| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 11,045,336 | 11,045,336 | 0 | 0.33 | 0.63 | +0.29 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 8,306,433 | 8,262,296 | -44,137 | 0.00 | 0.01 | +0.00 | sell |
| RTW INVESTMENTS, LP | 6,395,732 | 7,140,352 | +744,620 | 0.33 | 0.70 | +0.37 | buy |
| BlackRock, Inc. | 5,775,896 | 6,069,633 | +293,737 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 3,479,395 | 3,776,198 | +296,803 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 2,924,125 | 3,693,107 | +768,982 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 1,361,079 | 2,981,580 | +1,620,501 | 0.00 | 0.00 | +0.00 | buy |
| FCPM III SERVICES B.V. | 4,158,368 | 2,808,368 | -1,350,000 | 3.48 | 3.58 | +0.10 | sell |
| D. E. Shaw & Co., Inc. | 403,495 | 2,575,042 | +2,171,547 | 0.00 | 0.02 | +0.02 | buy |
| TORONTO DOMINION BANK | 1,372,052 | 2,229,527 | +857,475 | 0.01 | 0.04 | +0.03 | buy |
| Erste Asset Management GmbH | 1,630,000 | 2,120,000 | +490,000 | 0.07 | 0.17 | +0.10 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 1,807,368 | +1,807,368 | 0.00 | 0.03 | +0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,695,448 | 1,750,194 | +54,746 | 0.00 | 0.00 | +0.00 | buy |
| Commodore Capital LP | 0 | 1,425,000 | +1,425,000 | 0.00 | 0.92 | +0.92 | buy |
| Rosalind Advisors, Inc. | 0 | 1,410,497 | +1,410,497 | 0.00 | 5.00 | +5.00 | buy |
| ADAR1 Capital Management, LLC | 978,894 | 1,241,322 | +262,428 | 0.41 | 0.90 | +0.50 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,251,501 | 1,119,357 | -132,144 | 0.00 | 0.00 | +0.00 | sell |
| Redmile Group, LLC | 535,818 | 1,099,756 | +563,938 | 0.22 | 0.79 | +0.57 | buy |
| JPMORGAN CHASE & CO | 38,016 | 925,173 | +887,157 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,589,745 | 834,562 | -755,183 | 0.01 | 0.01 | +0.00 | sell |
| MORGAN STANLEY | 1,375,519 | 814,888 | -560,631 | 0.00 | 0.00 | +0.00 | sell |
| Boxer Capital Management, LLC | 1,050,000 | 750,000 | -300,000 | 1.40 | 1.60 | +0.19 | sell |
| Jefferies Financial Group Inc. | 0 | 714,226 | +714,226 | 0.00 | 0.06 | +0.06 | buy |
| GOLDMAN SACHS GROUP INC | 1,134,751 | 658,096 | -476,655 | 0.00 | 0.00 | +0.00 | sell |
| Invesco Ltd. | 154,301 | 613,015 | +458,714 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 606,844 | +606,844 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 901,630 | 604,313 | -297,317 | 0.00 | 0.00 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 515,400 | 587,890 | +72,490 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 584,275 | 584,330 | +55 | 0.00 | 0.01 | +0.00 | buy |
| NAN FUNG TRINITY (HK) Ltd | 465,527 | 575,527 | +110,000 | 0.19 | 0.44 | +0.25 | buy |
| Woodline Partners LP | 855,988 | 570,988 | -285,000 | 0.02 | 0.02 | +0.00 | sell |
| NORTHERN TRUST CORP | 614,193 | 539,600 | -74,593 | 0.00 | 0.00 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 13,762 | 460,704 | +446,942 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 157,499 | 444,074 | +286,575 | 0.00 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 405,053 | +405,053 | 0.00 | 0.01 | +0.01 | buy |
| Quinn Opportunity Partners LLC | 650,721 | 392,915 | -257,806 | 0.20 | 0.17 | -0.03 | sell |
| Jump Financial, LLC | 243,767 | 296,843 | +53,076 | 0.02 | 0.04 | +0.02 | buy |
| BARCLAYS PLC | 455,862 | 292,185 | -163,677 | 0.00 | 0.00 | +0.00 | sell |
| TD ASSET MANAGEMENT INC | 284,052 | 266,484 | -17,568 | 0.00 | 0.00 | +0.00 | sell |
| Omega Fund Management, LLC | 248,672 | 248,672 | 0 | 0.47 | 0.84 | +0.38 | hold |
| DIADEMA PARTNERS LP | 0 | 230,997 | +230,997 | 0.00 | 1.34 | +1.34 | buy |
| Caption Management, LLC | 170,000 | 228,570 | +58,570 | 0.04 | 0.10 | +0.06 | buy |
| BANK OF AMERICA CORP /DE/ | 109,284 | 215,330 | +106,046 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 201,307 | 209,222 | +7,915 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 227,016 | 208,669 | -18,347 | 0.00 | 0.00 | +0.00 | sell |
| HRT FINANCIAL LP | 174,051 | 183,592 | +9,541 | 0.00 | 0.01 | +0.00 | buy |
| Trexquant Investment LP | 0 | 180,494 | +180,494 | 0.00 | 0.02 | +0.02 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 217,586 | 178,911 | -38,675 | 0.00 | 0.00 | +0.00 | sell |
| Resolute Capital Asset Partners LLC | 0 | 175,000 | +175,000 | 0.00 | 0.82 | +0.82 | buy |
| CITADEL ADVISORS LLC | 120,232 | 158,359 | +38,127 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 153,650 | +153,650 | 0.00 | 0.01 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 139,736 | 148,086 | +8,350 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 108,592 | 140,909 | +32,317 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 20,765 | 128,380 | +107,615 | 0.00 | 0.01 | +0.01 | buy |
| SummitTX Capital, L.P. | 0 | 108,803 | +108,803 | 0.00 | 0.03 | +0.03 | buy |
| MARSHALL WACE, LLP | 0 | 93,585 | +93,585 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 155,380 | 90,724 | -64,656 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 99,315 | 89,311 | -10,004 | 0.00 | 0.00 | +0.00 | sell |
| Point72 Asset Management, L.P. | 3,629,902 | 72,210 | -3,557,692 | 0.03 | 0.00 | -0.03 | sell |
| SG Americas Securities, LLC | 98,731 | 71,955 | -26,776 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 0 | 70,000 | +70,000 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 71,807 | 67,271 | -4,536 | 0.00 | 0.00 | +0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 0 | 66,875 | +66,875 | 0.00 | 0.01 | +0.01 | buy |
| Nan Fung Group Holdings Ltd | 63,719 | 63,719 | 0 | 0.45 | 0.55 | +0.11 | hold |
| ALLIANCEBERNSTEIN L.P. | 63,540 | 62,140 | -1,400 | 0.00 | 0.00 | +0.00 | sell |
| Persistent Asset Partners Ltd | 0 | 61,488 | +61,488 | 0.00 | 0.29 | +0.29 | buy |
| Nuveen, LLC | 57,614 | 57,614 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 73,640 | 56,723 | -16,917 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 539,567 | 53,944 | -485,623 | 0.00 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 52,961 | 52,961 | 0 | 0.00 | 0.01 | +0.01 | hold |
| PROFUND ADVISORS LLC | 23,669 | 52,145 | +28,476 | 0.00 | 0.02 | +0.01 | buy |
| NEOS Investment Management LLC | 42,966 | 52,052 | +9,086 | 0.00 | 0.00 | +0.00 | buy |
| TEMA ETFS LLC | 42,966 | 51,282 | +8,316 | 0.01 | 0.04 | +0.02 | buy |
| RAYMOND JAMES FINANCIAL INC | 186,994 | 47,364 | -139,630 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 21,192 | 45,161 | +23,969 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 44,632 | +44,632 | 0.00 | 0.01 | +0.01 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 42,774 | 44,045 | +1,271 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 258,960 | 41,181 | -217,779 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 37,732 | 40,352 | +2,620 | 0.00 | 0.00 | +0.00 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 0 | 36,038 | +36,038 | 0.00 | 0.01 | +0.01 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 35,220 | +35,220 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 26,073 | 35,200 | +9,127 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 40,538 | 34,328 | -6,210 | 0.00 | 0.00 | +0.00 | sell |
| XTX Topco Ltd | 0 | 33,163 | +33,163 | 0.00 | 0.01 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 12,448 | 32,093 | +19,645 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 30,700 | +30,700 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 19,286 | 29,147 | +9,861 | 0.01 | 0.02 | +0.02 | buy |
| AlphaQuest LLC | 25,030 | 28,080 | +3,050 | 0.01 | 0.02 | +0.01 | buy |
| Virtus Investment Advisers, LLC | 11,511 | 26,133 | +14,622 | 0.01 | 0.07 | +0.06 | buy |
| Dynamic Technology Lab Private Ltd | 20,124 | 25,905 | +5,781 | 0.01 | 0.06 | +0.04 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 2,628,100 | 25,319 | -2,602,781 | 0.02 | 0.00 | -0.02 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 24,704 | 24,704 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ballentine Partners, LLC | 21,944 | 23,665 | +1,721 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 894 | 20,952 | +20,058 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 7,127 | 20,194 | +13,067 | 0.00 | 0.00 | +0.00 | buy |
| HighTower Advisors, LLC | 16,129 | 20,123 | +3,994 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 19,862 | +19,862 | 0.00 | 0.04 | +0.04 | buy |
| Police & Firemen's Retirement System of New Jersey | 18,445 | 18,445 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Centiva Capital, LP | 0 | 18,000 | +18,000 | 0.00 | 0.01 | +0.01 | buy |
| INCEPTIONR LLC | 0 | 17,656 | +17,656 | 0.00 | 0.05 | +0.05 | buy |