| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 925,521 | 971,927 | +46,406 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 1,766,701 | 1,785,218 | +18,517 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 17,146 | 33,270 | +16,124 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 201,219 | 209,419 | +8,200 | 0.00 | 0.00 | -0.00 | buy |
| Almitas Capital LLC | 1,298,119 | 1,300,581 | +2,462 | 0.27 | 0.28 | +0.01 | buy |
| Tower Research Capital LLC (TRC) | 3,633 | 5,191 | +1,558 | 0.00 | 0.00 | +0.00 | buy |
| VIKING GLOBAL INVESTORS LP | 4,194,777 | 4,194,777 | 0 | 0.01 | 0.01 | -0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 91,600 | 91,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Hartford Financial Management Inc. | 6,500 | 6,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Mariner, LLC | 404,546 | 404,546 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Laurion Capital Management LP | 735,543 | 735,543 | 0 | 0.04 | 0.04 | -0.01 | hold |
| CAPTRUST FINANCIAL ADVISORS | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Utah Retirement Systems | 13,240 | 13,240 | 0 | 0.00 | 0.00 | -0.00 | hold |
| New Leaf Venture Partners, L.L.C. | 3,301,603 | 3,301,603 | 0 | 4.24 | 4.78 | +0.54 | hold |
| AJU IB Investment Co., Ltd. | 754,678 | 754,678 | 0 | 0.71 | 0.59 | -0.12 | hold |
| Aberdeen Group plc | 1,727,067 | 1,727,067 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GREAT VALLEY ADVISOR GROUP, INC. | 15,000 | 15,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| 5AM Venture Management, LLC | 3,630,724 | 3,630,724 | 0 | 0.83 | 0.90 | +0.07 | hold |
| Pivotal bioVenture Partners Investment Advisor LLC | 2,404,644 | 2,404,644 | 0 | 1.56 | 1.26 | -0.29 | hold |
| TPG GP A, LLC | 3,028,414 | 3,028,414 | 0 | 0.05 | 0.04 | -0.01 | hold |
| ADAR1 Capital Management, LLC | 13,400 | 13,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JOHNSON & JOHNSON | 3,636,363 | 3,636,363 | 0 | 0.90 | 0.70 | -0.21 | hold |
| BARCLAYS PLC | 15,390 | 15,390 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MERCER GLOBAL ADVISORS INC /ADV | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 90,247 | 90,247 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE STREET CORP | 62,072 | 62,072 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 1,100 | 983 | -117 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 247,827 | 247,552 | -275 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 91,300 | 91,020 | -280 | 0.00 | 0.00 | -0.00 | sell |
| SBI Securities Co., Ltd. | 5,356 | 4,488 | -868 | 0.00 | 0.00 | -0.00 | sell |
| HSBC HOLDINGS PLC | 14,078 | 12,054 | -2,024 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 2,447 | 0 | -2,447 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 5,991 | 2,209 | -3,782 | 0.00 | 0.00 | -0.00 | sell |
| Point72 (DIFC) Ltd | 5,929 | 975 | -4,954 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 76,811 | 66,711 | -10,100 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 22,652 | 10,007 | -12,645 | 0.01 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 14,817 | 0 | -14,817 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 73,602 | 38,124 | -35,478 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 35,736 | 0 | -35,736 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 441,318 | 396,500 | -44,818 | 0.00 | 0.00 | -0.00 | sell |
| Allostery Investments LP | 803,398 | 752,235 | -51,163 | 1.51 | 0.71 | -0.80 | sell |
| Northeast Financial Consultants Inc | 96,422 | 0 | -96,422 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 338,909 | 227,230 | -111,679 | 0.00 | 0.00 | -0.00 | sell |
| Canaan Partners XI LLC | 1,697,684 | 1,532,552 | -165,132 | 2.11 | 1.51 | -0.60 | sell |