| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 22,362,850 | 15,219,994 | -7,142,856 | 1.02 | 1.00 | -0.03 | sell |
| TANG CAPITAL MANAGEMENT LLC | 11,052,632 | 13,496,208 | +2,443,576 | 1.16 | 1.77 | +0.61 | buy |
| Blackstone Inc. | 10,025,151 | 10,025,151 | 0 | 0.08 | 0.12 | +0.03 | hold |
| Enavate Sciences GP, LLC | 7,788,150 | 7,788,150 | 0 | 11.15 | 11.47 | +0.32 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 0 | 7,149,493 | +7,149,493 | 0.00 | 0.70 | +0.70 | buy |
| BlackRock, Inc. | 7,109,090 | 6,413,133 | -695,957 | 0.00 | 0.00 | +0.00 | sell |
| Vivo Capital, LLC | 3,556,023 | 6,043,466 | +2,487,443 | 0.89 | 1.61 | +0.71 | buy |
| MPM BioImpact LLC | 8,442,783 | 5,622,505 | -2,820,278 | 2.76 | 2.53 | -0.22 | sell |
| Rock Springs Capital Management LP | 4,962,955 | 4,962,955 | 0 | 0.54 | 0.80 | +0.26 | hold |
| VANGUARD GROUP INC | 4,838,006 | 4,850,005 | +11,999 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,975,000 | 4,424,868 | +449,868 | 0.01 | 0.02 | +0.01 | buy |
| FMR LLC | 4,134,287 | 4,134,655 | +368 | 0.00 | 0.00 | +0.00 | buy |
| Blue Owl Capital Holdings LP | 2,954,712 | 2,591,525 | -363,187 | 1.81 | 2.17 | +0.36 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,364,896 | 2,319,132 | -45,764 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 2,185,480 | 2,125,717 | -59,763 | 0.00 | 0.00 | +0.00 | sell |
| STATE STREET CORP | 1,949,677 | 1,971,368 | +21,691 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 874,869 | 1,249,781 | +374,912 | 0.35 | 0.67 | +0.32 | buy |
| MILLENNIUM MANAGEMENT LLC | 545,088 | 851,205 | +306,117 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 803,138 | 734,694 | -68,444 | 0.00 | 0.00 | +0.00 | sell |
| Caption Management, LLC | 0 | 725,510 | +725,510 | 0.00 | 0.17 | +0.17 | buy |
| DAFNA Capital Management LLC | 0 | 526,660 | +526,660 | 0.00 | 0.38 | +0.38 | buy |
| SG Americas Securities, LLC | 940,784 | 372,681 | -568,103 | 0.01 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 222,505 | 348,040 | +125,535 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 297,880 | 273,472 | -24,408 | 0.00 | 0.00 | +0.00 | sell |
| UBS Group AG | 0 | 263,526 | +263,526 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 304,504 | 259,211 | -45,293 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 118,731 | 241,721 | +122,990 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 321,500 | 224,600 | -96,900 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 243,565 | 211,183 | -32,382 | 0.00 | 0.00 | +0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 138,802 | 172,227 | +33,425 | 0.00 | 0.00 | +0.00 | buy |
| Monashee Investment Management LLC | 448,164 | 165,000 | -283,164 | 0.10 | 0.23 | +0.13 | sell |
| ROYAL BANK OF CANADA | 0 | 151,142 | +151,142 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 127,272 | +127,272 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 21,440 | 116,670 | +95,230 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 233,522 | 116,348 | -117,174 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 120,029 | 113,487 | -6,542 | 0.00 | 0.00 | +0.00 | sell |
| CANTOR FITZGERALD, L. P. | 150,000 | 100,000 | -50,000 | 0.01 | 0.01 | -0.00 | sell |
| Simplicity Wealth,LLC | 46,543 | 84,636 | +38,093 | 0.01 | 0.01 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 102,041 | 83,897 | -18,144 | 0.00 | 0.00 | +0.00 | sell |
| JANE STREET GROUP, LLC | 178,002 | 75,532 | -102,470 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 0 | 74,597 | +74,597 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 60,778 | +60,778 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 37,167 | 58,946 | +21,779 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 37,157 | 58,735 | +21,578 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 61,213 | 52,724 | -8,489 | 0.00 | 0.00 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 61,040 | 50,164 | -10,876 | 0.00 | 0.00 | +0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 0 | 48,451 | +48,451 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 46,942 | 46,942 | 0 | 0.00 | 0.00 | +0.00 | hold |
| INTECH INVESTMENT MANAGEMENT LLC | 78,294 | 44,223 | -34,071 | 0.00 | 0.00 | -0.00 | sell |
| CAXTON CORP | 43,465 | 43,465 | 0 | 1.63 | 1.15 | -0.48 | hold |
| SIG BROKERAGE, LP | 0 | 36,393 | +36,393 | 0.00 | 0.03 | +0.03 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 39,501 | 35,553 | -3,948 | 0.00 | 0.00 | +0.00 | sell |
| XTX Topco Ltd | 0 | 32,415 | +32,415 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 131,237 | 31,710 | -99,527 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 30,407 | 30,407 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMERICAN CENTURY COMPANIES INC | 73,682 | 27,607 | -46,075 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 29,488 | 27,159 | -2,329 | 0.00 | 0.00 | +0.00 | sell |
| Walleye Trading LLC | 25,000 | 25,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ADAR1 Capital Management, LLC | 0 | 25,000 | +25,000 | 0.00 | 0.01 | +0.01 | buy |
| Marex Group plc | 23,600 | 23,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 22,933 | 22,933 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Squarepoint Ops LLC | 0 | 20,773 | +20,773 | 0.00 | 0.00 | +0.00 | buy |
| CAPTRUST FINANCIAL ADVISORS | 19,993 | 20,325 | +332 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 22,079 | 18,795 | -3,284 | 0.00 | 0.00 | +0.00 | sell |
| Independent Advisor Alliance | 18,450 | 18,420 | -30 | 0.00 | 0.00 | +0.00 | sell |
| STRS OHIO | 17,900 | 17,900 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 17,730 | 17,730 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Sequoia Financial Advisors, LLC | 27,934 | 16,485 | -11,449 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 51,239 | 16,097 | -35,142 | 0.00 | 0.00 | -0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 170,607 | 15,840 | -154,767 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 22,522 | 14,578 | -7,944 | 0.00 | 0.00 | -0.00 | sell |
| Focus Partners Wealth | 13,601 | 13,599 | -2 | 0.00 | 0.00 | +0.00 | sell |
| ROVIN CAPITAL /UT/ /ADV | 13,495 | 13,495 | 0 | 0.01 | 0.01 | +0.00 | hold |
| North Star Investment Management Corp. | 12,500 | 12,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Creative Planning | 0 | 11,484 | +11,484 | 0.00 | 0.00 | +0.00 | buy |
| CIBC WORLD MARKETS CORP | 22,630 | 11,294 | -11,336 | 0.00 | 0.00 | -0.00 | sell |
| Stonebrook Private Inc. | 12,294 | 10,596 | -1,698 | 0.01 | 0.01 | +0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 10,488 | +10,488 | 0.00 | 0.00 | +0.00 | buy |
| ACT Advisors, LLC. | 10,761 | 10,376 | -385 | 0.01 | 0.01 | +0.00 | sell |
| Legal & General Group Plc | 8,648 | 9,643 | +995 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 11,132 | 9,485 | -1,647 | 0.00 | 0.00 | +0.00 | sell |
| Ameritas Investment Partners, Inc. | 7,536 | 7,536 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 7,390 | 7,390 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EverSource Wealth Advisors, LLC | 21 | 6,229 | +6,208 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 0 | 5,337 | +5,337 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 848 | 5,248 | +4,400 | 0.00 | 0.00 | +0.00 | buy |
| Fortitude Family Office, LLC | 5,145 | 4,983 | -162 | 0.00 | 0.00 | +0.00 | sell |
| AMALGAMATED BANK | 3,077 | 3,077 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VSM Wealth Advisory, LLC | 0 | 3,000 | +3,000 | 0.00 | 0.00 | +0.00 | buy |
| MCF Advisors LLC | 0 | 2,770 | +2,770 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 1,760 | 1,275 | -485 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 878 | 1,246 | +368 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 954 | +954 | 0.00 | 0.00 | +0.00 | buy |
| Briaud Financial Planning, Inc | 0 | 700 | +700 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 354 | 354 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Brooklyn Investment Group | 0 | 236 | +236 | 0.00 | 0.00 | +0.00 | buy |
| Marshall & Sterling Wealth Advisors Inc. | 200 | 200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Russell Investments Group, Ltd. | 193 | 193 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ROTHSCHILD INVESTMENT LLC | 0 | 120 | +120 | 0.00 | 0.00 | +0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 879 | 0 | -879 | 0.00 | 0.00 | -0.00 | sell |