| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 0 | 1,787,767 | +1,787,767 | 0.00 | 0.03 | +0.03 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 1,787,610 | +1,787,610 | 0.00 | 0.03 | +0.03 | buy |
| Nantahala Capital Management, LLC | 0 | 1,730,600 | +1,730,600 | 0.00 | 0.15 | +0.15 | buy |
| Ikarian Capital, LLC | 0 | 893,000 | +893,000 | 0.00 | 0.28 | +0.28 | buy |
| AIGH Capital Management LLC | 0 | 865,400 | +865,400 | 0.00 | 0.41 | +0.41 | buy |
| ADAR1 Capital Management, LLC | 0 | 432,700 | +432,700 | 0.00 | 0.07 | +0.07 | buy |
| DAFNA Capital Management LLC | 0 | 401,136 | +401,136 | 0.00 | 0.10 | +0.10 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 237,400 | +237,400 | 0.00 | 0.01 | +0.01 | buy |
| BARCLAYS PLC | 0 | 25,000 | +25,000 | 0.00 | 0.00 | +0.00 | buy |
| CLEAR STREET LLC | 0 | 1,101 | +1,101 | 0.00 | 0.00 | +0.00 | buy |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| XTX Topco Ltd | 20,781 | 0 | -20,781 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 22,800 | 0 | -22,800 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 250,000 | 0 | -250,000 | 0.00 | 0.00 | -0.00 | sell |
| 8VC GP I, LLC | 1,086,191 | 108,621 | -977,570 | 0.45 | 0.15 | -0.30 | sell |
| JOHNSON & JOHNSON | 1,923,201 | 192,321 | -1,730,880 | 0.16 | 0.05 | -0.12 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 6,110,098 | 0 | -6,110,098 | 0.03 | 0.00 | -0.03 | sell |
| ORBIMED ADVISORS LLC | 13,773,653 | 0 | -13,773,653 | 0.09 | 0.00 | -0.09 | sell |