| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TANG CAPITAL MANAGEMENT LLC | 16,790,809 | 17,990,782 | +1,199,973 | 4.51 | 1.79 | -2.72 | buy |
| ORBIMED ADVISORS LLC | 15,219,994 | 15,219,994 | 0 | 1.76 | 0.63 | -1.12 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 14,307,379 | 14,101,159 | -206,220 | 2.05 | 0.65 | -1.40 | sell |
| BlackRock, Inc. | 9,506,080 | 11,281,781 | +1,775,701 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 6,694,976 | 9,953,653 | +3,258,677 | 0.00 | 0.00 | -0.00 | buy |
| Enavate Sciences GP, LLC | 7,788,150 | 7,788,150 | 0 | 11.72 | 4.94 | -6.78 | hold |
| Vivo Capital, LLC | 9,545,466 | 7,757,060 | -1,788,406 | 4.20 | 1.55 | -2.65 | sell |
| Palo Alto Investors LP | 1,514,504 | 5,831,813 | +4,317,309 | 1.23 | 1.76 | +0.54 | buy |
| MILLENNIUM MANAGEMENT LLC | 846,220 | 4,713,247 | +3,867,027 | 0.00 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,565,770 | 3,815,189 | +249,419 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 2,550,356 | 3,687,489 | +1,137,133 | 0.02 | 0.01 | -0.01 | buy |
| Blue Owl Capital Holdings LP | 2,941,525 | 3,624,076 | +682,551 | 4.18 | 1.21 | -2.97 | buy |
| CITADEL ADVISORS LLC | 721,410 | 3,570,674 | +2,849,264 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,995,394 | 3,531,000 | +1,535,606 | 0.00 | 0.00 | -0.00 | buy |
| Rock Springs Capital Management LP | 3,305,308 | 3,524,929 | +219,621 | 1.03 | 0.38 | -0.65 | buy |
| AQR CAPITAL MANAGEMENT LLC | 200,428 | 3,509,137 | +3,308,709 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 1,465,867 | 1,675,000 | +209,133 | 4.41 | 1.72 | -2.70 | buy |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 0 | 1,400,000 | +1,400,000 | 0.00 | 0.41 | +0.41 | buy |
| Fisher Asset Management, LLC | 1,348,259 | 1,391,890 | +43,631 | 0.00 | 0.00 | -0.00 | buy |
| ROYCE & ASSOCIATES LP | 1,619,798 | 1,336,780 | -283,018 | 0.08 | 0.02 | -0.06 | sell |
| FMR LLC | 1,801,721 | 1,212,196 | -589,525 | 0.00 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 8,486,500 | 1,186,500 | -7,300,000 | 0.07 | 0.00 | -0.07 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 1,161,231 | +1,161,231 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 1,048,558 | 1,140,914 | +92,356 | 0.00 | 0.00 | -0.00 | buy |
| Atle Fund Management AB | 41,831 | 1,048,593 | +1,006,762 | 0.99 | 0.62 | -0.37 | buy |
| Nuveen, LLC | 290,972 | 1,010,562 | +719,590 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 50,202 | 1,007,507 | +957,305 | 0.00 | 0.00 | +0.00 | buy |
| Blackstone Inc. | 1,857,848 | 899,936 | -957,912 | 0.04 | 0.01 | -0.03 | sell |
| FIRST TRUST ADVISORS LP | 0 | 807,004 | +807,004 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 847,702 | 789,399 | -58,303 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 360,372 | 735,186 | +374,814 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 598,238 | 713,907 | +115,669 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 2,391,333 | 712,763 | -1,678,570 | 0.00 | 0.00 | -0.00 | sell |
| Burkehill Global Management, LP | 700,000 | 700,000 | 0 | 0.18 | 0.06 | -0.13 | hold |
| Point72 Asset Management, L.P. | 0 | 686,577 | +686,577 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 849,076 | 595,213 | -253,863 | 3.19 | 0.91 | -2.29 | sell |
| BANK OF AMERICA CORP /DE/ | 865,613 | 566,919 | -298,694 | 0.00 | 0.00 | -0.00 | sell |
| CM Management, LLC | 0 | 550,000 | +550,000 | 0.00 | 0.77 | +0.77 | buy |
| DIMENSIONAL FUND ADVISORS LP | 439,784 | 541,178 | +101,394 | 0.00 | 0.00 | -0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 497,818 | 523,777 | +25,959 | 0.01 | 0.00 | -0.00 | buy |
| Artia Global Partners LP | 0 | 383,200 | +383,200 | 0.00 | 0.16 | +0.16 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 360,125 | 378,687 | +18,562 | 0.00 | 0.00 | -0.00 | buy |
| ArrowMark Colorado Holdings LLC | 514,793 | 364,742 | -150,051 | 0.07 | 0.03 | -0.04 | sell |
| Bank of New York Mellon Corp | 297,301 | 351,032 | +53,731 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 0 | 334,869 | +334,869 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 33,100 | 320,312 | +287,212 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 157,025 | 308,295 | +151,270 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 36,780 | 308,110 | +271,330 | 0.00 | 0.01 | +0.01 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 303,139 | +303,139 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 371,058 | 303,139 | -67,919 | 0.00 | 0.00 | -0.00 | sell |
| NATIXIS | 0 | 297,715 | +297,715 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 0 | 276,165 | +276,165 | 0.00 | 0.37 | +0.37 | buy |
| Caption Management, LLC | 0 | 263,577 | +263,577 | 0.00 | 0.02 | +0.02 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 222,179 | +222,179 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 70,121 | 217,485 | +147,364 | 0.01 | 0.01 | -0.00 | buy |
| Orion Porfolio Solutions, LLC | 0 | 213,863 | +213,863 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 65,967 | 204,487 | +138,520 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 195,867 | 190,126 | -5,741 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 106,191 | 182,841 | +76,650 | 0.00 | 0.00 | -0.00 | buy |
| ALPS ADVISORS INC | 146,607 | 182,777 | +36,170 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 139,642 | 177,814 | +38,172 | 0.00 | 0.00 | -0.00 | buy |
| Mariner, LLC | 0 | 172,821 | +172,821 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 220,700 | 171,700 | -49,000 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 19,851 | 170,102 | +150,251 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 83,940 | 161,880 | +77,940 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 52,846 | 161,181 | +108,335 | 0.08 | 0.08 | +0.01 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 25,100 | 160,900 | +135,800 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 147,016 | 158,444 | +11,428 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 133,352 | 134,350 | +998 | 0.00 | 0.00 | -0.00 | buy |
| IEQ CAPITAL, LLC | 0 | 122,948 | +122,948 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 139,000 | 122,132 | -16,868 | 0.04 | 0.01 | -0.03 | sell |
| WELLS FARGO & COMPANY/MN | 47,740 | 109,793 | +62,053 | 0.00 | 0.00 | -0.00 | buy |
| Quadrature Capital Ltd | 13,845 | 108,250 | +94,405 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 106,570 | +106,570 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 105,113 | +105,113 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 99,522 | 104,251 | +4,729 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 87,681 | 95,209 | +7,528 | 0.02 | 0.01 | -0.01 | buy |
| Schonfeld Strategic Advisors LLC | 1,076,004 | 92,227 | -983,777 | 0.05 | 0.00 | -0.05 | sell |
| TUDOR INVESTMENT CORP ET AL | 88,931 | 90,044 | +1,113 | 0.00 | 0.00 | -0.00 | buy |
| Jain Global LLC | 0 | 88,302 | +88,302 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 0 | 83,567 | +83,567 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 74,084 | 82,459 | +8,375 | 0.00 | 0.00 | -0.00 | buy |
| GROUP ONE TRADING LLC | 30,229 | 81,557 | +51,328 | 0.01 | 0.01 | -0.00 | buy |
| Cerity Partners LLC | 0 | 80,973 | +80,973 | 0.00 | 0.00 | +0.00 | buy |
| Optimize Financial Inc | 80,439 | 80,160 | -279 | 0.21 | 0.06 | -0.15 | sell |
| SG Americas Securities, LLC | 47,670 | 76,355 | +28,685 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 75,103 | 75,103 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MetLife Investment Management, LLC | 64,205 | 71,421 | +7,216 | 0.00 | 0.00 | -0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 70,179 | +70,179 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 101,207 | 69,818 | -31,389 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 67,466 | 68,217 | +751 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 112,316 | 67,713 | -44,603 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 44,030 | 67,478 | +23,448 | 0.00 | 0.00 | -0.00 | buy |
| Wealthcare Advisory Partners LLC | 0 | 60,962 | +60,962 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 720 | 60,826 | +60,106 | 0.00 | 0.01 | +0.01 | buy |
| JANE STREET GROUP, LLC | 0 | 59,955 | +59,955 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 25,851 | 57,790 | +31,939 | 0.00 | 0.00 | -0.00 | buy |
| Focus Partners Wealth | 14,292 | 53,121 | +38,829 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 790,041 | 50,397 | -739,644 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 10,900 | 50,223 | +39,323 | 0.00 | 0.00 | +0.00 | buy |