| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 4,750,000 | 7,764,842 | +3,014,842 | 0.67 | 1.40 | +0.73 | buy |
| Sofinnova Investments, Inc. | 2,028,886 | 3,365,446 | +1,336,560 | 0.39 | 0.78 | +0.39 | buy |
| Blue Owl Capital Holdings LP | 2,591,525 | 3,466,525 | +875,000 | 2.82 | 5.74 | +2.93 | buy |
| Birchview Capital, LP | 872,938 | 1,592,938 | +720,000 | 2.31 | 5.01 | +2.70 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 840,090 | 1,093,300 | +253,210 | 3.04 | 3.99 | +0.95 | buy |
| ADAR1 Capital Management, LLC | 50,000 | 139,000 | +89,000 | 0.02 | 0.06 | +0.04 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 14,101,159 | 14,182,379 | +81,220 | 1.26 | 1.56 | +0.30 | buy |
| ALPS ADVISORS INC | 83,007 | 146,040 | +63,033 | 0.00 | 0.00 | 0.00 | buy |
| WELCH & FORBES LLC | 15,000 | 19,000 | +4,000 | 0.00 | 0.00 | +0.00 | buy |
| Simplicity Wealth,LLC | 37,034 | 33,869 | -3,165 | 0.01 | 0.01 | +0.00 | sell |
| SIG BROKERAGE, LP | 26,365 | 17,076 | -9,289 | 0.00 | 0.00 | +0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 16,811,963 | 16,790,809 | -21,154 | 2.27 | 4.45 | +2.19 | sell |
| CAXTON CORP | 53,503 | 29,495 | -24,008 | 0.82 | 3.70 | +2.88 | sell |
| Atom Investors LP | 106,674 | 77,281 | -29,393 | 0.03 | 0.03 | +0.00 | sell |
| CM Management, LLC | 150,000 | 100,000 | -50,000 | 0.44 | 0.45 | +0.01 | sell |
| Monashee Investment Management LLC | 1,250,000 | 1,000,000 | -250,000 | 2.18 | 3.03 | +0.84 | sell |
| Rock Springs Capital Management LP | 4,474,702 | 3,927,202 | -547,500 | 0.92 | 1.08 | +0.17 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,186,500 | 4,436,500 | -750,000 | 0.03 | 0.04 | +0.01 | sell |
| Logos Global Management LP | 2,050,000 | 1,150,000 | -900,000 | 0.71 | 0.41 | -0.30 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 2,833,988 | 1,051,343 | -1,782,645 | 1.44 | 0.82 | -0.62 | sell |