| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 22,362,850 | 22,362,850 | 0 | 0.70 | 0.81 | +0.11 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 9,880,000 | 11,130,000 | +1,250,000 | 0.03 | 0.04 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 6,547,231 | 6,492,900 | -54,331 | 0.01 | 0.01 | +0.00 | sell |
| Blackstone Inc. | 6,189,551 | 6,189,551 | 0 | 0.04 | 0.05 | +0.01 | hold |
| Cormorant Asset Management, LP | 0 | 5,560,300 | +5,560,300 | 0.00 | 0.49 | +0.49 | buy |
| Rock Springs Capital Management LP | 5,513,788 | 5,513,788 | 0 | 0.21 | 0.28 | +0.07 | hold |
| FMR LLC | 4,551,506 | 4,515,137 | -36,369 | 0.00 | 0.00 | +0.00 | sell |
| VANGUARD GROUP INC | 4,081,189 | 4,152,197 | +71,008 | 0.00 | 0.00 | +0.00 | buy |
| Vivo Capital, LLC | 3,556,023 | 3,556,023 | 0 | 0.45 | 0.55 | +0.10 | hold |
| Opaleye Management Inc. | 0 | 3,170,000 | +3,170,000 | 0.00 | 1.37 | +1.37 | buy |
| Blue Owl Capital Holdings LP | 2,829,712 | 2,829,712 | 0 | 1.06 | 1.12 | +0.06 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 1,992,028 | 2,075,335 | +83,307 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 0 | 1,971,402 | +1,971,402 | 0.00 | 0.63 | +0.63 | buy |
| STATE STREET CORP | 1,726,304 | 1,826,177 | +99,873 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 1,557,630 | 1,557,630 | 0 | 0.03 | 0.04 | +0.01 | hold |
| NORTHERN TRUST CORP | 759,733 | 766,911 | +7,178 | 0.00 | 0.00 | +0.00 | buy |
| Monashee Investment Management LLC | 500,000 | 500,000 | 0 | 0.14 | 0.12 | -0.02 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 320,621 | +320,621 | 0.00 | 0.00 | +0.00 | buy |
| CM Management, LLC | 125,000 | 310,000 | +185,000 | 0.16 | 0.52 | +0.36 | buy |
| Bank of New York Mellon Corp | 271,164 | 252,505 | -18,659 | 0.00 | 0.00 | +0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 212,965 | 240,800 | +27,835 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 246,012 | 240,195 | -5,817 | 0.00 | 0.00 | +0.00 | sell |
| Pennant Investors, LP | 199,000 | 199,000 | 0 | 0.10 | 0.11 | +0.01 | hold |
| MILLENNIUM MANAGEMENT LLC | 494,092 | 193,767 | -300,325 | 0.00 | 0.00 | -0.00 | sell |
| EXCHANGE TRADED CONCEPTS, LLC | 65,819 | 146,874 | +81,055 | 0.00 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 166,137 | 144,185 | -21,952 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 192,700 | 141,642 | -51,058 | 0.00 | 0.00 | -0.00 | sell |
| Pale Fire Capital SE | 181,055 | 125,968 | -55,087 | 0.04 | 0.03 | -0.01 | sell |
| GOLDMAN SACHS GROUP INC | 206,597 | 122,712 | -83,885 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 116,532 | 119,474 | +2,942 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 116,882 | 116,882 | 0 | 0.04 | 0.05 | +0.01 | hold |
| UBS Group AG | 102,548 | 110,211 | +7,663 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 125,486 | 75,913 | -49,573 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 176,799 | 70,400 | -106,399 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 70,800 | 59,300 | -11,500 | 0.00 | 0.00 | +0.00 | sell |
| Squarepoint Ops LLC | 88,720 | 50,812 | -37,908 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 49,953 | 50,530 | +577 | 0.00 | 0.00 | +0.00 | buy |
| B. Riley Wealth Advisors, Inc. | 50,000 | 50,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMERICAN INTERNATIONAL GROUP, INC. | 45,360 | 44,974 | -386 | 0.00 | 0.00 | +0.00 | sell |
| CAXTON CORP | 43,465 | 43,465 | 0 | 0.37 | 0.49 | +0.12 | hold |
| DEUTSCHE BANK AG\ | 44,614 | 42,688 | -1,926 | 0.00 | 0.00 | +0.00 | sell |
| Invesco Ltd. | 43,190 | 41,763 | -1,427 | 0.00 | 0.00 | +0.00 | sell |
| Simplicity Wealth,LLC | 0 | 40,243 | +40,243 | 0.00 | 0.00 | +0.00 | buy |
| Bleakley Financial Group, LLC | 0 | 40,243 | +40,243 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 37,520 | 38,386 | +866 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 38,181 | 38,077 | -104 | 0.00 | 0.00 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 39,556 | 32,198 | -7,358 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 27,728 | 31,819 | +4,091 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 47,624 | 28,741 | -18,883 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 23,355 | 24,055 | +700 | 0.00 | 0.00 | +0.00 | buy |
| New Capital Management LP | 21,131 | 21,131 | 0 | 0.01 | 0.01 | +0.00 | hold |
| STRS OHIO | 19,000 | 17,900 | -1,100 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 13,402 | 17,042 | +3,640 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 16,580 | +16,580 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 15,104 | 16,396 | +1,292 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 13,480 | 13,480 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 11,117 | 11,117 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NORDEN GROUP LLC | 0 | 10,640 | +10,640 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 11,972 | 10,586 | -1,386 | 0.00 | 0.00 | +0.00 | sell |
| HSBC HOLDINGS PLC | 32,145 | 10,476 | -21,669 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 0 | 10,206 | +10,206 | 0.00 | 0.01 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 11,031 | 10,021 | -1,010 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 15,021 | 9,176 | -5,845 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 21,548 | 7,867 | -13,681 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 7,536 | 7,536 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 8,461 | 3,077 | -5,384 | 0.00 | 0.00 | -0.00 | sell |
| METROPOLITAN LIFE INSURANCE CO/NY | 1,122 | 1,926 | +804 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 3,541 | 933 | -2,608 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 158 | 161 | +3 | 0.00 | 0.00 | 0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 65 | 20 | -45 | 0.00 | 0.00 | -0.00 | sell |
| Avior Wealth Management, LLC | 0 | 16 | +16 | 0.00 | 0.00 | +0.00 | buy |
| WEXFORD CAPITAL LP | 12,700 | 0 | -12,700 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 10,215 | 0 | -10,215 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 28,054 | 0 | -28,054 | 0.00 | 0.00 | -0.00 | sell |
| ELEMENT CAPITAL MANAGEMENT LLC | 293,888 | 0 | -293,888 | 1.55 | 0.00 | -1.55 | sell |
| Avidity Partners Management LP | 1,599,600 | 0 | -1,599,600 | 0.10 | 0.00 | -0.10 | sell |
| Ally Bridge Group (NY) LLC | 834,630 | 0 | -834,630 | 0.78 | 0.00 | -0.78 | sell |
| BRAIDWELL LP | 317,761 | 0 | -317,761 | 0.02 | 0.00 | -0.02 | sell |
| JPMORGAN CHASE & CO | 62,332 | 0 | -62,332 | 0.00 | 0.00 | -0.00 | sell |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 26,320 | 0 | -26,320 | 0.00 | 0.00 | -0.00 | sell |