| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MPM BioImpact LLC | 1,971,402 | 5,005,086 | +3,033,684 | 0.63 | 0.78 | +0.15 | buy |
| Blackstone Inc. | 6,189,551 | 7,691,561 | +1,502,010 | 0.05 | 0.03 | -0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 193,767 | 433,755 | +239,988 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,075,335 | 2,290,683 | +215,348 | 0.00 | 0.00 | -0.00 | buy |
| Ground Swell Capital, LLC | 0 | 124,394 | +124,394 | 0.00 | 0.12 | +0.12 | buy |
| CITADEL ADVISORS LLC | 144,185 | 267,772 | +123,587 | 0.00 | 0.00 | -0.00 | buy |
| HRT FINANCIAL LP | 0 | 122,038 | +122,038 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 122,712 | 235,506 | +112,794 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 141,642 | 215,050 | +73,408 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 70,400 | 140,600 | +70,200 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 68,268 | +68,268 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 65,922 | +65,922 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 59,300 | 113,800 | +54,500 | 0.00 | 0.00 | -0.00 | buy |
| Virtu Financial LLC | 0 | 51,233 | +51,233 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 0 | 50,000 | +50,000 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 46,017 | +46,017 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 240,195 | 286,191 | +45,996 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 42,688 | 86,164 | +43,476 | 0.00 | 0.00 | -0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 40,701 | +40,701 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 4,152,197 | 4,192,529 | +40,332 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 1,826,177 | 1,860,169 | +33,992 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 252,505 | 283,938 | +31,433 | 0.00 | 0.00 | -0.00 | buy |
| TOWNSQUARE CAPITAL LLC | 0 | 19,195 | +19,195 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 50,812 | 64,133 | +13,321 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 31,819 | 44,810 | +12,991 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 119,474 | 131,789 | +12,315 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 13,480 | 24,180 | +10,700 | 0.00 | 0.00 | -0.00 | buy |
| HSBC HOLDINGS PLC | 10,476 | 19,046 | +8,570 | 0.00 | 0.00 | -0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 8,231 | +8,231 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 17,042 | 23,131 | +6,089 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 28,741 | 33,150 | +4,409 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 24,055 | 28,112 | +4,057 | 0.00 | 0.00 | -0.00 | buy |
| FEDERATED HERMES, INC. | 933 | 3,592 | +2,659 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 10,021 | 11,465 | +1,444 | 0.00 | 0.00 | -0.00 | buy |
| Hartford Financial Management Inc. | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 20 | 601 | +581 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 391 | +391 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 38,077 | 38,207 | +130 | 0.00 | 0.00 | -0.00 | buy |
| ORBIMED ADVISORS LLC | 22,362,850 | 22,362,850 | 0 | 0.81 | 0.44 | -0.37 | hold |
| Ameritas Investment Partners, Inc. | 7,536 | 7,536 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 11,130,000 | 11,130,000 | 0 | 0.04 | 0.02 | -0.02 | hold |
| BAKER BROS. ADVISORS LP | 1,557,630 | 1,557,630 | 0 | 0.04 | 0.02 | -0.02 | hold |
| ALGERT GLOBAL LLC | 16,580 | 16,580 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CAXTON CORP | 43,465 | 43,465 | 0 | 0.49 | 0.22 | -0.27 | hold |
| DAFNA Capital Management LLC | 116,882 | 116,882 | 0 | 0.05 | 0.03 | -0.02 | hold |
| Rock Springs Capital Management LP | 5,513,788 | 5,513,788 | 0 | 0.28 | 0.17 | -0.11 | hold |
| Monashee Investment Management LLC | 500,000 | 500,000 | 0 | 0.12 | 0.06 | -0.05 | hold |
| Vivo Capital, LLC | 3,556,023 | 3,556,023 | 0 | 0.55 | 0.33 | -0.22 | hold |
| Pennant Investors, LP | 199,000 | 199,000 | 0 | 0.11 | 0.05 | -0.05 | hold |
| CM Management, LLC | 310,000 | 310,000 | 0 | 0.52 | 0.28 | -0.23 | hold |
| Blue Owl Capital Holdings LP | 2,829,712 | 2,829,712 | 0 | 1.12 | 0.79 | -0.33 | hold |
| DIMENSIONAL FUND ADVISORS LP | 11,117 | 11,117 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| STRS OHIO | 17,900 | 17,900 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 3,077 | 3,077 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Avior Wealth Management, LLC | 16 | 0 | -16 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 161 | 143 | -18 | 0.00 | 0.00 | 0.00 | sell |
| Legal & General Group Plc | 7,867 | 7,410 | -457 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 10,586 | 10,000 | -586 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 9,176 | 7,390 | -1,786 | 0.00 | 0.00 | -0.00 | sell |
| METROPOLITAN LIFE INSURANCE CO/NY | 1,926 | 0 | -1,926 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 32,198 | 28,689 | -3,509 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 16,396 | 12,223 | -4,173 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 41,763 | 37,402 | -4,361 | 0.00 | 0.00 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 240,800 | 231,525 | -9,275 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 10,206 | 0 | -10,206 | 0.01 | 0.00 | -0.01 | sell |
| NORDEN GROUP LLC | 10,640 | 0 | -10,640 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 75,913 | 57,631 | -18,282 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 766,911 | 747,564 | -19,347 | 0.00 | 0.00 | -0.00 | sell |
| New Capital Management LP | 21,131 | 0 | -21,131 | 0.01 | 0.00 | -0.01 | sell |
| MetLife Investment Management, LLC | 50,530 | 24,377 | -26,153 | 0.00 | 0.00 | -0.00 | sell |
| EXCHANGE TRADED CONCEPTS, LLC | 146,874 | 112,020 | -34,854 | 0.01 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 38,386 | 0 | -38,386 | 0.00 | 0.00 | -0.00 | sell |
| Simplicity Wealth,LLC | 40,243 | 0 | -40,243 | 0.00 | 0.00 | -0.00 | sell |
| Bleakley Financial Group, LLC | 40,243 | 0 | -40,243 | 0.00 | 0.00 | -0.00 | sell |
| Pale Fire Capital SE | 125,968 | 82,777 | -43,191 | 0.03 | 0.01 | -0.03 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 44,974 | 0 | -44,974 | 0.00 | 0.00 | -0.00 | sell |
| B. Riley Wealth Advisors, Inc. | 50,000 | 0 | -50,000 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 320,621 | 243,650 | -76,971 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 110,211 | 0 | -110,211 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 4,515,137 | 4,130,375 | -384,762 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 6,492,900 | 5,216,342 | -1,276,558 | 0.01 | 0.00 | -0.00 | sell |
| Opaleye Management Inc. | 3,170,000 | 0 | -3,170,000 | 1.37 | 0.00 | -1.37 | sell |
| Cormorant Asset Management, LP | 5,560,300 | 2,030,823 | -3,529,477 | 0.49 | 0.12 | -0.37 | sell |