| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TANG CAPITAL MANAGEMENT LLC | 16,790,809 | 16,790,809 | 0 | 4.45 | 4.51 | +0.06 | hold |
| ORBIMED ADVISORS LLC | 15,219,994 | 15,219,994 | 0 | 1.67 | 1.76 | +0.08 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 14,182,379 | 14,307,379 | +125,000 | 1.90 | 2.05 | +0.15 | buy |
| Vivo Capital, LLC | 9,545,466 | 9,545,466 | 0 | 3.31 | 4.20 | +0.88 | hold |
| BlackRock, Inc. | 9,388,624 | 9,506,080 | +117,456 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,436,500 | 8,486,500 | +4,050,000 | 0.04 | 0.07 | +0.03 | buy |
| Enavate Sciences GP, LLC | 7,788,150 | 7,788,150 | 0 | 8.25 | 11.72 | +3.47 | hold |
| BVF INC/IL | 7,764,842 | 7,764,842 | 0 | 1.40 | 1.31 | -0.10 | hold |
| STATE STREET CORP | 4,890,525 | 6,694,976 | +1,804,451 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 2,500,000 | 4,186,599 | +1,686,599 | 0.13 | 0.22 | +0.09 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,606,000 | 3,606,000 | 0 | 0.25 | 0.23 | -0.02 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 3,502,526 | 3,565,770 | +63,244 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 3,927,202 | 3,305,308 | -621,894 | 1.08 | 1.03 | -0.05 | sell |
| Logos Global Management LP | 1,150,000 | 3,150,000 | +2,000,000 | 0.41 | 0.86 | +0.45 | buy |
| Blue Owl Capital Holdings LP | 3,466,525 | 2,941,525 | -525,000 | 5.74 | 4.18 | -1.56 | sell |
| Qube Research & Technologies Ltd | 441,805 | 2,550,356 | +2,108,551 | 0.00 | 0.02 | +0.02 | buy |
| UBS Group AG | 167,856 | 2,391,333 | +2,223,477 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 3,365,446 | 2,056,161 | -1,309,285 | 0.78 | 0.54 | -0.23 | sell |
| GOLDMAN SACHS GROUP INC | 1,517,415 | 1,995,394 | +477,979 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 2,786,778 | 1,965,106 | -821,672 | 0.48 | 0.35 | -0.13 | sell |
| Blackstone Inc. | 6,126,182 | 1,857,848 | -4,268,334 | 0.14 | 0.04 | -0.10 | sell |
| FMR LLC | 2,579,711 | 1,801,721 | -777,990 | 0.00 | 0.00 | -0.00 | sell |
| ROYCE & ASSOCIATES LP | 285,988 | 1,619,798 | +1,333,810 | 0.02 | 0.08 | +0.07 | buy |
| AMERIPRISE FINANCIAL INC | 823,174 | 1,596,815 | +773,641 | 0.00 | 0.00 | +0.00 | buy |
| Palo Alto Investors LP | 2,532,419 | 1,514,504 | -1,017,915 | 1.89 | 1.23 | -0.67 | sell |
| Birchview Capital, LP | 1,592,938 | 1,465,867 | -127,071 | 5.01 | 4.41 | -0.59 | sell |
| GREAT POINT PARTNERS LLC | 0 | 1,350,000 | +1,350,000 | 0.00 | 1.75 | +1.75 | buy |
| Fisher Asset Management, LLC | 0 | 1,348,259 | +1,348,259 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 1,593,275 | 1,119,090 | -474,185 | 0.02 | 0.01 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 452,442 | 1,076,004 | +623,562 | 0.01 | 0.05 | +0.03 | buy |
| NORTHERN TRUST CORP | 972,935 | 1,048,558 | +75,623 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 266,434 | 865,613 | +599,179 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,051,343 | 859,049 | -192,294 | 0.82 | 0.54 | -0.28 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 1,093,300 | 849,076 | -244,224 | 3.99 | 3.19 | -0.79 | sell |
| JPMORGAN CHASE & CO | 870,014 | 847,702 | -22,312 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 3,109,286 | 846,220 | -2,263,066 | 0.01 | 0.00 | -0.01 | sell |
| Y-Intercept (Hong Kong) Ltd | 462,166 | 828,879 | +366,713 | 0.06 | 0.08 | +0.03 | buy |
| BARCLAYS PLC | 594,776 | 790,041 | +195,265 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 105,682 | 721,410 | +615,728 | 0.00 | 0.00 | +0.00 | buy |
| Burkehill Global Management, LP | 700,000 | 700,000 | 0 | 0.25 | 0.18 | -0.06 | hold |
| CITIGROUP INC | 261,876 | 598,238 | +336,362 | 0.00 | 0.00 | +0.00 | buy |
| ArrowMark Colorado Holdings LLC | 0 | 514,793 | +514,793 | 0.00 | 0.07 | +0.07 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 191,724 | 497,818 | +306,094 | 0.00 | 0.01 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 314,750 | 494,300 | +179,550 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 341,596 | 439,784 | +98,188 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 421,831 | +421,831 | 0.00 | 0.02 | +0.02 | buy |
| Blue Owl Capital Holdings LP | 0 | 400,000 | +400,000 | 0.00 | 0.13 | +0.13 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 22,629 | 375,320 | +352,691 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 371,400 | +371,400 | 0.00 | 0.03 | +0.03 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 410,157 | 371,058 | -39,099 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 365,245 | 360,372 | -4,873 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 316,849 | 360,125 | +43,276 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 77,281 | 344,933 | +267,652 | 0.03 | 0.13 | +0.10 | buy |
| Bank of New York Mellon Corp | 312,480 | 297,301 | -15,179 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 288,924 | 290,972 | +2,048 | 0.00 | 0.00 | +0.00 | buy |
| Monashee Investment Management LLC | 1,000,000 | 258,865 | -741,135 | 3.03 | 0.74 | -2.28 | sell |
| Swiss National Bank | 0 | 220,700 | +220,700 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 155,218 | 200,428 | +45,210 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 185,423 | 200,279 | +14,856 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 151,743 | 195,867 | +44,124 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 44,742 | 157,025 | +112,283 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 134,605 | 147,016 | +12,411 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 146,040 | 146,607 | +567 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 139,642 | +139,642 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 139,000 | 139,000 | 0 | 0.06 | 0.04 | -0.01 | hold |
| Tidal Investments LLC | 0 | 138,276 | +138,276 | 0.00 | 0.00 | +0.00 | buy |
| TEMA ETFS LLC | 100,176 | 138,276 | +38,100 | 0.04 | 0.05 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 109,273 | 133,352 | +24,079 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 80,142 | 121,889 | +41,747 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 0 | 115,113 | +115,113 | 0.00 | 0.08 | +0.08 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 8,056 | 112,316 | +104,260 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 108,144 | 106,191 | -1,953 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 63,901 | 101,207 | +37,306 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 70,488 | 99,522 | +29,034 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 88,931 | +88,931 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 57,246 | 87,681 | +30,435 | 0.01 | 0.02 | +0.01 | buy |
| Harvest Investment Services, LLC | 0 | 87,652 | +87,652 | 0.00 | 0.08 | +0.08 | buy |
| ALLIANCEBERNSTEIN L.P. | 83,940 | 83,940 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Optimize Financial Inc | 0 | 80,439 | +80,439 | 0.00 | 0.21 | +0.21 | buy |
| AMERICAN CENTURY COMPANIES INC | 40,412 | 78,328 | +37,916 | 0.00 | 0.00 | +0.00 | buy |
| DRW Securities, LLC | 0 | 76,493 | +76,493 | 0.00 | 0.02 | +0.02 | buy |
| Legal & General Group Plc | 12,753 | 75,103 | +62,350 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 69,576 | 74,084 | +4,508 | 0.00 | 0.00 | -0.00 | buy |
| Aquatic Capital Management LLC | 0 | 73,338 | +73,338 | 0.00 | 0.01 | +0.01 | buy |
| Persistent Asset Partners Ltd | 57,253 | 72,193 | +14,940 | 0.15 | 0.15 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 71,753 | +71,753 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 115,634 | 70,121 | -45,513 | 0.02 | 0.01 | -0.01 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 40,325 | 67,466 | +27,141 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 66,607 | 66,607 | 0 | 0.00 | 0.00 | -0.00 | hold |
| D. E. Shaw & Co., Inc. | 51,482 | 65,967 | +14,485 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 73,985 | 64,205 | -9,780 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 0 | 55,600 | +55,600 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 51,556 | 52,846 | +1,290 | 0.08 | 0.08 | +0.00 | buy |
| Squarepoint Ops LLC | 126,192 | 50,202 | -75,990 | 0.00 | 0.00 | -0.00 | sell |
| Cinctive Capital Management LP | 0 | 48,740 | +48,740 | 0.00 | 0.02 | +0.02 | buy |
| WELLS FARGO & COMPANY/MN | 144,798 | 47,740 | -97,058 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 106,533 | 47,670 | -58,863 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 0 | 44,030 | +44,030 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 43,914 | +43,914 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 43,066 | +43,066 | 0.00 | 0.01 | +0.01 | buy |