| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Blackstone Inc. | 7,691,561 | 10,025,151 | +2,333,590 | 0.03 | 0.08 | +0.05 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 1,812,995 | +1,812,995 | 0.00 | 0.24 | +0.24 | buy |
| MPM BioImpact LLC | 5,005,086 | 5,641,894 | +636,808 | 0.78 | 1.56 | +0.78 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 180,000 | +180,000 | 0.00 | 0.03 | +0.03 | buy |
| GOLDMAN SACHS GROUP INC | 235,506 | 371,129 | +135,623 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 5,513,788 | 5,629,239 | +115,451 | 0.17 | 0.34 | +0.17 | buy |
| BARCLAYS PLC | 57,631 | 170,245 | +112,614 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 747,564 | 844,389 | +96,825 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 4,192,529 | 4,283,186 | +90,657 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 140,600 | 222,600 | +82,000 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 68,268 | 141,611 | +73,343 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 23,131 | 74,281 | +51,150 | 0.00 | 0.00 | +0.00 | buy |
| Blue Owl Capital Holdings LP | 2,829,712 | 2,879,712 | +50,000 | 0.79 | 1.03 | +0.24 | buy |
| JPMORGAN CHASE & CO | 0 | 44,464 | +44,464 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 42,671 | +42,671 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 20,221 | +20,221 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,290,683 | 2,309,778 | +19,095 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 16,292 | +16,292 | 0.00 | 0.00 | +0.00 | buy |
| ROVIN CAPITAL /UT/ /ADV | 0 | 13,495 | +13,495 | 0.00 | 0.01 | +0.01 | buy |
| North Star Investment Management Corp. | 0 | 12,500 | +12,500 | 0.00 | 0.00 | +0.00 | buy |
| Bleakley Financial Group, LLC | 0 | 11,404 | +11,404 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 45,556 | 55,958 | +10,402 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 28,689 | 37,663 | +8,974 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 28,112 | 35,616 | +7,504 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 12,223 | 19,271 | +7,048 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 16,580 | 22,588 | +6,008 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 4,130,375 | 4,136,273 | +5,898 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 33,150 | 38,665 | +5,515 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,860,169 | 1,863,977 | +3,808 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 19,046 | 22,460 | +3,414 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 7,410 | 10,171 | +2,761 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 44,810 | 46,822 | +2,012 | 0.00 | 0.00 | +0.00 | buy |
| Fortitude Family Office, LLC | 0 | 1,832 | +1,832 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 143 | 676 | +533 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 231,525 | 232,049 | +524 | 0.00 | 0.00 | +0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 172 | +172 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 22,362,850 | 22,362,850 | 0 | 0.44 | 0.75 | +0.31 | hold |
| Ameritas Investment Partners, Inc. | 7,536 | 7,536 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 7,390 | 7,390 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 24,180 | 24,180 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 11,130,000 | 11,130,000 | 0 | 0.02 | 0.04 | +0.02 | hold |
| BAKER BROS. ADVISORS LP | 1,557,630 | 1,557,630 | 0 | 0.02 | 0.03 | +0.01 | hold |
| GSA CAPITAL PARTNERS LLP | 65,922 | 65,922 | 0 | 0.00 | 0.01 | +0.00 | hold |
| CAXTON CORP | 43,465 | 43,465 | 0 | 0.22 | 0.33 | +0.11 | hold |
| DAFNA Capital Management LLC | 116,882 | 116,882 | 0 | 0.03 | 0.05 | +0.02 | hold |
| LPL Financial LLC | 50,000 | 50,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Monashee Investment Management LLC | 500,000 | 500,000 | 0 | 0.06 | 0.10 | +0.03 | hold |
| Vivo Capital, LLC | 3,556,023 | 3,556,023 | 0 | 0.33 | 0.54 | +0.21 | hold |
| CM Management, LLC | 310,000 | 310,000 | 0 | 0.28 | 0.46 | +0.17 | hold |
| DIMENSIONAL FUND ADVISORS LP | 11,117 | 11,117 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 38,207 | 38,207 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STRS OHIO | 17,900 | 17,900 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 286,191 | 286,191 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 3,077 | 3,077 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 86,164 | 86,164 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 601 | 429 | -172 | 0.00 | 0.00 | +0.00 | sell |
| Corebridge Financial, Inc. | 54,868 | 54,532 | -336 | 0.00 | 0.00 | +0.00 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 391 | 0 | -391 | 0.00 | 0.00 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 11,465 | 10,892 | -573 | 0.00 | 0.00 | +0.00 | sell |
| Hartford Financial Management Inc. | 1,000 | 0 | -1,000 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 37,402 | 35,465 | -1,937 | 0.00 | 0.00 | +0.00 | sell |
| MetLife Investment Management, LLC | 24,377 | 21,026 | -3,351 | 0.00 | 0.00 | +0.00 | sell |
| FEDERATED HERMES, INC. | 3,592 | 0 | -3,592 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 131,789 | 125,294 | -6,495 | 0.00 | 0.00 | +0.00 | sell |
| Point72 (DIFC) Ltd | 8,231 | 0 | -8,231 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 10,000 | 0 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| EXCHANGE TRADED CONCEPTS, LLC | 112,020 | 97,931 | -14,089 | 0.00 | 0.00 | +0.00 | sell |
| TOWNSQUARE CAPITAL LLC | 19,195 | 0 | -19,195 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 215,050 | 193,259 | -21,791 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA ADVISERS, LP | 113,800 | 86,400 | -27,400 | 0.00 | 0.00 | +0.00 | sell |
| Cubist Systematic Strategies, LLC | 40,701 | 0 | -40,701 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 46,017 | 4,334 | -41,683 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 51,233 | 0 | -51,233 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 283,938 | 231,934 | -52,004 | 0.00 | 0.00 | +0.00 | sell |
| Pale Fire Capital SE | 82,777 | 30,507 | -52,270 | 0.01 | 0.01 | -0.00 | sell |
| Squarepoint Ops LLC | 64,133 | 0 | -64,133 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 122,038 | 0 | -122,038 | 0.00 | 0.00 | -0.00 | sell |
| Ground Swell Capital, LLC | 124,394 | 0 | -124,394 | 0.12 | 0.00 | -0.12 | sell |
| Pennant Investors, LP | 199,000 | 0 | -199,000 | 0.05 | 0.00 | -0.05 | sell |
| CITADEL ADVISORS LLC | 267,772 | 64,226 | -203,546 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 243,650 | 0 | -243,650 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 433,755 | 169,403 | -264,352 | 0.00 | 0.00 | -0.00 | sell |
| Cormorant Asset Management, LP | 2,030,823 | 0 | -2,030,823 | 0.12 | 0.00 | -0.12 | sell |
| JANUS HENDERSON GROUP PLC | 5,216,342 | 1,843,286 | -3,373,056 | 0.00 | 0.00 | -0.00 | sell |