | 35,000 | 42,500 | +7,500 | 0.55 | 0.32 | -0.23 | buy |
| RHUMBLINE ADVISERS | 70,544 | 77,165 | +6,621 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 1,509 | 6,833 | +5,324 | 0.01 | 0.01 | +0.00 | buy |
| MetLife Investment Management, LLC | 21,505 | 26,645 | +5,140 | 0.00 | 0.00 | -0.00 | buy |
| Walleye Trading LLC | 0 | 4,163 | +4,163 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 20,733 | 24,577 | +3,844 | 0.00 | 0.00 | -0.00 | buy |
| HSBC HOLDINGS PLC | 19,718 | 23,532 | +3,814 | 0.00 | 0.00 | -0.00 | buy |
| Quantbot Technologies LP | 0 | 3,200 | +3,200 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,249 | 4,207 | +2,958 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 16,807 | 19,292 | +2,485 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 30,449 | 32,866 | +2,417 | 0.00 | 0.00 | -0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 5,849 | 7,837 | +1,988 | 0.00 | 0.00 | -0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 30,467 | 32,311 | +1,844 | 0.11 | 0.05 | -0.06 | buy |
| FIRST TRUST ADVISORS LP | 10,020 | 11,803 | +1,783 | 0.00 | 0.00 | -0.00 | buy |
| SIGNATUREFD, LLC | 40 | 1,419 | +1,379 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 13,651 | 15,026 | +1,375 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 167,431 | 168,573 | +1,142 | 0.00 | 0.00 | -0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 11,854 | 12,844 | +990 | 0.00 | 0.00 | -0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 44 | 837 | +793 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 34,095 | 34,742 | +647 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 240 | +240 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 6 | 150 | +144 | 0.00 | 0.00 | +0.00 | buy |
| PRIVATE TRUST CO NA | 0 | 83 | +83 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 35 | +35 | 0.00 | 0.00 | 0.00 | buy |
| Global Retirement Partners, LLC | 0 | 32 | +32 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 22,192 | 22,220 | +28 | 0.00 | 0.00 | -0.00 | buy |
| BOKF, NA | 0 | 15 | +15 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 0 | 14 | +14 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 4 | 6 | +2 | 0.00 | 0.00 | 0.00 | buy |
| LMR Partners LLP | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 4,393 | 4,393 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Artal Group S.A. | 500,000 | 500,000 | 0 | 0.37 | 0.14 | -0.23 | hold |
| Ameritas Investment Partners, Inc. | 4,017 | 4,017 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TD ASSET MANAGEMENT INC | 267,646 | 267,646 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Ensign Peak Advisors, Inc | 270,007 | 270,007 | 0 | 0.01 | 0.00 | -0.01 | hold |
| Daiwa Securities Group Inc. | 200 | 200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Omega Fund Management, LLC | 3,001,319 | 3,001,319 | 0 | 47.17 | 20.50 | -26.67 | hold |
| Nan Fung Group Holdings Ltd | 184,739 | 184,739 | 0 | 2.56 | 0.97 | -1.59 | hold |
| Woodline Partners LP | 293,622 | 293,622 | 0 | 0.06 | 0.03 | -0.03 | hold |
| WOLFF WIESE MAGANA LLC | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Atlas Venture Life Science Advisors, LLC | 2,098,300 | 2,098,300 | 0 | 5.56 | 2.11 | -3.45 | hold |
| Erste Asset Management GmbH | 11,900 | 11,900 | 0 | 0.00 | 0.00 | -0.00 | hold |
| METROPOLITAN LIFE INSURANCE CO/NY | 2,616 | 2,616 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Allworth Financial LP | 13 | 0 | -13 | 0.00 | 0.00 | -0.00 | sell |
| Versant Capital Management, Inc | 25 | 0 | -25 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 14,748 | 14,700 | -48 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 9,592 | 9,529 | -63 | 0.00 | 0.00 | -0.00 | sell |