| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TANG CAPITAL MANAGEMENT LLC | 13,496,208 | 16,811,963 | +3,315,755 | 1.77 | 2.27 | +0.49 | buy |
| ORBIMED ADVISORS LLC | 15,219,994 | 15,219,994 | 0 | 1.00 | 1.28 | +0.28 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 7,149,493 | 14,101,159 | +6,951,666 | 0.70 | 1.50 | +0.80 | buy |
| Blackstone Inc. | 10,025,151 | 9,840,108 | -185,043 | 0.12 | 0.15 | +0.03 | sell |
| Vivo Capital, LLC | 6,043,466 | 9,545,466 | +3,502,000 | 1.61 | 2.69 | +1.08 | buy |
| Enavate Sciences GP, LLC | 7,788,150 | 7,788,150 | 0 | 11.47 | 8.32 | -3.15 | hold |
| BlackRock, Inc. | 6,413,133 | 7,370,747 | +957,614 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 4,850,005 | 7,062,799 | +2,212,794 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,424,868 | 5,186,500 | +761,632 | 0.02 | 0.03 | +0.01 | buy |
| MPM BioImpact LLC | 5,622,505 | 5,075,970 | -546,535 | 2.53 | 2.91 | +0.38 | sell |
| BVF INC/IL | 0 | 4,750,000 | +4,750,000 | 0.00 | 0.67 | +0.67 | buy |
| Rock Springs Capital Management LP | 4,962,955 | 4,474,702 | -488,253 | 0.80 | 0.92 | +0.11 | sell |
| FMR LLC | 4,134,655 | 4,137,562 | +2,907 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 851,205 | 3,237,572 | +2,386,367 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 1,971,368 | 3,106,513 | +1,135,145 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,319,132 | 2,944,469 | +625,337 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,249,781 | 2,833,988 | +1,584,207 | 0.67 | 1.44 | +0.77 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 2,826,362 | +2,826,362 | 0.00 | 0.02 | +0.02 | buy |
| Blue Owl Capital Holdings LP | 2,591,525 | 2,591,525 | 0 | 2.17 | 2.82 | +0.64 | hold |
| RTW INVESTMENTS, LP | 0 | 2,500,000 | +2,500,000 | 0.00 | 0.11 | +0.11 | buy |
| Logos Global Management LP | 0 | 2,050,000 | +2,050,000 | 0.00 | 0.71 | +0.71 | buy |
| Sofinnova Investments, Inc. | 0 | 2,028,886 | +2,028,886 | 0.00 | 0.44 | +0.44 | buy |
| JPMORGAN CHASE & CO | 2,125,717 | 1,999,278 | -126,439 | 0.00 | 0.00 | +0.00 | sell |
| ROYAL BANK OF CANADA | 151,142 | 1,700,927 | +1,549,785 | 0.00 | 0.00 | +0.00 | buy |
| Monashee Investment Management LLC | 165,000 | 1,250,000 | +1,085,000 | 0.23 | 2.18 | +1.96 | buy |
| GOLDMAN SACHS GROUP INC | 116,348 | 1,039,671 | +923,323 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 526,660 | 946,661 | +420,001 | 0.38 | 0.82 | +0.44 | buy |
| Birchview Capital, LP | 0 | 872,938 | +872,938 | 0.00 | 2.31 | +2.31 | buy |
| NORTHERN TRUST CORP | 734,694 | 861,935 | +127,241 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 840,090 | +840,090 | 0.00 | 3.04 | +3.04 | buy |
| Burkehill Global Management, LP | 0 | 700,000 | +700,000 | 0.00 | 0.14 | +0.14 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 476,291 | +476,291 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 273,472 | 335,250 | +61,778 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 348,040 | 318,124 | -29,916 | 0.00 | 0.00 | +0.00 | sell |
| Nuveen, LLC | 259,211 | 259,211 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CITADEL ADVISORS LLC | 0 | 233,271 | +233,271 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 211,183 | 223,176 | +11,993 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 241,721 | 222,418 | -19,303 | 0.00 | 0.00 | +0.00 | sell |
| UBS Group AG | 263,526 | 198,271 | -65,255 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 172,227 | 175,556 | +3,329 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 725,510 | 154,170 | -571,340 | 0.17 | 0.03 | -0.14 | sell |
| CM Management, LLC | 0 | 150,000 | +150,000 | 0.00 | 0.44 | +0.44 | buy |
| SG Americas Securities, LLC | 372,681 | 149,313 | -223,368 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 113,487 | 139,313 | +25,826 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 0 | 106,674 | +106,674 | 0.00 | 0.03 | +0.03 | buy |
| ALLIANCEBERNSTEIN L.P. | 116,670 | 104,160 | -12,510 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 83,897 | 95,785 | +11,888 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 20,773 | 87,853 | +67,080 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 74,597 | 83,007 | +8,410 | 0.00 | 0.00 | +0.00 | buy |
| CANTOR FITZGERALD, L. P. | 100,000 | 80,000 | -20,000 | 0.01 | 0.01 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 224,600 | 79,000 | -145,600 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 0 | 70,959 | +70,959 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 52,724 | 68,173 | +15,449 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 11,484 | 60,927 | +49,443 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 58,735 | 60,656 | +1,921 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 48,451 | 59,148 | +10,697 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 58,946 | 58,347 | -599 | 0.00 | 0.00 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 46,942 | 56,588 | +9,646 | 0.00 | 0.00 | +0.00 | buy |
| CAXTON CORP | 43,465 | 53,503 | +10,038 | 1.15 | 0.82 | -0.33 | buy |
| ADAR1 Capital Management, LLC | 25,000 | 50,000 | +25,000 | 0.01 | 0.02 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 50,164 | 49,850 | -314 | 0.00 | 0.00 | +0.00 | sell |
| Quadrature Capital Ltd | 0 | 47,427 | +47,427 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 45,877 | +45,877 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 41,400 | +41,400 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 44,223 | 38,936 | -5,287 | 0.00 | 0.00 | +0.00 | sell |
| Simplicity Wealth,LLC | 84,636 | 37,034 | -47,602 | 0.01 | 0.01 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 35,553 | 33,161 | -2,392 | 0.00 | 0.00 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 30,407 | 30,407 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 22,933 | 28,331 | +5,398 | 0.00 | 0.00 | +0.00 | buy |
| SIG BROKERAGE, LP | 36,393 | 26,365 | -10,028 | 0.03 | 0.02 | -0.00 | sell |
| Walleye Trading LLC | 25,000 | 25,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CAPTRUST FINANCIAL ADVISORS | 20,325 | 20,524 | +199 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 9,485 | 19,523 | +10,038 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 17,900 | 17,900 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Independent Advisor Alliance | 18,420 | 17,894 | -526 | 0.00 | 0.00 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 27,159 | 17,214 | -9,945 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 18,795 | 17,004 | -1,791 | 0.00 | 0.00 | +0.00 | sell |
| XTX Topco Ltd | 32,415 | 16,950 | -15,465 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 0 | 16,468 | +16,468 | 0.00 | 0.00 | +0.00 | buy |
| Focus Partners Wealth | 13,599 | 15,805 | +2,206 | 0.00 | 0.00 | +0.00 | buy |
| Sequoia Financial Advisors, LLC | 16,485 | 15,753 | -732 | 0.00 | 0.00 | +0.00 | sell |
| WELCH & FORBES LLC | 0 | 15,000 | +15,000 | 0.00 | 0.00 | +0.00 | buy |
| ROVIN CAPITAL /UT/ /ADV | 13,495 | 13,495 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Virtu Financial LLC | 0 | 12,681 | +12,681 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 10,488 | 12,652 | +2,164 | 0.00 | 0.00 | +0.00 | buy |
| North Star Investment Management Corp. | 12,500 | 12,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Strategic Wealth Partners, Ltd. | 0 | 12,100 | +12,100 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 31,710 | 10,651 | -21,059 | 0.00 | 0.00 | -0.00 | sell |
| ACT Advisors, LLC. | 10,376 | 10,376 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Stonebrook Private Inc. | 10,596 | 10,230 | -366 | 0.01 | 0.01 | +0.00 | sell |
| Apollon Wealth Management, LLC | 0 | 10,015 | +10,015 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 9,643 | 9,643 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Russell Investments Group, Ltd. | 193 | 7,785 | +7,592 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 7,536 | 7,536 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 7,390 | 7,394 | +4 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 6,229 | 6,229 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Tower Research Capital LLC (TRC) | 14,578 | 6,039 | -8,539 | 0.00 | 0.00 | -0.00 | sell |
| PNC FINANCIAL SERVICES GROUP, INC. | 5,337 | 5,822 | +485 | 0.00 | 0.00 | +0.00 | buy |
| MCF Advisors LLC | 2,770 | 5,540 | +2,770 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 5,248 | 5,248 | 0 | 0.00 | 0.00 | +0.00 | hold |