| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 3,606,000 | +3,606,000 | 0.00 | 0.25 | +0.25 | buy |
| BVF INC/IL | 4,750,000 | 7,764,842 | +3,014,842 | 0.67 | 1.40 | +0.73 | buy |
| BRAIDWELL LP | 0 | 2,786,778 | +2,786,778 | 0.00 | 0.48 | +0.48 | buy |
| Palo Alto Investors LP | 0 | 2,532,419 | +2,532,419 | 0.00 | 1.89 | +1.89 | buy |
| BlackRock, Inc. | 7,370,747 | 9,388,624 | +2,017,877 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 3,106,513 | 4,890,525 | +1,784,012 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 2,028,886 | 3,365,446 | +1,336,560 | 0.44 | 0.78 | +0.34 | buy |
| MARSHALL WACE, LLP | 0 | 1,263,647 | +1,263,647 | 0.00 | 0.01 | +0.01 | buy |
| VANGUARD GROUP INC | 7,062,799 | 8,048,374 | +985,575 | 0.00 | 0.00 | +0.00 | buy |
| Blue Owl Capital Holdings LP | 2,591,525 | 3,466,525 | +875,000 | 2.82 | 5.74 | +2.93 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 823,174 | +823,174 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 0 | 800,000 | +800,000 | 0.00 | 0.56 | +0.56 | buy |
| Birchview Capital, LP | 872,938 | 1,592,938 | +720,000 | 2.31 | 5.01 | +2.70 | buy |
| Atle Fund Management AB | 0 | 584,332 | +584,332 | 0.00 | 1.00 | +1.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,944,469 | 3,502,526 | +558,057 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,039,671 | 1,517,415 | +477,744 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 462,166 | +462,166 | 0.00 | 0.06 | +0.06 | buy |
| Qube Research & Technologies Ltd | 0 | 441,805 | +441,805 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 222,418 | 594,776 | +372,358 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 0 | 365,245 | +365,245 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 314,750 | +314,750 | 0.00 | 0.00 | +0.00 | buy |
| ROYCE & ASSOCIATES LP | 0 | 285,988 | +285,988 | 0.00 | 0.02 | +0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 266,434 | +266,434 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 840,090 | 1,093,300 | +253,210 | 3.04 | 3.99 | +0.95 | buy |
| CITIGROUP INC | 10,651 | 261,876 | +251,225 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 0 | 245,532 | +245,532 | 0.00 | 0.34 | +0.34 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 210,249 | +210,249 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 205,024 | +205,024 | 0.00 | 0.03 | +0.03 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 191,724 | +191,724 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 175,556 | 341,596 | +166,040 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 41,400 | 185,423 | +144,023 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 133,810 | +133,810 | 0.00 | 0.06 | +0.06 | buy |
| NORTHERN TRUST CORP | 861,935 | 972,935 | +111,000 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 0 | 101,676 | +101,676 | 0.00 | 0.00 | +0.00 | buy |
| TEMA ETFS LLC | 0 | 100,176 | +100,176 | 0.00 | 0.04 | +0.04 | buy |
| XTX Topco Ltd | 16,950 | 115,634 | +98,684 | 0.00 | 0.02 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 59,148 | 155,218 | +96,070 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 223,176 | 312,480 | +89,304 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 50,000 | 139,000 | +89,000 | 0.02 | 0.06 | +0.04 | buy |
| SummitTX Capital, L.P. | 0 | 81,449 | +81,449 | 0.00 | 0.01 | +0.01 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 14,101,159 | 14,182,379 | +81,220 | 1.50 | 1.90 | +0.40 | buy |
| Rafferty Asset Management, LLC | 70,959 | 151,743 | +80,784 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 80,142 | +80,142 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 68,173 | 144,798 | +76,625 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 335,250 | 410,157 | +74,907 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 45,877 | 118,528 | +72,651 | 0.00 | 0.01 | +0.01 | buy |
| JANE STREET GROUP, LLC | 0 | 70,063 | +70,063 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 66,607 | +66,607 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 83,007 | 146,040 | +63,033 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 57,253 | +57,253 | 0.00 | 0.15 | +0.15 | buy |
| Graham Capital Management, L.P. | 0 | 53,427 | +53,427 | 0.00 | 0.01 | +0.01 | buy |
| Virtus Investment Advisers, LLC | 0 | 51,556 | +51,556 | 0.00 | 0.08 | +0.08 | buy |
| D. E. Shaw & Co., Inc. | 0 | 51,482 | +51,482 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 60,927 | 108,144 | +47,217 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 44,742 | +44,742 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 41,378 | +41,378 | 0.00 | 0.05 | +0.05 | buy |
| PROFUND ADVISORS LLC | 16,468 | 57,246 | +40,778 | 0.00 | 0.01 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 40,412 | +40,412 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 87,853 | 126,192 | +38,339 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 259,211 | 288,924 | +29,713 | 0.00 | 0.00 | +0.00 | buy |
| Avanza Fonder AB | 0 | 27,347 | +27,347 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 24,579 | +24,579 | 0.00 | 0.03 | +0.03 | buy |
| STIFEL FINANCIAL CORP | 0 | 23,973 | +23,973 | 0.00 | 0.00 | +0.00 | buy |
| Abel Hall, LLC | 0 | 22,882 | +22,882 | 0.00 | 0.03 | +0.03 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 49,850 | 69,576 | +19,726 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 58,347 | 73,985 | +15,638 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 15,200 | +15,200 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 14,900 | +14,900 | 0.00 | 0.00 | +0.00 | buy |
| M&T BANK CORP | 0 | 14,894 | +14,894 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 56,588 | 70,488 | +13,900 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 95,785 | 109,273 | +13,488 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 13,163 | +13,163 | 0.00 | 0.03 | +0.03 | buy |
| Neuberger Berman Group LLC | 0 | 12,807 | +12,807 | 0.00 | 0.00 | +0.00 | buy |
| XPONANCE, INC. | 0 | 10,201 | +10,201 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 28,331 | 35,503 | +7,172 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 33,161 | 40,325 | +7,164 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 17,004 | 23,972 | +6,968 | 0.00 | 0.00 | +0.00 | buy |
| FLAGSHIP HARBOR ADVISORS, LLC | 0 | 6,000 | +6,000 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 17,214 | 22,629 | +5,415 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 5,244 | +5,244 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 4,867 | +4,867 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 4,093 | 8,912 | +4,819 | 0.00 | 0.00 | +0.00 | buy |
| WELCH & FORBES LLC | 15,000 | 19,000 | +4,000 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 7,785 | 11,558 | +3,773 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 60,656 | 63,901 | +3,245 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 9,643 | 12,753 | +3,110 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 7,536 | 10,621 | +3,085 | 0.00 | 0.00 | +0.00 | buy |
| VSM Wealth Advisory, LLC | 0 | 3,000 | +3,000 | 0.00 | 0.00 | +0.00 | buy |
| Focus Partners Wealth | 15,805 | 18,595 | +2,790 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 0 | 2,042 | +2,042 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 12,652 | 14,311 | +1,659 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 1,891 | 3,059 | +1,168 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 3,077 | 4,111 | +1,034 | 0.00 | 0.00 | +0.00 | buy |
| Cape Investment Advisory, Inc. | 1,317 | 2,002 | +685 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 7,394 | 8,056 | +662 | 0.00 | 0.00 | +0.00 | buy |
| Federation des caisses Desjardins du Quebec | 0 | 500 | +500 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 3,335 | 3,827 | +492 | 0.00 | 0.00 | +0.00 | buy |
| CAPTRUST FINANCIAL ADVISORS | 20,524 | 20,846 | +322 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 388 | 680 | +292 | 0.00 | 0.00 | +0.00 | buy |