| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 6,380,000 | 9,880,000 | +3,500,000 | 0.03 | 0.03 | +0.00 | buy |
| Blue Owl Capital Holdings LP | 0 | 2,829,712 | +2,829,712 | 0.00 | 1.06 | +1.06 | buy |
| ELEMENT CAPITAL MANAGEMENT LLC | 0 | 293,888 | +293,888 | 0.00 | 1.55 | +1.55 | buy |
| Pennant Investors, LP | 0 | 199,000 | +199,000 | 0.00 | 0.10 | +0.10 | buy |
| MILLENNIUM MANAGEMENT LLC | 306,623 | 494,092 | +187,469 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 25,700 | 192,700 | +167,000 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 166,137 | +166,137 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 26,800 | 176,799 | +149,999 | 0.00 | 0.00 | +0.00 | buy |
| Pale Fire Capital SE | 45,155 | 181,055 | +135,900 | 0.01 | 0.04 | +0.04 | buy |
| CM Management, LLC | 0 | 125,000 | +125,000 | 0.00 | 0.16 | +0.16 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,892,321 | 1,992,028 | +99,707 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 30,303 | 125,486 | +95,183 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 88,720 | +88,720 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 132,792 | 212,965 | +80,173 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 59,045 | 102,548 | +43,503 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 38,600 | 70,800 | +32,200 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 32,145 | +32,145 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 28,054 | +28,054 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 49,129 | 65,819 | +16,690 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 183 | 13,402 | +13,219 | 0.00 | 0.00 | +0.00 | buy |
| WEXFORD CAPITAL LP | 0 | 12,700 | +12,700 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 11,031 | +11,031 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 38,807 | 47,624 | +8,817 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 22,192 | 27,728 | +5,536 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 6,138 | 10,215 | +4,077 | 0.00 | 0.00 | -0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 3,541 | +3,541 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 11,856 | 15,104 | +3,248 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 20,463 | 23,355 | +2,892 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 0 | 158 | +158 | 0.00 | 0.00 | 0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 65 | +65 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 22,362,850 | 22,362,850 | 0 | 0.95 | 0.70 | -0.25 | hold |
| Ameritas Investment Partners, Inc. | 7,536 | 7,536 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 39,556 | 39,556 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 13,480 | 13,480 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRINCIPAL FINANCIAL GROUP INC | 11,972 | 11,972 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 1,557,630 | 1,557,630 | 0 | 0.02 | 0.03 | +0.01 | hold |
| DAFNA Capital Management LLC | 116,882 | 116,882 | 0 | 0.07 | 0.04 | -0.03 | hold |
| Blackstone Inc. | 6,189,551 | 6,189,551 | 0 | 0.05 | 0.04 | -0.01 | hold |
| B. Riley Wealth Advisors, Inc. | 50,000 | 50,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MetLife Investment Management, LLC | 49,953 | 49,953 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rock Springs Capital Management LP | 5,513,788 | 5,513,788 | 0 | 0.29 | 0.21 | -0.08 | hold |
| Vivo Capital, LLC | 3,556,023 | 3,556,023 | 0 | 0.77 | 0.45 | -0.31 | hold |
| Avidity Partners Management LP | 1,599,600 | 1,599,600 | 0 | 0.13 | 0.10 | -0.03 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| STRS OHIO | 19,000 | 19,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 37,520 | 37,520 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 26,320 | 26,320 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DEUTSCHE BANK AG\ | 44,614 | 44,614 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 11,161 | 11,117 | -44 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 38,361 | 38,181 | -180 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 45,544 | 45,360 | -184 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 62,739 | 62,332 | -407 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 117,119 | 116,532 | -587 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 9,377 | 8,461 | -916 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 272,452 | 271,164 | -1,288 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 4,553,093 | 4,551,506 | -1,587 | 0.00 | 0.00 | -0.00 | sell |
| New Capital Management LP | 24,243 | 21,131 | -3,112 | 0.02 | 0.01 | -0.01 | sell |
| METROPOLITAN LIFE INSURANCE CO/NY | 5,176 | 1,122 | -4,054 | 0.00 | 0.00 | -0.00 | sell |
| FLAGSHIP HARBOR ADVISORS, LLC | 11,000 | 0 | -11,000 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 220,182 | 206,597 | -13,585 | 0.00 | 0.00 | -0.00 | sell |
| STIFEL FINANCIAL CORP | 15,000 | 0 | -15,000 | 0.00 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 15,515 | 0 | -15,515 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 263,276 | 246,012 | -17,264 | 0.00 | 0.00 | -0.00 | sell |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 21,566 | 0 | -21,566 | 0.00 | 0.00 | -0.00 | sell |
| Arizona State Retirement System | 21,612 | 0 | -21,612 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 66,096 | 43,190 | -22,906 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 24,314 | 0 | -24,314 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 46,872 | 21,548 | -25,324 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 4,107,519 | 4,081,189 | -26,330 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 1,756,113 | 1,726,304 | -29,809 | 0.00 | 0.00 | -0.00 | sell |
| SALEM INVESTMENT COUNSELORS INC | 30,000 | 0 | -30,000 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 33,963 | 0 | -33,963 | 0.00 | 0.00 | -0.00 | sell |
| CAXTON CORP | 86,773 | 43,465 | -43,308 | 0.65 | 0.37 | -0.28 | sell |
| NORTHERN TRUST CORP | 825,114 | 759,733 | -65,381 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 87,289 | 15,021 | -72,268 | 0.00 | 0.00 | -0.00 | sell |
| Ally Bridge Group (NY) LLC | 914,630 | 834,630 | -80,000 | 2.11 | 0.78 | -1.34 | sell |
| LMR Partners LLP | 80,692 | 0 | -80,692 | 0.01 | 0.00 | -0.01 | sell |
| ALPS ADVISORS INC | 94,115 | 0 | -94,115 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 6,660,638 | 6,547,231 | -113,407 | 0.01 | 0.01 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 114,158 | 0 | -114,158 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 163,400 | 0 | -163,400 | 0.00 | 0.00 | -0.00 | sell |
| Monashee Investment Management LLC | 1,226,142 | 500,000 | -726,142 | 1.01 | 0.14 | -0.87 | sell |
| Prosight Management, LP | 935,157 | 0 | -935,157 | 0.58 | 0.00 | -0.58 | sell |
| Foresite Capital Management V, LLC | 1,246,977 | 0 | -1,246,977 | 3.92 | 0.00 | -3.92 | sell |
| BRAIDWELL LP | 5,954,273 | 317,761 | -5,636,512 | 0.37 | 0.02 | -0.35 | sell |