| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TANG CAPITAL MANAGEMENT LLC | 1,812,995 | 5,900,000 | +4,087,005 | 0.24 | 0.57 | +0.33 | buy |
| MPM BioImpact LLC | 5,641,894 | 8,567,896 | +2,926,002 | 1.56 | 1.76 | +0.21 | buy |
| VANGUARD GROUP INC | 4,283,186 | 4,718,194 | +435,008 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 38,665 | 395,017 | +356,352 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 44,464 | 272,328 | +227,864 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 5,629,239 | 5,779,575 | +150,336 | 0.34 | 0.32 | -0.02 | buy |
| Blue Owl Capital Holdings LP | 2,879,712 | 2,954,712 | +75,000 | 1.03 | 0.99 | -0.04 | buy |
| BlackRock, Inc. | 6,820,452 | 6,887,615 | +67,163 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 222,600 | 278,600 | +56,000 | 0.00 | 0.00 | -0.00 | buy |
| Catalina Capital Group, LLC | 0 | 48,964 | +48,964 | 0.00 | 0.02 | +0.02 | buy |
| MetLife Investment Management, LLC | 21,026 | 63,141 | +42,115 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 116,882 | 158,394 | +41,512 | 0.05 | 0.06 | +0.01 | buy |
| STATE STREET CORP | 1,863,977 | 1,903,008 | +39,031 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 16,292 | 51,924 | +35,632 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 20,221 | 52,754 | +32,533 | 0.00 | 0.01 | +0.00 | buy |
| Sequoia Financial Advisors, LLC | 0 | 30,876 | +30,876 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 141,611 | 171,466 | +29,855 | 0.00 | 0.00 | -0.00 | buy |
| Bleakley Financial Group, LLC | 11,404 | 39,993 | +28,589 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,309,778 | 2,334,171 | +24,393 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 0 | 24,072 | +24,072 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 170,245 | 192,766 | +22,521 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 0 | 20,673 | +20,673 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 371,129 | 390,439 | +19,310 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 18,562 | +18,562 | 0.00 | 0.00 | +0.00 | buy |
| Independent Advisor Alliance | 0 | 17,948 | +17,948 | 0.00 | 0.00 | +0.00 | buy |
| Dakota Wealth Management | 0 | 14,000 | +14,000 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 13,887 | +13,887 | 0.00 | 0.00 | +0.00 | buy |
| Focus Partners Wealth | 0 | 13,591 | +13,591 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 46,822 | 59,860 | +13,038 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 4,334 | 17,251 | +12,917 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 35,616 | 46,942 | +11,326 | 0.00 | 0.00 | +0.00 | buy |
| Stonebrook Private Inc. | 0 | 11,288 | +11,288 | 0.00 | 0.00 | +0.00 | buy |
| ACT Advisors, LLC. | 0 | 10,528 | +10,528 | 0.00 | 0.01 | +0.01 | buy |
| ProShare Advisors LLC | 19,271 | 28,722 | +9,451 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 231,934 | 237,975 | +6,041 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 74,281 | 78,603 | +4,322 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 35,465 | 39,483 | +4,018 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 125,294 | 129,116 | +3,822 | 0.00 | 0.00 | -0.00 | buy |
| Fortitude Family Office, LLC | 1,832 | 5,145 | +3,313 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 324 | 3,464 | +3,140 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 55,958 | 58,466 | +2,508 | 0.00 | 0.00 | -0.00 | buy |
| CoreCap Advisors, LLC | 0 | 2,300 | +2,300 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 429 | 848 | +419 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 193 | +193 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 4,136,273 | 4,136,403 | +130 | 0.00 | 0.00 | -0.00 | buy |
| IFP Advisors, Inc | 0 | 16 | +16 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 22,362,850 | 22,362,850 | 0 | 0.75 | 0.67 | -0.08 | hold |
| Ameritas Investment Partners, Inc. | 7,536 | 7,536 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ROVIN CAPITAL /UT/ /ADV | 13,495 | 13,495 | 0 | 0.01 | 0.01 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 7,390 | 7,390 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 1,557,630 | 1,557,630 | 0 | 0.03 | 0.02 | -0.01 | hold |
| ALGERT GLOBAL LLC | 22,588 | 22,588 | 0 | 0.00 | 0.00 | -0.00 | hold |
| North Star Investment Management Corp. | 12,500 | 12,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CAXTON CORP | 43,465 | 43,465 | 0 | 0.33 | 0.38 | +0.05 | hold |
| Blackstone Inc. | 10,025,151 | 10,025,151 | 0 | 0.08 | 0.07 | -0.01 | hold |
| EXCHANGE TRADED CONCEPTS, LLC | 97,931 | 97,931 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Vivo Capital, LLC | 3,556,023 | 3,556,023 | 0 | 0.54 | 0.58 | +0.04 | hold |
| CM Management, LLC | 310,000 | 310,000 | 0 | 0.46 | 0.40 | -0.05 | hold |
| DIMENSIONAL FUND ADVISORS LP | 11,117 | 11,117 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Legal & General Group Plc | 10,171 | 10,171 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 38,207 | 38,207 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STRS OHIO | 17,900 | 17,900 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 286,191 | 286,191 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 3,077 | 3,077 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CWM, LLC | 676 | 559 | -117 | 0.00 | 0.00 | -0.00 | sell |
| EARNED WEALTH ADVISORS, LLC | 172 | 0 | -172 | 0.00 | 0.00 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 10,892 | 10,536 | -356 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 42,671 | 41,980 | -691 | 0.00 | 0.00 | -0.00 | sell |
| HSBC HOLDINGS PLC | 22,460 | 21,529 | -931 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 24,180 | 21,440 | -2,740 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 54,532 | 50,704 | -3,828 | 0.00 | 0.00 | -0.00 | sell |
| LPL Financial LLC | 50,000 | 45,000 | -5,000 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 37,663 | 32,561 | -5,102 | 0.00 | 0.00 | -0.00 | sell |
| Pale Fire Capital SE | 30,507 | 0 | -30,507 | 0.01 | 0.00 | -0.01 | sell |
| TWO SIGMA ADVISERS, LP | 86,400 | 51,000 | -35,400 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 844,389 | 801,225 | -43,164 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 193,259 | 145,238 | -48,021 | 0.00 | 0.00 | -0.00 | sell |
| Monashee Investment Management LLC | 500,000 | 448,164 | -51,836 | 0.10 | 0.09 | -0.01 | sell |
| CITADEL ADVISORS LLC | 64,226 | 0 | -64,226 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 65,922 | 0 | -65,922 | 0.01 | 0.00 | -0.01 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 232,049 | 156,871 | -75,178 | 0.00 | 0.00 | -0.00 | sell |
| CANTOR FITZGERALD, L. P. | 180,000 | 100,000 | -80,000 | 0.03 | 0.01 | -0.02 | sell |
| DEUTSCHE BANK AG\ | 86,164 | 0 | -86,164 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 169,403 | 33,857 | -135,546 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 1,843,286 | 0 | -1,843,286 | 0.00 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 11,130,000 | 5,994,810 | -5,135,190 | 0.04 | 0.02 | -0.02 | sell |