| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Almitas Capital LLC | 100,876 | 875,434 | +774,558 | 0.06 | 0.36 | +0.31 | buy |
| VANGUARD GROUP INC | 857,896 | 925,521 | +67,625 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 24,500 | 91,600 | +67,100 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 340,700 | 403,700 | +63,000 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 53,253 | 86,324 | +33,071 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 2,290,058 | 2,315,480 | +25,422 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 220,006 | 244,986 | +24,980 | 0.00 | 0.00 | -0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 67,695 | 90,247 | +22,552 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 14,649 | +14,649 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 37,800 | 50,300 | +12,500 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 11,200 | 13,300 | +2,100 | 0.00 | 0.00 | -0.00 | buy |
| FEDERATED HERMES, INC. | 6,217 | 7,964 | +1,747 | 0.00 | 0.00 | +0.00 | buy |
| VIKING GLOBAL INVESTORS LP | 4,194,777 | 4,194,777 | 0 | 0.02 | 0.02 | -0.00 | hold |
| HARBOURVEST PARTNERS LLC | 21,877 | 21,877 | 0 | 0.02 | 0.01 | -0.00 | hold |
| Hartford Financial Management Inc. | 6,500 | 6,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Utah Retirement Systems | 13,240 | 13,240 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Northeast Financial Consultants Inc | 22,088 | 22,088 | 0 | 0.00 | 0.00 | -0.00 | hold |
| New Leaf Venture Partners, L.L.C. | 3,301,603 | 3,301,603 | 0 | 5.38 | 3.97 | -1.41 | hold |
| Aberdeen Group plc | 1,727,067 | 1,727,067 | 0 | 0.00 | 0.00 | -0.00 | hold |
| 5AM Venture Management, LLC | 3,630,724 | 3,630,724 | 0 | 1.09 | 0.88 | -0.21 | hold |
| Pivotal bioVenture Partners Investment Advisor LLC | 2,404,644 | 2,404,644 | 0 | 2.48 | 1.67 | -0.81 | hold |
| Catalyst Funds Management Pty Ltd | 7,800 | 7,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TPG GP A, LLC | 3,028,414 | 3,028,414 | 0 | 0.06 | 0.06 | -0.00 | hold |
| JOHNSON & JOHNSON | 3,636,363 | 3,636,363 | 0 | 1.22 | 1.00 | -0.22 | hold |
| DIMENSIONAL FUND ADVISORS LP | 21,203 | 21,203 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Mariner, LLC | 405,631 | 405,629 | -2 | 0.00 | 0.00 | -0.00 | sell |
| Farther Finance Advisors, LLC | 9 | 0 | -9 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 25 | 0 | -25 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 36 | 0 | -36 | 0.00 | 0.00 | 0.00 | sell |
| Capital Advisors, Ltd. LLC | 82 | 0 | -82 | 0.00 | 0.00 | 0.00 | sell |
| CAPTRUST FINANCIAL ADVISORS | 10,094 | 10,000 | -94 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 267 | 0 | -267 | 0.00 | 0.00 | -0.00 | sell |
| MACQUARIE GROUP LTD | 1,574 | 0 | -1,574 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 1,822 | 0 | -1,822 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 65,222 | 62,072 | -3,150 | 0.00 | 0.00 | -0.00 | sell |
| HSBC HOLDINGS PLC | 17,531 | 14,078 | -3,453 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 96,200 | 91,600 | -4,600 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 6,390 | 1,049 | -5,341 | 0.00 | 0.00 | -0.00 | sell |
| Point72 (DIFC) Ltd | 13,933 | 8,146 | -5,787 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 13,179 | 3,460 | -9,719 | 0.00 | 0.00 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 10,367 | 0 | -10,367 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 10,372 | 0 | -10,372 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 26,539 | 15,390 | -11,149 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 31,917 | 18,364 | -13,553 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 13,800 | 0 | -13,800 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 16,270 | 0 | -16,270 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 18,800 | 0 | -18,800 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 20,751 | 55 | -20,696 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 45,531 | 22,119 | -23,412 | 0.01 | 0.00 | -0.01 | sell |
| HRT FINANCIAL LP | 24,971 | 0 | -24,971 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 54,201 | 10,664 | -43,537 | 0.00 | 0.00 | -0.00 | sell |
| Laurion Capital Management LP | 783,391 | 735,543 | -47,848 | 0.03 | 0.06 | +0.02 | sell |
| Centiva Capital, LP | 71,700 | 0 | -71,700 | 0.00 | 0.00 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 94,484 | 0 | -94,484 | 0.01 | 0.00 | -0.01 | sell |
| MILLENNIUM MANAGEMENT LLC | 459,966 | 342,944 | -117,022 | 0.00 | 0.00 | -0.00 | sell |
| Canaan Partners XI LLC | 2,059,712 | 1,910,987 | -148,725 | 3.34 | 1.89 | -1.45 | sell |
| NORTHERN TRUST CORP | 228,915 | 60,942 | -167,973 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 181,202 | 0 | -181,202 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 280,000 | 0 | -280,000 | 0.00 | 0.00 | -0.00 | sell |