| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Sofinnova Investments, Inc. | 48,138 | 3,149,522 | +3,101,384 | 0.04 | 2.78 | +2.74 | buy |
| TANG CAPITAL MANAGEMENT LLC | 1,200,000 | 2,700,000 | +1,500,000 | 0.94 | 2.16 | +1.22 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 9,879,250 | 10,962,883 | +1,083,633 | 0.01 | 0.02 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 10,045,336 | 11,045,336 | +1,000,000 | 1.16 | 1.43 | 0.00 | buy |
| RTW INVESTMENTS, LP | 1,133,787 | 2,065,010 | +931,223 | 0.18 | 0.38 | +0.20 | buy |
| Woodline Partners LP | 332,943 | 854,309 | +521,366 | 0.03 | 0.07 | +0.04 | buy |
| Redmile Group, LLC | 4,781,183 | 4,905,527 | +124,344 | 3.09 | 4.14 | +1.05 | buy |
| Parkman Healthcare Partners LLC | 763,747 | 869,759 | +106,012 | 1.07 | 1.40 | +0.33 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 193,122 | 241,570 | +48,448 | 0.17 | 0.24 | 0.00 | buy |
| J. Goldman & Co LP | 70,637 | 112,683 | +42,046 | 0.02 | 0.04 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 257,622 | 294,298 | +36,676 | 0.00 | 0.00 | +0.00 | buy |
| Nan Fung Group Holdings Ltd | 287,846 | 321,746 | +33,900 | 2.72 | 3.33 | +0.61 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 58,587 | 34,547 | +24,040 | 0.00 | 0.00 | 0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 128,208 | 107,416 | +20,792 | 0.01 | 0.01 | -0.00 | sell |
| ALPS ADVISORS INC | 52,301 | 60,917 | +8,616 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 13,140 | 16,317 | +3,177 | 0.02 | 0.02 | +0.00 | buy |
| ALGERT GLOBAL LLC | 42,763 | 45,820 | +3,057 | 0.01 | 0.01 | 0.00 | buy |
| HORIZON KINETICS ASSET MANAGEMENT LLC | 13,792 | 14,396 | +604 | 0.00 | 0.00 | -0.00 | buy |
| PDT Partners, LLC | 158,770 | 158,794 | +24 | 0.15 | 0.17 | +0.02 | buy |
| VIRTUS ADVISERS, LLC | 9,739 | 5,818 | -3,921 | 0.05 | 0.03 | -0.02 | sell |
| Rafferty Asset Management, LLC | 101,214 | 77,308 | -23,906 | 0.00 | 0.00 | -0.00 | sell |
| FCPM III SERVICES B.V. | 4,866,449 | 3,970,668 | -895,781 | 9.16 | 8.12 | -1.04 | sell |
| BRAIDWELL LP | 3,070,837 | 1,477,102 | -1,593,735 | 0.95 | 0.53 | -0.42 | sell |