| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Sofinnova Investments, Inc. | 48,138 | 3,149,522 | +3,101,384 | 0.04 | 2.80 | +2.75 | buy |
| TANG CAPITAL MANAGEMENT LLC | 1,200,000 | 2,700,000 | +1,500,000 | 0.94 | 2.16 | +1.22 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 9,879,250 | 10,962,883 | +1,083,633 | 0.01 | 0.02 | +0.00 | buy |
| MPM BioImpact LLC | 0 | 950,000 | +950,000 | 0.00 | 1.63 | +1.63 | buy |
| RTW INVESTMENTS, LP | 1,133,787 | 2,065,010 | +931,223 | 0.18 | 0.38 | +0.20 | buy |
| MARSHALL WACE, LLP | 0 | 896,184 | +896,184 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 242,398 | 1,096,744 | +854,346 | 0.00 | 0.00 | +0.00 | buy |
| Artisan Partners Limited Partnership | 0 | 611,013 | +611,013 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 332,943 | 854,309 | +521,366 | 0.03 | 0.07 | +0.04 | buy |
| Point72 Asset Management, L.P. | 0 | 283,966 | +283,966 | 0.00 | 0.01 | +0.01 | buy |
| Soleus Capital Management, L.P. | 0 | 262,500 | +262,500 | 0.00 | 0.24 | +0.24 | buy |
| Rosalind Advisors, Inc. | 0 | 260,000 | +260,000 | 0.00 | 1.70 | +1.70 | buy |
| JPMORGAN CHASE & CO | 249,349 | 486,609 | +237,260 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 545,341 | 778,163 | +232,822 | 0.00 | 0.00 | +0.00 | buy |
| Velan Capital Investment Management LP | 0 | 181,367 | +181,367 | 0.00 | 1.90 | +1.90 | buy |
| Crestline Management, LP | 0 | 172,202 | +172,202 | 0.00 | 0.07 | +0.07 | buy |
| VANGUARD GROUP INC | 3,466,247 | 3,595,848 | +129,601 | 0.00 | 0.00 | +0.00 | buy |
| Redmile Group, LLC | 4,781,183 | 4,905,527 | +124,344 | 3.09 | 4.14 | +1.05 | buy |
| Parkman Healthcare Partners LLC | 763,747 | 869,759 | +106,012 | 1.07 | 1.40 | +0.33 | buy |
| D. E. Shaw & Co., Inc. | 867,683 | 972,575 | +104,892 | 0.01 | 0.01 | +0.00 | buy |
| BlackRock, Inc. | 5,471,564 | 5,566,397 | +94,833 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 65,625 | +65,625 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 0 | 54,738 | +54,738 | 0.00 | 0.50 | +0.50 | buy |
| JANE STREET GROUP, LLC | 262,248 | 316,287 | +54,039 | 0.00 | 0.01 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 107,736 | 156,936 | +49,200 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 193,122 | 241,570 | +48,448 | 0.05 | 0.07 | +0.02 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 44,880 | +44,880 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 70,637 | 112,683 | +42,046 | 0.03 | 0.05 | +0.01 | buy |
| NORTHERN TRUST CORP | 549,501 | 589,635 | +40,134 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 45,722 | 85,379 | +39,657 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 38,250 | 77,371 | +39,121 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 65,900 | 103,700 | +37,800 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 257,622 | 294,298 | +36,676 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 36,536 | 71,443 | +34,907 | 0.01 | 0.02 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,154,821 | 1,189,662 | +34,841 | 0.01 | 0.01 | +0.00 | buy |
| Nan Fung Group Holdings Ltd | 287,846 | 321,746 | +33,900 | 2.72 | 3.33 | +0.61 | buy |
| TWO SIGMA INVESTMENTS, LP | 179,240 | 212,586 | +33,346 | 0.00 | 0.01 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 11,973 | 43,204 | +31,231 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 84,591 | 111,850 | +27,259 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 535,640 | 561,561 | +25,921 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 484,797 | 508,398 | +23,601 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 39,631 | 59,366 | +19,735 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 17,816 | +17,816 | 0.00 | 0.03 | +0.03 | buy |
| Allianz Asset Management GmbH | 0 | 17,400 | +17,400 | 0.00 | 0.00 | +0.00 | buy |
| MEEDER ASSET MANAGEMENT INC | 0 | 16,909 | +16,909 | 0.00 | 0.01 | +0.01 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 16,318 | +16,318 | 0.00 | 0.02 | +0.02 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 23,003 | 38,970 | +15,967 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 0 | 15,603 | +15,603 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 14,008 | +14,008 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 0 | 12,894 | +12,894 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 12,219 | +12,219 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 162,625 | 174,518 | +11,893 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 11,337 | +11,337 | 0.00 | 0.01 | +0.01 | buy |
| Quantinno Capital Management LP | 0 | 10,455 | +10,455 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 184,208 | 194,004 | +9,796 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 9,650 | +9,650 | 0.00 | 0.03 | +0.03 | buy |
| BARCLAYS PLC | 158,491 | 167,329 | +8,838 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 33,932 | 42,725 | +8,793 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 52,301 | 60,917 | +8,616 | 0.00 | 0.00 | +0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 93 | 8,276 | +8,183 | 0.00 | 0.04 | +0.04 | buy |
| RHUMBLINE ADVISERS | 88,148 | 95,465 | +7,317 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 850 | 6,772 | +5,922 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 15,541 | 20,788 | +5,247 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 91,017 | 95,447 | +4,430 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 22,917 | 26,291 | +3,374 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 13,140 | 16,317 | +3,177 | 0.02 | 0.02 | +0.00 | buy |
| ALGERT GLOBAL LLC | 42,763 | 45,820 | +3,057 | 0.01 | 0.01 | +0.00 | buy |
| MetLife Investment Management, LLC | 35,134 | 37,659 | +2,525 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 21,047 | 23,041 | +1,994 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 28,449 | 30,180 | +1,731 | 0.01 | 0.01 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 43,380 | 45,096 | +1,716 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 454 | 2,109 | +1,655 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,428,301 | 1,429,666 | +1,365 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 19,039 | 19,667 | +628 | 0.00 | 0.00 | +0.00 | buy |
| HORIZON KINETICS ASSET MANAGEMENT LLC | 13,792 | 14,396 | +604 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 135,779 | 136,364 | +585 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 1,545 | 2,056 | +511 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 37,287 | 37,699 | +412 | 0.00 | 0.00 | +0.00 | buy |
| Venturi Wealth Management, LLC | 0 | 401 | +401 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 342 | 559 | +217 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 123 | 288 | +165 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 4,994 | 5,151 | +157 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,471 | 2,564 | +93 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 59 | 105 | +46 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 158,770 | 158,794 | +24 | 0.15 | 0.17 | +0.02 | buy |
| US BANCORP \DE\ | 652 | 673 | +21 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 862 | 882 | +20 | 0.00 | 0.00 | -0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 115 | 125 | +10 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 0 | 4 | +4 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 4,393 | 4,393 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BESSEMER GROUP INC | 120 | 120 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 6,167 | 6,167 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MassMutual Private Wealth & Trust, FSB | 295 | 295 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BAKER BROS. ADVISORS LP | 11,045,336 | 11,045,336 | 0 | 1.25 | 1.43 | +0.17 | hold |
| JANUS HENDERSON GROUP PLC | 17,741 | 17,741 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 5,534 | 5,534 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EXCHANGE TRADED CONCEPTS, LLC | 16,010 | 16,010 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 200 | 200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EcoR1 Capital, LLC | 850,341 | 850,341 | 0 | 0.32 | 0.41 | +0.09 | hold |
| QUADRANT CAPITAL GROUP LLC | 1,956 | 1,956 | 0 | 0.00 | 0.00 | +0.00 | hold |