| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VIKING GLOBAL INVESTORS LP | 4,194,777 | 4,194,777 | 0 | 0.00 | 0.01 | +0.00 | hold |
| JOHNSON & JOHNSON | 3,636,363 | 3,636,363 | 0 | 0.36 | 0.36 | -0.00 | hold |
| 5AM Venture Management, LLC | 3,630,724 | 3,630,724 | 0 | 0.47 | 0.66 | +0.19 | hold |
| New Leaf Venture Partners, L.L.C. | 3,301,603 | 3,301,603 | 0 | 2.11 | 3.83 | +1.72 | hold |
| TPG GP A, LLC | 3,028,414 | 3,028,414 | 0 | 0.05 | 0.08 | +0.03 | hold |
| Pivotal bioVenture Partners Investment Advisor LLC | 2,404,644 | 2,404,644 | 0 | 0.50 | 0.69 | +0.19 | hold |
| FMR LLC | 1,870,276 | 1,694,388 | -175,888 | 0.00 | 0.00 | +0.00 | sell |
| Almitas Capital LLC | 1,817,492 | 1,538,727 | -278,765 | 0.15 | 0.18 | +0.02 | sell |
| VANGUARD GROUP INC | 909,941 | 999,627 | +89,686 | 0.00 | 0.00 | +0.00 | buy |
| AJU IB Investment Co., Ltd. | 754,678 | 754,678 | 0 | 0.28 | 0.33 | +0.05 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 485,032 | 714,800 | +229,768 | 0.00 | 0.00 | +0.00 | buy |
| Canaan Partners XI LLC | 940,984 | 450,000 | -490,984 | 0.19 | 0.22 | +0.03 | sell |
| Mariner, LLC | 404,546 | 404,546 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 245,009 | 245,009 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BlackRock, Inc. | 154,648 | 141,663 | -12,985 | 0.00 | 0.00 | +0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 90,247 | 90,247 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rangeley Capital, LLC | 0 | 83,007 | +83,007 | 0.00 | 0.04 | +0.04 | buy |
| STATE STREET CORP | 62,072 | 62,072 | 0 | 0.00 | 0.00 | +0.00 | hold |
| XTX Topco Ltd | 55,479 | 59,108 | +3,629 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 56,762 | 39,303 | -17,459 | 0.00 | 0.00 | +0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 0 | 38,400 | +38,400 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 38,124 | 38,124 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HRT FINANCIAL LP | 29,607 | 32,224 | +2,617 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 63,786 | 21,453 | -42,333 | 0.00 | 0.00 | -0.00 | sell |
| OneDigital Investment Advisors LLC | 0 | 20,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| GREAT VALLEY ADVISOR GROUP, INC. | 15,000 | 15,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Utah Retirement Systems | 13,240 | 13,240 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Tower Research Capital LLC (TRC) | 7,341 | 10,181 | +2,840 | 0.00 | 0.00 | +0.00 | buy |
| CAPTRUST FINANCIAL ADVISORS | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MERCER GLOBAL ADVISORS INC /ADV | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CITIGROUP INC | 0 | 9,895 | +9,895 | 0.00 | 0.00 | +0.00 | buy |
| Hartford Financial Management Inc. | 6,500 | 6,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BARCLAYS PLC | 15,390 | 5,719 | -9,671 | 0.00 | 0.00 | -0.00 | sell |
| SBI Securities Co., Ltd. | 4,448 | 4,248 | -200 | 0.00 | 0.00 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 983 | 980 | -3 | 0.00 | 0.00 | +0.00 | sell |
| Rockefeller Capital Management L.P. | 0 | 550 | +550 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 50 | 50 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FEDERATED HERMES, INC. | 2,209 | 0 | -2,209 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 179,839 | 0 | -179,839 | 0.00 | 0.00 | -0.00 | sell |
| Laurion Capital Management LP | 735,543 | 0 | -735,543 | 0.03 | 0.00 | -0.03 | sell |
| TWO SIGMA SECURITIES, LLC | 15,153 | 0 | -15,153 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 88,900 | 0 | -88,900 | 0.00 | 0.00 | -0.00 | sell |
| Aberdeen Group plc | 1,595,262 | 0 | -1,595,262 | 0.00 | 0.00 | -0.00 | sell |
| HSBC HOLDINGS PLC | 10,520 | 0 | -10,520 | 0.00 | 0.00 | -0.00 | sell |