| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TANG CAPITAL MANAGEMENT LLC | 5,900,000 | 11,052,632 | +5,152,632 | 0.57 | 1.16 | +0.60 | buy |
| JPMORGAN CHASE & CO | 272,328 | 2,185,480 | +1,913,152 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 874,869 | +874,869 | 0.00 | 0.35 | +0.35 | buy |
| MORGAN STANLEY | 0 | 839,176 | +839,176 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 395,017 | 940,784 | +545,767 | 0.00 | 0.01 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 33,857 | 545,088 | +511,231 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 383,503 | +383,503 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 0 | 340,772 | +340,772 | 0.00 | 0.00 | +0.00 | buy |
| Propel Bio Management, LLC | 0 | 228,317 | +228,317 | 0.00 | 0.50 | +0.50 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 222,505 | +222,505 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 6,887,615 | 7,109,090 | +221,475 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 178,002 | +178,002 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 0 | 130,807 | +130,807 | 0.00 | 0.04 | +0.04 | buy |
| DIMENSIONAL FUND ADVISORS LP | 11,117 | 138,802 | +127,685 | 0.00 | 0.00 | +0.00 | buy |
| Simplify Asset Management Inc. | 0 | 120,000 | +120,000 | 0.00 | 0.01 | +0.01 | buy |
| VANGUARD GROUP INC | 4,718,194 | 4,838,006 | +119,812 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 102,041 | +102,041 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 73,682 | +73,682 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 62,844 | +62,844 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA HOLDINGS INC | 0 | 58,700 | +58,700 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 78,603 | 131,237 | +52,634 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 52,478 | +52,478 | 0.00 | 0.00 | +0.00 | buy |
| CANTOR FITZGERALD, L. P. | 100,000 | 150,000 | +50,000 | 0.01 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 47,700 | +47,700 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,903,008 | 1,949,677 | +46,669 | 0.00 | 0.00 | +0.00 | buy |
| Simplicity Wealth,LLC | 0 | 46,543 | +46,543 | 0.00 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 278,600 | 321,500 | +42,900 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 32,245 | +32,245 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,334,171 | 2,364,896 | +30,725 | 0.00 | 0.00 | +0.00 | buy |
| Vontobel Holding Ltd. | 0 | 29,882 | +29,882 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 51,924 | 78,294 | +26,370 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Trading LLC | 0 | 25,000 | +25,000 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 0 | 24,000 | +24,000 | 0.00 | 0.04 | +0.04 | buy |
| Marex Group plc | 0 | 23,600 | +23,600 | 0.00 | 0.00 | +0.00 | buy |
| CIBC WORLD MARKETS CORP | 0 | 22,630 | +22,630 | 0.00 | 0.00 | +0.00 | buy |
| CAPTRUST FINANCIAL ADVISORS | 0 | 19,993 | +19,993 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 17,730 | +17,730 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 12,187 | +12,187 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 286,191 | 297,880 | +11,689 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 237,975 | 243,565 | +5,590 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 17,251 | 22,522 | +5,271 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 58,466 | 61,040 | +2,574 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 801,225 | 803,138 | +1,913 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 59,860 | 61,213 | +1,353 | 0.00 | 0.00 | +0.00 | buy |
| Stonebrook Private Inc. | 11,288 | 12,294 | +1,006 | 0.00 | 0.01 | +0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 879 | +879 | 0.00 | 0.00 | +0.00 | buy |
| Independent Advisor Alliance | 17,948 | 18,450 | +502 | 0.00 | 0.00 | +0.00 | buy |
| CoreCap Advisors, LLC | 2,300 | 2,664 | +364 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 559 | 878 | +319 | 0.00 | 0.00 | +0.00 | buy |
| ACT Advisors, LLC. | 10,528 | 10,761 | +233 | 0.01 | 0.01 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 65 | +65 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 21 | +21 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| Focus Partners Wealth | 13,591 | 13,601 | +10 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 22,362,850 | 22,362,850 | 0 | 0.67 | 1.02 | +0.35 | hold |
| Ameritas Investment Partners, Inc. | 7,536 | 7,536 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ROVIN CAPITAL /UT/ /ADV | 13,495 | 13,495 | 0 | 0.01 | 0.01 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 7,390 | 7,390 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 21,440 | 21,440 | 0 | 0.00 | 0.00 | +0.00 | hold |
| North Star Investment Management Corp. | 12,500 | 12,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CAXTON CORP | 43,465 | 43,465 | 0 | 0.38 | 1.63 | +1.25 | hold |
| Blackstone Inc. | 10,025,151 | 10,025,151 | 0 | 0.07 | 0.08 | +0.01 | hold |
| Monashee Investment Management LLC | 448,164 | 448,164 | 0 | 0.09 | 0.10 | +0.01 | hold |
| Dakota Wealth Management | 14,000 | 14,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| IFP Advisors, Inc | 16 | 16 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Vivo Capital, LLC | 3,556,023 | 3,556,023 | 0 | 0.58 | 0.89 | +0.32 | hold |
| Russell Investments Group, Ltd. | 193 | 193 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Blue Owl Capital Holdings LP | 2,954,712 | 2,954,712 | 0 | 0.99 | 1.81 | +0.82 | hold |
| Fortitude Family Office, LLC | 5,145 | 5,145 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Enavate Sciences GP, LLC | 7,788,150 | 7,788,150 | 0 | 8.11 | 11.15 | +3.04 | hold |
| Police & Firemen's Retirement System of New Jersey | 22,933 | 22,933 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Marshall & Sterling Wealth Advisors Inc. | 200 | 200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 46,942 | 46,942 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STRS OHIO | 17,900 | 17,900 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 3,077 | 3,077 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 848 | 848 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SBI Securities Co., Ltd. | 408 | 354 | -54 | 0.00 | 0.00 | +0.00 | sell |
| Corebridge Financial, Inc. | 50,704 | 49,963 | -741 | 0.00 | 0.00 | +0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 171,466 | 170,607 | -859 | 0.00 | 0.00 | +0.00 | sell |
| Legal & General Group Plc | 10,171 | 8,648 | -1,523 | 0.00 | 0.00 | +0.00 | sell |
| Sterling Capital Management LLC | 3,464 | 1,760 | -1,704 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 4,136,403 | 4,134,287 | -2,116 | 0.00 | 0.00 | +0.00 | sell |
| Invesco Ltd. | 39,483 | 37,157 | -2,326 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 41,980 | 39,501 | -2,479 | 0.00 | 0.00 | +0.00 | sell |
| LPL Financial LLC | 45,000 | 42,100 | -2,900 | 0.00 | 0.00 | +0.00 | sell |
| Sequoia Financial Advisors, LLC | 30,876 | 27,934 | -2,942 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 32,561 | 29,488 | -3,073 | 0.00 | 0.00 | +0.00 | sell |
| ProShare Advisors LLC | 28,722 | 22,079 | -6,643 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 18,562 | 11,132 | -7,430 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 38,207 | 30,407 | -7,800 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 129,116 | 120,029 | -9,087 | 0.00 | 0.00 | +0.00 | sell |
| Mariner, LLC | 20,673 | 11,381 | -9,292 | 0.00 | 0.00 | -0.00 | sell |
| HSBC HOLDINGS PLC | 21,529 | 11,923 | -9,606 | 0.00 | 0.00 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 10,536 | 0 | -10,536 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA SECURITIES, LLC | 13,887 | 0 | -13,887 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 22,588 | 0 | -22,588 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 24,072 | 0 | -24,072 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 63,141 | 37,167 | -25,974 | 0.00 | 0.00 | -0.00 | sell |
| Catalina Capital Group, LLC | 48,964 | 16,938 | -32,026 | 0.02 | 0.02 | -0.00 | sell |