| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,494,108 | 2,494,108 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Nantahala Capital Management, LLC | 2,493,309 | 2,493,309 | 0 | 0.08 | 0.08 | +0.00 | hold |
| Alyeska Investment Group, L.P. | 0 | 1,590,738 | +1,590,738 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 430,000 | 430,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DAFNA Capital Management LLC | 401,136 | 401,136 | 0 | 0.05 | 0.05 | +0.00 | hold |
| Ikarian Capital, LLC | 892,976 | 392,976 | -500,000 | 0.13 | 0.04 | -0.09 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 237,376 | 104,463 | -132,913 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 25,300 | 102,426 | +77,126 | 0.00 | 0.00 | +0.00 | buy |
| JOHNSON & JOHNSON | 96,866 | 96,866 | 0 | 0.01 | 0.01 | -0.00 | hold |
| ADAR1 Capital Management, LLC | 299,598 | 77,656 | -221,942 | 0.02 | 0.00 | -0.02 | sell |
| BARCLAYS PLC | 25,000 | 25,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TWO SIGMA INVESTMENTS, LP | 0 | 19,125 | +19,125 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 10,555 | 10,568 | +13 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 400 | 400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Carolina Wealth Advisors, LLC | 159 | 159 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Warberg Asset Management LLC | 80,000 | 0 | -80,000 | 0.01 | 0.00 | -0.01 | sell |
| XTX Topco Ltd | 24,893 | 0 | -24,893 | 0.00 | 0.00 | -0.00 | sell |
| AIGH Capital Management LLC | 1,566,944 | 0 | -1,566,944 | 0.33 | 0.00 | -0.33 | sell |