| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RENAISSANCE TECHNOLOGIES LLC | 0 | 488,100 | +488,100 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 35,571 | 196,779 | +161,208 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 318,462 | 399,662 | +81,200 | 0.00 | 0.00 | -0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 31,294 | +31,294 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 26,015 | +26,015 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 22,791 | +22,791 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 14,036 | 36,425 | +22,389 | 0.00 | 0.00 | +0.00 | buy |
| Northeast Financial Consultants Inc | 0 | 22,088 | +22,088 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 17,942 | +17,942 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 505,261 | 519,648 | +14,387 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 15,025 | 29,032 | +14,007 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,063,970 | 1,076,771 | +12,801 | 0.00 | 0.00 | -0.00 | buy |
| CAPTRUST FINANCIAL ADVISORS | 0 | 10,031 | +10,031 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 508,570 | 513,718 | +5,148 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 3,709 | 8,119 | +4,410 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 4,045 | +4,045 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 1,738 | +1,738 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 38,759 | 39,954 | +1,195 | 0.00 | 0.00 | -0.00 | buy |
| Mariner, LLC | 404,655 | 405,631 | +976 | 0.00 | 0.00 | -0.00 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 10,000 | 10,900 | +900 | 0.00 | 0.00 | -0.00 | buy |
| Capital Advisors, Ltd. LLC | 0 | 203 | +203 | 0.00 | 0.00 | 0.00 | buy |
| Bank of New York Mellon Corp | 90,278 | 90,316 | +38 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 9 | +9 | 0.00 | 0.00 | +0.00 | buy |
| Avior Wealth Management, LLC | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,525 | 2,525 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VIKING GLOBAL INVESTORS LP | 4,194,777 | 4,194,777 | 0 | 0.04 | 0.03 | -0.01 | hold |
| HARBOURVEST PARTNERS LLC | 21,877 | 21,877 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Laurion Capital Management LP | 783,391 | 783,391 | 0 | 0.07 | 0.04 | -0.03 | hold |
| Utah Retirement Systems | 13,240 | 13,240 | 0 | 0.00 | 0.00 | -0.00 | hold |
| New Leaf Venture Partners, L.L.C. | 3,301,603 | 3,301,603 | 0 | 6.36 | 5.35 | -1.01 | hold |
| Aberdeen Group plc | 1,727,067 | 1,727,067 | 0 | 0.01 | 0.01 | -0.00 | hold |
| 5AM Venture Management, LLC | 3,630,724 | 3,630,724 | 0 | 2.30 | 1.50 | -0.80 | hold |
| Pivotal bioVenture Partners Investment Advisor LLC | 2,404,644 | 2,404,644 | 0 | 1.46 | 2.86 | +1.40 | hold |
| Canaan Partners XI LLC | 2,059,712 | 2,059,712 | 0 | 6.15 | 4.20 | -1.95 | hold |
| Blue Owl Capital Holdings LP | 350,240 | 350,240 | 0 | 0.20 | 0.13 | -0.07 | hold |
| TPG GP A, LLC | 3,028,414 | 3,028,414 | 0 | 0.12 | 0.11 | -0.01 | hold |
| RESOURCES MANAGEMENT CORP /CT/ /ADV | 250 | 250 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 2,946 | 2,946 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 10,467 | 10,467 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 77,018 | 77,018 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STRS OHIO | 1,700 | 1,600 | -100 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 15,197 | 15,067 | -130 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 5,032 | 3,472 | -1,560 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 2,195 | 559 | -1,636 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 249,788 | 244,765 | -5,023 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 19,018 | 13,243 | -5,775 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 16,813 | 10,565 | -6,248 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 13,631 | 6,348 | -7,283 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 29,643 | 21,203 | -8,440 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 13,254 | 0 | -13,254 | 0.00 | 0.00 | -0.00 | sell |
| HSBC HOLDINGS PLC | 14,145 | 0 | -14,145 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 57,479 | 37,020 | -20,459 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 128,500 | 96,200 | -32,300 | 0.01 | 0.00 | -0.00 | sell |
| Anson Funds Management LP | 183,970 | 0 | -183,970 | 0.08 | 0.00 | -0.08 | sell |
| FMR LLC | 2,535,571 | 2,279,618 | -255,953 | 0.00 | 0.00 | -0.00 | sell |
| Novo Holdings A/S | 1,767,861 | 0 | -1,767,861 | 0.26 | 0.00 | -0.26 | sell |