| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 131,270 | +131,270 | 0.00 | 0.00 | +0.00 | buy |
| Nantahala Capital Management, LLC | 0 | 114,795 | +114,795 | 0.00 | 0.01 | +0.01 | buy |
| Ikarian Capital, LLC | 0 | 19,473 | +19,473 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 1,316 | +1,316 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,494,108 | 0 | -2,494,108 | 0.02 | 0.00 | -0.02 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 102,426 | 0 | -102,426 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 19,125 | 0 | -19,125 | 0.00 | 0.00 | -0.00 | sell |
| DAFNA Capital Management LLC | 401,136 | 0 | -401,136 | 0.05 | 0.00 | -0.05 | sell |
| TWO SIGMA SECURITIES, LLC | 10,568 | 0 | -10,568 | 0.00 | 0.00 | -0.00 | sell |
| Alyeska Investment Group, L.P. | 1,590,738 | 0 | -1,590,738 | 0.00 | 0.00 | -0.00 | sell |
| Nantahala Capital Management, LLC | 2,493,309 | 0 | -2,493,309 | 0.08 | 0.00 | -0.08 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 104,463 | 0 | -104,463 | 0.00 | 0.00 | -0.00 | sell |
| Ikarian Capital, LLC | 392,976 | 0 | -392,976 | 0.04 | 0.00 | -0.04 | sell |
| Carolina Wealth Advisors, LLC | 159 | 0 | -159 | 0.00 | 0.00 | -0.00 | sell |
| SBI Securities Co., Ltd. | 400 | 0 | -400 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 77,656 | 0 | -77,656 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 430,000 | 0 | -430,000 | 0.00 | 0.00 | -0.00 | sell |
| JOHNSON & JOHNSON | 96,866 | 0 | -96,866 | 0.01 | 0.00 | -0.01 | sell |
| BARCLAYS PLC | 25,000 | 0 | -25,000 | 0.00 | 0.00 | -0.00 | sell |