| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VIKING GLOBAL INVESTORS LP | 4,194,777 | 4,194,777 | 0 | 0.01 | 0.00 | -0.00 | hold |
| JOHNSON & JOHNSON | 3,636,363 | 3,636,363 | 0 | 0.70 | 0.36 | -0.33 | hold |
| 5AM Venture Management, LLC | 3,630,724 | 3,630,724 | 0 | 0.90 | 0.47 | -0.43 | hold |
| New Leaf Venture Partners, L.L.C. | 3,301,603 | 3,301,603 | 0 | 4.78 | 2.11 | -2.67 | hold |
| TPG GP A, LLC | 3,028,414 | 3,028,414 | 0 | 0.04 | 0.05 | +0.01 | hold |
| Pivotal bioVenture Partners Investment Advisor LLC | 2,404,644 | 2,404,644 | 0 | 1.26 | 0.50 | -0.76 | hold |
| FMR LLC | 1,785,218 | 1,870,276 | +85,058 | 0.00 | 0.00 | -0.00 | buy |
| Almitas Capital LLC | 1,300,581 | 1,817,492 | +516,911 | 0.28 | 0.15 | -0.13 | buy |
| Aberdeen Group plc | 1,727,067 | 1,595,262 | -131,805 | 0.00 | 0.00 | -0.00 | sell |
| Canaan Partners XI LLC | 1,532,552 | 940,984 | -591,568 | 1.51 | 0.19 | -1.33 | sell |
| VANGUARD GROUP INC | 971,927 | 909,941 | -61,986 | 0.00 | 0.00 | -0.00 | sell |
| AJU IB Investment Co., Ltd. | 754,678 | 754,678 | 0 | 0.59 | 0.28 | -0.31 | hold |
| Laurion Capital Management LP | 735,543 | 735,543 | 0 | 0.04 | 0.03 | -0.01 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 396,500 | 485,032 | +88,532 | 0.00 | 0.00 | -0.00 | buy |
| Mariner, LLC | 404,546 | 404,546 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 247,552 | 245,009 | -2,543 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 227,230 | 179,839 | -47,391 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 209,419 | 154,648 | -54,771 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 90,247 | 90,247 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TWO SIGMA ADVISERS, LP | 91,020 | 88,900 | -2,120 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 66,711 | 63,786 | -2,925 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 62,072 | 62,072 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Virtu Financial LLC | 0 | 56,762 | +56,762 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 55,479 | +55,479 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 38,124 | 38,124 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HRT FINANCIAL LP | 0 | 29,607 | +29,607 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 15,390 | 15,390 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TWO SIGMA SECURITIES, LLC | 0 | 15,153 | +15,153 | 0.00 | 0.00 | +0.00 | buy |
| GREAT VALLEY ADVISOR GROUP, INC. | 15,000 | 15,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Utah Retirement Systems | 13,240 | 13,240 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HSBC HOLDINGS PLC | 12,054 | 10,520 | -1,534 | 0.00 | 0.00 | -0.00 | sell |
| CAPTRUST FINANCIAL ADVISORS | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MERCER GLOBAL ADVISORS INC /ADV | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Tower Research Capital LLC (TRC) | 5,191 | 7,341 | +2,150 | 0.00 | 0.00 | -0.00 | buy |
| Hartford Financial Management Inc. | 6,500 | 6,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SBI Securities Co., Ltd. | 4,488 | 4,448 | -40 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 2,209 | 2,209 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 983 | 983 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Allworth Financial LP | 0 | 50 | +50 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 91,600 | 0 | -91,600 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 33,270 | 0 | -33,270 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 10,007 | 0 | -10,007 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 13,400 | 0 | -13,400 | 0.00 | 0.00 | -0.00 | sell |
| Allostery Investments LP | 752,235 | 0 | -752,235 | 0.71 | 0.00 | -0.71 | sell |
| Point72 (DIFC) Ltd | 975 | 0 | -975 | 0.00 | 0.00 | -0.00 | sell |