| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 7,149,493 | 14,101,159 | +6,951,666 | 0.70 | 1.50 | +0.80 | buy |
| BVF INC/IL | 0 | 4,750,000 | +4,750,000 | 0.00 | 0.67 | +0.67 | buy |
| Vivo Capital, LLC | 6,043,466 | 9,545,466 | +3,502,000 | 1.61 | 2.69 | +1.08 | buy |
| TANG CAPITAL MANAGEMENT LLC | 13,496,208 | 16,811,963 | +3,315,755 | 1.77 | 2.27 | +0.49 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 2,826,362 | +2,826,362 | 0.00 | 0.02 | +0.02 | buy |
| RTW INVESTMENTS, LP | 0 | 2,500,000 | +2,500,000 | 0.00 | 0.11 | +0.11 | buy |
| MILLENNIUM MANAGEMENT LLC | 851,205 | 3,237,572 | +2,386,367 | 0.00 | 0.01 | +0.01 | buy |
| VANGUARD GROUP INC | 4,850,005 | 7,062,799 | +2,212,794 | 0.00 | 0.00 | +0.00 | buy |
| Logos Global Management LP | 0 | 2,050,000 | +2,050,000 | 0.00 | 0.71 | +0.71 | buy |
| Sofinnova Investments, Inc. | 0 | 2,028,886 | +2,028,886 | 0.00 | 0.44 | +0.44 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,249,781 | 2,833,988 | +1,584,207 | 0.67 | 1.44 | +0.77 | buy |
| ROYAL BANK OF CANADA | 151,142 | 1,700,927 | +1,549,785 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,971,368 | 3,106,513 | +1,135,145 | 0.00 | 0.00 | +0.00 | buy |
| Monashee Investment Management LLC | 165,000 | 1,250,000 | +1,085,000 | 0.23 | 2.18 | +1.96 | buy |
| BlackRock, Inc. | 6,413,133 | 7,370,747 | +957,614 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 116,348 | 1,039,671 | +923,323 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 0 | 872,938 | +872,938 | 0.00 | 2.31 | +2.31 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 840,090 | +840,090 | 0.00 | 3.04 | +3.04 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,424,868 | 5,186,500 | +761,632 | 0.02 | 0.03 | +0.01 | buy |
| Burkehill Global Management, LP | 0 | 700,000 | +700,000 | 0.00 | 0.14 | +0.14 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,319,132 | 2,944,469 | +625,337 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 476,291 | +476,291 | 0.00 | 0.01 | +0.01 | buy |
| DAFNA Capital Management LLC | 526,660 | 946,661 | +420,001 | 0.38 | 0.82 | +0.44 | buy |
| CITADEL ADVISORS LLC | 0 | 233,271 | +233,271 | 0.00 | 0.00 | +0.00 | buy |
| CM Management, LLC | 0 | 150,000 | +150,000 | 0.00 | 0.44 | +0.44 | buy |
| NORTHERN TRUST CORP | 734,694 | 861,935 | +127,241 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 0 | 106,674 | +106,674 | 0.00 | 0.03 | +0.03 | buy |
| Rafferty Asset Management, LLC | 0 | 70,959 | +70,959 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 20,773 | 87,853 | +67,080 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 273,472 | 335,250 | +61,778 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 11,484 | 60,927 | +49,443 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 47,427 | +47,427 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 45,877 | +45,877 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 41,400 | +41,400 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 113,487 | 139,313 | +25,826 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 25,000 | 50,000 | +25,000 | 0.01 | 0.02 | +0.01 | buy |
| PROFUND ADVISORS LLC | 0 | 16,468 | +16,468 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 52,724 | 68,173 | +15,449 | 0.00 | 0.00 | +0.00 | buy |
| WELCH & FORBES LLC | 0 | 15,000 | +15,000 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 12,681 | +12,681 | 0.00 | 0.00 | +0.00 | buy |
| Strategic Wealth Partners, Ltd. | 0 | 12,100 | +12,100 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 211,183 | 223,176 | +11,993 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 83,897 | 95,785 | +11,888 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 48,451 | 59,148 | +10,697 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 9,485 | 19,523 | +10,038 | 0.00 | 0.00 | +0.00 | buy |
| CAXTON CORP | 43,465 | 53,503 | +10,038 | 1.15 | 0.82 | -0.33 | buy |
| Apollon Wealth Management, LLC | 0 | 10,015 | +10,015 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 46,942 | 56,588 | +9,646 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 74,597 | 83,007 | +8,410 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 193 | 7,785 | +7,592 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 22,933 | 28,331 | +5,398 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 172,227 | 175,556 | +3,329 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 954 | 4,093 | +3,139 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 4,134,655 | 4,137,562 | +2,907 | 0.00 | 0.00 | +0.00 | buy |
| MCF Advisors LLC | 2,770 | 5,540 | +2,770 | 0.00 | 0.00 | +0.00 | buy |
| Focus Partners Wealth | 13,599 | 15,805 | +2,206 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 10,488 | 12,652 | +2,164 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 1,275 | 3,335 | +2,060 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 58,735 | 60,656 | +1,921 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 0 | 1,642 | +1,642 | 0.00 | 0.00 | +0.00 | buy |
| Cape Investment Advisory, Inc. | 0 | 1,317 | +1,317 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 1,246 | 1,891 | +645 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 0 | 526 | +526 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 5,337 | 5,822 | +485 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 0 | 405 | +405 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 388 | +388 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 225 | +225 | 0.00 | 0.00 | +0.00 | buy |
| CAPTRUST FINANCIAL ADVISORS | 20,325 | 20,524 | +199 | 0.00 | 0.00 | +0.00 | buy |
| Sunbelt Securities, Inc. | 0 | 8 | +8 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 7,390 | 7,394 | +4 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 4 | +4 | 0.00 | 0.00 | +0.00 | buy |
| Clearstead Advisors, LLC | 0 | 4 | +4 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 15,219,994 | 15,219,994 | 0 | 1.00 | 1.28 | +0.28 | hold |
| Ameritas Investment Partners, Inc. | 7,536 | 7,536 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ROVIN CAPITAL /UT/ /ADV | 13,495 | 13,495 | 0 | 0.01 | 0.01 | +0.00 | hold |
| North Star Investment Management Corp. | 12,500 | 12,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Walleye Trading LLC | 25,000 | 25,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EverSource Wealth Advisors, LLC | 6,229 | 6,229 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ACT Advisors, LLC. | 10,376 | 10,376 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Blue Owl Capital Holdings LP | 2,591,525 | 2,591,525 | 0 | 2.17 | 2.82 | +0.64 | hold |
| Nuveen, LLC | 259,211 | 259,211 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Enavate Sciences GP, LLC | 7,788,150 | 7,788,150 | 0 | 11.47 | 8.32 | -3.15 | hold |
| Marshall & Sterling Wealth Advisors Inc. | 200 | 200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 9,643 | 9,643 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 30,407 | 30,407 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STRS OHIO | 17,900 | 17,900 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ROTHSCHILD INVESTMENT LLC | 120 | 120 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 3,077 | 3,077 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 5,248 | 5,248 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Fortitude Family Office, LLC | 4,983 | 4,978 | -5 | 0.00 | 0.00 | +0.00 | sell |
| SBI Securities Co., Ltd. | 354 | 330 | -24 | 0.00 | 0.00 | +0.00 | sell |
| Brooklyn Investment Group | 236 | 0 | -236 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 50,164 | 49,850 | -314 | 0.00 | 0.00 | +0.00 | sell |
| Stonebrook Private Inc. | 10,596 | 10,230 | -366 | 0.01 | 0.01 | +0.00 | sell |
| Independent Advisor Alliance | 18,420 | 17,894 | -526 | 0.00 | 0.00 | +0.00 | sell |
| MetLife Investment Management, LLC | 58,946 | 58,347 | -599 | 0.00 | 0.00 | +0.00 | sell |
| Briaud Financial Planning, Inc | 700 | 0 | -700 | 0.00 | 0.00 | -0.00 | sell |
| Sequoia Financial Advisors, LLC | 16,485 | 15,753 | -732 | 0.00 | 0.00 | +0.00 | sell |
| ProShare Advisors LLC | 18,795 | 17,004 | -1,791 | 0.00 | 0.00 | +0.00 | sell |