| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 6,395,732 | 7,140,352 | +744,620 | 0.33 | 0.70 | +0.37 | buy |
| Redmile Group, LLC | 535,818 | 1,099,756 | +563,938 | 0.22 | 0.79 | +0.57 | buy |
| Erste Asset Management GmbH | 1,630,000 | 2,120,000 | +490,000 | 0.07 | 0.17 | +0.10 | buy |
| ADAR1 Capital Management, LLC | 978,894 | 1,241,322 | +262,428 | 0.41 | 0.90 | +0.50 | buy |
| NAN FUNG TRINITY (HK) Ltd | 465,527 | 575,527 | +110,000 | 0.19 | 0.44 | +0.25 | buy |
| Rafferty Asset Management, LLC | 108,592 | 140,909 | +32,317 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 11,511 | 26,133 | +14,622 | 0.01 | 0.07 | +0.06 | buy |
| NEOS Investment Management LLC | 42,966 | 52,052 | +9,086 | 0.00 | 0.00 | +0.00 | buy |
| TEMA ETFS LLC | 42,966 | 51,282 | +8,316 | 0.01 | 0.04 | +0.02 | buy |
| Dynamic Technology Lab Private Ltd | 20,124 | 25,905 | +5,781 | 0.01 | 0.06 | +0.04 | buy |
| Ballentine Partners, LLC | 21,944 | 23,665 | +1,721 | 0.00 | 0.00 | 0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,647 | 1,540 | -107 | 0.00 | 0.00 | +0.00 | sell |
| HORIZON KINETICS ASSET MANAGEMENT LLC | 14,396 | 13,792 | -604 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 13,682 | 12,782 | -900 | 0.00 | 0.01 | +0.00 | sell |
| GRIFFIN ASSET MANAGEMENT, INC. | 19,559 | 16,400 | -3,159 | 0.01 | 0.02 | +0.01 | sell |
| Velan Capital Investment Management LP | 20,000 | 15,000 | -5,000 | 0.08 | 0.08 | +0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 8,306,433 | 8,262,296 | -44,137 | 0.00 | 0.01 | +0.00 | sell |
| Quinn Opportunity Partners LLC | 650,721 | 392,915 | -257,806 | 0.19 | 0.16 | -0.03 | sell |
| Boxer Capital Management, LLC | 1,050,000 | 750,000 | -300,000 | 1.40 | 1.60 | +0.19 | sell |
| FCPM III SERVICES B.V. | 4,158,368 | 2,808,368 | -1,350,000 | 3.48 | 3.58 | +0.10 | sell |