| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 11,045,336 | 11,045,336 | 0 | 1.25 | 1.43 | +0.17 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 9,879,250 | 10,962,883 | +1,083,633 | 0.01 | 0.02 | +0.00 | buy |
| BlackRock, Inc. | 5,471,564 | 5,566,397 | +94,833 | 0.00 | 0.00 | +0.00 | buy |
| Redmile Group, LLC | 4,781,183 | 4,905,527 | +124,344 | 3.09 | 4.14 | +1.05 | buy |
| FCPM III SERVICES B.V. | 4,866,449 | 3,970,668 | -895,781 | 9.16 | 8.12 | -1.04 | sell |
| VANGUARD GROUP INC | 3,466,247 | 3,595,848 | +129,601 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 48,138 | 3,149,522 | +3,101,384 | 0.04 | 2.80 | +2.75 | buy |
| TANG CAPITAL MANAGEMENT LLC | 1,200,000 | 2,700,000 | +1,500,000 | 0.94 | 2.16 | +1.22 | buy |
| STATE STREET CORP | 2,340,042 | 2,204,051 | -135,991 | 0.00 | 0.00 | +0.00 | sell |
| RTW INVESTMENTS, LP | 1,133,787 | 2,065,010 | +931,223 | 0.18 | 0.38 | +0.20 | buy |
| Omega Fund Management, LLC | 2,461,319 | 1,975,203 | -486,116 | 16.86 | 15.51 | -1.35 | sell |
| BRAIDWELL LP | 3,070,837 | 1,477,102 | -1,593,735 | 0.95 | 0.53 | -0.42 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,428,301 | 1,429,666 | +1,365 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,154,821 | 1,189,662 | +34,841 | 0.01 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 242,398 | 1,096,744 | +854,346 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,689,803 | 1,047,627 | -642,176 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 867,683 | 972,575 | +104,892 | 0.01 | 0.01 | +0.00 | buy |
| MPM BioImpact LLC | 0 | 950,000 | +950,000 | 0.00 | 1.63 | +1.63 | buy |
| MARSHALL WACE, LLP | 0 | 896,184 | +896,184 | 0.00 | 0.01 | +0.01 | buy |
| Parkman Healthcare Partners LLC | 763,747 | 869,759 | +106,012 | 1.07 | 1.40 | +0.33 | buy |
| Woodline Partners LP | 332,943 | 854,309 | +521,366 | 0.03 | 0.07 | +0.04 | buy |
| EcoR1 Capital, LLC | 850,341 | 850,341 | 0 | 0.32 | 0.41 | +0.09 | hold |
| DIMENSIONAL FUND ADVISORS LP | 545,341 | 778,163 | +232,822 | 0.00 | 0.00 | +0.00 | buy |
| Artisan Partners Limited Partnership | 0 | 611,013 | +611,013 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 549,501 | 589,635 | +40,134 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 619,512 | 571,022 | -48,490 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 535,640 | 561,561 | +25,921 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 484,797 | 508,398 | +23,601 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 249,349 | 486,609 | +237,260 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 489,009 | 440,612 | -48,397 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 626,412 | 347,282 | -279,130 | 0.00 | 0.00 | -0.00 | sell |
| Nan Fung Group Holdings Ltd | 287,846 | 321,746 | +33,900 | 2.72 | 3.33 | +0.61 | buy |
| JANE STREET GROUP, LLC | 262,248 | 316,287 | +54,039 | 0.00 | 0.01 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 257,622 | 294,298 | +36,676 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 283,966 | +283,966 | 0.00 | 0.01 | +0.01 | buy |
| Soleus Capital Management, L.P. | 0 | 262,500 | +262,500 | 0.00 | 0.24 | +0.24 | buy |
| Rosalind Advisors, Inc. | 0 | 260,000 | +260,000 | 0.00 | 1.70 | +1.70 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 193,122 | 241,570 | +48,448 | 0.05 | 0.07 | +0.02 | buy |
| TWO SIGMA INVESTMENTS, LP | 179,240 | 212,586 | +33,346 | 0.00 | 0.01 | +0.00 | buy |
| Trexquant Investment LP | 266,471 | 194,592 | -71,879 | 0.04 | 0.03 | -0.01 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 184,208 | 194,004 | +9,796 | 0.00 | 0.00 | +0.00 | buy |
| Velan Capital Investment Management LP | 0 | 181,367 | +181,367 | 0.00 | 1.90 | +1.90 | buy |
| Bank of New York Mellon Corp | 162,625 | 174,518 | +11,893 | 0.00 | 0.00 | +0.00 | buy |
| Crestline Management, LP | 0 | 172,202 | +172,202 | 0.00 | 0.07 | +0.07 | buy |
| TWO SIGMA ADVISERS, LP | 188,400 | 170,400 | -18,000 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 158,491 | 167,329 | +8,838 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 572,227 | 163,300 | -408,927 | 0.05 | 0.01 | -0.04 | sell |
| PDT Partners, LLC | 158,770 | 158,794 | +24 | 0.15 | 0.17 | +0.02 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 107,736 | 156,936 | +49,200 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 135,779 | 136,364 | +585 | 0.00 | 0.00 | -0.00 | buy |
| J. Goldman & Co LP | 70,637 | 112,683 | +42,046 | 0.03 | 0.05 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 84,591 | 111,850 | +27,259 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 111,957 | 111,066 | -891 | 0.00 | 0.00 | +0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 128,208 | 107,416 | -20,792 | 0.01 | 0.01 | -0.00 | sell |
| Swiss National Bank | 65,900 | 103,700 | +37,800 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 88,148 | 95,465 | +7,317 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 91,017 | 95,447 | +4,430 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 180,958 | 88,006 | -92,952 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 45,722 | 85,379 | +39,657 | 0.00 | 0.00 | +0.00 | buy |
| Fisher Asset Management, LLC | 77,663 | 77,663 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WELLS FARGO & COMPANY/MN | 38,250 | 77,371 | +39,121 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 101,214 | 77,308 | -23,906 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 36,536 | 71,443 | +34,907 | 0.01 | 0.02 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 81,164 | 65,762 | -15,402 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 0 | 65,625 | +65,625 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 52,301 | 60,917 | +8,616 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 39,631 | 59,366 | +19,735 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 0 | 54,738 | +54,738 | 0.00 | 0.50 | +0.50 | buy |
| ALGERT GLOBAL LLC | 42,763 | 45,820 | +3,057 | 0.01 | 0.01 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 43,380 | 45,096 | +1,716 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 44,880 | +44,880 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 11,973 | 43,204 | +31,231 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 33,932 | 42,725 | +8,793 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 23,003 | 38,970 | +15,967 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 37,287 | 37,699 | +412 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 35,134 | 37,659 | +2,525 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 58,587 | 34,547 | -24,040 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 32,551 | 30,267 | -2,284 | 0.00 | 0.00 | +0.00 | sell |
| Graham Capital Management, L.P. | 28,449 | 30,180 | +1,731 | 0.01 | 0.01 | +0.00 | buy |
| SG Americas Securities, LLC | 22,917 | 26,291 | +3,374 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 34,948 | 23,328 | -11,620 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 21,047 | 23,041 | +1,994 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 15,541 | 20,788 | +5,247 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 19,039 | 19,667 | +628 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 19,564 | 18,482 | -1,082 | 0.00 | 0.00 | -0.00 | sell |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 17,816 | +17,816 | 0.00 | 0.03 | +0.03 | buy |
| JANUS HENDERSON GROUP PLC | 17,741 | 17,741 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Allianz Asset Management GmbH | 0 | 17,400 | +17,400 | 0.00 | 0.00 | +0.00 | buy |
| MEEDER ASSET MANAGEMENT INC | 0 | 16,909 | +16,909 | 0.00 | 0.01 | +0.01 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 16,318 | +16,318 | 0.00 | 0.02 | +0.02 | buy |
| China Universal Asset Management Co., Ltd. | 13,140 | 16,317 | +3,177 | 0.02 | 0.02 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 16,010 | 16,010 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MARTINGALE ASSET MANAGEMENT L P | 15,626 | 15,626 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 0 | 15,603 | +15,603 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 20,416 | 15,559 | -4,857 | 0.01 | 0.01 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 27,786 | 15,309 | -12,477 | 0.00 | 0.00 | -0.00 | sell |
| HORIZON KINETICS ASSET MANAGEMENT LLC | 13,792 | 14,396 | +604 | 0.00 | 0.00 | -0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 14,008 | +14,008 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 0 | 12,894 | +12,894 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 12,844 | 12,844 | 0 | 0.00 | 0.00 | +0.00 | hold |